The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Versus Treat to Avoid Symptoms by Daniel H. Solomon, Misti Paudel, Shravani Chitineni, Ana Fernandes, Tammy Pham, Shreya Billa, Chio Yokose, Kiara Tan, Julien J. Dedier, Maureen D. Dubreuil, John D. Fitzgerald, Sally L. Hodder, Tuhina Neogi, Michael H. Pillinger, Kevin R. Riggs, Kenneth G. Saag, Paul G. Shekelle, Zoe Tseng, Michael Toprover, David S. Wei, Michael J. Barry, Hyon K. Choi

“…Objective Controversy persists regarding the optimal management of gout in routine primary care. …”
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A study of the safety and immunogenicity of a new vaccine for the prevention of COVID-19 based on virus-like particles in phase I clinical trials by Tatiana V. Grebennikova, Olga N. Zaykova, Alexey A. Plotnikov, Lyudmila V. Kostina, Yana Yu. Chernoryzh, Olesia V. Eliseeva, Oleg E. Latyshev, Viktor F. Larichev, Irina T. Fedyakina, Milana A. Losich, Ilya M. Kirillov, Ilya E. Filatov, Marina V. Balandina, Valery V. Tsibezov, Kirill I. Yurlov, Ekaterina I. Lesnova, Valeria M. Kondratieva, Alina A. Kozlova, Marina S. Baranets, Aleksandr L. Gintsburg

“…Gamaleya of the Ministry of Health of the Russia has developed a VLP-based vaccine against COVID-19. The aim of this study is to evaluate the tolerability, safety and immunogenicity of a new vaccine for the prevention of COVID–19 based on VLP compared with placebo for 21 days after two intramuscular injections in phase I clinical trials. …”
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Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study by Marta Seco-Cervera, Marta Seco-Cervera, Marta Seco-Cervera, José Santiago Ibáñez-Cabellos, Federico V. Pallardo, Federico V. Pallardo, Federico V. Pallardo, José-Luis García-Giménez, José-Luis García-Giménez, José-Luis García-Giménez, Anna Aulinas, Anna Aulinas, Anna Aulinas, Luciana Martel-Duguech, Susan M. Webb, Susan M. Webb, Susan M. Webb, Elena Valassi, Elena Valassi, Elena Valassi

“…The mechanisms that determine these persistent muscle problems are not well known. We aimed to identify circulating microRNAs (miRNAs) with differential expression that could be potential biomarkers for the diagnosis and/or prognosis in CS.Patients and methodsThirty-six women in sustained remission for 13 ± 7 years (mean ± SD) from CS, with a median age (IQ range) of 51 (45.2–60) years and mean ± SD BMI of 27 ± 4 Kg/m2, and 36 matched healthy controls were investigated. …”
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Safety and Efficacy of Cobalt Chromium Everolimus‐Eluting Stents for Treatment of In‐Stent Restenosis: An ILUMIEN IV Substudy by Ziad A. Ali, Ulf Landmesser, Akiko Maehara, Doosup Shin, Koshiro Sakai, Mitsuaki Matsumura, Richard A. Shlofmitz, Giuseppe Calligaris, Aziz Maksoud, Youssef S. Abdelwahed, Paolo Canova, Nieves Gonzalo, Fernando Alfonso, Khady N. Fall, Bassem Chehab, Robert J. McGreevy, Robert W. McNutt, Hong Nie, Jin Wang, Jana Buccola, Gregg W. Stone

“…Background The optimal management strategy for in‐stent restenosis (ISR) remains unclear. …”
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Blood loss, complications, and the role of suction drains in shoulder arthroplasty: a systematic review and meta-analysis by Luiz Henrique Oliveira Almeida, MD, Vitor La Banca, MD, Octavio Matsumoto, MD, Arthur Steven de Sá, MD, Ana Victória Palagi Viganó, MD, Gabriel Kalman, MedStud, Felipe Fernandes Gonzalez, MD, MSc, Guilherme Henrique Vieira Lima, MD, Joel Murachovsky, MD, PhD, Roberto Yukio Ikemoto, MD, PhD

“…These findings suggest that the routine use of drains in shoulder arthroplasty may not provide tangible benefits and should be reconsidered to optimize patient outcomes.…”
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Impact of postoperative depression and immune-inflammatory biomarkers on the prognosis of patients with esophageal cancer receiving minimally invasive esophagectomy: a retrospectiv... by Pei-xin Tan, Lin-xin Wu, Shuang Ma, Shi-jing Wei, Tai-hang Wang, Bing-chen Wang, Bing-bing Fu, Jia-shuo Yang, Qing Zhao, Qing Zhao, Li Sun, Yi Liu, Tao Yan

