A novel, rapid, and practical prognostic model for sepsis patients based on dysregulated immune cell lactylation by Chang Li, Mei He, PeiChi Shi, Lu Yao, XiangZhi Fang, XueFeng Li, QiLan Li, XiaoBo Yang, JiQian Xu, You Shang, You Shang

“…The proposed individualized prognostic model, based on dysregulated immune cell metabolism, accurately predicts early mortality and may inform optimized clinical management of septic patients.…”
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Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T by Kexin Wang, Licheng Ju, Guanda Qiao, Yajie Liang, Yihan Wu, Chengyan Chu, Joshua Rogers, Yuguo Li, Suyi Cao, Valina L. Dawson, Ted M Dawson, Piotr Walczak, Jiadi Xu

“…This study aims to investigate the variations in guanidino (Guan), amine and amide chemical exchange saturation transfer (CEST) contrasts in ischemic stroke using permanent middle cerebral artery occlusion (pMCAO) and transient MCAO (tMCAO) models at high (9.4T) and clinical (3T) MRI fields. …”
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Educación Física en Casa de Calidad. Propuesta de aplicación curricular en Educación Secundaria Obligatoria (Quality Physical Education at Home. Curricular implementation proposal... by Rafael Burgueño, Alberto Bonet-Medina, Álvaro Cerván-Cantón, Rubén Espejo, Francisco Borja Fernández-Berguillo, Felipe Gordo-Ruiz, Hugo Linares-Martínez, Samuel Montenegro-Lozano, Natalia Ordoñez-Tejero, Juan José Vergara-Luque, Francisco Javier Gil-Espinosa

“…Therefore, this study aims at showing a didactic proposal that, based on Middle Secondary School Physical Education curriculum, promotes adolescents’ physical activity at home. …”
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Outcomes within 100 days of hematopoietic cell transplantation in pediatric patients: insights from an intensive care unit in Colombia by Rubén E. Lasso-Palomino, Rubén E. Lasso-Palomino, Diego Medina, Diego Medina, Alexis Antonio Franco, Alexis Antonio Franco, María José Soto-Aparicio, Eliana Manzi Tarapues, Eliana Manzi Tarapues, Diana Marcela Muñoz, Edgar Salazar, Jhon López, Angela Devia, Sofía Martínez-Betancur, Jimena Sierra, Anita V. Arias, Inés Elvira Gómez, Inés Elvira Gómez

“…These results underscore the importance of early risk factor identification and targeted interventions to optimize patient outcomes.…”
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Long COVID-19 alters muscle architecture and muscle-tendon force transmission: a one-year longitudinal study by Leandro Gomes de Jesus Ferreira, Leandro Gomes de Jesus Ferreira, Isabella da Silva Almeida, Isabella da Silva Almeida, Rochelle Rocha Costa, Gabrielle Vieira Roriz, Gabrielle Vieira Roriz, Jeam Marcel Geremia, João Luiz Quagliotti Durigan, João Luiz Quagliotti Durigan, Rita de Cássia Marqueti, Rita de Cássia Marqueti

“…Long COVID-19 rehabilitation and exercise physiologists should prioritize quadriceps strengthening strategies to restore muscle architecture and optimize force transmission.…”
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Mosquitocidal efficacy and pharmacokinetics of single-dose ivermectin versus three-day dose regimen for malaria vector control compared with albendazole and no treatment: An open-l... by Yvonne Kamau, Mercy Tuwei, Caroline Wanjiku, Kelly Ominde, Mwanajuma Ngama, Jonathan Karisa, Lawrence Babu, Martha Muturi, Mwaganyuma Mwatasa, Jane Adetifa, Charlotte Kern, Urs Duthaler, Felix Hammann, Regina Rabinovich, Carlos Chaccour, Marta Ferreira Maia

“…However, questions remain regarding the optimal dosing. This study aimed to compare the mosquitocidal effect and pharmacokinetics of two-dose regimens of ivermectin for malaria vector control. …”
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Fermented black soldier fly larvae as a sustainable replacement for marine fish in Asian swamp eel diets by Yifan Xiang, Shaoqi Gao, Yanhui Luo, Gaojian Tang, Xiuwei Zou, Kai Xie, Wenjie Niu, Xinyi Li, Junan Xiang, Ling Zhang, Zhu Tan, Xiaoyu Zeng, Bo Wang

“…Background and Aim: Fermented black soldier fly larvae (BSFL) have emerged as a sustainable and economically viable protein source in aquaculture. …”
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Performance of fasting plasma glucose for community-based screening of undiagnosed diabetes and pre-diabetes in sub-Saharan Africa by Assefa Mulu Baye, Assefa Mulu Baye, Teferi Gedif Fenta, Suvi Karuranga, Ifeyinwa Dorothy Nnakenyi, Ekenechukwu Esther Young, Colin Palmer, Ewan R. Pearson, Ifeoma Isabella Ulasi, Ifeoma Isabella Ulasi, Adem Y. Dawed

