Investigation of customized total knee implant with articular cartilage under loading conditions using finite element analysis. by Shady A Alshewaier, Mohamed Yacin Sikkandar, Ali Ahmed Ali Almakrami, S Sabarunisha Begum, Ahmad Alassaf, Ibrahim AlMohimeed, S Meenatchi Sundaram, Dheeraj Poojary, Natteri M Sudharsan, Eddie Y K Ng

“…This study offers a promising pathway toward reducing post-surgical discomfort. The proposed innovative solution has the potential to revolutionize total knee implant technology, offering enhanced functionality and improved patient outcomes for the Saudi Arabian population.…”
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Impact of cardiac rehabilitation on anxiety, depression, and health-related quality of life in cardiovascular patients by Estrella García-Sánchez, Mirian Santamaría-Peláez, Jerónimo J. González-Bernal, Josefa González-Santos, María Azucena Sedano García, Inmaculada De Juana Velasco, Jesús Sánchez Hernández, Héctor García Pardo, Jessica Fernández-Solana

“…Data were collected pre- and post-intervention. Statistical analyses included paired t tests for pre/post-comparisons and ANCOVA to evaluate the impact of initial anxiety and depression on health-related quality of life improvements. …”
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AERIFY-1/2: two phase 3, randomised, controlled trials of itepekimab in former smokers with moderate-to-severe COPD by Klaus F. Rabe, Fernando J. Martinez, Surya P. Bhatt, Tomotaka Kawayama, Borja G. Cosio, Robert M. Mroz, Maarten M. Boomsma, Helene Goulaouic, Michael C. Nivens, Michel Djandji, Xavier Soler, Ying Liu, Matthew P. Kosloski, Christine R. Xu, Nikhil Amin, Heribert Staudinger, David J. Lederer, Raolat M. Abdulai

“…In a phase 2 study, itepekimab, a human monoclonal antibody against IL-33, reduced exacerbations and improved lung function in a subgroup analysis of former smokers with COPD with an acceptable safety profile. …”
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Impact of Tacrolimus, Sirolimus, Age, and Body Mass Index on the Occurrence of Skin Cancer and Islet Dysfunction After Transplantation by Christopher Orr, Jeannette Stratton, Mohamed El-Shahawy, Elena Forouhar, Alice Peng, Gagandeep Singh, Keiko Omori, Meirigeng Qi, Fouad Kandeel

“…Results suggest that strategies targeting immunosuppression ratios based on age and BMI may minimize cancer risk while improving graft survival and function.…”
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Long-term effects of forest growth dynamics and climate change on groundwater recharge and evapotranspiration in a steep catchment of western Japan by Rendilicha Halake Guyo, Kunyang Wang, Shin-ichi Onodera, Mitsuyo Saito, Toshitsugu Moroizumi

“…In this study, forest growth trends, reflecting the complete developmental stages from juvenile to post-maturity of a representative species, were reconstructed using remote sensing data, forest inventories, and field studies, and incorporated into the SWAT model to evaluate their impacts on groundwater recharge and evapotranspiration as indicators of forest hydrological function and ecosystem health. …”
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Nicotinamide Riboside: A Promising Treatment for Type 1 Cardiorenal Syndrome in Myocardial Infarction‐Induced Acute Kidney Injury by Upregulating Nicotinamide Phosphoribosyltransfe... by Nada J. Habeichi, Ghadir Amin, Solene Boitard, Cynthia Tannous, Rana Ghali, Iman Momken, Reine Diab, George W. Booz, Mathias Mericskay, Fouad A. Zouein

“…Our findings showed no significant improvement in cardiac ejection fraction following NR treatment at days 4 and 7 post‐MI, whereas kidney functions were enhanced and morphological alterations and cell death decreased. …”
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Lung‐delivered IL‐10 mitigates Lung inflammation induced by repeated endotoxin exposures in male mice by Aaron D. Schwab, Todd A. Wyatt, Oliver W. Schanze, Amy J. Nelson, Angela M. Gleason, Michael J. Duryee, Deanna D. Mosley, Geoffrey M. Thiele, Ted R. Mikuls, Jill A. Poole

“…Lung function testing and longitudinal in vivo micro‐CT imaging were performed. …”
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Bone marrow mesenchymal stem cells modulate miR-202-3p to suppress neuronal apoptosis following spinal cord injury through autophagy activation via the AMPK, MAPK, and PI3K/AKT/mTO... by Ke Huang, Jing Fang, Weiming Sun, Yujia Zeng, Bowen Shi, Bingkai Ren, Haidi Bi, Lang Shuai

“…Collectively, our findings demonstrate that BMMSCs coordinate miR-202-3p to inhibit mTOR activation via the AMPK, MAPK, and PI3K/AKT pathways, thereby promoting TFEB dephosphorylation, modulating autophagy and neuronal apoptosis, and ultimately fostering functional recovery post-SCI.…”
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Individualized transcranial temporal interference stimulation (tTIS) for cognitive impairments and negative symptoms in patients with schizophrenia: a study protocol for a randomiz... by Shuzhe Wang, Junhao Chen, Linxuan Wang, Jingxuan Liu, Lijun Wang, Wenjie Sun, Shen Li, Jie Li

