Association of body composition with neuroimaging biomarkers and cognitive function; a population-based study of 70-year-oldsResearch in context by Jessica Samuelsson, Anna Marseglia, Ola Wallengren, Olof Lindberg, Caroline Dartora, Nira Cedres, Sara Shams, Silke Kern, Anna Zettergren, Eric Westman, Ingmar Skoog

“…Summary: Background: A better understanding of body-brain links may provide insights on targets for preventing cognitive decline. The aim was to explore associations of body composition with neuroimaging biomarkers and cognitive function among dementia-free 70-year-olds. …”
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Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis by Erica Ferrini, Costanza Bonfini, Giovanna Marchese, Martina Buccardi, Matteo Zoboli, Primetta Faccioli, Nicola Sverzellati, Gino Villetti, Simone Ottonello, Maria Ravo, Franco F. Stellari

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Unveiling Resmetirom: A systematic review and meta‐analysis on its impact on liver function and safety in non‐alcoholic steatohepatitis treatment by Hashim Talib Hashim, Ahmed Qasim Mohammed Alhatemi, Sania Riaz, Mohammedbaqer Ali Al‐Ghuraibawi, Arwa S. Alabide, Humza Saeed, Fatimah Abdullah Sulaiman, Mustafa Ali Abd Alhussain, Maythum Ali Shallan, Ahmed Dheyaa Al‐Obaidi, Omar Saab, Hasan Al‐Obaidi, Ali Talib Hashim, Nooraldin Merza

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Diastolic function and cardiovascular events in patients with preserved left ventricular ejection fraction. Improving risk stratification with left atrial strain by Ibon Rodriguez-Sanchez, Inaki Villanueva-Benito, Urko Agirre, Jose Juan Onaindia, Alazne Urkullu, Angela Cacicedo, Alberto Ullate, Idoia Bravo, Josu Florido, Alberto Salcedo, Sonia Velasco

“…Our aim was to assess the association between diastolic function and a combined event in which the left atrium plays a pivotal role, including heart failure (HF), atrial fibrillation (AF) and ischemic stroke. …”
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Automated extraction of functional biomarkers of verbal and ambulatory ability from multi-institutional clinical notes using large language models by Levi Kaster, Ethan Hillis, Inez Y. Oh, Bhooma R. Aravamuthan, Virginia C. Lanzotti, Casey R. Vickstrom, Brain Gene Registry Consortium, Christina A. Gurnett, Philip R. O. Payne, Aditi Gupta

“…Abstract Background Functional biomarkers in neurodevelopmental disorders, such as verbal and ambulatory abilities, are essential for clinical care and research activities. …”
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Insights into the effects of apelin-13 on renal function and NHE3 activity following ischemia/reperfusion-induced acute kidney injury by Guilherme Lopes-Gonçalves, Juliana Martins Costa-Pessoa, Mariana Charleaux de Ponte, Heitor Macedo Braz, Maria Oliveira-Souza

“…Thus, the present study aims to evaluate the effects of exogenous administration of apelin-13 in the renal ischemia/reperfusion (I/R) model, with particular focus on renal function, injury markers, and tubular proliferation.MethodsMale C57BL/6 mice were initially treated with a vehicle or high dose of apelin-13 (200 μg/kg/day) and subjected to kidney bilateral ischemia procedure for 30 min or a sham surgery. …”
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Evaluation of Visual, Refractive, and Functional Outcomes after Implantation of an Extended Depth of Focus Intraocular Lens in Patients with Stable and Mild Glaucoma by Aritz Urcola, Gorka Lauzirika, Igor Illarramendi, Andrea Soto-Velasco, Ronald Sánchez-Avila, Carlota Fuente-García, Aitor Fernández-García

