Novel transferrin receptor-mediated enzyme replacement therapy efficiently treats myogenic and neurogenic aspects of Pompe disease in mice by Kelly George, Raquel Riley, Shan Zhou, Elizabeth Allen, Laurie Smith, Elena Kistanova, Sofia Kinton, Lilu Guo, Dinesh Bangari, Ayman Ismail, Jayaprakash Thummapudi, Fawzi Boumezbeur, Erwan Selingue, Dorothée Tamarelle, Cecile Capdevila, Tuan-Minh Do, Dominique Lesuisse, Nina Leksa, Pablo Sardi, Arjan van der Flier

“…These data support the theory that the neurogenic and myogenic manifestations of PD can be effectively treated by anti-TfR-GAA.…”
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Chronic exposure to GLP-1 increases GLP-1 synthesis and release in a pancreatic alpha cell line (α-TC1): evidence of a direct effect of GLP-1 on pancreatic alpha cells. by Salvatore Piro, Loriana G Mascali, Francesca Urbano, Agnese Filippello, Roberta Malaguarnera, Salvatore Calanna, Agata M Rabuazzo, Francesco Purrello

“…It is still unclear how the resulting high hormone concentrations may affect pancreatic alpha cells. The present study was designed to investigate the effects of chronic exposure to high GLP-1 levels on a cultured pancreatic alpha cell line.…”
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Effect of potent nucleos(t)ide analog on alpha fetoprotein changes and occurrence of hepatocellular carcinoma in patients with chronic hepatitis B by Qianqian Ma, Junzhao Ye, Ling Luo, Yanhong Sun, Wei Wang, Shiting Feng, Bing Liao, Bihui Zhong

“…However, it is unclear whether different antiviral medications have varying effects on AFP levels. The purpose of this study was to evaluate this issue in those treated with entecavir (ETV) versus tenofovir disoproxil fumarate (TDF). …”
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Effects of soybean isoflavone on mRNA expression of ER-alpha, NGF, IL-2 and AR in cerebellum of ovariectomized rat by CHEN Zheng-li, ZHU Chun-mei, LUO Qi-hui, PAN Kang-cheng

“…To observe the direct accommodation and effect of different dosage soybean isoflavone on the cerebellum of ovariectomized rat, the expression and distribution of estrogen receptor alpha (ER α), nerve growth factor (NGF), interleukin-2 (IL-2) and androgen receptor (AR) mRNA in the cerebellum was studied by establishing the model of ovariectomized rat and using in situ hybridization technique. …”
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α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

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Exploring Salvia miltiorrhiza’s Therapeutic Effects on Adenomyosis by Inhibiting TNF-α/HIF-1α/IL-17-Driven Inflammatory Cascade: Mechanistic Insights... by Yang Q, Hong J, Zheng X, Liu X, Lin H, Chen L, Zhong F, Zhang Q, Jiang J, Sun P

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Antifibrotic effects of eupatilin on TGF-β1-treated human vocal fold fibroblasts. by Sung Joon Park, Hyunsu Choi, Ji Heon Kim, Choung-Soo Kim

“…However, until recently, few studies investigated the therapeutic effects of eupatilin. We investigated the antifibrogenic effects of eupatilin on TGF-β1-treated human vocal fold fibroblasts (hVFFs). …”
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The Effect of Alpha Mangostin on The Expression of TGF-β1, SMAD3, Type I Collagen, Proliferation and Migration of Keloid Fibroblasts by Ennesta Asri, Rina Gustia, Indah Indria Sari, Jefrizal Wirman, Yufaz Aidi Mahesa

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Enhanced engraftment and immunomodulatory effects of integrin alpha-2-overexpressing mesenchymal stromal cells in lipopolysaccharide-induced acute lung injury by Hana Kang, Ok-Hyeon Kim, Eun Seo Chang, Jinho Kim, Ji-Young Kim, Geun-Seup Shin, Chul-Hong Kim, Younghyun Lim, Young-Jin Seo, Jung-Woong Kim, Hyun Jung Lee

“…Accordingly, MSCs are primed to boost their therapeutic efficacy for treating a variety of diseases. In our previous study, we discovered that culturing MSCs in a functional polymer-based 3D niche, which simulates the in vivo microenvironment, significantly increased integrin alpha 2 (ITGA2) expression compared to traditional 2D cultures, as revealed by RNA-seq analysis. …”
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Effect of anti-tumor necrosis factor alpha therapy on bone health and biomarkers of bone turnover in Indian patients with ankylosing spondylitis by Shefali Khanna Sharma, Sandeep Mohanan, Surender K Sharma

