Functional outcome after Brachytherapy with bi-nuclide (Ru-106/Iodine-125) plaques in large uveal melanomas by Leyla Jabbarli, Miltiadis Fiorentzis, Philipp Rating, Boerge Schmidt, Eva Biewald, Nika Guberina, Dirk Flühs, Norbert Bornfeld, Wolfgang Sauerwein, Martin Stuschke, Nikolaos E. Bechrakis, Maja Guberina

“…Abstract Objective Preservation of visual acuity remains a challenging issue after globe sparing therapy of large uveal melanoma. The aim of our study was analyzing the functional outcome after brachytherapy with bi-nuclide plaques (BBNP), maintaining prognostic factors for legal blindness (LB). …”
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Cognitive, Behavioral, and Learning Profiles of Children with Above-Average Cognitive Functioning: Insights from an Italian Clinical Sample by Daniela Pia Rosaria Chieffo, Valentina Arcangeli, Valentina Delle Donne, Giulia Settimi, Valentina Massaroni, Angelica Marfoli, Monia Pellizzari, Ida Turrini, Elisa Marconi, Laura Monti, Federica Moriconi, Delfina Janiri, Gabriele Sani, Eugenio Maria Mercuri

“…Although the cognitive and behavioral characteristics of giftedness have been widely studied in Anglophone countries, evidence remains limited in Southern Europe. This study aimed to investigate the cognitive, academic, and emotional–behavioral profiles of Italian children and adolescents with above-average cognitive functioning, using an inclusive, dimensional approach (IQ > 114). …”
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Investigating POU3F4 in cancer: Expression patterns, prognostic implications, and functional roles in tumor immunity by Weiwei Chen, Yaya Ji, Rui Wang, Ruijie Ji, Yujian Lin, Yuhang Wu, Lehan Liu, Tianle Sha, Wen Li, Lei Zhang, Longfei Yang, Xinhua Zhang, Jianxiang Song

“…Nevertheless, comprehensive pan-cancer analyses focusing on POU3F4 remain limited. This study aims to assess the prognostic value of POU3F4 in thirty-three cancers and explore its immune-related functions. …”
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The absence of IL17A favours cytotoxic cell function and improves antigen‐specific immunotherapies in pancreatic adenocarcinoma by Giorgia Tiberi, Alessandro Scagliotti, Claudia Curcio, Ermes Candiello, Paula Ariadna Diez Villegas, Silvia Brugiapaglia, Gianluca Mucciolo, Cecilia Roux, Giancarlo Castellano, Roberta Curto, Maddalena Arigoni, Raffaele A. Calogero, Giuseppina Barutello, Niccolò Bolli, Mauro Giulio Papotti, Giulia Adriani, Francesco Novelli, Paola Cappello

“…NK cell depletion in untreated models further demonstrated NK cells’ critical function in controlling tumour growth when IL17A was absent. …”
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Effectiveness of 2 Just-in-Time Adaptive Interventions for Reducing Stress and Stabilizing Cardiac Autonomic Function: Microrandomized Trials by Andreas Richard Schwerdtfeger, Josef Martin Tatschl, Christian Rominger

“…This metric is quantified by regressing bodily movement on the root mean square of successive differences and identifying reductions <0.5 SD of the predicted value in real time in everyday life. ObjectiveWe aimed to apply this measure using wearables in everyday life to trigger low-threshold, 1-minute just-in-time adaptive interventions (JITAIs) to stabilize autonomic function and relieve perceived stress and ruminative thoughts. …”
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Effect of two-dimensional functional fillers size on the performance of BN/EPDM flexible neutron protection composite materials by ZONG Bo, ZENG Deyang, WANG Kaikai, TANG Wencai, FU Jiajia, CHANG Shuquan, HE Jialin, CHEN Fanglei, LI Ziping, LI Da

