Artificial intelligence–enhanced mapping of the international classification of functioning, disability and health via a mobile app: a randomized controlled trial by Zhandos Kurban, Didar Khassenov, Didar Khassenov, Zhandos Burkitbaev, Sholpan Bulekbayeva, Azat Chinaliyev, Serik Bakhtiyar, Samat Saparbayev, Tokan Sultanaliyev, Ulzhalgas Zhunissova, Natalia Slivkina, Elena Titskaya, Luis Arias, Dana Aldakuatova, Gulfairus Yessenbayeva, Zhanerke Ermakhan

“…BackgroundMobile health applications and artificial intelligence (AI) are increasingly utilized to streamline clinical workflows and support functional assessment. The International Classification of Functioning, Disability and Health (ICF) provides a standardized framework for evaluating patient functioning, yet AI-driven ICF mapping tools remain underexplored in routine clinical settings.ObjectiveThis study aimed to evaluate the efficiency and accuracy of the MedQuest mobile application—featuring integrated AI-based ICF mapping—compared to traditional paper-based assessment in hospitalized patients.MethodsA parallel-group randomized controlled trial was conducted in two medical centers in Astana, Kazakhstan. …”
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Impact of fatigue in Crohn's disease is negatively related to resting state functional connectivity between the superior parietal lobule and parahippocampal gyrus/hippocampus by Theresa A. McIver, Theresa A. McIver, Theresa A. McIver, Charles N. Bernstein, Charles N. Bernstein, Ruth Ann Marrie, Ruth Ann Marrie, Chase R. Figley, Chase R. Figley, Md Nasir Uddin, Md Nasir Uddin, Md Nasir Uddin, John D. Fisk, Lesley A. Graff, Lesley A. Graff, Ronak Patel, Erin L. Mazerolle, Jennifer Kornelsen, Jennifer Kornelsen, Jennifer Kornelsen

“…This study aimed to address this knowledge gap by identifying fatigue-related differences in brain resting state functional connectivity. in Crohn's disease.MethodsParticipants included 49 adults with Crohn's Disease (Mage 53 yrs, 35 females) and 49 healthy controls (Mage 50 yrs, 31 females). …”
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Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2 by Tianwei Guo, Hongyue Wang, Fujian Wu, Wenjing Lu, Min Zhu, Shuhong Ma, Yongshuai Zhang, Yuting Yan, Meng Zhou, Didaer Talanaite, Siyu Liu, Man Qi, Feng Lan, Xujie Liu

“…This study aimed to investigate JPH2’s role in human cardiac function and disease using a novel stem cell-derived model, while introducing a new indicator to evaluate related cardiac impairments. …”
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Comparative mid-term evaluation of unilateral and bilateral total knee arthroplasty utilizing metal-backed components: An assessment of functional and clinical outcomes by Ponnanna Karineravanda Machaiah, Supreet Bajwa, Ravi Teja Rudraraju, Kunal Aneja, Haresh P. Bhalodiya, Rakesh Kumar Singh, Vividh Makwana, Avtar Singh, Vivek Logani, Buddhadev Chatterjee, Devendra S. Solanki, Hemant Wakankar, Sanjeev Mahajan, Chandra-Shekhar Yadav, Ashokkumar Thakkar, Udita Chandra, Sanaa Ansari, Shivadharshni Sivakumar

“…Objective: This prospective, post-marketing surveillance (PMS) study (Freedom 400) aimed to evaluate the clinical and functional outcomes of both unilateral and bilateral total knee arthroplasty (TKA) utilizing cruciate retaining/posterior stabilized (CR/PS) implants with metal-backed components (MBC). …”
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Effects of Proanthocyanidins on Growth Performance, Intestinal Inflammation and Barrier Function, and Bile Acid Metabolism-Related Genes in Weaned Piglets Challenged with Lipopolys... by Aiying Yu, Zhenjiang Wang, Sutian Wang, Weiguo Zhao, Lian Chen, Dan Wang, Zhiyi Li, Yuan Wang, Zhengfeng Fang, Sen Lin

“…This study aims to investigate the effects of dietary proanthocyanidins (PACs) on growth performance, intestinal inflammation and barrier function, and bile acid metabolism-related genes in weaned piglets challenged with lipopolysaccharide (LPS). …”
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Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer by Taojian Tu, Handan Hong, Diala Alhousari, Lina He, Mario Alba, Yiwei Gu, Brittney Hua, Phillip Nguyen, Qi Tang, Tianyi Xia, Karam Ashouri, Anastasia Martynova, Christina Nakhoul, Whitaker Cohn, Genshu Wang, Geyang Xu, Zhang-Xu Liu, Curtis Okamoto, Enrique Cadenas, Julian Whitelegge, Weiming Yuan, Shefali Chopra, Keigo Machida, Liyun Yuan, Anthony El-Khoueiry, Bangyan L. Stiles