“…Background: We evaluated the relationship between bone mineral density (BMD) and biomarkers of bone turnover in ankylosing spondylitis (AS) patients treated with anti-tumor necrosis factor alpha (TNF-α) agents. …”
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Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferon by Patrícia Alessandra Dastoli, Jardel Mendonça Nicácio, Nasjla Saba Silva, Andrea Maria Capellano, Silvia R.C. Toledo, Daniela Ierardi, Sérgio Cavalheiro

“…OBJECTIVE: To assess whether the cystic craniopharyngiomas can be controlled with the use of intratumoral applications of interferon alpha. METHOD: Nineteen patients with the diagnosis of cystic craniopharyngioma were treated with intratumoral chemotherapy with interferon alpha from January 2002 to April 2006. …”
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Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome by Franca Fruzzetti, Elena Benelli, Tiziana Fidecicchi, Massimo Tonacchera

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Anti-inflammatory, analgesic, antioxidant, and alpha-amylase inhibitory effects of the hydroethanolic leaf extract of Aleuritopteris bicolor (Roxb.) Fraser-Jenk. by Prabhat Kumar Jha, Bipindra Pandey, Ram Kishor Yadav, K C Sindhu, Sandesh Poudel, Sushil Panta

“…Fraser-Jenk. is used in traditional medicine in Nepal to treat a variety of ailments. This study aimed to investigate qualitative phytochemical screening, quantitative phytochemical analysis (total phenolic and flavonoid content estimation), in vitro antioxidant activity, alpha-amylase inhibitory activity of Aleuritopteris bicolor (Roxb.) …”
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Cytotoxic Effect of 6-Ethyl-Chenodeoxycholic Acid and Cabazitaxel on PC-3 Cells by M. H. Zalzala, W. S. Al-khfajy, R. A. Khaleel

“…On the other hand, Cabazitaxel's therapeutic success is constrained by chemoresistance and side effects.Aim. To assess whether 6 alpha-ethylchenodeoxycholic acid (6-ECDCA), a selective agonist for bile acid receptors will enhance the efficacy of CBZ in androgen-independent prostate cancer cells.Materials and methods. …”
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Effects of Treatment with Temsirolimus versus Interferon Alpha on Survival of Patients with Metastatic Renal Cell Carcinoma – Single-Center Real-World Experience by Ivan Levakov, Saša Vojinov, Miloš Maletin, Dimitrije Jeremić, Mladen Popov, Olivera Levakov, Dragan Grbić

“…In conclusion, temsirolimus therapy had a significantly positive effect on survival in patients with mRCC. Patients treated with temsirolimus showed significantly longer median survival and median PFS compared to patients treated with IFN-alpha.…”
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Tumor necrosis factor-α-treated human adipose-derived stem cells enhance inherent radiation tolerance and alleviate in vivo radiation-induced capsular contracture by Chanutchamon Sutthiwanjampa, Seung Hyun Kang, Mi Kyung Kim, Jin Hwa Choi, Han Koo Kim, Soo Hyun Woo, Tae Hui Bae, Woo Joo Kim, Shin Hyuk Kang, Hansoo Park

“…The influence of tumor necrosis factor-alpha (TNF-α) on ADSCs has been reported to enhance the paracrine effect of ADSCs, promoting wound healing by modulating inflammatory responses. …”
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Effects of Spent Mushroom Substrate Treated with Plant Growth-Promoting Rhizobacteria on Blueberry Growth and Soil Quality by Mengjiao Wang, Desheng Sun, Zhimin Xu

“…Alpha diversity index analysis revealed significant differences in microbial diversity between the PGPR-treated substrates and the control. …”
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Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and Central Tumor Necrosis Factor Alpha in Rats with Depression-Chronic Somatic Pain Comorbidity by Xiao Guo, Yuanyuan Zhao, Feng Huang, Shaoyuan Li, Man Luo, Yu Wang, Jinling Zhang, Liang Li, Yue Zhang, Yue Jiao, Bin Zhao, Junying Wang, Hong Meng, Zhangjin Zhang, Peijing Rong

“…In this study, we investigated the effects of acupuncture on blood and brain regional tumor necrosis factor alpha (TNF-α) in rats with depression and chronic somatic pain comorbidity. …”
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Glutathione's Antioxidant Effects and Its Ability to Shield Mice's Hepatocytes From Damage Caused by Furan by Ibrahim, M. Ibrahim, Hend, M. Saleh, Alshaimaa, M. Hamouda

“…Furan is commonly found in several kinds of heat-treated foods, the existence of furan in food causes public health issues. …”
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Effects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials by Han-Chien Hsueh, Guan-Ru Ho, Shiang I. Tzeng, Kai-Hsiang Liang, Yi-Shiung Horng

“…Conclusion Curcumin led to a decrease in the serum CRP and TNF-alpha levels in patients with knee OA. Additional large-scale studies or even synovial fluid analyses are recommended to further evaluate the effects of curcumin on proinflammatory biomarkers in patients with knee OA.…”
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