“…Their performances are closely related to the properties of functional fillers, but the effect of size of 2D functional fillers on the performance of composites is not yet clear.PurposeThis study aims to explore the influence of two-dimensional (2D) functional filler size on the mechanical properties and neutron shielding performance of composite materials.MethodsFirstly, ethylene propylene diene monomer (EPDM) rubber with good performance such as high temperature resistance, weather resistance, radiation stability, mechanical properties, and high hydrogen content was used as flexible substrate material, and layered boron bitride (BN) with a high thermal neutron absorption cross-section was taken as 2D functional filler, and the surface of BN was modified by mercapto group through two-step chemical grafting. …”
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Impact of Beta-Blockers on Pneumonia, Mortality and Functional Outcomes of Patients with Intracerebral Hemorrhage-A Retrospective Multicenter Study by Gao B, Wang A, Zhang X, Zhang J, Ju Y, Zhao X, Wang W

“…Fanyang Road, Fengtai District, Beijing, 100070, People’s Republic of China, Tel +86-132-6971-0690, Email tong_ttyy@163.comPurpose: Given the current lack of research on the impact of beta-blockers (BB) on clinical outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to evaluate the effect of BB on pneumonia, functional outcomes, and mortality in adult patients with primary ICH.Patients and Methods: This was a retrospective study of a registry cohort of patients with ICH from 13 stroke centers in Beijing, China. …”
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The influence of milk thistle, metiphene, and sylimevit on the protein synthesis function of the liver of laying hens under cadmium load by A. O. Ostapyuk, B. V. Gutyj, O. V. Kozenko, I. V. Dvyliuk, A. R. Shcherbatyi, T. V. Martyshuk, N. V. Magrelo, H. V. Klym, N. Yu. Krempa, U. M. Vus, A. O. Vysotskyi

“…The work aimed to study the effect of milk thistle, metiphene, and sylimevit on the protein synthesizing function of the liver of laying hens under experimental chronic cadmium toxicosis. 32 laying hens aged 78 weeks were selected for the research. …”
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Evaluation of water supply function in the Economic Belt of the Northern Slope of the Tianshan Mountains based on the InVEST model by Wei Liu, Hao Tian, Xingang Xu, Guang Yang

“…This study aimed to explore the land use changes and the spatial variability of water supply service functions in the region at the macro level and uses the land transfer matrix as an important tool to study the changes in land use in the different years of 2000, 2005, 2010, 2015, and 2020. …”
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Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank by Zijian Kang, Jianzheng Zhang, Chen Zhu, Ying Zhu, Hanlei Jiang, Qiang Tong, Sheng-Ming Dai

“…However, its link to gout risk remains unclear. The study aimed to investigate the relationship between pulmonary function and the risk of developing gout and the underlying biological mechanisms. …”
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Abnormal Gray Matter Volume and Functional Connectivity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder by Xu Jiang, Zhuang Wu, Min Zhong, Bo Shen, Jun Zhu, Yang Pan, Jun Yan, Wenbin Zhang, Pingyi Xu, Chaoyong Xiao, Li Zhang

“…Therefore, this study aimed to detect the structural and functional differences in patients with PD-RBD and PD without RBD (PD-nRBD). …”
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Immediate impact of augmented reality visual training on choroidal thickness and accommodative function: A small sample study by Guo-rui Hu, Zhi-xing Xu, Chang-feng Pan, Zheng-yang Tao, Hang Chu, Zong-yue Lv, Ze-feng Kang, Hong-wei Deng

“…Objective: The aim of this study is to evaluate the immediate effects of a single AR visual training session, integrated with a vision function restoration model, on ChT and AF. …”
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Effect of dapagliflozin on the structural and functional properties of arterial vessels in patients with type 2 diabetes mellitus in combination with obesity by О. А. Soloviuk, R. L. Kulynych

“…The aim of the study was to establish the possibility of correction of structural and functional disorders of arterial vessels in patients with type 2 DM in combination with excess body weight (EBW) and obesity with dapagliflozin as part of complex therapy. …”
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Long-term behaviour of non-functioning pituitary microadenomas: experience from a tertiary care centre in Romania by Mădălina Elena Iftimie, Mădălina Elena Iftimie, Iulia Florentina Burcea, Iulia Florentina Burcea, Ramona Dobre, Ramona Dobre, Stella Pigni, Flavia Prodam, Cătălina Poiană, Cătălina Poiană