“…IntroductionEarly diabetes screening is critical in sub-Saharan Africa (SSA), where the prevalence is increasing, yet a large proportion of cases remain undiagnosed. This study aimed to evaluate the performance of fasting plasma glucose (FPG) in screening diabetes and/or prediabetes compared to the 2-hour plasma glucose (2-h PG)-level in SSA.MethodsData from a population-based, cross-sectional diabetes screening survey involving 1550 individuals in Butajira, Ethiopia, and Enugu state, Nigeria were analyzed. …”
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Instantaneous dose rate as a crucial factor in reducing mortality and normal tissue toxicities in murine total-body irradiation: a comparative study of dose rate combinations by Hongyu Zhu, Shihua Liu, Jiaqi Qiu, Ankang Hu, Wanyi Zhou, Jian Wang, Weihang Gu, Yinuo Zhu, Hao Zha, Rong Xiang, Junli Li, Rui Qiu, Chong Zhao, Peng Huang, Xiaowu Deng

“…Understanding these dose rate effects and biological responses are crucial for optimizing radiotherapy strategies and exploring the potential benefits of UHDR irradiation.…”
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Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning by Smita Sahay, Jingran Wen, Daniel R. Scoles, Anton Simeonov, Thomas S. Dexheimer, Ajit Jadhav, Stephen C. Kales, Hongmao Sun, Stefan M. Pulst, Julio C. Facelli, David E. Jones

“…Compounds were clustered based on structural similarity independently for the three models using the SimpleKMeans algorithm into the optimal number of clusters (<i>n</i> = 26). For each model, the maximum response assay values were analyzed, and E values and total rank values were applied. …”
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Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse®... by Marcella Catania, Claudia Battipaglia, Alberto Perego, Erika Salvi, Emanuela Maderna, Federico Angelo Cazzaniga, Paolo M. Rossini, Camillo Marra, Nicola Vanacore, Alberto Redolfi, Daniela Perani, Patrizia Spadin, Maria Cotelli, Stefano Cappa, Naike Caraglia, Pietro Tiraboschi, Fabrizio Tagliavini, Giuseppe Di Fede

“…Food and Drug Administration and the European Medicine Agency makes it necessary to optimize non-invasive and cost-effective tools for the identification of subjects at-risk of developing Alzheimer’s Disease (AD). …”
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Green manure incorporation with nitrogen reduction improves water productivity of spring wheat in arid areas by Bo Yin, Aizhong Yu, Pengfei Wang, Yulong Wang, Yongpan Shang, Dongling Zhang, Yalong Liu, Xiaoneng Pang, Keqiang Jiang, Jianzhe Huo, Feng Wang, Yue Li

“…An appropriate amount of green manure (GM) incorporation with nitrogen (N) reduction can ensure high and stable crop yields, but it remains unclear whether this approach can enhance soil moisture status and optimize water use characteristics. This study aimed to investigate the effects of different amounts of GM incorporation with N reduction on the grain yield and water use characteristics of wheat. …”
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Ribose-5-phosphate metabolism protects E. coli from antibiotic lethality by Tatyana Seregina, Rustem Shakulov, Giulio Quarta, Konstantin Shatalin, Svetlana Sklyarova, Irina Petrushanko, Artemy P. Fedulov, Alexander V. Ivanov, Vladimir Mitkevich, Alexander Makarov, Alexander S. Mironov, Evgeny Nudler

“…However, there is still no clear understanding of which key metabolic nodes are optimal targets to improve the effectiveness of bacterial infection treatment. …”
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Clinical and laboratory predictors of mortality in Staphylococcus aureus bacteremia by Deniz Borcak, Yusuf Emre Ozdemir, Zuhal Yesilbag, Samiha Akkaya, Esra Ensaroglu, Aysegul Inci Sezen, Esra Canbolat Unlu, Fatma Bayrak Erdem, Sevtap Senoglu, Zeynep Cizmeci, Hayat Kumbasar Karaosmanoglu, Kadriye Kart Yasar

“…Abstract This study aimed to describe the epidemiological and clinical features of patients admitted to non-intensive care hospital wards due to Staphylococcus aureus bacteremia (SAB) and to identify predictors of mortality to improve patient outcomes. …”
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The PCOS Phenotypes in Unselected Populations (P-PUP) study: participant clinical features and data harmonization on analysis of individual participant data by Asmamaw Demis Bizuneh, Sylvia Kiconco, Arul Earnest, Mahnaz Bahri Khomami, Raja Ram Dhungana, Ricardo Azziz, Larisa V. Suturina, Xiaomiao Zhao, Alessandra Gambineri, Fahimeh Ramezani Tehrani, Bulent O. Yildiz, Jin Ju Kim, Liangzhi Xu, Christian Chigozie Makwe, Helena J. Teede, Anju E. Joham, Chau Thien Tay

