Preliminary research indicates that mechanical force through Pioze1 enhances local immunity during NPWT treatment for spinal infections by Hao Xing, Junlin Pan, Huan Liu, Yanan Wang, Zhengqi Chang

“…This study not only provides a molecular biology basis for a deeper understanding of the therapeutic effects of NPWT, but also offers new insights for optimizing treatment strategies for spinal infections.…”
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Comparing Park Table - Augmented and Standard Surgical Doses in Acute Acquired Comitant Esotropia: A Retrospective Analysis by Srimanan W

“…Further research is warranted to identify additional prognostic factors and refine treatment strategies for optimal ACE management.Plain Language Summary: Acquired comitant esotropia (ACE) is a rare eye condition in which one or both eyes suddenly turn inward, often causing double vision. …”
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Clinician Attitudes and Perceptions of Point-of-Care Information Resources and Their Integration Into Electronic Health Records: Qualitative Interview Study by Marlika Marceau, Sevan Dulgarian, Jacob Cambre, Pamela M Garabedian, Mary G Amato, Diane L Seger, Lynn A Volk, Gretchen Purcell Jackson, David W Bates, Ronen Rozenblum, Ania Syrowatka

“…ConclusionsParticipants favored integration to improve usability and optimize workplace efficiency by reducing the amount of time spent seeking answers to their medication- and disease-related questions. …”
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Human immunodeficiency virus/acquired immune deficiency syndrome antiretroviral therapy initiated on the same day in treatment-naïve people with human immunodeficiency virus: A com... by Jing Yuan, Changgang Deng, Qisui Li, Yanyu Sun, Wei Huang, Wei Zhang, Min Liu, Yanjie Yin

“…The study aims to provide a realistic reference for rapid initiation of ART. …”
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Effect of Angiotensin Receptor-neprilysin Inhibitor on Acute Kidney Injury in Patients With Acute Decompensated Heart Failure by Gonghao Li, Yanli Zhao, Zhongxing Peng, Kun Liu, Delu Yin, Yunfeng Zhao

“…The risk of acute kidney injury (AKI) is high in patients with acute decompensated heart failure (ADHF). The aim of this study is to analyze the role of urinary neutrophil gelatinase-associated lipocalin (uNGAL) in diagnosing AKI in patients with ADHF and evaluate the therapeutic effect of angiotensin receptor-neprilysin inhibitor (ARNI) on AKI. …”
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Enhancing Immersion in Virtual Reality–Based Advanced Life Support Training: Randomized Controlled Trial by Dilek Kitapcioglu, Mehmet Emin Aksoy, Arun Ekin Ozkan, Tuba Usseli, Dilan Cabuk Colak, Tugrul Torun

“…Further research should explore ways to optimize AI’s role in education through VR. …”
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O IMPACTO DAS EXPERIÊNCIAS ESTIGMATIZADORAS E AUTOESTIGMA NA SAÚDE MENTAL E NO COMPORTAMENTO SUICIDA: UM ESTUDO EM PAÍSES DE LÍNGUA PORTUGUESA by Henrique Marques Pereira, Mariana Quelhas Marques Coelho

“…Conclusions: Self-stigmatization has a negative impact on mental health and suicidal behavior, and countries should initiate mental health promotion campaigns and suicide prevention campaigns whose central goal should be to optimize people's quality of life…”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…This finding identifies RES as a potentially effective therapeutic agent for inhibiting BC progression and optimizing NK cell-based cancer immunotherapy.…”
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Identifying breast cancer risk factors and evaluating biennial mammography screening efficacy using big data analysis in Taiwan by Chi-Cheng Huang, Tzu-Pin Lu, Yu-Jen Wang, Bo-Fang Chen, Hui-Ting Yang, Wei-Pin Chang, Ling-Ming Tseng

“…Abstract Most evidence and experience with mammography screening originate from Western countries, and the optimal prevention strategy for Taiwanese women remains uncertain. …”
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Conveying Equipoise during Recruitment for Clinical Trials: Qualitative Synthesis of Clinicians' Practices across Six Randomised Controlled Trials. by Leila Rooshenas, Daisy Elliott, Julia Wade, Marcus Jepson, Sangeetha Paramasivan, Sean Strong, Caroline Wilson, David Beard, Jane M Blazeby, Alison Birtle, Alison Halliday, Chris A Rogers, Rob Stein, Jenny L Donovan, ACST-2 study group, By-Band-Sleeve study group, Chemorad study group, CSAW study group, Optima prelim study group, POUT study group

“…Interviews revealed that clinicians' sense of equipoise varied: although all were uncertain about which trial treatment was optimal, they expressed different levels of uncertainty, ranging from complete ambivalence to clear beliefs that one treatment was superior. …”
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Costs and Outcomes of a Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy: Multicenter Observational Study by Zareen Abbas Khan, Jørn Heggelund, Stian Lydersen, Kristian Kidholm, Henrik Pedersen, Imre Janszky, Tine Nordgreen, Vidar Halsteinli

