Organelle symphony: Nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in stroke pathobiology by Ziliang Hu, Mingyue Zhao, Hangyu Shen, Liangzhe Wei, Jie Sun, Xiang Gao, Yi Huang

“…It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function, endoplasmic reticulum stress, and lysosomal activity and regulating metabolic pathways and cytokine expression. …”
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Rapid and Efficient Synthesis of Succinated Thiol Compounds via Maleic Anhydride Derivatization by Hiroshi Yamaguchi, Hikari Sugawa, Himeno Takahashi, Ryoji Nagai

“…Succination is a non-enzymatic post-translational modification of cysteine (Cys) residues, resulting in the formation of <i>S</i>-(2-succino)cysteine (2SC). …”
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Carcinoma of unknown primary presenting as an apoplectic pituitary adenoma with suprasellar extension: a case report by Syeda Maria Ahmad Zaidi, Haissan Iftikhar, Shahzada Ahmed

“…In view of the unknown origin of the primary tumour, the patient received radiotherapy to the pituitary fossa, and was kept on surveillance for five years. His visual function improved, and he remained stable post treatment. …”
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Rewiring the seizing brain: stem cell grafts as neuromodulatory architects in epilepsy therapy by Zijie Wang, Yanan Ma, Xiqi Hu, Ying Xia

“…Recent studies have indicated that stem cell transplantation improves neurological function in epilepsy through multiple mechanisms. …”
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Paravalvular Leak by Fatima Qamar, Rowa H. Attar, Faisal Nabi

“…Despite improvements and advancements in surgical technique, paravalvular leaks (PVL) continue to present a challenge when caring for patients with prosthetic valve disease.1 Paravalvular leaks result from dehiscence of the surgical ring from the mitral annulus. …”
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The effect of transcranial random noise stimulation on the movement time and components of noise, co-variation, and tolerance in a perceptual-motor task by Fatemeh Salehi, Mohammadreza Doustan, Esmaeel Saemi

“…In addition, tRNS improved the function of the sensorimotor wave (p ≤ 0.05). …”
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L-arginine Supplementation in Endurance Athletes: A Systematic Review of Recovery Mechanisms and Performance Enhancement by Łukasz Karoń, Anna Ewa Zygmunt, Karolina Karoń, Wojciech Grabowski, Grzegorz Drapała, Emilia Pedrycz, Daria Pedrycz

“…Recognized for its multifaceted roles in cardiovascular, immune, and metabolic functions, L-arginine serves as a precursor to biologically active molecules, including nitric oxide (NO), creatine, and polyamines, which are integral to muscle function and recovery. …”
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Specifics of Epidural Compression Syndrome Surgery in Patients with Spinal Malignancy by O. I. Kit, D. E. Zakondyrin, E. E. Rostorguev, S. V. Yundin

“…A Karnofsky performance status was statistically improved post- vs. pre-surgery (p &lt; 0.05) at no significant change of Frankel neurological function status (p &gt; 0.05). …”
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Assessing the Use of 3D-Model Prostheses in White Storks: A Promising Method in Rehabilitation of Injured Wildlife by Rusko Petrov, Catarina Quinteira, Stefka Dimitrova

“…This work presents the development of 3D-printed orthopedic prostheses aimed at partially restoring biomechanical function and enabling the reintegration of amputated birds into their natural habitat. …”
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Evaluation of patient satisfaction and masticatory performance in mandible single implant-assisted overdenture by Swati Kashyap, Sanjeev Mittal, Navneet Sharma, Urvashi Sukhija, Mohit Kamra, Nitika Gupta

“…It insinuates the remarkable improvement of prosthesis function and oral comfort with minor surgical procedures.…”
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Neuroimaging insights into recent suicide attempters utilizing the raven task. by Morteza Fattahi, Milad Esmaeil-Zadeh, Hamid Soltanian-Zadeh, Nafee Rasouli, Niloofar Fallahinia, Amirhossein Jafari Mehdi Abad, Reza Khosrowabadi, Seyed Kazem Malakouti

“…<h4>Background</h4>Understanding brain function in individuals who have recently attempted suicide is critical for improving diagnosis and treatment strategies. …”
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Positive Collaboration in Rehabilitation Nursing Enhances Fall Efficacy and Confidence in Elderly Patients with Cerebral Infarction by Luo F, Xu W, Xu Y, Lou L, Xu C

“…The observation group also had greater improvements in ADL, SS-QOL, and rehabilitation confidence, with higher patient satisfaction (90.57% vs 71.70%, P&lt; 0.05).Conclusion: Positive collaboration rehabilitation nursing significantly improves neurological function, emotional well-being, fall efficacy, and quality of life in elderly patients with cerebral infarction. …”
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Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction by Zhaoyang Lu, Quanyou Chai, Wenbin Dai, Bo Yu, Qingbo Lv, Fuyu Qiu, Jing Gao, Juhong Zhang, Xiaohua Shen, Shengyu Chen, Zhida Shen, Min Shang, Wenbin Zhang, Guosheng Fu, Qiao Jin, Yanbo Zhao, Fan Jia

