Comparative cardiovascular outcomes and safety of hypoglycemic drug classes in patients with type 2 diabetes and hypertension: a multicenter cohort analysis by Zhiyuan Wei, Wanqian Xu, Yu Wang, Yu Tian, Zhongmin Wang, Shenqi Jing, Weina Liu, Sipeng Shen, Chenlong Qin, Xin Zhang, Jingsong Li, Yun Liu

“…This multicenter pooled analysis aims to directly compare the CV outcomes and safety profiles of these key agents in patients with T2D and hypertension. …”
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Erector spinae plane block versus transversus abdominis plane block with rectus sheath block for postoperative analgesia in laparoscopic hepatectomy: a randomized clinical trial by Mengke Liu, Xuan Mo, Ruonan Zhan, Han Wang, Yangxi Zhao, Yi Zhang

“…Although transversus abdominis plane block (TAPB) with rectus sheath block (RSB) and erector spinae plane block (ESPB) have shown promise in abdominal surgeries, few comparative studies exist between the two techniques for laparoscopic hepatectomy. This study aims to compare the efficacy of bilateral ultrasound-guided ESPB versus subcostal TAPB with RSB for postoperative analgesia, addressing the gap in current research and optimizing pain management strategies for this procedure. …”
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Machine learning models for coagulation dysfunction risk in inpatients administered β-lactam antibiotics by Yuqing Hua, Yuqing Hua, Na Li, Jiahui Lao, Zhaoyang Chen, Shiyu Ma, Xiao Li

“…On the test set, the optimal models for cefazolin sodium, cefoperazone/sulbactam sodium, cefminol sodium, amoxicillin/sulbactam sodium, and piperacillin/tazobactam sodium yielded AUC values of 0.798, 0.768, 0.919, 0.783, and 0.867, respectively. …”
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Levodopa / opicapone as a complement to STN-DBS in clinical practice. A retrospective single-centre analysis. by Moritz A. Loeffler, Philipp Klocke, Idil Cebi, Alireza Gharabaghi, Daniel Weiss

“…However, evidence is scarce on optimal medication adjustments following STN-DBS implantation. …”
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Role of Post-Operative Rehabilitation in TM Joint Arthritis: Functional Outcomes of Interposition Trapeziectomy vs. Prosthesis by Camillo Fulchignoni, Silvia Pietramala, Leopoldo Arioli, Emanuele Gerace, Domenico De Mauro, Giulia Frittella, Elisa Di Dio, Mirko Grauso, Gianfranco Merendi, Lorenzo Rocchi

“…However, the role of post-operative rehabilitation in optimizing outcomes for these procedures remains underexplored. …”
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Staff-reported barriers and facilitators to the implementation of healthcare interventions within regional and rural areas: a rapid review by Anna Chapman, Alison Buccheri, Devdini Mohotti, Anna Wong Shee, Catherine E. Huggins, Laura Alston, Alison M. Hutchinson, Sze Lin Yoong, Hannah Beks, Kevin Mc Namara, Anna Peeters, Anna Ugalde

“…Abstract Background Individuals in rural areas consistently demonstrate higher mortality and morbidity rates, and poorer access to healthcare, compared to their metropolitan counterparts. Optimizing the implementation of evidence-based interventions can reduce these inequities. …”
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Plasma methylated HIST1H3G as a non-invasive biomarker for diagnostic modeling of hepatocellular carcinoma by Weiwei Zhu, Weiwei Zhu, Huifen Wang, Huifen Wang, Yudie Cai, Yudie Cai, Jun Lei, Jun Lei, Jia Yu, Jia Yu, Ang Li, Zujiang Yu

“…HIST1H3G, PIVKA-II, total bilirubin (TBIL) and age were selected as the optimal markers and were included in the development of a diagnostic model. …”
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The Impact of Social Support on Postoperative Recovery in Retinal Detachment Surgery by Pedro-Raúl Castellano-Santana, Francisco Cabrera-López, María-DeLasNieves Martín-Alonso, Yésica Flores-Jardo, Jesús María González-Martín, Ariday-Miguel Díaz-Ginory, Abián-David Torres-Duchement, Yurena Santana-Socorro, José-Enrique Hernández-Rodríguez

“…These results support a multidisciplinary approach incorporating psychosocial support alongside surgical treatment to optimize patient outcomes.…”
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Sivelestat-Loaded Neutrophil-Membrane-Coated Antioxidative Nanoparticles for Targeted Endothelial Protection in Sepsis by Juexian Wei, Aijia Zhong, Yuting Zhang, Ehua Deng, Hengzong Mo, Hongyu Zhao, Jiayu Huang, Huaidong Peng, Kaiyin Zhang, Xiaohui Chen, Haifeng Mao, Yixin Chen, Yongcheng Zhu

“…<b>Background/Objectives</b>: This study aims to develop and evaluate neutrophil-membrane-coated nanoparticles (Siv@NMs) encapsulating sivelestat for the treatment of sepsis-induced endothelial injury. …”
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A new evaluation methodology study - Integrating ‘ancient literature - clinical research - expert consensus’ firstly proposes eight elements for taking Chinese medicine decoctions... by Feiyu Li, Jing Shang, Yixuan Li, Guoxiu Liu, Sijin Zhao, Jiankun Wu, Hongmei Chen, Wanlin Wu, Xuelong Zhao, Huaqiang Zhai

