Comparison of Efficacy and Safety Outcomes of Different Doses Schedules of Thalidomide for Treating Moderate-to-Severe β-Thalassemia Patients by Yang WJ, Shi LD, Liang Y, Liang LM, Zhang H, Wang L, Zhou Q

“…Wei-Jia Yang,1,* Lian-dong Shi,2,* Ye Liang,3,* Li-ming Liang,4,* Hao Zhang,5 Li Wang,2 Qian Zhou1 1Department of Eugenics and Genetics, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China; 2Department of Ultrasound, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China; 3Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, and Institute of Cardiovascular Diseases, Guangxi Academy of Medical Sciences, Nanning, 530000, People’s Republic of China; 4Department of Genetic Metabolism Center Laboratory, Guilin Women and Children’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541001, People’s Republic of China; 5Department of Pharmacy, Guilin People’s Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei-Jia Yang, Department of Eugenics and Genetics, Guilin People’s Hospital, No. 12 of Wenming Road, Xiangshan District, Guilin, Guangxi Zhuang Autonomous Region, 541002, People’s Republic of China, Tel +86 18977300052, Fax +86 07732881579, Email weijiayangywj@126.comObjective: In this study, we evaluated the effectiveness and safety of thalidomide by clinically observing 48 individuals with β-thalassemia who have been administered thalidomide in small and medium doses over a period of two years.Methods: Thalidomide’s efficacy was gauged by tracking hemoglobin (Hb) level alterations post its administration. Liver and kidney function impact was measured through tests for alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, and creatinine. …”
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The Effect of Vitamin E, &Bgr;-Carotene, and Acidophilus Probiotics on The Salivary Gland Flow Rate in Streptozotocin-Induced Diabetes in Rats: An in-vivo Study by Felemban MF, Bin Mubayrik AF, Alotaibi O

“…Data were analyzed using SPSS.Results: There was a significant reduction in SFR after diabetes induction (pre-diabetes: M=1.1 mL, SD=0.42; post-diabetes: M=0.6 mL, SD=0.24; t=12.925, p=0.000). …”
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Survival outcomes and prognostic factors of breast cancer spinal metastases: a retrospective study by Panpan Hu, Xin Wu, Yan Li, Feng Wei, Shengxin Zeng, Yu Xiao, Xiaoguang Liu, Zhongjun Liu

“…Postoperatively, both pain and neurological function significantly improved (P < 0.05). Radiotherapy, endocrine therapy, chemotherapy/targeted therapy were given to 56.4%, 60.3%, 61.5% patients, respectively. …”
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Online Attentive Kernel-Based Off-Policy Temporal Difference Learning by Shangdong Yang, Shuaiqiang Zhang, Xingguo Chen

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NATURAL MINERAL WATER ENRICHED WITH MAGNESIUM IN CHILDREN WITH CONSTIPATIONS by I. N. Zakharova, L. I. Elezova, L. L. Stepunina, L. A. Kataeva, N. A. Shmakov, I. B. Lagadze

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Polyethylene Insert Wear Leading to Early Aseptic Bilateral Total Knee Arthroplasty Failure: Case Report by Vishwajit Patil, Neeraj Adkar, Mangesh Patil, Ravi Kerhalkar, Prajwal Sadlagi, Narendra Nagle

“…Case Report: A 69-year-old patient with unusual presentation of bilateral TKA (Exactech, Hiflex) failure 6 years post-surgery due to polyethylene wear. Three months following surgery, the patient had no complications and had satisfactory radiological, pain, and functional outcomes. …”
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Development and validation of a CT-based multi-omics nomogram for predicting hospital discharge outcomes following mechanical thrombectomy by Feifan Liu, Jiayi Hong, Yuhan Chen, Huan Liu, Yue Wang, Lijian Su, Sheng Hu, Jingjing Fu

“…Our nomogram significantly outperformed clinical, radiomics, and DTL models, as well as physician assessments (senior physicians: 0.693, p = 0.001; junior physicians: 0.600, p &lt; 0.001).ConclusionThis multi-omics nomogram, integrating HIM-derived, clinical, radiomic, and DTL features, accurately predicts post-MT discharge outcomes, enabling early identification of high-risk patients and optimizing management to improve prognosis.…”
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The Effect of Mental Rotation Training on the Balance and Falling of the Elderly Women with Physical Training Method by Mohammad Taghi Aghdasi, Seyed Hojjat Zamani Sani, Saba Mohammad Alinezhad, Sahand Eslami, Fatemeh Farrokhzad 5

“…Method: The present study is a quasi-experimental study with a pre-test, post-test and two-way ANOVA, which is also t-test designed. …”
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Survivorship in robotic total knee arthroplasty compared with conventional total knee arthroplasty: A systematic review and meta-analysis by Jiawei Chen, Ryan Wai Keong Loke, Katelyn Kaye-Ling Lim, Barry Wei Loong Tan

