Long-term behaviour of non-functioning pituitary microadenomas: experience from a tertiary care centre in Romania by Mădălina Elena Iftimie, Mădălina Elena Iftimie, Iulia Florentina Burcea, Iulia Florentina Burcea, Ramona Dobre, Ramona Dobre, Stella Pigni, Flavia Prodam, Cătălina Poiană, Cătălina Poiană

“…ObjectiveAn optimal surveillance plan of micro-nonfunctioning pituitary adenomas (micro-NFPAs) is not well established despite high prevalence and increasing incidence of these tumors. …”
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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…We performed stage-specific transcriptomic profiling to identify differentially expressed key functional gene groups that relate to these functions and provide a fundamental understanding of the mechanisms S. molnari uses to optimize its parasitic lifestyle. We aimed to identify genes that are likely related to parasite pathogenicity and host cell exploitation mechanisms, and we hypothesize that genes unique to S. molnari might be indicative of evolutionary innovations and specific adaptations to host environments. …”
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ANN-SVM-IP: An Innovative Method for Rapidly and Efficiently Detecting and Classifying of External Defects of Apple Fruits by Nashaat M. Hussain Hassan, Mohamed M. Hassan Mahmoud, Mohamed A. Ismeil, M. Mourad Mabrook, A. A. Donkol, A. M. Mabrouk

“…This paper aims to provide a practical and systematic solution to an important problem in the field of agricultural automation. …”
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Pilot trial of an electronic decision support to improve care for emergency department patients with acute heart failure by Dana R. Sax, Dustin G. Mark, Jamal S. Rana, Jie Huang, Scott D. Casey, Robert P. Norris, Viliami Tillage, Mary E. Reed

“…Abstract Aims Emergency department (ED) providers play an important role in the management of patients with acute heart failure (AHF). …”
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Effects of Hole Irrigation Device Parameters on Soil Water Characteristics Under Different Biogas Slurry Ratios by Peng Xiang, Jian Zheng, Yan Wang, You Wu

“…Soil wetting front migration distance model (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>X</mi><mo>=</mo><mn>4.442</mn><msubsup><mi>f</mi><mn>0</mn><mrow><mn>0.375</mn></mrow></msubsup><msup><mi>t</mi><mrow><mn>0.24</mn></mrow></msup><mo>,</mo><mo> </mo><mi>Z</mi><mo>=</mo><mn>11.988</mn><msubsup><mi>f</mi><mn>0</mn><mrow><mn>0.287</mn></mrow></msubsup><msup><mi>t</mi><mrow><mn>0.124</mn></mrow></msup><mo>,</mo><mo> </mo><msub><mi>f</mi><mn>0</mn></msub><mo>=</mo><mn>96.947</mn><msubsup><mi>K</mi><mi>s</mi><mrow><mn>1.151</mn></mrow></msubsup><msup><mi>D</mi><mrow><mn>0.236</mn></mrow></msup><msup><mi>H</mi><mrow><mn>1.042</mn></mrow></msup></mrow></semantics></math></inline-formula>, NSE > 0.976, PBIAS ≤ ±0.13) and cumulative infiltration model (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>I</mi><mo>=</mo><mn>0.3365</mn><mi>S</mi></mrow></semantics></math></inline-formula>, NSE > 0.982, PBIAS ≤ ±0.10) established under biogas slurry hole irrigation exhibited good reliability. This study aims to determine optimal hole diameter, depth, and irrigation volume for biogas slurry hole irrigation by establishing a model for soil wetting front migration distance and cumulative infiltration based on crop root growth patterns, thereby providing a scientific basis for its practical application.…”
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Improving Leaf GOGAT Activity After the Post-Silking Period Contributes to High Grain Yield with Reduced Nitrogen in N-Efficient Maize by Haoyu Li, Yanbing Wang, Jian Wang, Meng Zhang, Wenbo Liu, Xiangling Li, Xiaohu Lin

