Associations between thyroid function, thyroid hormone sensitivity indices, and frailty: Insights from a large cross-sectional study by Yusheng Zhang, Daowen Zhang, Chenwen Yuan, Yiming Wang, Hao Zhu, Yu Duan

“…Background: This research aims to assess the relationships of thyroid hormones and thyroid hormone sensitivity with frailty among adults in the United States. …”
Get full text

Translingual neural stimulation induced changes in intra- and inter-network functional connectivity in mild-moderate traumatic brain injury patients by Daniel Y. Chu, Jiancheng Hou, Thomas Hosseini, Veena A. Nair, Nagesh Adluru, Yuri Danilov, Kurt A. Kaczmarek, Mary E. Meyerand, Mitchell Tyler, Mitchell Tyler, Vivek Prabhakaran

“…However, it is still unclear how interactions within and between functional networks in brain are affected by TLNS. The current study aimed to extend our previous resting-state functional connectivity (RSFC) study investigating the effects of TLNS intervention on outcome measures related to gait and balance.MethodsAn experimental PoNS device was utilized to deliver the TLNS. …”
Get full text

Correlation analysis between clinical effective emotional treatment and plasma N-methyl-D-aspartate receptor function-related indexes by Zuxing Feng, Yanli Li, Ying Cai, Fan Yang, Fan Yang, Xiangfeng Zhou, Maoyang Feng, Li Wu

“…Few studies have been conducted on changes of NMDAR-related indicators and inflammatory cytokines in major depressive disorder (MDD) patient’s peripheral blood before and after effective clinical perceptual recovery. This study aims to investigate changes in plasma biomarker levels related to NMDAR function in MDD patients receiving effective antidepressant treatment and their relationship with clinical outcomes.MethodsA total of 70 subjects of MDD having been discharged with an improvement rated a 50% or greater reduction by the Hamilton Depression Scale (HAMD-17) were hereby recruited. …”
Get full text

Periodic leg movements and cognitive function in middle-aged and elderly adults with mediating role of REM duration and PLMS-related arousal by Shutong Sun, Liwen Xu, Yixi Zheng, Wenyi Yu, Tianyu Jing, Gang Xu, Tieyu Tang, Cheng Chu

“…Abstract The relationship between periodic leg movements of sleep (PLMS) and cognitive function is controversial. This study aims to explore: (1) the effects of PLMS on cognitive function in middle-aged and elderly patients; and (2) the mediating role of rapid eye movement (REM) sleep duration and PLMS-related arousal between PLMS and cognitive performance. …”
Get full text

Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation by Xiaohu Wang, Mengxia Fu, Weiteng Wang, Songren Shu, Ningning Zhang, Ruojin Zhao, Xiao Chen, Xiumeng Hua, Xin Wang, Wei Feng, Xianqiang Wang, Jiangping Song

“…Abstract Background Functional mitral regurgitation (MR) is a common form of mitral valve dysfunction that often persists even after surgical intervention, requiring reoperation in some cases. …”
Get full text

Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers by Youxing Li, Youxing Li, Yaqin Pang, Yaqin Pang, Yaqin Pang, Dongshun Chen, Feiyu Lu, Hongyan Tian, Fengni Qin, Kuntao Wei, Ahmad Razali Bin Ishak, Mohd Shukri Bin Mohd Aris, Mohd Shukri Bin Mohd Aris, Guangzi Qi

“…However, the interactive effects of these hazards and genetic factors on cognitive function remain unclear.ObjectiveThis study aimed to identify the primary occupational hazards, examine their interaction with IL-1β gene polymorphisms in relation to cognitive function.MethodsA cross-sectional study was conducted in June 2024 at an electrolytic aluminum company in China, involving 478 male workers. …”
Get full text

Cardiomyopathy and kidney function in agalsidase beta‐treated female Fabry patients: a pre‐treatment vs. post‐treatment analysis by Christoph Wanner, Ulla Feldt‐Rasmussen, Ana Jovanovic, Aleš Linhart, Meng Yang, Elvira Ponce, Eva Brand, Dominique P. Germain, Derralynn A. Hughes, John L. Jefferies, Ana Maria Martins, Albina Nowak, Bojan Vujkovac, Frank Weidemann, Michael L. West, Alberto Ortiz

“…We compared long‐term cardiomyopathy and kidney function outcomes after agalsidase beta treatment with preceding treatment‐naive outcomes. …”
Get full text