“…The observed variance in costs per patient between hospitals underscores the importance of patient volume to optimize efficient use of resources.…”
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Morphological and pomological variations of Pistacia atlantica Desf. subsp. cabulica and subsp. mutica in Sistan-va-Baluchestan province, Iran by Ali Khadivi, Farhad Mirheidari, Abdolvahid Saeidifar, Younes Moradi, Yazgan Tunç

“…Most accessions showed moderate growth, intermediate vigor, and branching, optimizing photosynthesis. Leaf and petiole traits vary, reflecting adaptations to environmental conditions. …”
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ECG‐based epileptic seizure prediction: Challenges of current data‐driven models by Sotirios Kalousios, Jens Müller, Hongliu Yang, Matthias Eberlein, Ortrud Uckermann, Gabriele Schackert, Witold H. Polanski, Georg Leonhardt

“…Dysregulation in heart rate variability (HRV) has been found to precede epileptic seizures and may serve as an extracerebral predictive biomarker. This study aims to identify the preictal HRV dynamics and unveil the factors impeding the clinical application of ECG‐based seizure prediction. …”
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Decreasing electricity costs of clean room for cell products during non-operation by Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Hisashi Hasebe, Ichiro Sekiya

“…While cost-reduction strategies have been explored in the semiconductor industry, validations specific to cell processing facilities remain unreported. This study aims to verify whether optimizing air-conditioning management in cell processing facilities can achieve energy savings by using particle counters to measure air quality during both non-operational and hypothetical operational conditions. …”
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Development and application of artificial intelligence follow-up system in patients with coronary heart disease by Liping Zhang, Yanan Chen, Qiao Yang, Lijuan Lu, yishuang Cui, Miao Zhou, Xiaolu Jin, Shiyi Zhang, Xifei He

“…These findings highlight the potential of AI-enabled systems in optimizing chronic disease management and resource utilization.…”
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Effects of mineral fertilization (NPK) on combined high temperature and ozone damage in rice by So-Hye Jo, Ju-Hee Kim, Ji-Hyeon Moon, Seo-Yeong Yang, Jae-Kyeong Baek, Yeong-Seo Song, Ji-Young Shon, Nam-Jin Chung, Hyeon-Seok Lee

“…Conclusion The study highlights the potential of potassium fertilization to mitigate combined high-temperature and ozone stress in rice, suggesting it as a strategy to improve crop resilience and optimize fertilization. The findings offer insights into fertilization treatments and can guide future research on stress tolerance in crops.…”
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Evaluation of Blood Lactate Level as a Predictor of In-hospital Morbidity and Mortality in Patients Undergoing Surgery for Bowel Perforation: A Prospective Cohort Study by Anish Kumar Singh23, Sandeep Kumar, Nityasha, Mamta Jain, Mamta Jain, Teena Bansal, Amanpreet Singh

“…The predictive performance of blood lactate levels and their clearance varies depending on the timing of measurement, and the optimal time for measurement remains unclear. Aim: To evaluate perioperative lactate levels and their clearance as predictors of in-hospital M&M in bowel perforation surgery. …”
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Parental and Demographic Predictors of Engagement in an mHealth Intervention: Observational Study From the Let’s Grow Trial by Johanna Sandborg, Brittany Reese Markides, Savannah Simmons, Katherine L Downing, Jan M Nicholson, Liliana Orellana, Harriet Koorts, Valerie Carson, Jo Salmon, Kylie D Hesketh

“… BackgroundParents are integral in shaping early childhood health behaviors, and mobile health (mHealth) interventions offer an accessible method of supporting them in this role. Optimizing participant engagement is key to mHealth effectiveness and impact; however, research examining personal predictors of engagement remains underexplored. …”
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Chorioamnionitis: clinical, anamnestic and molecular-genetic parallels by I. V. Ignatko, A. D. Megrabyan, V. M. Anokhina, A. A. Churganova, T. V. Rasskazova, O. V. Zavyalov, V. A. Titov, V. O. Petrova

“…Aim: to determine clinical, anamnestic and molecular-genetic parallels in emergence of clinical chorioamnionitis (CA) and severe forms of intrauterine infections (IUI) in high-risk pregnant women.Materials and Methods. …”
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Exploring Youth Perspectives on Digital Mental Health Platforms: Qualitative Descriptive Study by Sarah Daniel, Lauren Volcko, Emilie Bassi, Julia Hews-Girard, Katherine Bright, Marianne Barker, Lia Norman, Karina Pintson, Geneca Henry, Sumaya Soufi, Chukwudumbiri Efrem Omorotionmwan, Melanie Fersovitch, Leanne Stamp, Karen Moskovic, David W Johnson, Gina Dimitropoulos

“…Insights from this study provide actionable recommendations for optimizing dMH platforms to meet the mental health needs of young people, particularly in diverse urban and rural settings. …”
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