Low‐Dose naltrexone restored TRPM3 ion channel function in natural killer cells from long COVID patients by Etianne Martini Sasso, Etianne Martini Sasso, Etianne Martini Sasso, Natalie Eaton-Fitch, Natalie Eaton-Fitch, Peter Smith, Peter Smith, Katsuhiko Muraki, Katsuhiko Muraki, Sonya Marshall-Gradisnik, Sonya Marshall-Gradisnik

“…Accumulating evidence suggests the potential therapeutic benefits of low-dose naltrexone (LDN) for people suffering from long COVID. Our study aimed to investigate the efficacy of LDN in restoring TRPM3 ion channel function in natural killer (NK) cells from long COVID patients.MethodsNK cells were isolated from nine individuals with long COVID, nine healthy controls, and nine individuals with long COVID who were administered LDN (3–4.5 mg/day). …”
Get full text

Effect of treadmill walking on cardiometabolic risk factors and liver function markers in older adults with MASLD: a randomized controlled trial by Jiyoun Kim, Sungju Lee, Yong-Seok Jee

“…Therefore, this study aimed to investigate the effects of a 12-week walking intervention on metabolic syndrome risk factors, liver function indicators, and liver ultrasound findings in older adults with both metabolic syndrome and MASLD. …”
Get full text

User Experience of a Semi-Immersive Musical Serious Game to Stimulate Cognitive Functions in Hospitalized Older Patients: Questionnaire Study by Laurent Samson, Lena Carcreff, Frédéric Noublanche, Sophie Noublanche, Hélène Vermersch-Leiber, Cédric Annweiler

“…Further studies are needed to evaluate the potential benefits of clinical factors such as neurocognitive functions, mood, depression, or quality of life.…”
Get full text

Assessment of muscle function deterioration in aging populations: Insights from the load-velocity relationship during the loaded sit-to-stand test by Daniel Jiménez-Lupión, Ignacio Chirosa-Ríos, Rodrigo Lizama-Pérez, Luis Chirosa-Ríos, Daniel Jerez-Mayorga

“…This study aimed to examine the relationship between variables derived from the L-V relationship (L0, V0, and Aline) obtained during the loaded sit-to-stand test and various muscle performance indices, including knee extension peak force (KEPF) and various muscle quality indices (MQI).A total of 113 participants (49 middle-aged adults and 64 older adults; age = 61 ± 9.92 years) performed the loaded 5-Sit-To-Stand using Functional Electromechanical Dynamometry. …”
Get full text

Trimester-specific thyroid function markers and gestational diabetes risk: evidence from a tertile-based cohort of euthyroid pregnancies by Erkan Sağlam, Serenat Eris Yalçın, Mustafa Raşit Özler, Bekır Siddik Yılmaz, Nuray Nerez

“…These findings suggest that even subtle thyroid hormone variations within normal limits may influence glucose metabolism and support the utility of early thyroid function evaluation for predicting gestational metabolic risk.…”
Get full text

Screening of Aflatoxin B1-Degrading Strains and Functional Mining of Key Enzyme Genes in Pseudomonas promysalinigenes CT1-8 by Zhaofu CHEN, Zhilin WANG, Jing LIU, Shijuan YAN, Junjin DENG

“…Homology alignment indicated that the outer membrane porin OprF shared 38.3% sequence similarity with the known AFB1-degrading enzyme OmpA. Functional annotation indicated that OprF gene belongs to an operon consisting of oprF, yiB, yiaD and rcpA, suggesting synergistic roles of this operon in AFB1 transport and metabolism.…”
Get full text

Association between the American heart association’s life’s essential 8 score and cognitive function: a cross-sectional NHANES study by Jiuyang Sun, Xinyu Tu, Shuwei Wang, Jie Wang, Jingxue Liang, Zhenguo Liu, Lu Song

Get full text

The Advances in Utilizing Right Ventricular Function as a Predictor of Peripartum Cardiomyopathy Recovery: A Single Centre Prospective Cohort Study by Akbar MR, Sakasasmita S, Achmad C, Dewi TI, Hasan M, Prameswari HS

“…One of the contemporary predictors studied in cardiomyopathy is right ventricular (RV) function during initial presentation.Purpose: This study aimed to determine the role of RV systolic function based on the various RV function parameters by two-dimensional transthoracic echocardiography (2DE) to predict PPCM recovery within 6 months of follow-up and identify the most accurate parameter among them.Patients and Methods: This was a prospective cohort study that include all patients registered in the “Long Term Registry on Patients with Peripartum Cardiomyopathy” at Dr. …”
Get full text

Comparison of cardiac magnetic resonance and speckle tracking echocardiography in cardiac evaluation of children with acute myocarditis with preserved left ventricular function by Fatos Alkan, Onur Bircan, Fatma Can, Yuksel Pabuscu, Senol Coskun

“…Abstract This study aimed to evaluate the reliability and efficacy of speckle tracking echocardiography (STE) compared to cardiac magnetic resonance (CMR) in assessing left ventricular function and segmental involvement in patients with acute myocarditis and preserved left ventricular systolic function. …”
Get full text