“…We hypothesize that participants receiving active tTIS will demonstrate significantly greater improvements in cognitive function and negative symptoms compared to those receiving sham stimulation. …”
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Social Determinants of Health‐Related Outcomes in an Intervention Following Initial Implantable Cardioverter‐Defibrillator Implantation by Megan M. Streur, Jonathan P. Auld, Wei‐Lun Chang, Fatemeh Choupani, Tao Zheng, Elizabeth Frazier, Ana Carolina Sauer Liberato, Kenneth C. Pike, Elaine A. Thompson, Cynthia M. Dougherty

“…Methods This secondary analysis used data from a comparative effectiveness randomized controlled trial of a post‐ICD patient intervention. Participants were followed for 1 year, and outcomes included ICD shocks, hospitalizations, death, physical function, psychological adjustment, and self‐efficacy. …”
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MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosis by Debmalya Mitra, Gabriel K. Armijo, Elizabeth H. Ober, Shenda M. Baker, Helen C. Turner, Constantinos G. Broustas

“…We show that MIIST305 improved intestinal epithelial barrier function and suppressed systemic inflammatory responses mediated by radiation-induced pro-inflammatory cytokines. …”
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Effect of transpedicular screw fixation on bone metabolism and clinical efficacy in thoracolumbar fractures by DU Kunyang, LIU Tao, ZHU Zhenjun

“…Conclusions In the treatment of thoracolumbar fractures, compared with the cross-pedicle screw fixation method, the transpedicular screw fixation method has an early stimulating effect on bone metabolism indicators, speeds up healing of fractures and has more advantages in maintaining spinal correction and improving spinal function.…”
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A probiotic and mixed-enzymes combination reduces the inflammatory response, faecal shedding and systemic spread of Campylobacter jejuni in broilers by K. Gibbs, L. Lacharme-Lora, Y. Dersjant-Li, C. Evans, P. Wigley

“…Achieving a favourable balance between the gut, immune function, microbiome and nutrition should be the goal for achieving good gastrointestinal health and optimal performance.…”
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Nanoantibiotics: A Tool Against Antimicrobial Resistance by Wasim Alamgir, Adnan Haider

“…Studies have shown that in contrast to free antibiotics, tailored functionalized nanoparticles and small antibiotic molecules have improved binding affinities and target specificity.6 Currently, these nanotechnology-based solutions have reported some problems like cytotoxicity, targeted selectivity, and bulk production. …”
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Energy efficient gateway based routing with maximized node coverage in a UAV assisted wireless sensor network. by Bilal Ahmad, Masroor Ahmed, Nadeem Anjum, Masood Ur Rehman, Naeem Ramzan

“…Ad-hoc wireless sensor networks face challenges of optimized node deployment for maximizing coverage and efficiently routing data to control centers in post disaster events. These challenges impact the outcome for extending the lifetime of wireless sensor networks. …”
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Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation by Joohyun Kim, MD, PhD, Michael T. Zimmermann, PhD, Angela J. Mathison, PhD, Gwen Lomberk, PhD, Raul Urrutia, MD, Johnny C. Hong, MD

“…Data were generated and then recipients grouped by post-OLT outcomes categories: immediate allograft function (IAF; n = 11) versus early allograft dysfunction (EAD; n = 6) groups. …”
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High-intensity resistance and impact training for patients with hormone-sensitive prostate cancer and bone metastases—study protocol of a randomized clinical trial by Anne-Mette Ragle, Marta Kramer Mikkelsen, Anders Vinther, Bo Zerahn, Carsten Bogh Juhl, Susann Theile, Kasper Madsen, Dorte Lisbet Nielsen, Peter Busch Østergren

“…Data will be collected at baseline, midway intervention (16 weeks), post-intervention (32 weeks), and follow-up (44 weeks). …”
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Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways by Duozi Wang, Jianhong Wang, Binghu Li, Shu Yang, Fuqiang Guo, Bo Zheng, Jian Wang

“…Results TZP treatment significantly improved neurological scores and reduced BBB permeability in MCAO mice. …”
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MODERN VIEWS ON PATHOGENETIC THERAPY OF RHEUMATOID ARTHRITIS by D. G. Rekalov, A. V. Kulynych, S. I. Svistun, E. V. Presnyakova

“…Highlights the key issues debatedinitial-and post-treatment of RA. Conclusion. …”
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Prediction of 12-month exacerbation-related readmission in hospitalized patients with COPD: a single-center study in China by Cong Zhang, Wenhao Ling, He Pan, Hongxia Tan, Li He

“…Abstract Background Patients with chronic obstructive pulmonary disease (COPD) who are hospitalized multiple times for exacerbations face substantially worse clinical outcomes, including higher mortality, faster lung function decline, and reduced quality of life. Identifying these high-risk individuals is essential for early intervention and improved disease management. …”
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