Anti-inflammatory and anti-atherosclerotic potential of opuntiol, opuntioside-I, and opuntiol’s silver nanoparticles: The role of cytokines and chemokines by Perbhat Ali, Talat Roome, Tehseen Fatima, Muhammad Usman, Uzma Zaman, Talat Mirza, Zamara Sarwar, Zara Aslam, Shaheen Faizi, Muhammad Raza Shah

“…One of the most promising areas of research in the pathogenesis of inflammation and atherogenesis is herbal medications and its bioactive compounds with better delivery to target the exact cell and tissues with high efficacy and fewer side effects in pharmaceutical exploration. Therefore, the aim of present study was to explore the anti-inflammatory effects of naturally derived compounds, i.e., opuntiol (OP), opuntioside-I (OPG), and opuntiol’s silver nanoparticles (OP-Ag) for achieving optimal therapeutic approach to address the underlying inflammatory processes in atherosclerosis and improving treatment outcomes. …”
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Effects of Different Molasses Levels and Slow-Release Urea Combinations on Growth Performance, Serum Biochemistry, Rumen Fermentation, and Microflora of Holstein Fattening Bulls by Zhiyuan Xu, Shuaihong Li, Fangzhou Yu, Yinghao Huang, Tao Xie, Hanbing Bian, Longfei Lv, Yapeng Hu, Ruoran Tao, Caiyun Fan, Sijia Liu, Jianbo Cheng

“…The aim of this study was to investigate the effects of different combinations of molasses levels and slow-release urea on Holstein fattening bulls. …”
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Lesion Volume as a Predictor for Return to Work After Endovascular Treatment: A 4‐Year Prospective Cohort Study by Gisle Berg Helland, Mona Kristiansen Beyer, Brian Anthony B. Enriquez, Hege Ihle‐Hansen, Håkon Ihle‐Hansen, Stein Andersson, Esten Høyland Leonardsen, Helle Stangeland, Bettina Ùjhelyi, Guri Hagberg, Hanne Flinstad Harbo, Anne Hege Aamodt, Einar August Høgestøl

“…Background There are no known objective biomarkers for predicting return to work (RTW) in ischemic stroke survivors. This study aims to explore the predictive utility and defines a cutoff value of lesion volume on RTW after endovascular treatment. …”
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Sexual Quality of Life in Postmenopausal Women: A Comparative Randomized Controlled Trial of Intravaginal PRP Therapy Versus Local Hormonal Treatments by Geanina Sacarin, Ahmed Abu-Awwad, Nitu Razvan, Marius Craina, Bogdan Hogea, Bogdan Sorop, Simona-Alina Abu-Awwad, Mircea Diaconu, Nicolae Ciprian Pilut, Madalina-Ianca Suba

“…Further long-term studies are needed to confirm these findings and optimize treatment protocols.…”
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NG2 MOLECULE EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA B CELLS: A FLOW-CYTOMETRIC MARKER FOR THE RAPID IDENTIFICATION OF KMT2A GENE REARRANGEMENTS by Maria Laura Bisegna, Nadia Peragine, Loredana Elia, Mabel Matarazzo, Maria Laura Milani, Stefania Intoppa, Mariangela Di Trani, Francesco Malfona, Maurizio Martelli, Maria Stefania De Propris

“…Considering the correlation between rat neuron glial-antigen 2 (NG2) chondroitin sulfate proteoglycan molecule expression and KMT2A-r, we aimed identifying an optimized cytofluorimetric diagnostic panel to predict the presence of KMT2A-r.                                                                                                                                           …”
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Sustainability of the rice–crayfish farming model in waterlogged land: A case study in Qianjiang County, Hubei Province, China by Peng-li YUAN, Jin-ping WANG, Can GUO, Zi-yuan GUO, Yao GUO, Cou-gui CAO

“…In RC2 and RC8, however, residual feed-nitrogen that was not used by crayfish was utilized by rice plants. Thus, an optimal amount of nitrogen in RC fields was proposed to improve the nitrogen use efficiency and reduce environmental pollution by nitrogen fertilizer. …”
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Investigating the effect of Cognitive Bias Modification towards sad faces on indicators of depression, hope, and life orientation by Ali Pakizeh, Sepideh Mahmoodzadeh, Seyed Nazifullah Habibi

“…For example, the findings of the study aimed at investigating the effectiveness of bias correction training for the treatment of depression led to a significant improvement in depression symptoms (Hsu et al., 2022). …”
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Preoperative psychological health impacts pain and disability outcomes following anterior cervical discectomy and fusion for cervical radiculopathy by Erin E. Cunningham, Erin Bigney, Stephan U. Dombrowski, Niels Wedderkopp, Neil Manson, Najmeddan Attabib, Edward Abraham, Chris Small, Eden Richardson, Michael M. H. Yang, Eric Crawford, Michael H. Weber, Jerome Paquet, Sean D. Christie, Raphaele Charest-Morin, Bernard LaRue, Andrew Nataraj, Hamilton Hall, Y. Raja Rampersaud, Charles Fisher, Nicolas Dea, Chris Bailey, Jeffrey J. Hébert