The Impact of Inorganic Nitrate-Rich Beetroot Juice on Microvascular Blood Flow, Cognitive Function, and Other Hemodynamic Outcomes in Postmenopausal Women by Begum Celik, Jeremy Spencer, Daniel Lamport, Noa Argomaniz, Charlotte Mills

“…Objective: the primary aim of the trial is to evaluate the effectiveness of nitrate-rich beetroot juice in enhancing microvascular blood flow and cognitive function in postmenopausal women. …”
Get full text

Comparison of cuffless blood pressure measurement using an electrocardiogram monitor with photoplethysmography function with measurement by the Korotkov method: a pilot study by N. A. Gogiberidze, Z. N. Sagirova, N. O. Kuznetsova, D. G. Gognieva, P. Sh. Chomakhidze, H. Saner, P. Yu. Kopylov

Get full text

Risk factors for cognitive decline in older Chinese adults: the impact of social activity on the relationship between hearing, functional mobility, and cognition by Hao Wang, Dan Chen, Daling Hu, Fangyuan Tian, Meifen Dai, Shuangyan Zhang, Liyu Jin

“…This study aims to explore whether engagement in social activities mediates the link between hearing or functional mobility impairment and cognitive decline.MethodsThis cross-sectional study was carried out in two cities in Jiangsu Province, Eastern China. …”
Get full text

The Effectiveness of the Be Prepared mHealth App on Recovery of Physical Functioning After Major Elective Surgery: Multicenter Randomized Controlled Trial by Miriam van der Velde, Marike van der Leeden, Edwin Geleijn, Cindy Veenhof, Karin Valkenet

“…We developed the Be Prepared mHealth app, which has shown potential in an earlier pilot study. ObjectiveThis study aims to evaluate the effectiveness of the Be Prepared app on postoperative recovery of physical functioning (PF) in patients undergoing major elective surgery. …”
Get full text

Evaluating the role of AI-simulated patients compared with peer-to-peer learning models in the enhancement of medical education: is it beyond theoretical functionality? by Pegin Poulose

“…Further advancements in this technology can improve the functionality of medical education in the modern age, although addressing its limitations, namely realism and lack of empathy in AI responses, is vital to ensure successful adjunction with conventional strategies within medical education.…”
Get full text

Cleaning, Disinfection, and Functional Tests for Bag Valve Masks in Hospitals Located in 117 Cities in China: A Cross-Sectional Study by Qin N, Zhu J, Huang H, Chen H, Rao J, Zhou X

“…The incidences of malfunctions in BVMs using high-temperature drying cabinets and using other drying methods were 50.55% and 38.73%, respectively (χ2 = 6.598, P < 0.05).Conclusion: The types of BVMs and the methods of cleaning, disinfection, drying, and storage conditions could affect the cleaning quality or functional integrity. This highlights the urgent need for standardized national guidelines in China.Keywords: central sterile supply department, bag valve mask, cleaning, disinfection, functional testing, cross-sectional study…”
Get full text

Evaluation of the use of the bedding function of City Clinical Hospital No. I. Pirogov during the period 2012–2021 based on statistical indicators by N. V. Shakhova

Get full text

Cognitive Functions in Children with D-Transposition of Great Arteries Who Underwent Senning Procedure: A Pilot Single Center Study by Amira El Tantawy, Fatma Al Zahraa Mostafa, Rewaa Ahmed, Noha Ali

“…Long- term hemodynamic circulatory complications in D-TGA may present from cyanosis, preoperative hypoxia, post-operative techniques, which may impact neurocognitive development. Aim of work: to assess cognitive function in children with D-TGA who underwent Senning atrial switch. …”
Get full text

Inflammatory markers CRP and WBC as predictors of liver function impairment in multiple injury trauma patients: a repeated measures analysis by Gang Wang, Cui Tang, Rui Wang, Chundao Xu, Tugang Shen, Gaokai Li

“…AimsTo investigate the relationship between liver function indices (AST, ALT, GGT) and inflammatory markers (CRP, white blood cell count) in multiple injury patients at different time points post-trauma.MethodsWe retrospectively analyzed 114 patients with multiple injuries admitted to a tertiary trauma center in Zhejiang Province (January 2023–December 2024). …”
Get full text

Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial by Hyeonsang Shin, Woohyun Seong, Yeonju Woo, Joo-Hee Kim, Kwang-Rak Park, Dong Hyuk Lee

“…Each group will undergo cognitive function tests, functional near-infrared spectroscopy imaging before and after acupuncture stimulation, and an assessment of CR. …”
Get full text

Functional Attributes of Synovial Fluid from Osteoarthritic Knee Exacerbate Cellular Inflammation and Metabolic Stress, and Fosters Monocyte to Macrophage Differentiation by Vanshika Srivastava, Abhay Harsulkar, Shama Aphale, Aare Märtson, Sulev Kõks, Priya Kulkarni, Shantanu Deshpande

“…<b>Background:</b> Besides conventional norms that recognize synovial fluid (SF) as a joint lubricant, nutritional channel, and a diagnostic tool in knee osteoarthritis (kOA), based on the authors previous studies, this study aims to define functional role of SF in kOA. <b>Methods:</b> U937, a monocytic, human myeloid cell line, was induced with progressive grades of kOA SF, and the induction response was assessed on various pro-inflammatory parameters. …”
Get full text