Integrating Gut Microbiome and Metabolomics with Magnetic Resonance Enterography to Advance Bowel Damage Prediction in Crohn’s Disease by Huang L, Meng J, Lin S, Peng Z, Zhang R, Shen X, Zheng W, Zheng Q, Wu L, Wang X, Wang Y, Mao R, Sun C, Li X, Feng ST

“…Although tools such as the Lémann Index help assess this damage, they mainly rely on clinical records and do not reveal the biological processes behind the damage. In this study, we aimed to develop a more accurate method for predicting bowel damage. …”
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Effects of temperature on the pollination biology of Luntai Xiaobai apricot by XIE Lixing, TIAN Baolian, TANG Zhanghu, ZHU Zongcai, Abulaike Niyazi, ZHANG Dahai, LUO Shudong

“…[Objective] The study aimed to investigate the influence of temperature on the pollination biology of Luntai Xiaobai apricot (Prunus armeniaca L.) in order to provide a theoretical foundation for determining the optimal timing for artificially assisted pollination. …”
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Interaction of Dissolved Oxygen and Feed Fat Levels on Physiological Functions of Nile Tilapia by Dandan WANG, Kai HUANG, Ting LIU, Ruijie GUO, Yuda LI, Xiangli LI

“…Owing to the low utilization rate of carbohydrates in fish, utilizing lipids to provide energy is the optimal choice for them to adapt to low-oxygen environments. …”
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Epicardial Adipose Tissue and Heterogeneity Parameters Combined with Inflammatory Cells to Predict the Value of Heart Failure with Preserved Ejection Fraction Patients Post Myocard... by Yu-jiao Song, Xiao-ying Zhao, Lu-jing Wang, Ting Ning, Ming-tian Chen, Pei Liu, Si-wen Chen, Xin-xiang Zhao

“…Time-dependent ROC curves were generated to evaluate the efficacy of each parameter in predicting HFpEF, the AIC values of each parameter and the final model were calculated to evaluate the predictive performance. The optimal cut-off values were identified using time-dependent ROC curves in R software, and Kaplan–Meier event-survival curves were plotted to illustrate the event-free rates based on these optimal thresholds.The median follow-up time was calculated using the reverse Kaplan–Meier method. …”
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Effects of pruning on canopy microenvironment, branch composition and nut quality in Xinjiang walnut by HAN Liqun, ZHAO Yu, ZHAO Guoqing, ZHANG Hui, MA Kai

“…The annual bearing branches and flower buds are critical for the formation of yield and quality. Pruning optimized light utilization and influenced the growth of annual bearing branches. …”
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Effect of different water supply on the growth of kiwiberry vine cultivated in substrate by LI Hao, SUN Xiaoxu, QI Xiujuan, GU Hong, LI Lan, CHENG Dawei, CHEN Jinyong, YANG Yingjun

“…[Objective] This study aimed to investigate the effects of different levels of irrigation on the growth dynamics of Zhong Hong Bei 7 hao kiwiberry (Actinidia arguta) vine under substrate cultivation. …”
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酶催化酯化法降低模型油中3-氯丙醇酯 和缩水甘油酯前体物质工艺研究 Reduction of 3-chloropropanol esters and glycidyl esters precursors in model oils by enzyme-catalyzed esterification... by 冯兆寒，周燕霞，孙尚德 FENG Zhaohan, ZHOU Yanxia, SUN Shangde

“…The results showed that the optimal esterification reaction conditions were Lipozyme RM IM as the enzyme, lipase dosage 5.64%, reaction temperature 78.82 ℃, substrate ratio 17.31∶ 1, and reaction time 29.05 h. …”
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Pomalidomide in relapsed and refractory multiple myeloma: multicenter retrospective study by V. G. Potapenko, E. V. Baumert, A. A. Bobrova, R. V. Vashchenkov, N. V. Dorofeeva, K. D. Kaplanov, E. V. Karyagina, A. N. Levanov, A. S. Luchinin, S. I. Moiseev, A. V. Novitskii, A. S. Nizamutdinova, О. V. Pirogova, S. A. Povzun, М. V. Platonov, V. V. Porunova, D. А. Ptashnikov, V. V. Ryabchikova, S. Ya. Simeniv, I. А. Skorokhod, Е. А. Ukrainchenko, D. А. Chaginskaya, T. V. Shelekhova, M. N. Shirokova, A. A. Shutylev, N. V. Medvedeva