“…Abstract This study aimed to estimate the effects of preoperative psychological health on postoperative outcomes in patients undergoing surgery for cervical spondylotic radiculopathy. …”
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Screening and Identification of Hypoxia-Inducible Factor Signaling Inhibitor with Antiangiogenic Activity by Chao Li, Yuanzheng Wei, Ping Wang, Xiaoxian Xue, Guangyao Wei, Mu Chen, Xinyun Zhang, Lei Cai, Yu Zhang, Xumu Zhang, Yingjun Li

“…Further studies are warranted to optimize HST3782's pharmacokinetics and therapeutic efficacy for antiangiogenic therapy in hypoxia-related malignancies.…”
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PET/CT Volumetric Parameters as Predictors of the Peritoneal Cancer Index in Advanced Ovarian Cancer Patients by Ariel Glickman, Blanca Gil-Ibáñez, Aida Niñerola-Baizán, Marta Tormo, Núria Carreras-Dieguez, Pere Fusté, Marta Del Pino, Eduardo González-Bosquet, Inmaculada Romero-Zayas, Cristina Celada-Castro, Tiermes Marina, Lydia Gaba, Adela Rodriguez Hernández, Adela Saco, Laura Buñesch, Josep Lluís Carrasco, Katherine Quintero, David Fuster, Berta Díaz-Feijóo, Aureli Torné, Pilar Paredes

“…<b>Background:</b> Assessment of the peritoneal cancer burden is crucial for determining the optimal treatment in advanced ovarian cancer (AOC). …”
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Risk factors for prolonged hospitalization in acute decompensated heart failure from the HEROES study by Mateusz Lucki, Przemysław Mitkowski, Ewa Lucka, Marek Grygier, Ewa Straburzyńska-Migaj, Robert Morawiec, Agnieszka Kapłon-Cieślicka, Agata Galas, Katarzyna Byczkowska, Piotr Hamala, Iwona Gorczyca-Głowacka, Anna Furman-Niedziejko, Dominika Klimczak-Tomaniak, Agnieszka Major, Adrian Stefański, Mateusz Guzik, Małgorzata Zachura, Mateusz Staciwa, Ewa Pierzchała, Maciej Nadel, Maciej Lesiak

“…Early identification of high-risk patients may facilitate personalized management and optimize healthcare resource utilization.…”
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Unveiling the influence of CAR-negative T-cells: enhancing efficacy and ensuring safety in CAR-T therapies by Belén Sierro-Martínez, Beatriz Guijarro-Albaladejo, Ricardo Fernández-Cisnal, Alfonso Rodríguez-Gil, Paola Hernández-Díaz, María de la Rosa-Garrido, Inmaculada Carrasco-Brocal, Maribel Lara-Chica, Virginia Escamilla-Gómez, Raquel Muñoz-García, Ángela Bella, Francisco Jose García-Cózar, Jose Antonio Pérez-Simón, Estefanía García-Guerrero

“…Purification of CAR-pos T cells could potentially optimize product characteristics.…”
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Efficacy and safety of dual antiplatelet therapy in the elderly for stroke prevention: a subgroup analysis of the CHANCE-2 trial by Liping Liu, Yongjun Wang, Yilong Wang, Zixiao Li, Xingquan Zhao, Jing Jing, Philip M Bath, Hao Li, Xia Meng, Anxin Wang, Yong Jiang, Xinmiao Zhang, Jianhua Li, Jinxi Lin, S Claiborne Johnston, Xinsheng Han, Qin Xu, Weifeng Chen, Xuewei Xie, Xuhai Gong

“…Objectives Evidence of the optimal antiplatelet therapy for elderly patients who had a stroke is limited, especially those elder than 80 years. …”
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Functional recovery following hospitalisation of patients diagnosed with COVID-19: a protocol for a longitudinal cohort study by Julie C Reid, Maureen Markle-Reid, Ameen Patel, Andrew P Costa, Maura Marcucci, MyLinh Duong, Connie Schumacher, Aaron Jones, Mats Junek, Marla K Beauchamp, Parminder Raina, Lauren E Griffith, Sophie Corriveau, Shariq Haider, Terence Ho, Rebecca Kruisselbrink, Hope Morrison, Natya Raghavan, Leslie Martin, Carla Girolametto

