The landscape in the gut microbiome of long-lived families reveals new insights on longevity and aging – relevant neural and immune function by Jingjing Wang, Jinlong Qie, Danrong Zhu, Xuemei Zhang, Qingqing Zhang, Yuyu Xu, Yipeng Wang, Kai Mi, Yang Pei, Yang Liu, Guozhong Ji, Xingyin Liu

“…Dynamic characteristics of the gut microbiome during aging associated with longevity, neural, and immune function remained unknown. Here, we aim to reveal the synergistic changes in gut microbiome associated with decline in neural and immune system with aging and further obtain insights into the establishment of microbiome homeostasis that can benefit human longevity. …”
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Associations of lung function impairment and biological aging with mortality and cardiovascular disease incidence: findings from UK biobank participants by Jiali Chen, Cheng Wang, Pengyu Duan, Yonghong Bi, Yao Meng, Weiyu Feng, Zhehao Jin, Hangbing Li, Huihui Wang, Xiaoyan Li, Kun Zuo, Xiangcheng Zhao, Longfei Li, Yuling Xing, Lan Luo, Yang Yu, Miao Yu, Muyan Cui, Bing Zhang

“…This study aimed to investigate the mediating role of biological aging, as well as the interactions and joint effects of lung function impairment and biological aging on adverse health outcomes.MethodsA total of 349,456 UK Biobank participants (aged 40–69 years) were categorized into normal, PRISm, and AL groups based on baseline spirometric measurements. …”
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Improvement of organisation for road transport functioning in a multimodal logistics system for grain delivary from Volgograd region to Iran by A. V. Kulikov, E. A. Bliznyakova, P. A. Pavlov, A. A. Kulikov

“…To determine the optimal modes of road transport functioning (with the further aim of increasing its efficiency of functioning) in the logistics links of export grain supplies at the micro level, it is proposed to perform using the ‘Sowing fields – regional barn-floors’ graph, at the meso level – the ‘Regional barn-floors – regional grain storages’ graph, at the macro level – the ‘Regional grain storages – port grain storages’ graph. …”
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Nutritional, anti-nutritional, physicochemical and functional properties of raw and roasted Salvia Schimperi (Lamiaceae) seeds: Ethiopian indigenous plant by Yewlsew Belay, Meseret Azene, Zeweter Abebe, Abebe Habtamu, Benson Chucks Iweriebor, Nqobile Monate Mkolo, Workineh Shibeshi, Solomon Assefa, Abebe Ayelign

“…Therefore, this study aimed to determine the nutritional, anti-nutritional, physicochemical, and functional properties of raw and roasted S. schimperi seeds. …”
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Anthrahydroquinone-2,6-Disulfonate Restores Lung Function in COPD Through Keap1/Nrf2 Pathway Activation by Li Z, Chen J, Zhang J, Li N, Yi Y, Lu H, Li M, Liu R, Chen Y, Liu X

“…This study aimed to investigate the therapeutic effects of AH2QDS on COPD by exploring its mechanisms involving the Keap1-Nrf2 pathway via in vivo and in vitro models.Methods: This study induced COPD-like pathology by using LPS in combination with CS / CSE, establishing both in vivo and in vitro models to evaluate the effects of AH2QDS on lung function, histopathology, oxidative stress markers, levels of inflammatory cytokines, and apoptosis. …”
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Clinical practice guidelines for the diagnosis of constipation-predominant irritable bowel syndrome and functional constipation in adults: a scoping review by Jingyuan Luo, Wing Lam Wendy To, Qianqian Xu, Jialing Zhang, Yanfang Ma, Sen Chow, Danny J. Yu, Chun-Su Yuan, Zhaoxiang Bian

“…Abstract Background Constipation-predominant irritable bowel syndrome (IBS-C) and functional constipation (FC) are prevalent disorders with overlapping and fluctuating symptoms, which pose challenges for accurate diagnosis. …”
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The joint effects of inflammation and renal function status on in-hospital outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis by Zhichao Huang, Xiaoyue Zhu, Xiuman Xu, Yi Wang, Yafang Zhu, Dongqin Chen, Yongjun Cao, Xia Zhang