“…Therefore, we suggest that molecular breeding programs should focus on the <i>GOGAT2</i> gene in low-N-efficient maize varieties, and cultivation techniques should aim to improve the GOGAT enzyme activity after the post-silking period to achieve high yields and N utilization efficiencies with less N fertilizer.…”
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Evaluation of EUCAST Rapid Antimicrobial Susceptibility Testing for Gram-Negative Bacteria Directly from Positive Blood Cultures by Tian PP, Yang H, Wang T, Wang L, Du MY, Su SS, Zhu LS, Wang XM, Xie LC, Fan W, Tian T, Yi HW

“…Utilizing RAST at various reading times (6 hours and 16– 20 hours) optimizes clinical workflows, enhances antimicrobial stewardship, and improves patient outcomes.Keywords: blood culture, rapid antimicrobial susceptibility testing, EUCAST, gram-negative bacteria, bloodstream infection, short-term incubation…”
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‘Time is of the essence’: upper-body aerobic exercise to improve cardiovascular health during inpatient rehabilitation within the first year following spinal cord injury – protocol... by Samuel J E Lucas, Tom E Nightingale, Naveen Kumar, Shin-Yi Chiou, Afroditi Stathi, Manish Kalla, Daniel D Hodgkiss, Shane J T Balthazaar, Aheed E F Osman, Srinivasa C Budithi, Joy Roy Chowdhury

“…Consequently, early aerobic exercise to reduce CVD risks is not standard practice in subacute SCI care, potentially missing an opportunity for optimal cardiovascular rehabilitation, especially given observed reductions in cardiac structure and function within the first year post-SCI. …”
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Qualitative Analysis of Valeriana officinalis leaf by Thin-Layer Chromatography by A. Yu. Fisiuk, O. V. Mushkina, N. S. Golyak, O. A. Yorshyk

“…It was found that extracts from the leaves of V. officinalis contain rutin and chlorogenic acid, do not contain quercetin and caffeic acid. The optimal mobile phase for the separation of sesquiterpenic acids from valerian leaf is the glacial acetic acid — ethyl acetate — cyclohexane (2:38:60) system.CONCLUSIONS. …”
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Role of Single Nucleotide Polymorphism of СУР17А Gene in the Development of Stroke by S. Yu. Nikulina, V. A. Shulman, A. A. Chernova, D. A. Nikulin, A. A. Semenchukov, O. V. Marilovceva, S. S. Tret'jakova, I. I. Lebedeva, V. N. Maksimov

“…Gene CYP17A1 is one of the many genes that can participate in the formation of predisposition to the development of stroke.Aim. To examine association of the single nucleotide polymorphisms rs1004467 CYP17A1 gene with the development of stroke.Material and methods. …”
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Comparison of four MRI diffusion models to differentiate benign from metastatic retropharyngeal lymph nodes by Jun Liu, Li Hua, Fei Wang, Ming Chen, Yinan Sun, Zhi Hu, Luqing Shu, Andong He, Mengxiao Liu, Qing Yang, Juan Zhu, Yinfeng Qian

“…Multivariate logistic regression analysis identified βCTRW as the optimal single diffusion indicator (AUC = 0.913). …”
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Integrative habitat analysis and multi-instance deep learning for predictive model of PD-1/PD-L1 immunotherapy efficacy in NSCLC patients: a dual-center retrospective study by Xiaoxiao Huang, Xiaoxin Huang, Yurun Xie, Kui Wang, Housheng Bai, Ruiling Ning, Xiqi Zhu, Deyou Huang, Guanqiao Jin

“…This dual-center study aimed to integrate habitat radiomics and multi-instance deep learning to predict durable clinical benefits from immunotherapy. …”
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Atrial fibrillation and chronic kidney disease: main clinical characteristics of patients in selected subjects of the Russian Federation by M. A. Druzhilov, T. Yu. Kuznetsova, O. Yu. Druzhilova, U. D. Arustamova, D. V. Gavrilov, A. V. Gusev

“…Aim. To compare clinical characteristics of patients with atrial fibrillation (AF) depending on renal filtration function based on a retrospective analysis of data in individual subjects of the Russian Federation (RF).Material and methods. …”
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Exploring the dynamics of stroke survivors’ care dependency, fatigue, and coping strategy in their caregivers: a structural equation modeling analysis by Jinyao Wang, Shuangyan Tu, Jun Cui, Rong Yang, Yan Jiang, Lihong Zhao