“…However, there is limited evidence on the trajectory of functional recovery in those hospitalised with COVID-19. The primary aim of the Coronavirus Registry Functional Recovery (COREG-FR) study is to understand the trajectory of functional recovery among individuals hospitalised for COVID-19 over the medium (up to 6 months) and longer term (6–12 months) that will guide clinical care and optimal management of serious COVID-19 illness and recovery.Methods and analysis COREG-FR is a multicentre longitudinal cohort study. …”
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Thresholds of Body Composition Changes Associated with Survival During Androgen Deprivation Therapy in Prostate Cancer by Pin-Chi Chen, Pai-Kai Chiang, Jhen-Bin Lin, Wei-Kung Tsai, Wan-Chun Lin, Ya-Ting Jan, Kun-Pin Wu, Jie Lee

“…However, the threshold for body composition changes associated with survival during ADT remains unclear. This study aimed to identify body composition change thresholds for all-cause mortality during ADT. …”
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Belimumab versus telitacicept in sequential treatment after rituximab for refractory lupus nephritis: a real-world multicentre study by Fei Han, Hong Pan, Yi Yang, Jianghua Chen, Jing Xue, Lan Lan, Yiting Chen, Pingping Ren, Yaomin Wang, Xin Lei, Jianhang Xu, Xiaochan Chen, Qiankun Zhang, Junni Wang, Nan Shi, Liangliang Chen, Lie Jin

“…Further investigation is necessary to establish optimal protocols and long-term benefits.…”
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Biosynthesis of Palladium Nanoparticles by Using Aqueous Bark Extract of <i>Quercus dalechampii</i>, <i>Q. frainetto,</i> and <i>Q. petraea</i> for Potential Antioxidant and Antimi... by Nastaca-Alina Coman, Mihai Babotă, Alexandru Nicolescu, Alexandra Nicolae-Maranciuc, Lavinia Berta, Adrian Man, Dan Chicea, Lenard Farczadi, Corneliu Tanase

“…To optimize PdNPs biosynthesis, various parameters were explored, including the concentration of PdCl₂, the extract-to-PdCl₂ ratio, and the pH of the solution. …”
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Clinical spectrum of rectal cancer identifies hallmarks of early‐onset patients and next‐generation treatment strategies by Dingcheng Shen, Puning Wang, Yumo Xie, Zhuokai Zhuang, Mingxuan Zhu, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu

“…Abstract Background The incidence of colorectal cancer is increasing among young adults and more rectal cancers are reported. This study aimed to identify the clinical features specific for early‐onset rectal cancer and provide insights on cancer management. …”
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Validation of urinary biomarkers for accurate diagnosis of urinary tract infections in older adults across primary care, hospitals and long-term care facilities in the Netherlands... by Simon P Mooijaart, Simon P Conroy, Abimbola A Akintola, Wilco P Achterberg, Janneke E Stalenhoef, Cees van Nieuwkoop, Jelle J Goeman, Christa M Cobbaert, Paul L A M Corstjens, Martijn Sijbom, Martha T van der Beek, Leo G Visser, Nora El Moussaoui, Esther van Andel, Jessica A Vlot, Manu P Bilsen, Fanny N Lauw, Nathalie M Delfos, Eliane M S Leyten, Janneke I M van Uhm, Merel M C Lambregts

“…A previous pilot study proposed a higher cut-off for pyuria and identified five promising biomarkers for the diagnosis of UTIs in older adults. The UTI-GOLD study aims to validate these five new biomarkers and the higher leucocyte cut-off as a diagnostic tool for UTIs in older people in a real-world setting.Methods and analysis Between August 2024 and December 2027, an observational multicentre diagnostic accuracy study is being conducted across primary, secondary and tertiary healthcare facilities in the Netherlands and the UK. …”
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The Effect of Systemic Inflammation and Clinicopathologic Features on Survival in Malignant Pleural Mesothelioma: A Multicenter Analysis by Nadiye Sever, Sedat Yıldırım, Ali Fuat Gurbuz, Delyadil Karakaş Kılıç, Esra Zeynelgil, Yunus Emre Altintaş, Berivan Deniz Çimik, Yeşim Ağyol, Ali Kaan Güren, Pınar Erel, Erkam Kocaaslan, Burak Paçacı, Mustafa Alperen Tunç, Abdussamet Çelebi, Nazım Can Demircan, Selver Işık, Rukiye Arıkan, Murat Araz, Serdar Karakaya, Murat Sarı, Osman Köstek, İbrahim Vedat Bayoğlu

“…Identifying reliable prognostic factors is crucial for risk stratification and optimizing treatment strategies. This study aimed to evaluate the impact of clinicopathologic factors and systemic inflammatory markers on survival outcomes in patients with MPM. …”
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