“…Our work has also provided new insight into the individualized and comprehensive management of patients with EC, underscoring the necessity for comprehensive psychosocial interventions alongside conventional anticancer therapies to optimize clinical endpoints.…”
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Clinical features of non-compaction cardiomyopathy across age groups: a retrospective study of 415 patients by Ying Li, Jimei Chen, Min Qiu, Miao Tian, Ziqin Zhou, Ruyue Zhang, Jiazichao Tu, Linjiang Han, Shuheng Zhou, Xinming Li, Jian Zhuang, Shusheng Wen

“…Understanding these age-specific clinical characteristics is crucial for accurate diagnosis, optimal therapeutic management and future research directions in NCM.…”
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Long-term outcomes of graves disease in children treated with anti-thyroid drugs by Ya-Ting Chiang, Wei-Hsin Ting, Chi-Yu Huang, Shih-Kang Huang, Chon-In Chan, Bi-Wen Cheng, Chao-Hsu Lin, Yi-Lei Wu, Chen-Mei Hung, Hsin-Jung Li, Chia-Jung Chan, Yann-Jinn Lee

“…We aimed to investigate long-term outcomes of pediatric GD patients receiving ATD. …”
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The clinical value of the neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio for predicting the sever... by Xin Zhao, Fen Wu, Shunfeng Zhao, Wenna Chen, Wei Si, Yuanrui Li, Dengke Zhang, Jing Wang, Ningning Wang, Lina Sun, Zhiyu Sun, Haoxiao Chang, Ganqin Du

“…NLR and MLR had similar predictive ability (AUC = 0.654; AUC = 0.608) and were superior to PLR. The optimal NLR cut-off value for the incidence of ICU was 3.906.ConclusionIncreased SII, NLR, MLR and PLR at admission are positively correlated with the CASE score of AE patients. …”
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Prognostic impact of being underweight in patients undergoing mitral TEER: The OCEAN‐Mitral registry by Ryosuke Higuchi, Masaki Izumo, Yuki Izumi, Mike Saji, Mitsuaki Isobe, Yoshihiro Akashi, Masanori Yamamoto, Masahiko Asami, Yusuke Enta, Masaki Nakashima, Shinichi Shirai, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiro Yamawaki, Hiroshi Ueno, Kazuki Mizutani, Shunsuke Kubo, Toshiaki Otsuka, Kentaro Hayashida, the OCEAN‐Mitral Investigators

“…Abstract Aims Mitral transcatheter edge‐to‐edge repair (M‐TEER) is a valid treatment option for severe mitral regurgitation (MR), necessitating accurate risk stratification of M‐TEER candidates for effective patient selection, optimal periprocedural care and improved long‐term outcomes. …”
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Longitudinal analysis of hsa-miR-3163, hsa-miR-124-3p, hsa-miR-548c-3p, and hsa-miR-27a-3p as prognostic biomarkers in HIV-infected patients by Ilker Inanç Balkan, Ilker Inanç Balkan, Ilker Inanç Balkan, Andleeb Shahzadi, Haktan Sönmez, Burhaneddin Oktan, Muhammad Ihtisham Umar, Bilgül Mete, Fehmi Tabak, Günnur Deniz, Umut Can Küçüksezer

“…ROC analysis identified miR-3163 as a promising prognostic marker, with an AUC of 0.8561, (95% CI: 0.756–0.9265).DiscussionOur findings highlight the potential of miR-3163 as a robust prognostic biomarker for monitoring HIV progression and optimizing ART strategies. Validation in larger cohorts is warranted to confirm its clinical utility.…”
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Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trialsResearch in context by Sabri Soussi, Tuukka Tarvasmäki, Antoine Kimmoun, Mojtaba Ahmadiankalati, Feriel Azibani, Claudia C. dos Santos, Kevin Duarte, Etienne Gayat, Jacob C. Jentzer, Veli-Pekka Harjola, Benjamin Hibbert, Christian Jung, Lassus Johan, Bruno Levy, Zihang Lu, Patrick R. Lawler, John C. Marshall, Janine Pöss, Malha Sadoune, Alexis Nguyen, Alexandre Raynor, Katell Peoc'h, Holger Thiele, Rebecca Mathew, Alexandre Mebazaa

“…Summary: Background: Cardiogenic shock (CS) is a heterogeneous clinical syndrome, making it challenging to predict patient trajectory and response to treatment. This study aims to identify biological/molecular CS subphenotypes, evaluate their association with outcome, and explore their impact on heterogeneity of treatment effect (ShockCO-OP, NCT06376318). …”
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Excellent patient-reported long-term quality of life after an Ivor Lewis esophagectomy for cancer by Alisa N. Blumenthaler, Cyrus A. Feizpour, Shadia I. Jalal, Kevin J. Lopez, Neal K. Ramchandani, Joshua McAlister, Susan M. Perkins, Yan Han, Karen M. Rieger, JoAnn Brooks, Kenneth A. Kesler