“…Abstract Introduction The aim of this study is to describe the visual, refractive, functional, and patients’ satisfaction outcomes of the AcrySof™ IQ Vivity™ extended depth-of-focus intraocular lens (EDOF IOL) in patients with mild primary open-angle glaucoma (POAG). …”
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Association of over-the-counter mouthwash use with markers of nitric oxide metabolism, inflammation, and endothelial function—a cross-sectional study by Kai Guo, Kaumudi Joshipura, Karina Ricart, Rakesh P. Patel, Barbara A. Gower, Oelisoa Mireille Andriankaja, Evangelia Morou-Bermudez

“…IntroductionRegular use of mouthwash can disrupt nitrate reduction by oral bacteria and may affect systemic nitric oxide (NO) levels, which are important for inflammation and endothelial function. We aim to assess the association between over-the-counter (OTC) mouthwash use and nitrate/nitrite, markers of inflammation (IL-6, TNF-α, CRP) and endothelial function (sICAM-1, sVCAM-1) in serum and saliva, and to assess the relationship between nitrate/nitrite levels and these biomarkers, as well as how OTC mouthwash modulated this relationship. …”
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Effects of Physical Activity on Cardiotoxicity and Cardio respiratory Function in Cancer Survivors Undergoing Chemotherapy: A Systematic Review and Meta-Analysis by Kang Chen MS, Hui Guan MS, Meixia Sun MS, Yukun Zhang MS, Wenwen Zhong MS, Xiaonan Guo MS, Anqi Zuo MS, He Zhuang PhD

“…Introduction: Physical activity, as a promising complementary therapy, has shown considerable potential for reducing chemotherapy-related cardiotoxicity (CTRCT) and enhancing cardiorespiratory function (CRF). This study aimed to systematically assess the effects of physical activity on CTRCT and CRF in various cancer survivors receiving chemotherapy. …”
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Changes of biventricular contractile function depending on the types of left ventricular involvement in patients 1 year after COVID-19 pneumonia by N. E. Shirokov, E. I. Yaroslavskaya, D. V. Krinochkin, N. A. Osokina, E. A. Gorbatenko, I. O. Korovina, A. V. Migacheva

“…Aim. To study the changes of biventricular contractile function depending on the types of left ventricular involvement according to the speckle tracking echocardiography (STE).Material and methods. …”
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Functional disability in basic and instrumental activities of daily living among older adults globally: a systematic review and meta-analysis by Baye Tsegaye Amlak, Mamaru Getinet, Addisu Getie, Worku Misganaw Kebede, Tadesse Tsehay Tarekegn, Daniel Gashaneh Belay

“…This study aims to review existing research worldwide to estimate the overall pooled prevalence of functional disability in these areas. …”
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Relationship Between Internet Use and Cognitive Function Among Middle-Aged and Older Chinese Adults: 5-Year Longitudinal Study by Bowen Chen, Chun Yang, Shanshan Ren, Penggao Li, Jin Zhao

“…Moreover, we assessed the mediating role of internet use on cognitive function for characteristics significantly linked to cognition in stratified analysis. …”
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Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy by Nairong Ruan, Nairong Ruan, Ming Liang, Ming Liang, Yuehong Liu, Xi Mei, Chengying Zheng

“…ObjectiveThe most prevalent types of dementia in older adults are Alzheimer's disease (AD) and Lewy body dementia (LBD), and they have overlapping clinical symptoms. We aimed to define amounts of cortical activation and to identify indicators of brain function to better distinguish between these types of dementia and aid diagnosis using functional near-infrared spectroscopy (fNIRS).MethodsOxygenated hemoglobin (HbO) concentrations in the brains of patients with AD and LBD were detected using fNIRS. …”
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Clinical and functional evaluation of intramyocardial implantation of autologous bone marrow cells treated with erythropoietinduring the CAD surgery (6-month results) by A. V. Fomichev, A. M. Chernyavskiy, K. K. Gulyaeva, O. V. Poveschenko, A. P. Lykov, J. E. Kareva, S. M. Minin, N. A. Nikitin

