Impact of Storage Conditions on Bronchoalveolar Lavage Fluid Analysis: A Human Study by Yu Shionoya, Kanae Maruyama, Takeshi Kawasaki, Mayumi Ono, Yushi Murai, Ryutaro Hirama, Dai Horiuchi, Noriko Sakuma, Shinsuke Kitahara, Shun Sato, Kohei Takahashi, Yoshihito Ozawa, Takuji Suzuki

“…Despite established guidelines, variability in sample handling may affect diagnostic accuracy. This study aimed to evaluate how different storage conditions impact BALF cell counts and differentials to guide optimal sample handling practices. …”
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Diabetic Retinopathy Assessment through Multitask Learning Approach on Heterogeneous Fundus Image Datasets by Hongkang Wu, MS, Kai Jin, MD, PhD, Yiyang Jing, MD, Wenyue Shen, MD, Yih Chung Tham, PhD, Xiangji Pan, PhD, Victor Koh, MD, PhD, Andrzej Grzybowski, MD, PhD, Juan Ye, MD, PhD

“…Objective: To develop and validate an artificial intelligence (AI)-based system, Diabetic Retinopathy Analysis Model Assistant (DRAMA), for diagnosing diabetic retinopathy (DR) across multisource heterogeneous datasets and aimed at improving the diagnostic accuracy and efficiency. …”
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South Asia anthropogenic ammonia emission inversion through assimilating IASI observations by J. Xia, Y. Zhou, L. Fang, Y. Qi, D. Li, H. Liao, J. Jin

“…This study aims to estimate ammonia emissions in this region by integrating the prior emission inventory from the Community Emissions Data System (CEDS) and the columned ammonia concentration retrievals from the Infrared Atmospheric Sounder Interferometer (IASI). …”
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Effects of dietary metabolizable energy and crude protein levels on production performance, meat quality and cecal microbiota of Taihe Silky Fowl during growing period by Yutian Shen, Wentao Li, Lixia Kai, Yuqing Fan, Youping Wu, Fengqin Wang, Yizhen Wang, Zeqing Lu

“…This experiment aimed to investigate the effects of dietary metabolizable energy (ME) and crude protein (CP) levels and their interaction on the performance, meat quality, and cecal microbiota of Taihe Silky Fowl (Gallus gallus domesticus Brisson) during the growing period. …”
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Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis by Rutao Li, Na Li, Qianqian Yang, Xing Tong, Wei Wang, Chang Li, Jun Zhao, Dong Jiang, Haitao Huang, Chen Fang, Kai Xie, Jiamin Yuan, Shaomu Chen, Guangbin Li, Haitao Luo, Zhibo Gao, Dongfang Wu, Xiaoli Cui, Wei Jiang, Lingchuan Guo, Haitao Ma, Yu Feng

“…Abstract Background Understanding the stepwise progression of esophageal squamous cell carcinoma (ESCC) is crucial for developing customized strategies for early detection and optimal clinical management. Herein, we aimed to unravel the transcriptional and immunologic alterations occurring during malignant transformation and identify clinically significant biomarkers of ESCC. …”
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The influence of the ratio of liver cells and bone marrow in the implantable cell-engineering structures of the liver on the recovery efficiency of functional and morphological par... by M. Yu. Shagidulin, N. A. Onishchenko, M. E. Krasheninnikov, A. O. Nikolskaya, E. A. Volkova, I. M. Iljinsky, N. P. Mogeiko, V. I. Sevastianov, S. V. Gautier

“…Aim: to determinate the most effective liver cells and multipotent mesenchymal stromal cells of bone marrow (MMSC BM) ratio into implantable cell engineering constructions (CECs) used for chronic liver failure (CLF) correcting.Materials and methods. …”
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Patient-centered outcomes with subcutaneous immunoglobulin use for infection control in primary and secondary immunodeficiencies: data of a GEIE Spanish Registry by Sandra Martínez Mercader, Victor Garcia-Bustos, Victor Garcia-Bustos, Pedro Moral Moral, Pedro Moral Moral, Carmen Martínez Buenaventura, Elisa Escudero Vergara, María Carmen Montaner Bosch, Héctor Balastegui-Martín, Héctor Balastegui-Martín, Sonia Galindo Maycas, Berta Palací Mur, Marian Escobar Palazón, María Moreno Mulet, Ignacio Campanero Carrasco, Alicia López, Carlos Daniel Hernández Ruiz, Laura Ruiz-López, Rocío Guzmán Guzmán, Rocío Guzmán Guzmán, Marta Dafne Cabañero-Navalon, Marta Dafne Cabañero-Navalon