“…Abstract Objective We aimed to determine the predictive value of renal function status [estimating glomerular filtration rate (eGFR)] in conjunction with inflammatory biomarkers [white blood cell(WBC) and C-reactive protein (CRP)] for in-hospital outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT). …”
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Gender Differences in Predictors of Physical Functioning Limitations Among the Elderly Population in Serbia: A Population-Based Modeling Study by Dejan Nikolic, Natasa Mujovic, Milena Santric-Milicevic, Sindi Mitrovic, Nevena Krstic, Ana Radic, Diana Radovic, Ardak Nurbakyt, Dinara Sukenova, Milena Kostadinovic

“…This study aimed to assess self-perceived general health and related health characteristics among the elderly population in Serbia, with a focus on varying degrees of functional limitations, as well as to analyze the predictors of physical functioning limitations in relation to gender. …”
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Cuproptosis-related lncRNAs emerge as a novel signature for predicting prognosis in prostate carcinoma and functional experimental validation by Yangbai- Lu, Jinfeng- Wu, Xianzhe Li, Xianzhe Li, Qu- Leng, Jian- Tan, Hongxing- Huang, Rui- Zhong, Zhenjie- Chen, Yongxin- Zhang

“…Additionally, in vitro cellular functional experiments, we knocked down SNHG9 that is the most significantly differentially expressed ClncRNA among the three key ClncRNAs. …”
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Phenotype and functions of human dendritic cells derived from CD14+ monocyte subsets opposed to CD16 expression by E. R. Chernykh, T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, Yu. D. Kurochkina, E. A. Oleynik, L. V. Sakhno, A. A. Ostanin

“…The aim of the study was to analyze the relationship between monocyte subpopulations and phenotype/ functions of monocyte-derived dendritic cells (DCs), as well as DC sensitivity to the tolerogenic effect of dexamethasone.Materials and methods. …”
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Impact of positive end-expiratory pressure and recruitment maneuver on healthy lungs in dogs assessed by functional and anatomical monitoring methods by Martina Mosing, Martina Mosing, Andreas D. Waldmann, Thom C. Gent, Giselle Hosgood, Nadja S. Sieber-Ruckstuhl, Matthias Dennler, Peter Herrmann, Karin Unger

“…However, both techniques may be associated with side effects in healthy lungs, and close monitoring is indicated. This study aimed to evaluate the effects of PEEP and RM in healthy dogs and to compare functional lung monitoring methods by electrical impedance tomography (EIT), volumetric capnography (VCap), and blood gas analysis with the gold-standard anatomical monitoring provided by computed tomography (CT).Methods and materialsNine healthy Beagle dogs underwent anesthesia and mechanical ventilation three times. …”
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Functions of Smartphone Apps and Wearable Devices Promoting Physical Activity: Six-Month Longitudinal Study on Japanese-Speaking Adults by Naoki Konishi, Takeyuki Oba, Keisuke Takano, Kentaro Katahira, Kenta Kimura

“…The secondary objective was to explore which functions and features of PA apps predict changes in PA levels. …”
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The Experience of Observational Departments’ Functioning for Treatment of Patients with Tuberculosis from COVID-19 Contact and Convalescents after COVID-19 by E. M. Bogorodskaya, E. A. Kotova, E. L. Khristoforova, I. V. Nozdrevatykh

“…The evaluation data on functioning efficacy of observational departments for patients with tuberculosis from COVID-19 contact and convalescent patients with tuberculosis after COVID-19 within the large medical institution hospital of physiatry profile. …”
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Abstract 013: Infarct density: a novel imaging biomarker of long‐term functional outcome after endovascular thrombectomy by Christopher G. Favilla, Heta Patel, Mohammad Hossein Abassi, Jesse Thon, Michael T. Mullen, Scott E. Kasner, Jae W. Song, Stephanie Cummings, Steven R. Messe

