Study of the immunological efficacy and safety of a candidate vaccine against Lassa hemorrhagic fever by O. Popova, O. V. Zubkova, T. A. Ozharovskaia, D. I. Zrelkin, D. V. Voronina, P. P. Goldovskaya, V. Yu. Kan, I. V. Dolzhikova, A. V. Kovyrshina, D. M. Grousova, I. A. Ermolova, D. V. Shcheblyakov, D. Yu. Logunov, A. L. Gintsburg

“…Both recombinant vectors contain the codon-optimized sequence of Lassa virus glycoprotein. Two experimental batches of the candidate vaccine were produced under GMP-conditions and analyzed. …”
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Co-design of a Mobile Stroke Unit pathway highlights uncertainties and trade-offs for viable system-wide implementation in the English and Welsh NHS by L. Moseley, P. McMeekin, M. Allen, G. A. Ford, M. James, A. Laws, S. McCarthy, G. McClelland, L. J. Park, K. Pearn, D. Phillips, C. Price, L. Shaw, P. White, D. Wilson, J. Scott

“…Routine use of MSUs across the English and Welsh National Health Service (NHS) has not yet been considered, and as such no pathway for their operation exists. This study aimed to co-design a viable pathway, detailing dispatch, staffing and treatment decisions, for MSUs within the NHS context. …”
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Comprehensive analysis of 1103 infants referred to a single center due to positive newborn screening test for phenylketonuria by Ayça Burcu Kahraman, Kısmet Çıkı, Begüm Poşul, Mustafa Güvercin, Yılmaz Yıldız, Ali Dursun, Serap Sivri, Turgay Coşkun, Ayşegül Tokatlı

“…Future research should address regional disparities and optimize screening protocols to improve outcomes for affected infants. …”
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Genetic polymorphism of msp2 in Plasmodium falciparum isolates among asymptomatic malaria infections from two ecological settings in Cameroon by Aline G. Bouopda-Tuedom, Luc Abate, Brice L. Feufack-Donfack, Christelle M. Ngou, Albert N. Bayibeki, Carole E. Eboumbou Moukoko, Lawrence S. Ayong, Antoine Berry, Thierry Lefèvre, Isabelle Morlais, Sandrine E. Nsango

“…A better knowledge of parasite genotypes circulating in different disease endemic areas could help to optimize local malaria interventions. This study aimed at determining P. falciparum genetic diversity from isolates collected in forest (Mfou) and humid savanna (Tibati) eco-epidemiological settings in Cameroon. …”
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Interpretable multiparametric MRI radiomics-based machine learning model for preoperative differentiation between benign and malignant prostate masses: a diagnostic, multicenter st... by Wenjun Zhou, Wenjun Zhou, Zhangcheng Liu, Zhangcheng Liu, Jindong Zhang, Shuai Su, Yu Luo, Lincen Jiang, Kun Han, Guohua Huang, Jue Wang, Jianhua Lan, Delin Wang

“…ObjectiveThe study aimed to develop and externally validate multiparametric MRI (mpMRI) radiomics-based interpretable machine learning (ML) model for preoperative differentiating between benign and malignant prostate masses.MethodsPatients who underwent mpMRI with suspected malignant prostate masses were retrospectively recruited from two independent hospitals between May 2016 and May 2023. …”
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Global burden of disease changes related to high red meat diets and breast cancer from 1990 to 2021 and its prediction up to 2030 by Yujun Tong, Hong Ning, Zhen Zhang, Xiaohong Zhang, HongMei Tu, Min Yang, Xiaoan Li, Tiantian Liang

“…In the future, it is essential to prioritize addressing the burden in low-SDI regions and developing targeted interventions to optimize health resources, thereby mitigating the public health threat of breast cancer.…”
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The role of imaging in defining cardiovascular risk to help cancer patient management: a scoping review by Roberto Farì, Giulia Besutti, Pierpaolo Pattacini, Guido Ligabue, Francesco Piroli, Francesca Mantovani, Alessandro Navazio, Mario Larocca, Carmine Pinto, Paolo Giorgi Rossi, Luigi Tarantini

“…Routinely performed CTs predict cardiovascular risk, optimizing the management of cancer patients. Graphical Abstract…”
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Prevalence of AOX1 and CYP1A2 gene polymorphisms associated with response to favipiravir therapy in novel coronavirus infection COVID-19 among ethnic groups of the North Caucasus by A. T. Leinsoo, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, A. V. Kryukov, S. N. Mammaev, Zh. A. Sozaeva, M. S.-Kh. Sozaeva, K. A. Akmalova, L. Z. Bolieva, A. I. Dobroselskaya, M. L. Maksimov, K. B. Mirzaev, D. A. Sychev

“…The results may be useful for optimizing therapy with medicines that are AOX1 substrates, which include favipiravir, used to treat patients with COVID-19.…”
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The effectiveness of nurse-led palliative care needs assessment on patients’ quality of life and symptom burden: a systematic review by Gursharan K. Singh, Claudia Virdun, Megan Rattray, Roslyn Prichard, Rochelle Wynne

“…Background: Optimal palliative care requires a correct assessment of needs. …”
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Dose–response association between fluid overload and in-hospital mortality in critically ill patients: a multicentre, prospective, observational cohort study by Wei Li, Bin Du, Yan He, Li Jiang, Guangxu Liu, Meiping Wang, Jing Wen, Wen Li, Bo Zhu, Ying Wen, Xiuming Xi