“…AimsTo evaluate the interactions among stroke survivors’ care dependency, caregivers’ negative coping strategy, and fatigue.DesignDescriptive quantitative research design.SettingPatients with acute stroke and their caregivers were enrolled in a General Hospital in West China from July 2022 to April 2023.Primary and secondary outcome measuresData collection adopted the Care Dependency Scale (CDS), the Simple Coping Style Questionnaire (SCSQ), and the Fatigue Scale-14 (FS-14). …”
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Association between alactic base excess on mortality in sepsis patients: a retrospective observational study by Jiahui Liu, Yang Chen, Bin Yang, Jiabao Zhao, Qiang Tong, Yuan Yuan, Ye Kang, Tianshu Ren

“…The identified thresholds (2.5 mmol/L for 30-day mortality and 2.2 mmol/L for 90-day mortality) indicate optimal ABE levels that may be associated with improved survival outcomes. …”
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Integrative analysis of signaling and metabolic pathways, immune infiltration patterns, and machine learning-based diagnostic model construction in major depressive disorder by Lei Tang, Liling Wu, Mengqin Dai, Nian Liu, Lu liu

“…Abstract Major depressive disorder (MDD) is a multifactorial disorder involving genetic and environmental factors, with unclear pathogenesis. This study aims to explore the pathogenic pathway of MDD and its relationship with immune responses and to discover its potential targets by bioinformatics methods. …”
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A Prediction Model of Stable Warfarin Doses in Patients After Mechanical Heart Valve Replacement Based on a Machine Learning Algorithm by Bowen Guo, Cong Chen, Junhang Jia, Jubing Zheng, Yue Song, Taoshuai Liu, Kui Zhang, Yang Li, Ran Dong

“…The performance of these algorithms was evaluated and compared using R-squared (R2), mean absolute error (MAE), and ideal prediction percentage to identify the optimal algorithm for predicting the stable warfarin dose and verify its clinical significance. …”
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PROGRAM KOMUNIKASI BADAN NARKOTIKA NASIONAL PROVINSI (BNNP) DIY DALAM UPAYA MENGATASI BAHAYA PEREDARAN NARKOBA by Lailatun Najihah, Suranto Aw

“…Kata kunci: Komunikasi, Program Komunikasi, Analisis SWOT, dan BNNP DIY   Abstract             The aims of this research are: (1) to find out what NNP DIY is in BNNP DIY's communication program in an effort to overcome the dangers of drug trafficking, (2) to find out the results of the SWOT analysis of the communication program at BNNP DIY in an effort to overcome the dangers of drug trafficking, (3) to find out the success factors BNNP DIY communication program in an effort to overcome the dangers of drug trafficking. …”
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Nomogram Predictive Model for Vaginal Birth after One Prior Cesarean Section: A Retrospective Study by Fangyuan Zheng, Yangfang Sun, Xuening Liang, Jinying Zhou, Yun Chen

“…TOLAC rates are low in China, and success rates vary between 60% and 80%. This study aims to develop a nomogram-based predictive model for VBAC in China and improve existing, less rigorous scoring models. …”
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Investigating the Impact of Different Oil Production Processes on the Quality and Flavor Characteristics of Hainan Camellia Oil Based on E-nose, GC-MS, and GC-IMS Analyses by Tao LAN, Lipin CHEN, Tao WANG, Meizhen XIE, Weimin ZHANG, Yonghuan YUN, Liangxiao ZHANG

“…To clarify the impact of oil extraction processes on the overall quality and flavor of Hainan camellia oil, the quality and flavor characteristics of oils extracted by pressing (NT-P, HT-P), subcritical butane extraction (NT-SBE, HT-SBE), and supercritical CO2 extraction (NT-SCE, HT-SCE) under ambient and high temperatures were compared in this study, with the aim of exploring the optimal processing technology. …”
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