Clinical, Functional, and Hemodynamic Profile of Schistosomiasis-Associated Pulmonary Arterial Hypertension Patients in Brazil: Systematic Review and Meta-Analysis by Camila M. C. Loureiro, André L. Scheibler Filho, Vitor M. A. S. Menezes, Ricardo A. Correa, Rudolf K. F. Oliveira, Claudia Mickael, Joan F. Hilton, Brian B. Graham

“…Therefore, this study aimed to describe baseline demographic data, hemodynamic severity of disease, and functional impairment of Sch-PAH patients at diagnosis. …”
Get full text

Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson’s disease model by Xiaoyu Sun, Jianyi Shen, Yimei Shu, Tianshi Wang, Lu He, Ruinan Shen, Yifan Zhou, Jinke Cheng, Suzhen Lin, Jianqing Ding

“…However, the pathway(s) through which MPTP impairs mitochondrial CI function remain to be elucidated. In this study, we aim to identify the molecular mechanisms through which MPTP modulates CI function and define the specific subunits of mitochondrial CI affected by MPTP. …”
Get full text

Exploring the association between hemoglobin glycation index and cognitive function in older adults with hypertension: a cross-sectional study by Hong Ding, Tingyue Kang, Wenbo Gao, Qi Wang, Shu Liu, Xiaowei Zhang, Jing Yu

“…Nonetheless, a significant gap exists in the current literature concerning the association between HGI and cognitive function. This study aims at testing such association in older adults with hypertension, a topic that has not yet been extensively investigated. …”
Get full text

Predictors of renal function decline in patients with gastroenteropancreatic neuroendocrine tumors undergoing [177Lu]Lu-DOTA-TATE therapy by Felix L. Herr, Christian Dascalescu, Victoria Fusch, Caroline Smith, Ricarda Ebner, Mathias J. Zacherl, Florian Eckenweber, Konrad Klimek, Christoph J. Auernhammer, Christine Spitzweg, Jens Ricke, Maurice M. Heimer, Clemens C. Cyran, Rudolf A. Werner, Gabriel T. Sheikh

“…While overall renal safety is high, the kidneys remain an organ at risk. This study aimed to determine whether clinical parameters can predict the risk of PRRT-associated renal function decline. …”
Get full text

Population-level impact of COVID-19 on thyroid function tests: Results from a repeated cross-sectional study by Gabriel Berkebile, Françoise Barbé, Catherine Malaplate, Lauriane Le Collen, Jean-Louis Guéant, Marc Klein, Abderrahim Oussalah

“…However, population-level studies on COVID-19’s impact on thyroid hormone levels are limited. We aimed to assess the impact of the COVID-19 pandemic on thyroid function tests at the population level. …”
Get full text

Effects of indoor biophilic environments on cognitive function in elderly patients with diabetes: study protocol for a randomized controlled trial by Jiajia Dai, Jiajia Dai, Mohan Wang, Han Zhang, Zhengfang Wang, Xue Meng, Xue Meng, Yanan Sun, Yanan Sun, Yuan Sun, Yuan Sun, Wenhui Dong, Zhiying Sun, Kuo Liu, Kuo Liu

Get full text

PEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production by Tulinska J, Kobylinska L, Lehotska Mikusova M, Babincova J, Mitina N, Rollerova E, Liskova A, Madrova N, Alacova R, Zaichenko A, Lesyk R, Horvathova M, Szabova M, Lukan N, Vari S