“…Background and aimSubcutaneous immunoglobulin (SCIg) has emerged as an alternative to intravenous administration for patients with primary (PID) and secondary immunodeficiencies (SID), offering benefits such as fewer systemic adverse reactions and greater patient autonomy. …”
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Chronic lymphocytic leukemia in combination with COVID-19: clinical features and unfavorable prognosis factors by O. L. Kochneva, E. A. Baryakh, E. N. Misyurina, E. I. Zhelnova, K. V. Yatskov, T. S. Chudnova, Yu. Yu. Polyakov, A. B. Makeshova, M. A. Mingalimov, D. D. Ivanova, L. T. Shimanovskaya, E. N. Zotina, T. N. Tolstykh, E. Yu. Grishina, D. E. Gagloeva, V. N. Yakimets, A. I. Koneva, E. A. Karimova

“…Patients with chronic lymphocytic leukemia, characterized by profound immune dysfunction, have risk factors for severe viral disease.Aim. To identify risk factors for hospital mortality and severe course of COVID-19, as well as to optimize therapeutic and preventive measures.Materials and methods. …”
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Silver Jubilee of HER2 targeting: a clinical success in breast cancer by Jianli Zhao, Ziyue Zhou, Phei Er Saw, Erwei Song

“…Additionally, tyrosine kinase inhibitors and monoclonal antibodies optimized for antibody-dependent cellular cytotoxicity have expanded treatment options, allowing for effective therapies in breast cancers with lower HER2 expression levels. …”
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Regulation of intestinal health by Lactobacillus rhamnosus GG during fasting-induced molting in laying hens by Zhixuan Luo, Yujie Gong, Qiang Li, Mengyan Zhang, Jun Zhang, Hao Zhang, Qingduo Zeng, Yidan Zhu, Yujie Guo, Donghua Li, Yadong Tian, Xiangtao Kang, Ruirui Jiang

“…This study aims to investigate the regulatory effects of adding Lactobacillus rhamnosus GG (LGG) during the fasting-induced molting (FIM) process on the intestinal mucosal barrier and microbiota of laying hens. …”
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Clinical and genetic features of CNGA3 achromatopsia in preschool children: novel insights into retinal architecture and therapeutic window for clinical trials by Yanting Lai, Yanting Lai, Aohan Hou, Aohan Hou, Linyan Zhang, Linyan Zhang, Limei Sun, Limei Sun, Miner Yuan, Miner Yuan, Xiaoyan Ding, Xiaoyan Ding

“…Ultimately, our research may aid in formulating guidelines for selecting patients and determining the optimal timing for interventions in upcoming gene replacement therapies.…”
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The Minimum Dietary Diversity For Women Indicator Can Be Extended To Children And Adolescents aged 4-15 Years As A Proxy Population Indicator For Good Micronutrient Adequacy Of Die... by Loty Diop, Aulo Gelli, Lieven Huybregts, Joanne E Arsenault, Lilia Bliznashka, Erick Boy, Megan Deitchler, Carl Lachat, Mourad Moursi, Angelica M Ochoa-Avilés, Deanna K Olney, Elodie Becquey

“…Objectives: This study aims to validate FGS-10 and its related cutoffs against micronutrient intake adequacy in 4–15-y-old children/adolescents in LMICs. …”
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CRO-INSIGHT: Utilization of Implantable Cardioverter Defibrillators in Non-ischemic and Ischemic Cardiomyopathy in a Single Croatian Tertiary Hospital Centre by Mislav Puljevic, Eugen Ciglenecki, Vedran Pasara, Ivan Prepolec, Mia Dubravcic Dosen, Pero Hrabac, Ana-Marija Brekalo, Martina Lovric Bencic, Miroslav Krpan, Richard Matasic, Borka Pezo-Nikolic, Davor Puljevic, Davor Milicic, Vedran Velagic

“…Further research is needed to refine clinical guidelines and optimize patient selection for ICD therapy.…”
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Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation by Edith Pituskin, Stephen Foulkes, Rachel J. Skow, Thomas McMurtry, Calvin Kruger, Janet E. Bates, Daena Lamoureux, Joseph Brandwein, Elena Lieuw, Cynthia Wu, Nancy Zhu, Peng Wang, Daniel Sawler, Minakshi Taparia, Marlene Hamilton, Tiffany Comfort-Riddle, Tara Meyer, Gabor T. Gyenes, Ian Paterson, Carla M. Prado, Mark J. Haykowsky, Justin G. Greiner, Margaret L. McNeely, Puneeta Tandon, Richard B. Thompson