“…Meanwhile the antioxidant byproduct 4-hydroxybenzyl alcohol further scavenges the overwhelming ROS, reducing the production of RNS and improving the bioavailability of NO. The CTP-PBA-ISN efficiently inhibited myocardial apoptosis, improved myocardial function, and ameliorated adverse cardiac remodeling post-MI in mice by relief of oxidative stress, promotion of angiogenesis and restoration of mitochondrial homeostasis and function. …”
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Robotic ileal ureter replacement for panureteral stricture disease: a step-by-step guide by Emily Ji, Devin Boehm, Jonathan Rosenfeld, Rebecca Arteaga, Jaewoo Kim, Aidan Raikar, Ziho Lee

“…No patients developed electrolyte abnormalities from urine reabsorption that required medical treatment (Table 1).Table 1 Pre and postoperative imaging findings.Table 1PatientEtiologyLaterality, severityPreoperative ImagingPostoperative imagingPre/Post creatinineF/u (mo)1Iatrogenic, stone surgeryL, 7 cm obliterated proximalCT mild L hydro with PCN, Renal scan 47 % functionRenal scan (28mo PO), no obstruction, mild hydro (54 % function)1.54/1.47282Iatrogenic, stone surgeryL, obliterated panureteralCT no hydro with PCNRenal scan (20mo PO), no obstruction, no hydro, (39 % function)0.7/0.8203Iatrogenic, stone surgeryR, obliterated panureteralCT no hydro with PCNRBUS (27mo PO), moderate R hydro, endoscopic evaluation without obstruction2.04/1.90274TraumaR, obliterated panureteralCT no hydro with PCN, 35 % functionCT (20mo PO), no hydro0.74/0.84205Iatrogenic, stone surgeryL, 11 cm obliteratedCT severe L hydroRBUS (18mo PO), no hydro1.78/1.85206Iatrogenic/malignant, UTUCR, failed prior Boari with urinary extravasationCT moderate R hydroRBUS (13mo PO) no hydro, Renal scan no obstruction (67 % function), cancer recurrence in contralateral kidney1.45/2.16157Iatrogenic, stone surgeryR, complete ureteral avulsionCT moderate R hydro with PCNCT (4mo PO) stable R hydro, no obstruction on endoscopic evaluation0.69/0.6148Iatrogenic, stone surgery failed prior repairL, 14 cm narrowingCT moderate L hydro with ureteral stentCT (3mo PO) improved L hydro, Renal scan no obstruction, 82 % function (found to have obstructing stone in contralateral kidney)0.99/1.393UTUC = upper tract urothelial carcinoma, L = left, R = right, cm=centimeters, PO = postoperative, PCN = percutaneous nephrostomy, hydro=hydronephrosis, CT = computed tompgraphy, mo= months, RBUS = renal bladder ultrasound. …”
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Total hip arthroplasty for crowe type IV developmental dysplasia of the hip using a dual mobility acetabular cup by Skender Ukaj, Shaip Krasniqi, Dren Ukaj, Fatime Dervishaj, Dea Dyla, Sefedin Muçaj, Bernard Tahirbegolli

“…Using dual mobility acetabular components and compression in the osteotomy led to improved outcomes and faster recovery. It can restore the anatomic hip center and improve functional outcomes while reducing the risk of dislocation.…”
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Optimized approach to surgical treatment of wound surfaces by O. V. Ponomarenko, V. I. Pertsov

“…Treatment of traumatic defects and chronic venous ulcers is one of the persistent problems of medical science. Objective. To improve outcomes of patients with wounds, traumatic, functional and aesthetic defects by developing a comprehensive program of surgery to restore form and functions of the body. …”
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Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study by Dabin Yun, Jung-Ho Yang, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Sun-Seog Kweon, Nan Song

“…The two-stage GWAS revealed statistically significant associations among MKLN1 (rs75170436, 7q32.3, beta (log odds ratio) = − 0.90, P meta  = 5.90 × 10–13), MMP14 (rs3751489, 14q11.2, beta (log odds ratio) = − 1.91, P meta  = 2.31 × 10–12). Post-GWAS functional analysis revealed strong associations on two genes highlighting deleterious effects and increased gene expression. …”
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Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence by Mengyu Liu, Hanfei Zhu, Xiaowei Zhou, Jingru Duan, Yuhong Shen, Aijun Zhang

“…In our previous study, CEFFE successfully improved ovarian function in mice without adverse effects; however whether it can prevent DOR remains unclear. …”
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Long term clinical outcomes of minimally invasive transforaminal interbody fusion (MIS-TLIF) for lumbar spondylolisthesis in a geriatric (>65 years) population: a systematic review... by Talgat Kerimbayev, Yerzhan Kuanyshbekov, Serik Akshulakov, Indira Karibayeva

“…The findings suggest that MIS-TLIF is associated with significant reductions in back and leg pain, as well as improvements in disability scores over 12 months post-operatively. …”
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Management of Isolated Medial Gutter Ankle Arthritis with Lateralizing Calcaneal Osteotomy and Allograft Lateral Ligament Reconstruction by Morgan Motsay BS, Meghan Hughes MD, Clifford Jeng MD

“…This combined approach yields significant improvement on patient-reported pain, overall functional status, and radiographic outcomes, such as tibiotalar tilt and clear space ratio. …”
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