“…Jana Tulinska,1,* Lesya Kobylinska,2,* Miroslava Lehotska Mikusova,1 Julia Babincova,3 Natalia Mitina,4 Eva Rollerova,1 Aurelia Liskova,1 Nikola Madrova,1 Radka Alacova,3 Alexander Zaichenko,4 Roman Lesyk,5 Mira Horvathova,1 Michaela Szabova,1 Norbert Lukan,1 Sandor Vari6 1Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia; 2Department of Biochemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine; 3Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia; 4Department of Organic Chemistry, Lviv Polytechnic National University, Lviv, Ukraine; 5Department of Pharmaceutical, Organic and BioOrganic Chemistry Danylo Halytsky Lviv National Medical University, Lviv, Ukraine; 6International Research and Innovation in Medicine Program, Cedars - Sinai Medical Center, Los Angeles, CA, USA*These authors contributed equally to this workCorrespondence: Lesya Kobylinska, Department of Biochemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, Email KobylinskaLesya@meduniv.lviv.ua Norbert Lukan, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia, Email norbert.lukan@szu.skPurpose: Our study aimed to assess the effects of anticancer 4-thiazolidinone-based free water-insoluble therapeutics Les-3288 and Les-3833 and their waterborne complexes with branched PEG-containing polymeric carriers (A24-PEG550 and A24-PEG750) on immune response.Methods: Human peripheral blood was used to study in vitro lymphocyte proliferative function, leukocyte phagocytic activity and respiratory burst, and cytokine production.Results: The binding of the polymer to the anticancer drug Les-3288, which is intended to mitigate the immunosuppressive effects of the free drug on the proliferative activity of T lymphocytes and T-dependent B cells, demonstrated comparable efficacy for both A24-PEG750 and A24-PEG550 nanocarriers. …”
Get full text

Repetitive transcranial magnetic stimulation for motor function in stroke: a systematic review and meta-analysis of randomized controlled studies by Guanli Xie, Tao Wang, Li Deng, Liming Zhou, Xia Zheng, Chongyu Zhao, Li Li, Haoming Sun, Jianglong Liao, Kai Yuan

“…Abstract Objective This study aimed to systematically evaluate the safety and effectiveness of repetitive transcranial magnetic stimulation (rTMS) in treating motor dysfunction in stroke patients. …”
Get full text

One-month atogepant treatment induces rapid changes in delta-band functional connectivity in migraine: an HD-EEG study by Matteo Conti, Silvio Bagetta, Federico Carparelli, Valerio Ferrari, Vittoria Carla D’Agostino, Fabio Placidi, Alessandro Stefani, Nicola Biagio Mercuri, Maria Albanese

“…While its peripheral mechanisms are well characterized, little is known about its potential effects on central functional brain networks. This study aims to investigate changes in resting-state functional connectivity (FC) using high-density EEG (HD-EEG) after one month of atogepant treatment in patients with migraine, and to assess the relationship between these changes and clinical response. …”
Get full text

Association between brain structure and fine motor function: findings from the population-based Rhineland StudyResearch in context by Xingwang Yang, Weiyi Zeng, Santiago Estrada, Monique M.B. Breteler, N. Ahmad Aziz

“…We aimed to investigate whether decreased fine motor function is reflected in age- and sex-associated changes in brain structure across the adult lifespan in a large community dwelling cohort study. …”
Get full text

Respiratory Function and Information Processing Speed in Coal Power Plant Workers: Moderating Effects of Physical Activity and Sedentary Behavior by Kim PS, Lai TF, Park JH, Jang M, Shin YK, Kim DR, Wang IJ, Choi HJ, Lee JI

“…These findings highlight the importance of considering occupational factors in health interventions and suggest that promoting physical activity and reducing sedentary time could have multifaceted benefits for this workforce.Keywords: Respiratory function, cognitive performance, coal power plant workers, physical activity, sedentary behavior, occupational health, occupational exposure…”
Get full text

Disulfidptosis-related gene in acute myocardial infarction and its diagnostic value and functions based on bioinformatics analysis and machine learning by Liwen Chen, Jinru Wei, Jinru Wei, Guoxiong Deng, Guoxiong Deng, Guien Xu

Get full text

The effect of Zataria multiflora on respiratory symptoms, pulmonary functions, and oxidative stress parameters: a systematic review and meta-analysis by Naheed Aryaeian, Fahimeh Agh, Ali Nouri, Seyed Mojtaba Ghoreishy, Amirhossein Ramezani Ahmadi, Narges Dehghanseresht, Narges Sadeghi, Mehrnaz Morvaridi

“…Given the widespread prevalence of respiratory disorders and inconclusive outcomes from previous trials, this research aims to conduct a systematic review and meta-analysis to evaluate Z. multiflora’s impact on respiratory symptoms, pulmonary function, and oxidative stress markers using available randomized controlled trials (RCTs). …”
Get full text