“…Background & Aims: Steatosis is a comorbid factor for cancer development. …”
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Circ-0000197 derived from porcine milk small extracellular vesicles promotes intestinal barrier function by sponging miR-429 by Yuxuan Wang, Bilan Chen, Tingzhou Xuan, Kun Ouyang, Jingshen Chen, Hailong Wang, Junyi Luo, Jiajie Sun, Qianyun Xi, Yongliang Zhang, Ting Chen

“…However, there is a paucity of research demonstrating how milk-derived sEV influence intestinal barrier function through the transport of circRNAs. Results In this study, we aimed to investigate the effects of porcine milk sEV (PM-sEV) circRNA on intestinal barrier function. …”
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Dietary supplementation with Chinese herb ultrafine powder improves intestinal morphology and physical barrier function by altering jejunal microbiota in laying hens by Jue Gui, Jue Gui, Md Abul Kalam Azad, Wenchao Lin, Wenchao Lin, Chengwen Meng, Chengwen Meng, Xin Hu, Yadong Cui, Wei Lan, Jianhua He, Xiangfeng Kong, Xiangfeng Kong, Xiangfeng Kong

“…Therefore, this study aimed to evaluate the effects of dietary CHUP supplementation on jejunal morphology, physical barrier function, and microbiota in laying hens.MethodsA total of 576 Xinyang black-feather laying hens (300 days old) were randomly assigned into eight groups, with eight replicates per group and nine hens per replicate. …”
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Long-Term Functional Outcomes and Quality of Life After Microvascular Reconstruction of Ankle and Foot Defects: A Monocentric Controlled Cohort Study by Sarah Pfeifenberger, Andrzej Hecker, Nikolaus Watzinger, Maximilian Moshammer, Anna-Lisa Pignet, Alexander Draschl, Ron Martin, Charalambos Louca, Lars-Peter Kamolz, Stephan Spendel

“…The aim of this study was to investigate the long-term post-operative functional outcome, health-related quality of life, scar quality, and aesthetic satisfaction in patients following microsurgical reconstructions of defects of the foot and ankle area. …”
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L-shaped association between oxidative balance score and vision-related functional burden in adults in the United States, NHANES 2005–2008 by Juntong Li, Juntong Li, Sheng Ye, Xiang Li, Xiang Li, Hui Liu, Yue Yang, Xuelei Lu, Heyue Jin, Li Liu, Li Liu

“…ObjectiveThis study aims to investigate the relationship between oxidative balance score (OBS) and vision-related functional burden (VRFB) in US adults.MethodsThe study utilized data from two consecutive cycles of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008. …”
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Does Syndesmotic Fixation Technique Impact Complication Rates and Functional Outcomes Measured by PROMIS Scores Following Operative Repair of Ankle Fractures? by Steven Hadley BA, Rachel Bergman MD, John Peabody MD, Sarah Westvold MPH, Ryan Filler MD, Milap Patel DO, Anish Kadakia MD

“…It remains unclear whether syndesmotic fixation technique impacts complication rates and outcomes. This study aims to determine which repair technique results in the fewest complications and best functional outcomes as measured by Patient Reported Outcome Measurement Information System (PROMIS) computerized adaptive tests (CATs) of physical function (PF) and pain interference (PI). …”
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Enhancing the functionality of extruded snack (namkeen) using indigenous ingredients of Uttarakhand, India: A predictive modelling approach for shelf-life optimization by Rohan Kandpal, Subrato Anand, Aditya Choudhary, Tanya Kunwar, Arun Kumar Gupta, Ravneet Kaur, Avinash Kumar Jha, Hemanta Chutia, Bindu Naik, Vijay Kumar, Hilal Ahmad Makroo, Sarvesh Rustagi, Milad Tavassoli

“…Abstract This study aimed to assess the impact of incorporating indigenous ingredients of Uttarakhand, India, on the properties of flour and the development of extruded snack (namkeen). …”
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Variabilidad cardiaca y función pulmonar en deportistas de iniciación paralímpicos (Cardiac variability and lung function in paralympic initiation athletes) by Olga Lucia Hincapié Gallón, Stefanie Tonguino Rosero, Julián Andrés Rivera Mota

“…Palabras claves: variabilidad cardiaca, función pulmonar, atletas paralímpicos, iniciación deportiva, discapacidad física Abstract. The aim of the research was to describe characteristics of cardiac variability and lung function, as well as to analyze their correlation in the context of Paralympic athletes in the process of sports initiation. …”
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Pulmonary and functional hallmarks after SARS-CoV-2 infection across three WHO severity level-groups: an observational study by Patrícia Blau Margosian Conti, Maria Ângela Gonçalves Oliveira Ribeiro, Carla Cristina Souza Gomez, Aline Priscila Souza, Daniela Souza Paiva Borgli, Eulália Sakano, Mauro Alexandre Pascoa, Silvana Dalge Severino, Tayná Castilho, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson, Fernando Augusto Lima Marson, José Dirceu Ribeiro, UNICOVID Study Group, Adyléia Aparecida Dalbo Contrera Toro, Aline Cristina Gonçalves, Andrea de Melo Alexandre Fraga, André Moreno Morcillo, Andressa Oliveira Peixoto, Andrei Carvalho Sposito, Bianca Aparecida Siqueira, Emília Silva Gonçalves, Emília Raposo Nascimento, Gil Guerra Junior, Jenniffer Tayna Orzechowski Furtado, Lucas Rodrigues de Moraes, Maria de Fatima Corrêa Pimenta Servidoni, Mariana Zorron, Marcos Tadeu Nolasco da Silva, Maíra Seabra Assumpção, Milena Baptistela Grotta, Renan Marrichi Mauch, Simone Appenzeller, Thiago Luís Infanger Serrano