“…Pomalidomide is ап immunomodulatory agent that was registered for the treatment of patients with double refractory multiple myeloma.Aim. To evaluate efficacy, safety and optimal course of the therapy with pomalidomide in routine practice in patients with double refractory multiple myeloma.Materials and methods. …”
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Understanding patient pathways to Mother and Baby Units: a longitudinal retrospective service evaluation in the UK by Nikolina Jovanović, Žan Lep, Giles Berrisford, Aysegul Dirik, Julia Barber, Bukola Kelani, Olivia Protti

“…This dual interpretation calls for future research to explore whether pathway differences among ethnic groups result from optimal clinical decision-making or gaps in care provision. …”
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Mejora en la detección, diagnóstico y tratamiento temprano de la enfermedad renal crónica en España. Proyecto IntERKit by José Luis Górriz, Fran Adán Gil, Manuel A. Botana López, Antonio Buño Soto, Francisco José Campos Cabrera, Angeles Cisneros, Silvia Cobo Guerrero, María Dolores Conejos, Isabel Egocheaga Cabello, M. Concepción Fernández Planelles, Lisardo García-Matarín, Natalia Jiménez, Juan Carlos Julián Mauro, David León Jiménez, Daniel Martínez Gamote, Pilar Mazón Ramos, Alberto Ortiz, Gemma Palau, Julia Quevedo Rivera, J. Emilio Sánchez-Álvarez, Rita Tristancho Ajamil, Cristina Varga Martín, Roser Vallés Fernández

“…Several publications have shown that, to date, both the detection of CKD and its initial management are not optimal. The IntERKit project provides healthcare organizations with a structured framework to optimize the early approach of CKD efficiently, achieving a real, measurable, sustainable and scalable impact, which can evolve depending on the results obtained.…”
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Improvement in the detection, diagnosis, and early treatment of chronic kidney disease in Spain. The IntERKit project by José Luis Górriz, Fran Adán Gil, Manuel A. Botana López, Antonio Buño Soto, Francisco José Campos Cabrera, Angeles Cisneros, Silvia Cobo Guerrero, María Dolores Conejos, Isabel Egocheaga Cabello, M. Concepción Fernández Planelles, Lisardo García-Matarín, Natalia Jiménez, Juan Carlos Julián Mauro, David León Jiménez, Daniel Martínez Gamote, Pilar Mazón Ramos, Alberto Ortiz, Gemma Palau, Julia Quevedo Rivera, J. Emilio Sánchez-Álvarez, Rita Tristancho Ajamil, Cristina Varga Martín, Roser Vallés Fernández

“…Several publications have shown that, to date, neither the detection of CKD nor its initial management are optimal. The IntERKit project emerged with the aim of improving the early detection, diagnosis, and initial management of CKD by promoting collaboration with health organizations through tools easily implemented by these organizations. …”
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Development and validation of a novel prognostic model to predict 1-year post-transplant mortality for acute-on-chronic hepatitis B liver failure: a nationwide, multicentre, cohort... by Li Zhuang, Yimou Lin, Yu Jia, Jun Fang, Yujian Zheng, Taishi Fang, Meiching Ong, Aibo Mu, Jiaxing Zhu, Mengchao Wang, Dong Zhao, Feiwen Deng, Qiucheng Lei, Leibo Xu, Zuozhong Yang, Qiang Sun, Wei Qu, Chenwei Xu, Zhijun Zhu, Chuanjiang Li, Hanyu Jiang, Jimin Liu, Xiaoshun He, Shusen Zheng, Zhiyong Guo, Qi Ling