Probiotics may improve vaginal microbiota, metabolic disorders and ovarian function-related markers by modulating gut microbiota in POI mice by Jinxiang Cao, Wenjie Ma, Xiaoxia Chang, Danhua Pu, Rongrong Tan, Luanqian Hu, Tongtong Hong, Yugui Cui, Li Gao, Jie Wu

“…This study aimed to explore the impacts of probiotics on the gut and vaginal microbiota, ovarian function and metabolic indexes in a mouse model of POI. …”
Get full text

Heel kicking exercise rapidly improves pain and function in patients with acute lateral ankle sprain: a randomized controlled trial by Qi-Ning Qin, Xin Zhang, Ying-Feng Cai, Tian-Zhao Tian, Jian-Peng Zhou, Lin Li, Min Shi, Peng Huang, Hao-dong Liang, Jia-Hui Li, Zhan-Liang Tan, Yi-Xuan Fang, Jia-Wen Wang, Fang Zheng, Bao-Xin Liu

“…In traditional Chinese medicine (TCM), bone-setting technique (BST) can quickly relieve ankle pain and improve walking function, but physicians require high skills and physical strength. …”
Get full text

Effectiveness of a brief multicomponent intervention to improve physical activity level and functional capacity in fibromyalgia and chronic fatigue syndrome (Synchronize+) by Carme Martín-Borràs, Carme Martín-Borràs, Carme Martín-Borràs, Carme Martín-Borràs, Gemma González Serra, Gemma González Serra, Noèlia Carrasco-Querol, Oriol Sansano-Nadal, Oriol Sansano-Nadal, Oriol Sansano-Nadal, Nerea Bueno Hernández, Pau Bestraten del Pino, Pau Bestraten del Pino, Marta Pastor Cazalla, Marta Pastor Cazalla, Rosa Caballol Angelats, Rosa Caballol Angelats, Pilar Montesó-Curto, Pilar Montesó-Curto, Pilar Montesó-Curto, Elisabet Castro Blanco, Macarena Pozo Ariza, José Fernández-Sáez, José Fernández-Sáez, M. Rosa Dalmau Llorca, M. Rosa Dalmau Llorca, Alessandra Queiroga Gonçalves, Alessandra Queiroga Gonçalves, Carina Aguilar Martín, Carina Aguilar Martín

“…Low cardiorespiratory fitness and muscle function with habitual intolerance to efforts are common characteristics of FM and CFS. …”
Get full text

Colonic bacterial community responding to selenium-enriched yeast supplementation associated with improved gut mucus function in growing-finishing pigs by Lingling Su, Hongbo Yi, E Xu, Mingfei Xiao, Yanhua Gao

“…In conclusion, SeY doses of 0.3 mg/kg have beneficial effects on intestinal health, whereas prolonged SeY doses up to 5 mg/kg may compromise the intestinal mucus function in growing-finishing pigs.…”
Get full text

The differences in temperament–character traits, suicide attempts, impulsivity, and functionality levels of patients with bipolar disorder I and II by Izci F, fındıklı E, Zincir S, Bozkurt Zincir S, Iris Koc M

“…Filiz Izci,1 Ebru Kanmaz Findikli,2 Serkan Zincir,3 Selma Bozkurt Zincir,4 Merve Iris Koc4 1Department of Psychiatry, School of Medicine, Istanbul Bilim University, Istanbul, 2Department of Psychiatry, School of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, 3Department of Psychiatry, Kocaeli Gölcük Military Hospital, Kocaeli, 4Department of Psychiatry, Erenköy Training and Research Hospital for Psychiatric and Neurological Disorders, Istanbul, Turkey Background: The primary aim of this study was to compare the differences in temperament-character traits, suicide attempts, impulsivity, and functionality levels of patients with bipolar disorder I (BD-I) and bipolar disorder II (BD-II).Methods: Fifty-two BD-I patients and 49 BD-II patients admitted to Erenköy Mental and Neurological Disease Training and Research Hospital psychiatry clinic and fifty age- and sex-matched healthy control subjects were enrolled in this study. …”
Get full text

Association of Platelet Indices with Cardiac Enzymes and Left Ventricular Function in Patients with Acute Myocardial Infarction: A Cross-sectional Study by P Kireeti, Rajesh Singh Laishram, Mayanglambam Bijoy, Sunil Kumar Leishangthem, Rajkumar Ajaykumar, Keisham Jaya Chanu, Ningthoukhongjam Reema, Dhanaraj Singh Chongtham