“…We expect the findings to inform the optimal timing and patient preferences to develop studies examining risk-specific, individualized interventions (including exercise, pharmacotherapy, combination treatments) to reduce or prevent symptoms and dysfunction. …”
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The Practical, Robust Implementation and Sustainability (PRISM)-capabilities model for use of Artificial Intelligence in community-engaged implementation science research by Nabila El-Bassel, James David, Trena I. Mukherjee, Maneesha Aggarwal, Elwin Wu, Louisa Gilbert, Scott Walters, Redonna Chandler, Tim Hunt, Victoria Frye, Aimee Campbell, Dawn A. Goddard-Eckrich, Katherine Keyes, Shoshana N. Benjamin, Raymond Balise, Smaranda Muresan, Eric Aragundi, Marc Chen, Parixit Davé, David Lounsbury, Nasim Sabounchi, Dan Feaster, Terry Huang, Tian Zheng

“…This paper also proposes next steps to validate the model using the HEALing Communities Study (HCS), the largest community-engaged research study to date, which aimed to reduce fatal overdose deaths in 67 highly impacted communities in the United States. …”
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3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study by Yurong Jiang, Jiawei Zhang, Zhaochen Liu, Jinxiong Zhang, Xiangrong Yu, Danyan Lin, Dandan Dong, Mingyue Cai, Chongyang Duan, Shuyi Liu, Wenhui Wang, Yuan Chen, Qiyang Li, Weiguo Xu, Meiyan Huang, Sirui Fu

“…Abstract Background Besides tumorous information, synergistic liver parenchyma assessments may provide additional insights into the prognosis of hepatocellular carcinoma (HCC). This study aimed to investigate whether 3D synergistic tumor-liver analysis could improve the prediction accuracy for HCC prognosis. …”
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Automatic vessel segmentation and reformation of non-contrast coronary magnetic resonance angiography using transfer learning-based three-dimensional U-net with attention mechanism by Lu Lin, Yijia Zheng, Yanyu Li, Difei Jiang, Jian Cao, Jian Wang, Yueting Xiao, Xinsheng Mao, Chao Zheng, Yining Wang

“…It has the potential to become a standard component of daily workflows, optimizing the clinical application of CMRA in the future.…”
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Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson’s disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a... by Dongning Su, Zhijin Zhang, Zhe Zhang, Rui Yan, Wanlin Zhu, Ning Wei, Yue Suo, Xinyao Liu, Ying Jiang, Lingyan Ma, Huiqing Zhao, Zhan Wang, Xuemei Wang, Huizi Ma, Xin Liu, Chaodong Wang, Zhirong Wan, Fangfei Li, Yuan Li, Joyce S. T. Lam, Junhong Zhou, Ning Zhang, Tao Wu, Jing Jing, Tao Feng

“…Abstract Background Dorsal nigral hyperintensity (DNH) abnormality associated with excessive iron deposition in the substantia nigra, is recognized as an imaging characteristic of Parkinson’s disease (PD) and can be effectively visualized using 7T MRI. This study was aimed to develop and validate the optimal DNH assessment method as a biomarker for PD, idiopathic rapid eye movement sleep behavior disorder (iRBD), and Parkinson-plus syndromes, and to explore the nigral iron deposition patterns in these diseases. …”
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Towards a sustainable phosphorus network in Africa by M.G. Manzeke-Kangara, M.S.A. Blackwell, W.J. Brownlie, E. Zaja, K.A. Frimpong, A.A. Asante, D. Cordell, J.J. Elser, E.K. Gbekor, K. Harris-Gilliam, D. Touhami, J.X. Kugbe, I.H. Lewis, V. Logah, M. Miyittah, E.K. Nartey, M. Owusu, Z. Oyetunde-Usman, C.K. Tay, F.M. Tetteh, P.M. Haygarth, B.M. Spears

“…Africa’s use of phosphorus fertilisers is sub-optimal, with a reported decline in phosphorus fertiliser use of about 233 % by the turn of the 21st century, and remains low. …”
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Comprehensive analysis of culture-negative periprosthetic joint infection with metagenomic next-generation sequencing by Lan Lin, Lan Lin, Lan Lin, Jiayu Li, Jiayu Li, Jiayu Li, Canhong Zhang, Juncheng Li, Juncheng Li, Juncheng Li, Baijian Wu, Baijian Wu, Baijian Wu, Zida Huang, Zida Huang, Zida Huang, Jianhua Lv, Mingzhong Liu, Wenbo Li, Wenbo Li, Wenbo Li, Wenming Zhang, Wenming Zhang, Wenming Zhang, Xinyu Fang, Xinyu Fang, Xinyu Fang

“…With advancements in sample collection, optimized culture methods, molecular diagnostic tools, and early targeted therapies, CN PJI may achieve clinical outcomes comparable to CP PJI.…”
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