Disorders of the central nervous system cognitive and mnestic functions in genetic arterial hypertension and with the use of beta-blockers of different generations by A. O. Svitlytskyi, A. A. Yehorov, O. V. Melnikova, T. A. Hrekova

“…Aim. To comparatively analyze the effect of β-blockers from different generations on cognitive and memory functional parameters of the central nervous system in rats with genetically determined hypertension. …”
Get full text

Effect of Airofit Pro Device on Lung Function, Capacity and Quality of Life in COPD: A Protocol for Randomised Controlled Trial by Pooja Ramesh Tiwari, Vishnu Vardhan

“…Participants with COPD will be recruited for this randomised controlled trial based on predetermined criteria, with caregiver consent obtained. Aim: To evaluate the effects of the Airofit Pro device on MEP, pulmonary functions, functional capacity, and QoL in patients with COPD. …”
Get full text

Cerebral hemodynamics and functional connectivity changes in stroke patients with dysphagia under acidic taste stimulation: a preliminary study by Jiliang Kang, Jiliang Kang, Junyue Lu, Mengbi Gu, Shuang Gong, Xiaohan Li, Xiaojuan Li, Lifeng Tang, Lifeng Tang, Yu Jin, Youliang Wen, Min Tang

“…The cortical activation patterns in patients with dysphagia following a stroke may be influenced by different taste stimuli, but the underlying neural mechanisms remain unclear.ObjectivesThe aim of this study was to investigate the changes in brain cortical hemodynamic signals and functional connectivity in stroke patients with dysphagia during acidic taste stimulation.MethodsWe recruited 15 patients with first-time swallowing difficulties due to stroke (53% male; mean age 69 ± 9.43 years; duration 2.47 ± 1.31 months post-stroke, onset between 2 weeks and 6 months). …”
Get full text

Adolescent and Current Exercise Habits in Chronic Obstructive Pulmonary Disease: Associations with Body Composition, Physical Activity, and Pulmonary Function by Iriyama T, Matsuo Y, Tsunoda Y, Yamazaki A, Uchida Y, Nakagawa H, Kinose D, Yamaguchi M, Nakano Y, Ogawa E

“…However, the associations of exercise habits during adolescence compared to current exercise habits on physical activity (PA), body composition, pulmonary function, and CT imaging parameters remain unclear. …”
Get full text

Interplay between worsening kidney function and cardiovascular events in patients with type 2 diabetes: an analysis from the ACCORD trial by João Pedro Ferreira, Patrick Rossignol, Faiez Zannad, Abhinav Sharma, Diana Ferrao, Francisco Vasques-Novoa, Adelino Leite-Moreira

“…Introduction Patients with type 2 diabetes (T2D) have an increased risk of worsening kidney function (WKF) over time compared with patients without diabetes. …”
Get full text

Types of Injuries and the Severity of Shoulder Dysfunction Associated with Diabetes Mellitus in Patients with Functional Impairment: A Case–Control Study by Mercedes Fuentes-Murguia, Karla B. Carrazco-Peña, Osiris G. Delgado-Enciso, Joel Castellanos-Gomez, Gustavo A. Hernandez-Fuentes, Fabian Rojas-Larios, Carmen A. Sanchez-Ramirez, Margarita L. Martinez-Fierro, Iram P. Rodriguez-Sanchez, José Guzmán-Esquivel, Idalia Garza-Veloz, José E. Del-Río-Valdivia, Jorge E. Plata-Florenzano, Iván Delgado-Enciso

“…This study aimed to assess the association between diabetes and specific shoulder injuries, as well as the degree of functional impairment in affected patients. …”
Get full text

Investigation of early-stage cardiovascular-kidney-metabolic syndrome on retinal structure and function evaluated by optical coherence tomography angiography by Yunyi Liang, Congbi Liang, Jianping Yang, Wanhua Li, Runyi Liang, Kun Li, Jingfeng Zhang, Peiqiong Lao, Junhua Zhu, Lin An, Zhaohao Liang, Chubin Ou

Get full text