“…Future efforts should prioritize expanded clinical validation and scenario-specific protocols to optimize standardization and safety.…”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Future studies should expand on these findings to optimize care and guide therapeutic strategies.…”
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Prognostic Significance of Left Ventricular Global Work Efficiency in Obese Patients with Acute ST-Segment Elevation Myocardial Infarction—A Pilot Study by Alexandra-Cătălina Frișan, Marius Simonescu, Mihai-Andrei Lazăr, Simina Crișan, Aniko Mornoș, Raluca Șoșdean, Andreea-Roxana Morar, Daniel-Miron Brie, Constantin-Tudor Luca, Cristian Mornoș

“…Left ventricular myocardial work (LVMW) represents an emerging, load-adjusted marker of myocardial performance. This study aimed to assess the prognostic relevance of LVMW in obese STEMI patients. …”
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Mechanistic insights into the Bushen Huatan Huoxue Formula and its components in ameliorating obesity-associated polycystic ovary syndrome by Yu-Xin Jin, Hang-Qi Hu, Jia-Cheng Zhang, Yu-Tian Zhu, Hao-Lin Zhang, Xi-Yan Xin, Rui-Wen Fan, Yang Ye, Yin Li, Dong Li

“…Future research should focus on identifying core active compounds and optimizing treatment according to individual PCOS phenotypes.…”
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Exploring advanced genomic and immunoinformatics techniques for identifying drug and vaccine targets against SARS-CoV-2 by Syed Luqman Ali, Awais Ali, Waseef Ullah, Abdulaziz Alamri, Elham Mohammed Khatrawi, Gulzira Sagimova, Aigul Almabayeva, Farida Rakhimzhanova, Gulsum Askarova, Fatima Suleimenova, Nabras Al-Mahrami, Prasanta Kumar Parida

“…Even if there is no cure for it, the infection is still progressing naturally, and the only time that optimal treatment choices, such as doxycycline, work is at the beginning of the infection. …”
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Seasonal variation in bystander efforts and survival after out-of-hospital cardiac arrest by Niels Saaby Hald, Harman Yonis, Mathias Hindborg, Helle Collatz Christensen, Jannie Kristine Bang Gram, Erika Frischknecht Christensen, Fredrik Folke, Gunnar Gislason, Christian Torp-Pedersen, Kristian Bundgaard Ringgren

“…Background: This study investigated the hypothesis that out-of-hospital cardiac arrest (OHCA) incidence, public automated external defibrillator (PAD) utilization and outcome vary by season, with increased incidence and lower survival rates expected in winter. The aim was to provide insights that might optimize resuscitation efforts throughout the year. …”
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Usefulness of differential somatic cell count for udder health monitoring: Association of differential somatic cell count and somatic cell score with quarter-level milk yield and m... by Mariana Fonseca, Daryna Kurban, Jean-Philippe Roy, Débora E. Santschi, Elouise Molgat, Simon Dufour

“…These results could be used to optimize udder health management.…”
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Outcome of Classical Hodgkin’s Lymphoma Treatment Based on High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation: The Experience in the NI Pirogov Russian N... by NE Mochkin, VO Sarzhevskii, YuN Dubinina, EG Smirnova, DA Fedorenko, AE Bannikova, DS Kolesnikova, VS Bogatyrev, NM Faddeev, VYa Mel’nichenko

“…Aim. To estimate the long-term outcome of the programmed treatment of classical Hodgkin’s lymphoma (cHL) including high-dose chemotherapy (HDCT) and autologous hematopoietic stem cell transplantation (auto-HSCT) as well as the effect of various factors on the achieved results in a single-center study. …”
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Essential newborn care practices at health facilities and homes in Ethiopia: a cross-sectional study by Tadesse Guadu, Kassahun Alemu, Joanna Schellenberg, Della Berhanu, Seblewengel Lemma, Atkure Defar, Theodros Getachew, Girum Taye, Solomon Shiferaw, Zewditu Abdissa, Amare Tariku, Meseret Zelalem, Lars Åke Persson

“…Conclusion Neonates born at health facilities had higher, although not optimal, coverage of thermal care, cord care, early breastfeeding initiation, and the first immunizations. …”
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Prediction of EGFR mutations in non-small cell lung cancer: a nomogram based on 18F-FDG PET and thin-section CT radiomics with machine learning by Jianbo Li, Qin Shi, Yi Yang, Jikui Xie, Qiang Xie, Ming Ni, Xuemei Wang, Xuemei Wang

“…BackgroundThis study aimed to develop and validate radiomics-based nomograms for the identification of EGFR mutations in non-small cell lung cancer (NSCLC).MethodsA retrospective analysis was performed on 313 NSCLC patients, who were randomly divided into training (n = 250) and validation (n = 63) groups. …”
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Effect of Nitrogen Regimes on Grain Yield, Nitrogen Utilization, Radiation Use Efficiency, and Sheath Blight Disease Intensity in Super Hybrid Rice by Di-qin LI, Qi-yuan TANG, Yun-bo ZHANG, Jian-quan QIN, Hu LI, Li-jun CHEN, Sheng-hai YANG, Ying-bin ZOU, Shao-bing PENG

“…Nitrogen application regimes and diseases control in rice caused obvious effects on light interception rate, RUE, and HI. Optimal N rate is helpful to get higher light interception rate, RUE, and HI. …”
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