“…Summary: Background: Liver transplantation (LT) provides a potential cure for hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). We aimed to develop and externally validate a prognostic model to predict 1-year post-LT mortality in patients with HBV-ACLF. …”
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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…Background & Aims: Atezolizumab/bevacizumab (A/B) is now a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but the optimal second-line regimen is not known. …”
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Multicentre comparison of various microaxial pump devices as a bridge to durable assist device implantation by Marta L. Medina, Daniel Lewin, Hendrik Treede, Sebastian V. Rojas, Alexander Bernhardt, Michael Billion, Anna L. Meyer, Ivan Netuka, Janajade Kooij, Marina Pieri, Antonio Loforte, Mauro Rinaldi, Mariusz K. Szymanski, Adriaan O. Kraajieveld, Christian J.H. Moeller, Payam Akhyari, Khalil Jawad, Bastian Schmack, Gloria Färber, Assad Haneya, Daniel Zimpfer, Gaik Nersesian, Ilija Djordjevic, Diyar Saeed, Finn Gustafsson, Anna M. Scandroglio, Bart Meyns, Steffen Hofmann, Jan Belohlavek, Jan Gummert, Pia Lanmueller, Evgenij V. Potapov, Mehmet Oezkur

“…This study aimed to assess the efficacy of different microaxial flow pump (mAFP) support devices (Impella®) in achieving optimal left ventricular unloading for preconditioning and facilitating definitive treatment in this high‐risk patient cohort. …”
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Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study... by Jing Zhang, Yu Chen, Mingzhu Wang, Nan Xia, Jinghong Li, Weiqiang Liang, Yangyang Yin, Linhan Zhai, Qiuxia Wang

“…Among these, the cortico-reticulospinal tract (CRST) has gained attention in rehabilitation due to its unique ascending and descending structural features as well as its cellular properties which position it as an excellent candidate to compensate for inadequate motor control post-stroke. However, the optimal strategies to harness the CRST for motor recovery remain unknown. …”
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Caregiver insights on challenges and needs in fecal incontinence products: a mixed methods study by Lanlan Yu, Lanlan Yu, Fengming Hao, Fengming Hao, Jie Li, Jie Li, Yingjie Hu, Yingjie Hu, Fei Xiong, Ling Chen, Ling Chen, Wenzhi Cai, Wenzhi Cai

“…AimsThis study explores the real–world use and challenges of fecal incontinence (FI) collection products—both absorbent items (pads, diapers) and dedicated fecal-collection devices with adhesive fixators—among long-term, bed-bound hospital patients, while also considering broader public-health implications. …”
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Incorporation of liver chemistry score in predicting survival of liver‐involved advanced gastric cancer patients who received palliative chemotherapy by Ying Feng, Cheng Zhang, Zhijun Wu, Hui Xu, Xiaopeng Zhang, Chong Feng, Jingyi Shao, Minmin Xie, Yahui Yang, Yi Zhang, Tai Ma

“…Abstract Background Gastric cancer liver metastasis (GCLM) patients usually accompany by abnormal serum liver function tests (LFTs) more or less; however, the prognostic value of LFTs is not fully understood. This study aimed to develop a liver chemistry score (LCS) based on LFTs and incorporate it into prognosis determination for GCLM patients who received palliative chemotherapy. …”
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Pharmacokinetics and tissue distribution analysis of ginsenoside Rh3 in rats using a novel LC-MS/MS quantification strategy by Cong Hu, Cong Hu, Yuheng Wang, Yu Liu, Xiaojing Wang, Peifang Song, Hong Ma, Ling Yang, Ling Yang

“…These findings provide a foundation for optimizing GRh3 dosing regimens and guiding future preclinical studies.…”
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A new signature associated with anoikis predicts the outcome and immune infiltration in nasopharyngeal carcinoma by Yonglin Luo, Wenyang Wei, Yaxuan Huang, Jun Li, Weiling Qin, Quanxiang Hao, Jiemei Ye, Zhe Zhang, Yushan Liang, Xue Xiao, Yonglin Cai

“…Nevertheless, the prognostic significance of anoikis-related genes (ARGs) in NPC remains incompletely understood. This study aimed to create a predictive risk score using an ARGs signature for NPC patients and to investigate how this score relates to clinicopathologic features and immune infiltration in the tumor microenvironment. …”
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The improved prediction value of neutrophil to lymphocyte ratio to pneumonia severity scores for mortality in the older people with community-acquired pneumonia by Lixue Huang, Bingxuan Weng, Mengyuan Wang, Jianzhen Weng, Xiaoman Du, Yang Ju, Xuefeng Zhong, Xunliang Tong, Yanming Li

“…Abstract Objective We aimed to evaluate whether there is a linear relationship between neutrophil to lymphocyte ratio (NLR) and adverse outcomes in the older hospitalised patients with community-acquired pneumonia (CAP). …”
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