“…Here we aimed to quantify the relationship between functional outcome and a range of ADC thresholds on post‐EVT MRI. …”
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Individualized supplement of water-soluble vitamins: the influence of inflammation and renal function on circulating concentrations in critically digestive disease patients by Jingjing Wang, Jingjing Wang, Jing Yan, Jing Yan, Qi Chen, Linlin Shi, Ying Wang, Xiaoxiao Tian, Yumei Qi, Guoxun Li, Hailong Cao

“…Conventional vitamin supplementation may not efficiently alleviate vitamin C and B9 deficiency in patients with high inflammation, however, it may accelerate plasma vitamin B2, B5, and B6 accumulation with renal dysfunction.ConclusionWater-soluble vitamin levels were associated with inflammation and renal function. For high inflammation, vitamin C and B9 doses may need to exceed standard levels. …”
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The Functional Role and Prognostic Significance of TIM-3 Expression on NK Cells in the Diagnostic Bone Marrows in Acute Myeloid Leukemia by Kai Sun, Zong-Yan Shi, Dai-Hong Xie, Ya-Zhe Wang, Hao Jiang, Qian Jiang, Xiao-Jun Huang, Ya-Zhen Qin

“…<b>Background:</b> Compared to other immune checkpoint molecules, T cell immunoglobulin domain and mucin domain-3 (TIM-3) is highly expressed on natural killer (NK) cells, but its functional role and prognostic significance in acute myeloid leukemia (AML) remains unclear. …”
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A decrease in functional microbiomes represented as Faecalibacterium affects immune homeostasis in long-term stable liver transplant patients by Soon Kyu Lee, JooYeon Jhun, Seung Yoon Lee, Sukjung Choi, Sun Shim Choi, Myeong Soo Park, Seon-Young Lee, Keun-Hyung Cho, A Ram Lee, Joseph Ahn, Ho Joong Choi, Young Kyoung You, Pil Soo Sung, Jeong Won Jang, Si Hyun Bae, Seung Kew Yoon, Mi-La Cho, Jong Young Choi

“…This study aimed to document the functional microbiome affecting immune homeostasis in long-term post-liver transplantation (LT) patients. …”
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Fibrosis markers as prognostic markers of decline in kidney function in patients with neuroendocrine neoplasms undergoing peptide receptor radionuclide therapy by Tobias Stemann Lau, Tobias Stemann Lau, Tobias Stemann Lau, Lars Bossen, Lars Bossen, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Karsdal, Anne Kirstine Arveschoug, Anne Kirstine Arveschoug, Henning Grønbæk, Henning Grønbæk, Henning Grønbæk, Gitte Dam, Gitte Dam, Gitte Dam

“…We aimed to investigate the potential of circulating fibrosis markers reflecting formation and degradation of collagens in predicting decline in kidney function in NEN-patients undergoing PRRT.Material and methodsWe included NEN-patients referred for PRRT treatment. …”
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Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis by Chuanchuan Wang, Chuanchuan Wang, Yafei Chen, Jinyan Zhao, Jinyan Zhao, Xiaofang Feng, Xiaofang Feng, Ruoshuang Ma, Ruoshuang Ma, Hua Wang, Hua Wang, Lin Xue, Lin Xue, Jinli Tian, Jinli Tian, Lijuan Yang, Lijuan Yang, Yaling Gu, Yaling Gu, Juan Zhang, Juan Zhang

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Impact on physical function of the +AGIL Barcelona program in community-dwelling older adults with cognitive impairment: an interventional cohort study by Cristina Arnal, L Monica Pérez, Luís Soto, Álvaro Casas Herrero, Joan Ars, Sonia Baró, Francisco Díaz, Araceli Abilla, M Belén Enfedaque, Matteo Cesari, Marco Inzitari

“…It includes physical activity, nutrition, sleep hygiene, revision and adequacy of pharmacological treatment, detection of undesired loneliness and screening for CI; to improve physical function in community-dwelling older adults. We aimed to assess the + AGIL longitudinal impact on physical function among community-dwelling frail older persons with CI. …”
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