“…Research priorities include enhanced accuracy in defining cut-offs for diagnostic features. Here, we aim to describe participant clinical features and data harmonization in the international PCOS Phenotype in Unselected Populations (P-PUP) study. …”
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Variations in the clinical practice of blood pressure and sedo-analgesia management for intracerebral hemorrhage: a case-based survey of Chinese healthcare workers by Rui Dong, Jianwei Li, Qiming Chen, Jiehua Zhang, Zeli Zhang, Yunxing Cao, Mingbiao Yang, Ming Zhang, Kangyue Lin, Yuan Shi, Xiaopeng Li, Xinyu Du, Wenjin Chen, Fen Li, Hong Yang

“…Therefore, the aim of this study was to investigate the practice patterns and beliefs regarding BP management and sedo-analgesia among Chinese healthcare practitioners through questionnaires. …”
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Impact of three sequential orthogeriatric care models on time to surgery after hip fracture: a retrospective study by Sabine Drevet, Jérôme Tonetti, Pierre Bouzat, Mehdi Boudissa, Jules Greze, Olga Fajfrova, Laure Allan-Pattoglia, Frederic Olive, Magali Bouisse, Bastien Boussat, Catherine Bioteau, Gaetan Gavazzi

“…Monitoring TTS is key to finding the optimal model, but strong professional values and structures are vital.…”
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Harmonization trial on ESR1 testing strategies in ER+/HER2- breast cancer patients: an Italian experience by Francesco Pepe, Gianluca Russo, Konstantinos Venetis, Claudia Scimone, Lucia Palumbo, Mariantonia Nacchio, Domenica di Giovanni, Claudia Sarracino, Ilaria Tomaiuolo, Elisabetta Zulato, Matteo Fassan, Daniela Righi, Giuseppe Perrone, Dario de Biase, Gabriele Casati, Fabio Pagni, Lucia Gullotti, Antonio Rizzo, Alessandro Perez, Antonio Russo, Katia Zavaglia, Gianluca Gragnano, Domenico Cozzolino, Sabrina Alfano, Cristian Scatena, Sara D’andrea, Monica Schiappacassi, Giuseppina Roscigno, Alessia Paganotti, Renzo Boldorini, Francesco Esposito, Pierlorenzo Pallante, Daniela Furlan, Marta Sbaraglia, Angelo Paolo Dei Tos, Giancarlo Troncone, Nicola Fusco, Umberto Malapelle

“…Harmonized ring trials are key weapons to standardize analytical and post-analytical procedures optimizing clinical stratification of BC patients…”
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Consolidation therapy impact on survival outcomes in young patients with intracranial primary diffuse large B-cell lymphoma achieving complete remission: a propensity score matchin... by Ge Wen, Ge Wen, Miao Xiang, Hanyu Wang, Jijin Wang, Han Shao, Jinshan Zhang, Yujing Zhang

“…ObjectivesPrimary central nervous system lymphoma is an extremely aggressive type of non-Hodgkin lymphoma, and there is no consensus regarding the optimal management strategy for this disease. This study aimed to analyze the impact of consolidation therapy among young patients with intracranial primary diffuse large B-cell lymphoma (DLBCL).MethodsThis retrospective study analyzed the clinical data of 55 young patients (age &lt; 60 years) with intracranial primary DLBCL who achieved complete remission (CR) after high-dose methotrexate (HD-MTX)-based chemotherapy from March 2001 to October 2021. …”
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Predicting postoperative neurological outcomes of degenerative cervical myelopathy based on machine learning by Shuai Zhou, Shuai Zhou, Shuai Zhou, Shuai Zhou, Zexiang Liu, Zexiang Liu, Zexiang Liu, Haoge Huang, Haoge Huang, Haoge Huang, Hanxu Xi, Xiao Fan, Xiao Fan, Xiao Fan, Yanbin Zhao, Yanbin Zhao, Yanbin Zhao, Xin Chen, Xin Chen, Xin Chen, Yinze Diao, Yinze Diao, Yinze Diao, Yu Sun, Yu Sun, Yu Sun, Hong Ji, Feifei Zhou, Feifei Zhou, Feifei Zhou

“…After training and optimizing multiple ML algorithms, we generated a model with the highest area under the receiver operating characteristic curve (AUROC) to predict short-term outcomes following DCM surgery. …”
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