“…Aim. Clinical and functional evaluation of the implantation of autologous bone marrow cells treated with erythropoietin in laser channels during coronary bypass grafting in patients with end-stage coronary lesion.Materials and methods. 60 patients with coronary artery disease with diffuse and (or) distal right coronary artery disease were randomized into two groups: patients of group 1 (n = 30) underwent coronary bypass grafting, implantation of autologous bone marrow cells treated with erythropoietin in laser channels, patients of the 2nd group (n = 30) were operated with coronary bypass grafting of the left coronary artery system. …”
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11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats. by M. V. Korokin, V. O. Soldatov, A. A. Tietze, M. V. Golubev, A. E. Belykh, M. V. Kubekina, O. A. Puchenkova, T. A. Denisyuk, V. V. Gureyev, T. G. Pokrovskaya, O. S. Gudyrev, M. A. Zhuchenko, M. A. Zatolokina, M. V. Pokrovskiy

“…The aim of the study was to test whether P-αB can be positioned as a preventing and treating agent for cardiovascular diseases.Materials and methods. …”
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Validation of the role of apolipoproteins in coronary artery disease patients with impaired kidney function for prognosis: a prospective cohort study in China by Zixiang Ye, Enmin Xie, Zhangyu Lin, Chenxi Song, Rui zhang, Haoyu Wang, Yongbao Zhang, Kefei Dou

“…Abstract Objective This study aims to evaluate the relationship between apolipoproteins (ApoA1, ApoB, and the ApoB/A1 ratio) and the incidence of major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) and impaired kidney function, assessing their potential role in secondary prevention. …”
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Metformin-Enhanced Secretome from Periodontal Ligament Stem Cells Promotes Functional Recovery in an Inflamed Periodontal Model: In Vitro Study by Han Na Suh, Ju Young Ji, Jung Sun Heo

“…Among the favorable candidates for CM production, metformin as an anti-diabetic medication is currently considered a potential agent for dental hard tissue and periodontal regeneration. Here, we aimed to assess the composition of CM from periodontal ligament stem cells (PDLSCs) grown in metformin-preconditioned media (Met-CM) compared to normal PDLSC-CM and assess the ability of Met-CM to recover the function of inflamed PDLSCs. …”
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Nutritional risk, functional decline, and symptom burden in lung cancer: a study based on PG-SGA scores and biochemical data by Shasha Shen, Shasha Shen, Shiyun Xing, Shiyun Xing, Tingting Shen, Li Niu, Xiaojing Tian, Xiaojing Tian, Hu Ma, Hu Ma, Xiaoxia Gou, Xiaoxia Gou

“…ObjectiveThis study aims to investigate the relationship between nutritional status and quality of life (QOL) in patients with lung cancer, analyze the clinical application of nutritional support, and explore its association with biochemical markers and physical function.MethodsA total of 270 hospitalized lung cancer patients were enrolled. …”
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Odor induced functional connectivity alteration of POC-anterior frontal cortex-medial temporal cortex in patients with mild cognitive impairment by Weiping Li, Jianan Zhou, Shuying Li, Min Wu, Yajing Zhu, Qian Chen, Futao Chen, Xuefeng Ma, Xin Zhang, Zhengge Wang, Jiaming Lu, Bing Zhang, Bing Zhang, Bing Zhang, Bing Zhang, Bing Zhang, Bing Zhang, Bing Zhang

“…Olfactory impairment may indicate prodromal dementia, yet its underlying mechanisms are not fully understood. This study aimed to investigate the alterations in functional connectivity (FC) of odor-induced olfactory neural circuits in MCI patients.MethodsThe study included 39 MCI patients and 42 normal controls (NCs). …”
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Dietary effect of Galega orientalis Lam. flavonoid extract on broilers’ growth performance, antioxidant capacity, immune function, and bone metabolism by Nana I. Tchana, Huiyan Zhang, Yinchuan Pan, Shiyi Wang, Dieudonné M. Dansou, Xiaoxuan Xia, Qingyu Zhao, Chaohua Tang, Junmin Zhang

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