Optimization extraction process of Shenghua Decoction and evaluation of its analgesic effects by Zhonghui Pu, Lijuan Chen, Huaidan Liu, Jingzhu Deng, Li Li, Liang Xiong, Liuying Li

“…However, there has been no study published, to date, reporting the preparation process and analgesic effects of SHD. This study aimed to optimize the high-content SHD production process and investigate its analgesic activity. …”
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Optimized framework for evaluating F3 transgressive segregants in cayenne pepper by Ifayanti Ridwan, Muh Farid, Feranita Haring, Nuniek Widiayani, Ahmad Yani, Nirwansyah Amier, Muhammad Alfan Ikhlasul Amal, Jekvy Hendra, Nawab Ali, Mekhled M. Alenazi, Mahmoud F. Seleiman, Willy Bayuardi Suwarno, Muhammad Fuad Anshori

“…Therefore, a systematic evaluation framework integrating morphometric analysis, categorical assessment, and environmental correction is essential for optimizing F3 cayenne transgressive segregants. The study aims to develop a synchronized assessment and selection approach based on agronomic, fruit morphometric, and categorical traits in evaluating F3 cayenne transgressive segregants. …”
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Optimization of the Statin Therapy Algorithm in Outpatient Practice: Adherence and Economic Benefits by S. A. Davitashvili, D. V. Nebieridze, N. M. Akhmedzhanov, A. S. Lishuta, A. S. Safaryan

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Optimal Discharge Education: Evidence for Enhancing Family Preparedness for Premature Infants by Zhang L, He J, Zhou Y, Li X

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Optimization Process of Compound Probiotic Fermented Feed and Feeding Effect on Shrimp by Guotao ZHANG, Xin YU, Luqing PAN

“…This study focused on optimizing the process conditions of compound probiotic fermented feed by orthogonal experiments and investigating the effects on growth performance, digestion, and immunity function of P. vannamei fed with fermented feeds, with the aim of improving the nutritional performance of the compound feed and establishing a fermentation technology for shrimp feed. …”
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Many-Objective Truss Structural Optimization Considering Dynamic and Stability Behaviors by João Marcos P. Vieira, José Pedro G. Carvalho, Dênis E. C. Vargas, Érica C. R. Carvalho, Patrícia H. Hallak, Afonso C. C. Lemonge

“…This paper aims to propose seven innovative many-objective structural optimization problems (MOSOPs) applied to 25-, 56-, 72-, 120-, and 582-bar trusses, not yet presented in the literature, in which the main objectives, in addition to the structure’s weight, refer to the structures’ vibrational and stability aspects. …”
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Esketamine Optimized the Efficacy of Dexmedetomidine in Treating Sleep Disorders with Comorbid Depression by Ding Y, Wang Z, Huang J, Yi Y, Wu Z

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The Optimization of Stand Structure Can Significantly Alleviate the Flammability of Forest Ecosystems by Yan Zhang, Xiangwen Deng, Xiaoyong He, Xiaolong Zhang, Zhihong Huang, Liang Chen, Shuai Ouyang, Wenhua Xiang

“…ABSTRACT The accurate classification of forest fuels and the evaluation of the flammability of different forest types are crucial for effective forest fire control and classification management. We aimed to evaluate and classify the flammability of surface forest fuels in the subtropical area of China. …”
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AI-Driven Predictive Maintenance for Workforce and Service Optimization in the Automotive Sector by Şenda Yıldırım, Ahmet Deniz Yücekaya, Mustafa Hekimoğlu, Meltem Ucal, Mehmet Nafiz Aydin, İrem Kalafat

“…This study contributes to ongoing research on AI-driven workforce planning and service optimization, particularly within the scope of the AI4LABOUR project.…”
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Analysis and optimization experimental study on the influence of bolt end shape on eccentricity by Biao HOU, Wenjun JU, Zhen ZHANG, Xiaowei CHU, Kun PAN, Yinwei WANG, Hongzhi YANG

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The role of big data analysis for resources optimization of immunization programmes in Pakistan by Abdul Raheem Rizvie, Muhammed Ifham Imtiyas, Abdul Thawwab Ishaque

“…Despite recovery efforts, a substantial number of children globally remain under-vaccinated, with 14.3 million zero-dose children in 2022.[1] South Asia, primarily India, has shown notable progress, exceeding pre-pandemic coverage levels.[2] In Pakistan, the Expanded Programme on Immunization (EPI) launched in 1978 aims to combat high under-five mortality rates due to vaccine-preventable diseases.[3] However, vaccine coverage remains suboptimal, with only 66% of children aged 12-23 months receiving basic EPI vaccines.[3] This is compounded by reduced doses administered later in schedules, influenced by limited access, awareness gaps, and insufficient vaccinators, especially in rural areas. [3] Big data analytics can help tackle challenges, improve resource allocation, and optimize immunization in Pakistan. …”
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Optimizing cadaveric models for endovascular training through effective preparation techniques by Christopher Ibarra, MD, Alex D. Contreras, MS, Samantha Cervantes, MS, Rebecca Barnes, MBS, Stuart J. Corr, PhD, Alan B. Lumsden, MD, Maham Rahimi, MD