“…This study aimed to assess the pulmonary functional and structural characteristics of post-SARS-CoV-2 infection in patients with mild/moderate, severe, and critical clinical presentations.MethodsAn observational, analytical, and cross-sectional study was conducted between 2020 and 2022, including participants with a confirmed diagnosis of coronavirus disease (COVID)-19, with mild/moderate (G1), severe (G2), and critical (G3) clinical presentations, all evaluated at least 3 months after acute infection. …”
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Sensor-Derived Measures of Motor and Cognitive Functions in People With Multiple Sclerosis Using Unsupervised Smartphone-Based Assessments: Proof-of-Concept Study by Matthew Scaramozza, Aurélie Ruet, Patrizia A Chiesa, Laïtissia Ahamada, Emmanuel Bartholomé, Loïc Carment, Julie Charre-Morin, Gautier Cosne, Léa Diouf, Christine C Guo, Adrien Juraver, Christoph M Kanzler, Angelos Karatsidis, Claudia Mazzà, Joaquin Penalver-Andres, Marta Ruiz, Aurore Saubusse, Gabrielle Simoneau, Alf Scotland, Zhaonan Sun, Minao Tang, Johan van Beek, Lauren Zajac, Shibeshih Belachew, Bruno Brochet, Nolan Campbell

“…ObjectiveThis analysis aims to develop and apply an SDM selection framework, including automated data quality checks and the evaluation of statistical properties, to identify robust SDMs that describe the cognitive and motor function of people with multiple sclerosis (MS). …”
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Irrigation combined with organic fertilizer could promote the environmental health of soil available nutrients and improve the functional activity of saponins in Panax Notoginseng by Yunfei Tuo, Chunyan Xie, Shaojun Wang, Ping Xiang, Qiliang Yang, Xiahong He

“…It also assessed their role in promoting the environmental health of soil nutrient availability. The research aimed to clarify the functional activities of notoginsenosides R1, Rg1, Re, Rb1, Rd, explore their correlations, identify key influencing factors, and propose the optimal irrigation and organic fertilizer combination scheme. …”
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Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis by Raimondo Sollazzo, Domenica Donatella Li Puma, Giuseppe Aceto, Fabiola Paciello, Claudia Colussi, Maria Gabriella Vita, Guido Maria Giuffrè, Francesco Pastore, Alessia Casamassa, Jessica Rosati, Agnese Novelli, Sabrina Maietta, Francesco Danilo Tiziano, Camillo Marra, Cristian Ripoli, Claudio Grassi

“…Abstract Background Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by the accumulation of pathological proteins and synaptic dysfunction. This study aims to investigate the molecular and functional differences between human induced pluripotent stem cells (hiPSCs) derived from patients with sporadic AD (sAD) and age-matched controls (healthy subjects, HS), focusing on their neuronal differentiation and synaptic properties in order to better understand the cellular and molecular mechanisms underlying AD pathology. …”
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Functional Performance Decline Outperforms Sarcopenia and Its Components in Predicting New-Onset Chronic Kidney Disease: A Nationwide Multicenter Study by Liangyu Yin, Furong Li, Tangli Xiao, Jun Zhang, Yan Li, Jicong Luo, Jinghong Zhao, Jiachuan Xiong

“…Background: This study aimed to investigate the associations of functional performance, sarcopenia, and components of sarcopenia with the onset of chronic kidney disease (CKD), while also determining the optimal predictive factor. …”
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Aerobic-Resistance Training with Royal Jelly Supplementation Has a Synergistic Effect on Paraoxonase 1 Changes and Liver Function in Women with MASLD by Roya Askari, Nazanin Rabani, Hamid Marefati, Marzie Sadat Azarnive, Matteo Pusceddu, Gian Mario Migliaccio

“…Among the ways to treat it, we can mention regular sports exercises and the use of natural supplements. Therefore, the aim of this research is to investigate and compare the effects of aerobic-resistance training with royal jelly supplementation on changes in paraoxonase 1, oxidized LDL, liver function, and lipid profile in postmenopausal women with Dysfunction-Associated Steatotic Liver Disease. …”
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Effects of <i>Caragana korshinskii</i> aqueous extract on growth performance, antioxidant capacity, and immune function of sheep under cold stimulation by B. Pan, J. Yang, J. Li, M. Xu, M. Yang, M. Yang, M. Peng, J. Cheng, S. Xue, J. Wang

“…<p>Cold stimulation can impair the immune and antioxidant functions of animals, which further leads to a decline in animal production performance. …”
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