“…Objectives Fluid management is important in ensuring haemodynamic stability in critically ill patients, but can easily lead to fluid overload (FO). However, the optimal fluid balance plot or range for critically ill patients is unknown. …”
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Effect of Spirulina on the Rumen Microbiota and Serum Biochemical Parameters of Lambs by Zhijun Wang, Xiangdong Liu, Muqier Zhao, Weiqin Ma, Yuxuan Wang, Yushan Jia, Gentu Ge

“…The aim of this study was to evaluate whether dietary supplementation with Spirulina has a beneficial effect on the rumen microbial community and serum indices in lambs. …”
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Predictors of Futile Recanalization in Patients With Basilar Artery Occlusion With Large Versus Nonlarge Infarcts by Pan Zhang, Miaomiao Hu, Yingjie Xu, Jinghui Zhong, Xinfeng Liu, Wen Sun

“…The findings underscore the importance of individualized treatment strategies and timely intervention to optimize endovascular treatment outcomes in high‐risk patients.…”
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The Value of PET/CT-Based Radiomics in Predicting Adrenal Metastases in Patients with Cancer by Qiujun He, Xiangxing Kong, Xiangxi Meng, Xiuling Shen, Nan Li

“…Based on the selected features, the optimal model was chosen from ten machine learning algorithms, and the nomogram was constructed. …”
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Perceived Worries in the Adoption of Artificial Intelligence Among Healthcare Professionals in Saudi Arabia: A Cross-Sectional Survey Study by Abdulaziz R. Alsaedi, Nada Alneami, Fahad Almajnoni, Ohoud Alamri, Khulud Aljohni, Maha K. Alrwaily, Meshal Eid, Abdulaziz Budayr, Maram A. Alrehaili, Marha M. Alghamdi, Eqab D. Almutairi, Mohammed H. Eid

“…The use of AI in the healthcare sector is facing some formidable concerns raised by the practitioners themselves. This study aimed to establish the concerns that surround the adoption of AI among Saudi Arabian healthcare professionals. …”
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From mine drainage to river lifeline: An ecological indicator-driven framework for circular water management and SDG synergies in mining basins by Fu Yicheng, Zhang Jian, Li Haixue, Fu Min, Chen Hao

“…This study aims to transform mine water from an environmental liability into a strategic resource for ecological restoration and Sustainable Development Goal (SDG) achievement in mining basins, by developing and applying an ecological indicator-driven framework for managing circular hydrosystems and optimizing flow allocation. …”
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Methods for the detection of tumor-specific single nucleotide somatic mutations in plasma cDNA samples by L. M. Dyakov, O. M. Krivtsova, P. A. Khesina, I. F. Kustova, N. A. Dyakova, N. S. Muge, N. E. Kudashkin, Yu. I. Patyutko, N. L. Lazarevich

“…Liquid biopsy is considered as a minimally invasive method of molecular genetic analysis that can be used for early diagnosis, prognosis of disease development, monitoring of residual disease or treatment outcomes, and selection of optimal drug therapy schemes for a patient. Along with the development of tests based on the study of panels of oncologically significant genes or their regions, for various forms of genetically heterogeneous tumors a promising approach could be the use as an object of liquid biopsy of an individual spectrum of somatic mutations of a particular patient that can be detected on the basis of high-throughput sequencing of tumor tissue.Aim. …”
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Distribution characteristics and value range of numerical simulation mechanical parameters in coal seam mining by Nan WANG, Yang LI, Gustavo André PANEIRO, Xinghai LEI, Xiaoming SHI, Yihang LI, Yutong CUI, Haotian LIU, Jinlong CAO, Tieji WANG

“…Based on this dataset, methods for setting and dynamically optimizing the credibility weights of data from various provinces are presented. …”
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Resistin alleviates lipopolysaccharide-induced inflammation in bovine alveolar macrophages by activating the AMPK/mTOR signaling pathway and autophagy by Xiaoping Ma, Aining Yang, Xiaoben Fan, Hong Liu, Yu Gu, Zhisheng Wang, Hongrui Guo, Jing Fang, Hengmin Cui, Liping Gou, Junliang Deng, Dongjie Cai, Zhicai Zuo

“…Methods: The optimal concentration of RETN + lipopolysaccharide (LPS) on macrophages was screened and then used to co-culture with alveolar macrophages. …”
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Self-monitoring blood pressure in pregnancy: evaluation of women’s experiences of the BUMP trials by Alison Chisholm, Katherine L Tucker, Carole Crawford, Marcus Green, Sheila Greenfield, James Hodgkinson, Layla Lavallee, Paul Leeson, Lucy Mackillop, Christine McCourt, Jane Sandall, Hannah Wilson, Lucy C Chappell, Richard J McManus, Lisa Hinton

“…This paper reports the qualitative evaluation which aimed to understand how the intervention worked, the perspectives of participants in the trials, and, crucially, those who declined to participate. …”
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Approach to shoulder instability: a randomized, controlled trial by Julien Caron, MD FRCSC, Kellen Walsh, MD FRCSC, Tinghua Zhang, MSc, Rashed AlAhmed, MBChB MSc FRCSC, Peter B. MacDonald, MD FRCSC, Cristina Bassi, MD, J Whitcomb Pollock, MD FRCSC MSc, Katie McIlquham, BSc, Peter Lapner, MD FRCSC

“…The aim was to compare two surgical treatment algorithms: the ISI score and a conventional treatment algorithm (CTA). …”
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