“…Prior models have been created, and our institutional experience highlights the foundation of these techniques, whereas future studies will aim to test these models in trainees.…”
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Optimal Targeted Temperature Management for Patients with Post-Cardiac Arrest Syndrome by Tsukasa Yagi, Eizo Tachibana, Wataru Atsumi, Keiichiro Kuronuma, Kazuki Iso, Satoshi Hayashida, Shonosuke Sugai, Yusuke Sasa, Yoshikuni Shoji, Satoshi Kunimoto, Shigemasa Tani, Naoya Matsumoto, Yasuo Okumura

“…This study aimed to clarify the optimal targeted core temperature and cooling duration, selected according to the time interval from collapse to return of spontaneous circulation (ROSC) in patients with PCAS due to cardiac etiology. …”
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Optimizing carbohydrate quality: a path to better health for women with PCOS by Li Zhang, Yuxin Jin, Aili Yang, Xinwen Yu, Yi Li, Xin Wang, Chunni Heng, Biao Qi, Bin Gao, Guohong Zhao, Guohong Zhao, Guohong Zhao

“…High-fiber and LGI diets increased Sex Hormone-Binding Globulin (SHBG) and reduced Free androgen index (FAI).DiscussionThis meta-analysis highlights the significant benefits of optimizing dietary carbohydrate quality on glycolipid metabolism, sex hormone levels, and weight in women with PCOS. …”
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Optimal Indocyanine Green Dosage for Repetitive Angiography for Laparoscopic Colorectal Surgery by Gyung Mo Son, Sang-Ho Park, Nam Su Kim, Mi Sook Yun, In Young Lee, Myeong-Sook Kwon, Tae Kyun Kim, Eun Hwa Lee, Eun Jung Hwang, Kwang-Ryul Baek

“…<i>Background and Objectives</i>: This study aimed to determine the minimal effective dose of indocyanine green (ICG) required for accurately assessing colonic perfusion during laparoscopic colorectal surgery using a laser-assisted laparoscopic near-infrared (NIR) camera system. …”
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Optimizing the design of a pediatric blood pump through orthogonal experimentation by Kaiyun Gu, Kaiyue Yang, Changlong Zhao, Qiang Shu, Ru Lin

“…Background: Pediatric heart failure patients weighing less than 30 kg are prioritized for small axial flow blood pumps due to their smaller body size. This study aims to optimize the blade design of pediatric axial flow blood pumps by conducting orthogonal experiments on blade parameters and integrating hydraulic experiments with hemodynamic numerical simulations, so as to improve the hydraulic performance of pediatric blood pumps while reducing blood damage. …”
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Optimal group and individual prenatal care visit patterns and preterm birth by Moonseong Heo, Jessica L. Britt, Lu Zhang, Emily A. Doherty, Amy H. Crockett

“…The impacts of participant engagement patterns with prenatal care on preterm birth (PTB) are not clearly understood. We aimed to characterize prenatal care visit patterns, examine their associations with PTB, and provide optimal cutoffs for care patterns. …”
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Zinc nutrition optimization for better cotton productivity on alkaline calcareous soil by M. Ashraf, F. Qamar, M. Mehran, S. Masood, S. M. Shahzad, M. S. Javed, M. T. Azhar

“…Crop species and varieties within species differently require Zn for optimum productivity. The current study aimed to optimize Zn level and mode of application for better growth, yield, and fiber quality of cotton (Gossypium hirsutum L.). …”
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Optimal immunotherapy duration in advanced NSCLC: defining the ideal treatment window by Kaibo Ding, Dujiang Liu, Xinyue Li, Zhongsheng Peng, Lin Zhu, Yanjun Xu

“…Objective: Immune checkpoint inhibitors (ICIs) have demonstrated substantial efficacy in patients with advanced non-small cell lung cancer (NSCLC). However, the optimal duration of ICI therapy remains unclear, and limited real-world data are available. …”
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Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy by Xuemei Li, Xuemei Li, Xuemei Li, Xuemei Li, Xuemei Li, Chao Xiong, Chao Xiong, Chao Xiong, Chao Xiong, Chao Xiong, Siyi Wang, Siyi Wang, Siyi Wang, Zhangjun Ren, Zhangjun Ren, Zhangjun Ren, Qi Jin, Qi Jin, Qi Jin, Jinhai Yu, Jinhai Yu, Jinhai Yu, Jinhai Yu, Jinhai Yu, Yunxiu Chen, Yunxiu Chen, Yunxiu Chen, Puying Gan, Puying Gan, Puying Gan, Puying Gan, Qihua Xu, Qihua Xu, Qihua Xu, Qihua Xu, Qihua Xu, Yaohua Wang, Yaohua Wang, Yaohua Wang, Yaohua Wang, Yaohua Wang, Hongfei Liao, Hongfei Liao, Hongfei Liao, Hongfei Liao, Hongfei Liao

“…Ferroptosis is a form of programmed cell death driven by the accumulation of reactive oxygen species (ROS), iron metabolism disorder, and lipid peroxidation. This study aims to identify and validate the optimal feature genes (OFGs) of ferroptosis with diagnostic and therapeutic potential in TAO orbital adipose tissue through bioinformatics analysis and to assess their correlation with disease-related immune cell infiltration.MethodsSearch of the Gene Expression Omnibus database for TAO-related gene datasets led to the selection of GSE58331 for differential gene expression analysis. …”
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