Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…The additional primary aim was to propose recommendations to solve or improve the limitations found. …”
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Genome-Wide Identification and Expression Analysis of the HSP90 Gene Family in Relation to Developmental and Abiotic Stress in Ginger (<i>Zingiber officinale</i> Roscoe) by Daoyan Xiao, Yajun Jiang, Zhaofei Wang, Xingyue Li, Hui Li, Shihao Tang, Jiling Zhang, Maoqin Xia, Meixia Zhang, Xingfeng Deng, Hong-Lei Li, Huanfang Liu

“…This suggests that the HSP90 gene family in ginger possesses both conserved functions and species-specific adaptations to optimize stress responses. Overall, this research provides valuable insights into the molecular functions of the HSP90 gene family in ginger and lays the groundwork for future studies aimed at enhancing crop resilience through genetic engineering. …”
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Shorter versus longer-duration antibiotic treatments for immunocompetent patients with bloodstream infections: a systematic review and meta-analysisResearch in context by Ming Liu, Ya Gao, Li Zheng, Zhifan Li, Liang Yao, Jianguo Xu, Qingyong Zheng, Ping Zeng, Jinhui Tian

“…Summary: Background: The optimal duration of antibiotic treatment for bloodstream infections remains uncertain. …”
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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

“…However, there are no commercially available NCM cell lines, nor is there a detailed protocol for developing an oncogene-mutated CM line (MutCM) to study UM development. This study aimed to establish and characterize premalignant CM models from human donor eyes to recapitulate the cell populations at the origin of UM. …”
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Serum 1,5-Anhydroglucitol to Glycated Albumin Ratio Can Help Early Distinguish Fulminant Type 1 Diabetes Mellitus from Newly Onset Type 1A Diabetes Mellitus by Lingwen Ying, Xiaojing Ma, Yun Shen, Jingyi Lu, Wei Lu, Wei Zhu, Yufei Wang, Yuqian Bao, Jian Zhou

“…AGI can help facilitate the early differential diagnosis of FT1DM and T1ADM when HbA1c<8.7%, with an optimal cut-off point of 0.3.…”
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Histogram analysis based on DTI and NODDI for differentiating atypical high-grade glioma from primary central nervous system lymphoma by Shanshan Zhao, Shanshan Zhao, Xiaoyue Ma, Xiaoyue Ma, Linlin Li, Eryuan Gao, Eryuan Gao, Kai Zhao, Kai Zhao, Mengzhu Wang, Guang Yang, Hongbin Zheng, Jingliang Cheng, Jingliang Cheng, Guohua Zhao, Guohua Zhao

“…The 75th percentile of the orientation dispersion index (ODI75th) within the enhancing tumor region demonstrated the highest diagnostic performance (AUC = 0.985). At an optimal threshold of 0.604, ODI75th yielded a sensitivity of 96%, a specificity of 93.33%, and an accuracy of 94.55% for distinguishing HGG from PCNSL.ConclusionDTI-and NODDI-based histogram analysis demonstrates the potential to differentiate between atypical HGG and PCNSL. …”
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Objective measurement methods for the evaluation of socket comfort in patients with transfemoral amputation: a systematic review by Lisa Marie Tiesler, Lisa Marie Tiesler, Melanie Edel, Melanie Edel, Fangxing Wang, Fangxing Wang, Philipp Pieroh, Welf-Guntram Drossel, Welf-Guntram Drossel, Alina Carabello, Alina Carabello, Daniel Zipplies, Christoph-Eckhard Heyde, Stefan Schleifenbaum, Stefan Schleifenbaum, Stefan Schleifenbaum

“…ObjectiveAchieving optimal fitting for the socket-limb interface in transfemoral amputees remains a significant challenge. …”
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Longitudinal assessment of changes in muscle composition using proton density fat fraction and T2* in patients with and without incidental vertebral compression fractures by Yannick Stohldreier, Yannik Leonhardt, Jannik Ketschau, Florian T. Gassert, Marcus R. Makowski, Jan S. Kirschke, Georg C. Feuerriegel, Philipp Braun, Benedikt J. Schwaiger, Dimitrios C. Karampinos, Nina Hesse, Alexandra S. Gersing, Alexandra S. Gersing

“…ROC analyses identified a PDFF increase of 0.2% in the PSM as the optimal cutoff value to distinguish between patients with and without VCF (AUC 0.86, 95% CI [0.74-0.98], p&lt;0.001).ConclusionLongitudinal PDFF-based assessment of the PSM composition may be a useful indicator for the prediction of the development of vertebral compression fractures.…”
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Self-monitoring of blood pressure following a stroke or transient ischaemic attack (TASMIN5S): a randomised controlled trial by R. J. McManus, A. Smith, E. Temple, L. M. Yu, J. Allen, R. Doogue, G. A. Ford, L. Glynn, B. Guthrie, P. Hall, L. Hinton, F. D. R. Hobbs, J. Mant, B. McKinstry, G. Mead, K. Morton, T. Rai, C. Rice, C. Roman, A. Stoddart, L. Tarassenko, C. Velardo, M. Williams, L. Yardley, on behalf of the TASMIN5S investigators

“…Abstract Background Blood pressure (BP) control following stroke is important but currently sub-optimal. This trial aimed to determine whether self-monitoring of hypertension with telemonitoring and a treatment escalation protocol, results in lower BP than usual care in people with previous stroke or transient ischaemic attack (TIA). …”
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HESS Opinions: Towards a common vision for the future of hydrological observatories by P. Nasta, G. Blöschl, G. Blöschl, H. R. Bogena, S. Zacharias, R. Baatz, G. De Lannoy, K. H. Jensen, S. Manfreda, L. Pfister, L. Pfister, A. M. Tarquis, I. van Meerveld, M. Voltz, Y. Zeng, W. Kustas, X. Li, H. Vereecken, N. Romano