“…We have previously reported a side-to-side esophagogastric anastomotic technique, which optimizes anastomotic diameter and vascularity, resulting in a low incidence of leaks and strictures. …”
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Effects of oral supplementation of β -hydroxy-β -methylbutyrate on muscle mass and strength in individuals over the age of 50: a meta-analysis by Nan Li, Nan Li, Shanbin Chen, Yuxi He, Yamin Chen, Xiaosa Duan, Wenxing He, Qihe Wang, Sana Liu, Tongbo Liu, Haiqin Fang

“…Backgroundβ-Hydroxy β-Methylbutyrate (HMB) has shown potential in improving muscle protein turnover, which may be important for preventing muscle degradation in aging populations. The aim of this meta-analysis is to clarify the impact of HMB oral supplementation on muscle-related indicators and discover the interaction between dosage and duration. …”
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Does Levosimendan hasten veno-arterial ECMO weaning? A propensity score matching analysis by Nicolas Paulo, Antoine Kimmoun, David Hajage, Pierre Hubert, David Levy, Marc Pineton de Chambrun, Juliette Chommeloux, Ouriel Saura, Grégoire Del Marmol, Quentin Moyon, Guillaume Hékimian, Melchior Gautier, Charles Edouard Luyt, Guillaume Lebreton, Bruno Levy, Alain Combes, Matthieu Schmidt

“…Results from double-blinded randomized controlled trials are urgently needed to clarify the effectiveness and optimal timing of levosimendan in this specific population.…”
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Technical evaluation of Turbuhaler® use in children with bronchial asthma: combination of a checklist and inhalation parameters by Lina Liang, Ruogang Huang, Yun Li, Zhufeng Wang, Kang Peng, Junfeng Lin, Feifei Huang, Xiaoyin Yao, Jinping Zheng, Yi Gao

“…Nevertheless, the technique of using the Turbuhaler® in the real world remains ambiguous. This study aims to evaluate techniques in using Turbuhaler® by combining a checklist with inhalation parameters and to investigate the association between the patient characteristics and inhaler technique. …”
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Influence of agroclimatic factors on the efficiency of multi-ovulation in cattle in the Peruvian tropics by Gleni Tatiana Segura Portocarrero, Gleni Tatiana Segura Portocarrero, Gleni Tatiana Segura Portocarrero, Nilton Luis Murga Valderrama, Rainer Marco Lopez Lapa, José Américo Saucedo Uriarte, Deiner Jhonel Gongora Bardales, Hugo Frias Torres, Annie Yoselin Poclín Rojas, Benjamin Depaz Hizo, Ronald Will Vasquez Tarrillo, Lizeth Amparo Heredia Vilchez, Gustavo Ampuero Trigoso

“…Therefore, it is suggested to continue this study, as the literature on this topic is limited, and to conduct further research to optimize the well-being and productivity of livestock.…”
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Processing tomato (Lycopersicon esculentum Miller) yield and quality in arid regions through micro-nano aerated drip irrigation coupled with humic acid application by Jiaying Ma, Rui Chen, Yue Wen, Jinzhu Zhang, Feihu Yin, Tehseen Javed, Jiliang Zheng, Zhenhua Wang

“…However, it has led to reduced soil aeration, with a negative impact on crop growth and yield. Our study aims to tackle this issue by investigating the arid region of Northwest China, focusing on how humic acid (HA)-based water-fertilizer-gas coupled drip irrigation influences soil aeration, as well as the yield and quality of processing tomatoes. …”
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Endovascular Treatment in Patients with Large Vessel Occlusion Stroke of Different Mechanisms by Zhiyuan Feng, Ming Yang, Aoming Jin, Ning Ma, Feng Gao, Dapeng Mo, Xiaojuan Liu, Fangyuan Zhang, Xinchen Li, Yimeng Li, Qi Chu, Jing Xue, Aichun Cheng, Jinxi Lin, Hao Li, Xia Meng, Zhongrong Miao, Yongjun Wang, Jie Xu

“…Patients were classified according to three mechanisms. This study aimed to compare the clinical characteristics, lab results, EVT procedural factors, and prognosis of patients with AIS-LVO with three different mechanisms. …”
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Exploring lymphocyte subsets in COVID-19 patients: insights from a tertiary academic medical center with a high proportion of patients on immunosuppression by Katrijn Daenen, Katrijn Daenen, Samantha van Hooijdonk, Kirby Tong-Minh, Kirby Tong-Minh, Willem A. Dik, Petrus M. van Hagen, Petrus M. van Hagen, Jilske A. Huijben, Diederik Gommers, Eric C. M. van Gorp, Eric C. M. van Gorp, Henrik Endeman, Virgil A. S. H. Dalm, Virgil A. S. H. Dalm

“…Early identification of patients at risk for severe disease is crucial for optimizing care, accurately informing patients and their families, guiding therapeutic interventions, and improving patient flow in the ED. …”
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