“…Secondary outcomes included associated complications, post-operative pain scores, and functional outcomes. …”
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Effectiveness of transitional care interventions in patients with serious illness and their caregivers: a systematic review and metanalysis of randomized controlled trial by Marco Di Nitto, Angela Durante, Gabriele Caggianelli, Jacopo Fiorini, Silvia Sferrazza, Kusumam Pampoorickel, Roberto Accettone, Dhurata Ivziku, Daniela D’Angelo

“…Primary outcomes included mortality and/or survival, symptoms, functional status, caregiver burden, and health-related quality of life. …”
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Effect of sarcopenia combined with Metabolic Syndrome (MS) on the prognosis of intertrochanteric fractures: a retrospective clinical study by Cheng Zhang, Ding Wang, Xitao Wu, Qinrui Zhang, Lei Chen, Junzhe Lang, Congcong Wu

“…Comprehensive preoperative screening for sarcopenia and MS, coupled with tailored nutritional support and early rehabilitation, is critical to mitigate complications and improve functional recovery. These findings advocate for integrated care protocols targeting metabolic-musculoskeletal health in geriatric fracture management.…”
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Effects of two types of repetitive transcranial magnetic stimulation on brain network in Parkinson’s disease by Shuo Liu, Shuo Yang, Chen Wang, Jiarui Li, Lei Wang

“…This study demonstrates that compared to 10Hz-rTMS, iTBS can reduce treatment time while providing superior improvement in functional brain connectivity for PD patients.…”
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Effect of yoga and counselling on mental health issues among adolescents in an urban slum of Mumbai: An Interventional Study by Kinjal Chauhan, ,Sanjay Panchal, ,Vinay Kumar, ,Vandana Kashyap

“… ABSTRACT Mental health problems in young people is associated with suffering, functional impairment, exposure to stigma, discrimination, and enhanced risk of premature death. …”
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Hair cell regeneration after ATOH1 gene therapy in the cochlea of profoundly deaf adult guinea pigs. by Patrick J Atkinson, Andrew K Wise, Brianna O Flynn, Bryony A Nayagam, Rachael T Richardson

“…Collectively, these data suggest that, whilst ATOH1 alone can drive non-sensory cells towards an immature sensory hair cell phenotype in the mature cochlea, this does not result in functional improvements after aminoglycoside-induced deafness.…”
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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…Background For people receiving haemodialysis, a balance has to be struck between removing sufficient but not too much fluid during a treatment session and maintaining any remaining kidney function they might have. In the BISTRO trial, this study sought to establish if getting the balance right might be improved by the additional use of bioimpedance, a device that measures body fluid composition to help decide how much fluid to remove during dialysis. …”
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Cystoscopic Local Application of Mitomycin-C following Internal Urethrotomy for Recurrent Short Urethral Strictures in Children: A Preliminary Experience by Simmi K. Ratan, Nitesh Kumar Sharma, Gaurav Saxena, Sujoy Neogi

“…The time interval for re-intervention increased by 4–6 weeks, and on subsequent cystoscopic examinations at different time intervals, the urethral lumen was far much better (70%–80% improvement). The mean post-MtMC I-PSS score was 11 (moderate). …”
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Gallic Acid Bacteriostatic Activity and Mechanism Against Vibrio alginolyticus by Chunyuan WANG, Yingeng WANG, Weizhi ZHAO, Yongxiang YU, Zheng ZHANG, Xiaojun RONG, Dingyuan LIU

“…GA has good antibacterial, antiviral, anti-inflammatory, and antioxidative properties and can protect the liver and improve the immunological function of the body, thus it may be used to treat and prevent multiple animal diseases.Although GA has antibacterial effects on various bacteria, the bacteriostatic activity and possible mechanism against V. alginolyticus remains unelucidated. …”
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Initial Treatment of Meningocele and Myelomeningocele Lesion in Children by Ammar Anwer, Naveed Ahmad Khan, Obaid Ur Rehman, Javaria Siddiq, Abrar Ullah Khan

“…Group E showed fewer cases of hydrocephalus (62%) and smaller thoracic lumbar lesions were excluded from comparisons due to its unique profile assessed on days 3-4 post-birth. Conclusion: Early surgical intervention within the first 24 hours post-birth significantly improves survival and functional outcomes in children with MMC compared to delayed treatment or conservative management. …”
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Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury by Beibei Yu, Yongfeng Zhang, Yujie Yang, Shijie Yang, Haining Wu, Xue Gao, Yiming Hao, Shengyou Li, Bing Xia, Jintao Liu, Lingli Guo, Borui Xue, Mingze Qin, Huangtao Chen, Jianzhong Li, Shouping Gong, Teng Ma, Jinghui Huang

“…Here, we identified neonatal mice with balanced PCD post-SCI as an ideal model for adult SCI. Accordingly, we developed “Thanatoset”, an SCI-specific gene panel to map tissue and cellular pan-PCD dynamics across neonatal and adult mice. …”
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High-Precision Time Delay Estimation Algorithm Based on Generalized Quadratic Cross-Correlation by Menghao Sun, Ziang Niu, Xuzhen Zhu, Zijia Huang

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