“…Recently, some initiatives have emerged that aim to coordinate data acquisition and hypothesis<span id="page466"/> testing to facilitate an efficient cross-site synthesis of findings. …”
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Effect of different light qualities on photosynthetic characteristics and fruit quality of Shine Muscat grapevines grown under rain-sheltered cultivation by GONG Xiaomin, YU Guanghui, LI Xiujie, WANG Rong, CHEN Guangxia, WU Yusen, WU Xinying, ZHANG Zhichang, LI Bo, MA Yujiao

“…This study investigated the impacts of varied light qualities spectra on the ecophysiological responses of Shine Muscat (Vitis labrusca × V. vinifera), with emphasis on foliar morpho-anatomical adaptations, stem elongation dynamics, photosynthetic performance indices, fruit biochemical profiles and flower bud differentiation. The findings aim to establish a theoretical basis and practical guidance for optimizing supplementary lighting strategies under facility cultivation. …”
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Evidence and Gap Map of Whole‐School Interventions Promoting Mental Health and Preventing Risk Behaviours in Adolescence: Programme Component Mapping Within the Health‐Promoting Sc... by Roshini Balasooriya Lekamge, Ria Jain, Jenny Sheen, Pravik Solanki, Yida Zhou, Lorena Romero, Margaret M. Barry, Leo Chen, Md Nazmul Karim, Dragan Ilic

“…This facilitates identification of critical evidence gaps in need of research, with the aim of fostering optimal translation of the Framework into practice to promote mental health and prevent risk behaviours in adolescence. …”
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Reduction of Ascites Susceptibility in Broiler Chickens under Cold Stress by Guanidinoacetic Acid Supplementation by Mousa Ezatikia, parviz Farhoomand, Sina Payvastegan, Bahram Pirooz, Negin Delfani

“…However, the level of arginine required for optimal growth is not sufficient for the activity of macrophages and the pulmonary vascular epithelium to produce maximum nitric oxide (Khajali and Wideman, 2010). …”
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Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT by Lucy Thompson, Jessica Tanner, Matthew Breckons, Naomi Young, Laura Ternent, Thenmalar Vadiveloo, Philip Wilson, Danny Wight, Louise Marryat, Iain McGowan, Graeme MacLennan, Angus MacBeth, James McTaggart, Tim Allison, John Norrie

“…Baseline, follow-up and process evaluation data were analysed to allow optimal learning from the study. Direct communication (letter) combined with health visitor referral was a better means of recruitment. …”
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Identifying the Dimensions and Components of Virtual Arabic Language Education in Iraq by Abbas Taher Allavi Gharabat, Nasrolah Ghashghaeizadeh, Jalal Shanta Jabir, Faranak mosavi

“…Abstract The aim of this study is to identify the dimensions and components of virtual Arabic language education in Iraq. …”
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Community versus academic hospital community-acquired pneumonia patients: a nested cohort study by Jennifer L.Y. Tsang, Kian Rego, Alexandra Binnie, Terry Lee, Anne Mccarthy, Juthaporn Cowan, Patrick Archambault, Francois Lellouche, Alexis F. Turgeon, Jennifer Yoon, Francois Lamontagne, Allison Mcgeer, Josh Douglas, Peter Daley, Robert Fowler, David M. Maslove, Brent W. Winston, Todd C. Lee, Karen C. Tran, Matthew P. Cheng, Donald C. Vinh, John H. Boyd, Keith R. Walley, Joel Singer, John C. Marshall, Gregory Haljan, Fagun Jain, James A. Russell, For CAPTIVATE Investigators

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Comparison of in vitro antimicrobial susceptibility between mucoid and non-mucoid Pseudomonas aeruginosa and its guiding value for antibiotic therapy by Yun Wu, Aixin Wang, Jinghan Qu, Ruirui Ma, Wei Kang, Yali Liu, Yingchun Xu

“…ABSTRACT The aim of the study was to compare in vitro antimicrobial susceptibility between mucoid and non-mucoid Pseudomonas aeruginosa and its guiding value for antibiotic therapy. …”
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Evaluation criteria of centralization options in the architecture of multicomputer systems with traps and baits by Antonina Kashtalian, Sergii Lysenko, Anatoliy Sachenko, Bohdan Savenko, Oleg Savenko, Andrii Nicheporuk

“…Significant deviations in specific time intervals are addressed to achieve optimal centralization options.…”
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Minimum Effective Concentration of Ropivacaine for Ultrasound-Guided RISS Block in VATS: A Biased Coin Design Approach by Li P, Yang Z, Zhang L, Wu R, Zhu M, Xie J

“…The rhomboid intercostal and sub-serratus (RISS) block is effective in providing analgesia. This study aims to determine the minimum effective concentration (MEC) of ropivacaine for ultrasound-guided RISS block in patients undergoing VATS, thereby optimizing the analgesia protocol and enhancing its clinical significance.Methods: The biased coin design sequential method and isotonic regression were used. …”
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Multifactorial Risk Stratification in Patients with Heart Failure, Chronic Kidney Disease, and Atrial Fibrillation: A Comprehensive Analysis by Mihai Sorin Iacob, Nilima Rajpal Kundnani, Abhinav Sharma, Vlad Meche, Paul Ciobotaru, Ovidiu Bedreag, Dorel Sandesc, Simona Ruxanda Dragan, Marius Papurica, Livia Claudia Stanga

“…Personalized, integrated approaches are essential to optimize anticoagulation, reduce hospitalization, and improve prognosis.…”
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