“…Aim: To determine the association between platelet indices, cardiac enzymes, and LV function in patients with AMI. …”
Get full text

Transcutaneous Spinal Stimulation Combined with Locomotor Training Improves Functional Outcomes in a Child with Cerebral Palsy: A Case Study by Darryn Atkinson, Kristen Barta, Fabian Bizama, Hazel Anderson, Sheila Brose, Dimitry G Sayenko

“…He was classified in the Gross Motor Function Classification System (GMFCS) at Level III. …”
Get full text

Association Between Premorbid Frailty Status and Functional Independence in Acute Ischemic Stroke Patients Following Endovascular Treatment in the Late Window by Huang L, Gong C, Qiu Z, Jiang S, Song M, Wang Z, Chen Y, Xu T, Hu P, Chen S, Chen Y, Nguyen TN, Liu C

“…In multivariable analysis, frailty significantly reduced the likelihood of functional independence (aOR 0.37, 95% CI 0.21– 0.65, P< 0.001). …”
Get full text

Effects of gender affirming hormone therapy with testosterone on renal function of assigned female at birth transgender people: a meta-analysis by Daniele Tienforti, Daniele Tienforti, Luca Spagnolo, Luca Piscitani, Camilla Tonni, Vittoria Donatelli, Vittoria Donatelli, Giuliana Cordeschi, Marco Giorgio Baroni, Arcangelo Barbonetti

“…This study aimed to quantify through a meta-analytical approach the changes in estimated glomerular filtration rate (eGFR), a widely used clinical parameter that reflects how efficiently the kidneys filter waste products from the blood, and in secondary markers of kidney functions in this population during 24 months of GAHT. …”
Get full text

Functional evaluation after cortical button fixation for distal biceps ruptures – Is there any difference between manual or non-manual workers? by A. Batista, N. Moura, M. Sarmento, T. Coelho, D. Gomes, R. Ramos, A. Cartucho

“…Background: This study aims to compare clinical and functional results after distal biceps tendon repair in manual workers vs. non-manual workers. …”
Get full text

Psychometric evaluation of the NoMAD instrument in cancer care settings: assessing factorial validity, measurement invariance, and differential item functioning by Maja Kuharic, James Lorenz Merle, David Cella, Sandra A. Mitchell, Lisa DiMartino, Jennifer L. Ridgeway, Don S. Dizon, Roshan Paudel, Jessica D. Austin, Sandra L. Wong, Ann Marie Flores, Andrea L. Cheville, Justin D. Smith, the IMPACT Consortium

“…Model fit was defined by standard fit indices (Comparative Fit Index (CFI) and Tucker-Lewis Index (TLI) values ≥ 0.95, Root Mean Square Error of Approximation (RMSEA) values ≤ 0.06, and Standardized Root Mean Square Residual (SRMR) values ≤ 0.08. Differential item functioning (DIF) was evaluated using ordinal logistic regression and item response theory methods (ΔR2 ≥ 0.02 indicative of meaningful DIF). …”
Get full text

Associations of dietary choline intake and kidney function with hyperuricemia in Chinese children and adolescents: a cross-sectional studyResearch in context by Chengping Li, Jing Li, Zhiquan Diao, Lianhong Chen, Siwen Yu, Lianlong Yu, Qianrang Zhu, Xiaomei Dong, Yiya Liu, Tao Liu, Dan Liu

“…Summary: Background: Limited studies have suggested an effect of dietary choline intake on uric acid levels. We aim to investigate the associations between choline intake and hyperuricemia (HUA), as well as the mediating role of kidney function in this relationship, among the Chinese population aged 6–17 years. …”
Get full text

Short‐chain fatty acids enhance muscle mass and function through the activation of mTOR signalling pathways in sarcopenic mice by Chaoran Liu, Pui Yan Wong, Qianjin Wang, Hei Yuet Wong, Tao Huang, Can Cui, Ning Zhang, Wing Hoi Cheung, Ronald Man Yeung Wong

“…Colon inflammation levels, circulatory SCFAs concentration, muscle quality, function, and underlying pathways were detected by cell number counting, RT‐qPCR, gas chromatography–mass spectrometry, measurements of muscle wet weight and grip strength, ex vivo functional test, treadmill endurance test, transcriptomic sequencing, morphological and immunofluorescent staining, as well as western blot. …”
Get full text