“…Performing the first follow-up MRI at one year and if stable, delaying re-evaluation to 5 years, without pituitary function reassessment in absence of clinical manifestations, is a safe and cost-effective approach.…”
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ExerG – an exergame-based training device for the rehabilitation of older adults: a functional model usability study by Jane Muheim, Isabella Hotz, Franziska Kübler, Silvia Herren, Simon Sollereder, Katharina Kruszewski, Anna Lisa Martin‑Niedecken, Alexandra Schättin, Frank Behrendt, Sonja Böckler, Stefan Schmidlin, Roman Jurt, Stephan Niedecken, Yanick Riederer, Christian Brenneis, Leo H. Bonati, Barbara Seebacher, Corina Schuster‑Amft

“…By combining physical and cognitive training components, they aim to preserve independence in older adults and reduce their risk of falling. …”
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Functional recovery following hospitalisation of patients diagnosed with COVID-19: a protocol for a longitudinal cohort study by Julie C Reid, Maureen Markle-Reid, Ameen Patel, Andrew P Costa, Maura Marcucci, MyLinh Duong, Connie Schumacher, Aaron Jones, Mats Junek, Marla K Beauchamp, Parminder Raina, Lauren E Griffith, Sophie Corriveau, Shariq Haider, Terence Ho, Rebecca Kruisselbrink, Hope Morrison, Natya Raghavan, Leslie Martin, Carla Girolametto

“…The primary aim of the Coronavirus Registry Functional Recovery (COREG-FR) study is to understand the trajectory of functional recovery among individuals hospitalised for COVID-19 over the medium (up to 6 months) and longer term (6–12 months) that will guide clinical care and optimal management of serious COVID-19 illness and recovery.Methods and analysis COREG-FR is a multicentre longitudinal cohort study. …”
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Changes in Cardiac Function and Exercise Capacity Following Ferric Carboxymaltose Administration in HFrEF Patients with Iron Deficiency by Anastasios Tsarouchas, Constantinos Bakogiannis, Dimitrios Mouselimis, Christodoulos E. Papadopoulos, Efstratios K. Theofillogiannakos, Efstathios D. Pagourelias, Ioannis Kelemanis, Aristi. Boulmpou, Antonios P. Antoniadis, Nikolaos Fragakis, Georgios Efthimiadis, Theodoros D. Karamitsos, Vassilios P. Vassilikos

“…Intravenous ferric carboxymaltose (FCM) improves symptoms, but its effect on cardiac structure and function remains incompletely understood. The aim of this study was to assess the impact of intravenous FCM on echocardiographic indices of left ventricular (LV), left atrial (LA), and right ventricular (RV) morphology and function in HFrEF patients with ID and determine whether these changes correlate with improvements in exercise capacity. …”
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Continuous wavelet based transfer function analysis of cerebral autoregulation dynamics for neuromonitoring using near-infrared spectroscopy by Marcus Thudium, Evgeniya Kornilov, Evgeniya Kornilov, Stefan Moestl, Fabian Hoffmann, Fabian Hoffmann, Alex Hoff, Surat Kulapatana, Surat Kulapatana, Surat Kulapatana, Vasile Urechie, Vasile Urechie, Maximilian Oremek, Stefano Rigo, Stefano Rigo, Stefano Rigo, Karsten Heusser, Italo Biaggioni, Jens Tank, André Diedrich, André Diedrich

“…Derived parameters like cerebral oxygenation index or Fast Fourier Transform based coherence estimates between blood pressure and cerebral blood flow have their limitations of use for stationary data and low time resolution. Wavelet transfer function analysis can be employed to estimate coherence, gain and phase relationship between two signals without these restrictions.MethodsWe aimed to extend the previously described Grinsted wavelet package with rectified bias of power and transfer function gain estimation of cerebral autoregulation assessment. …”
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Effects of Physical Exercise on the Body Composition and Functionality in Individuals with Chronic Obstructive Pulmonary Disease: A Systematic Review by Daysa de Souza-Santos, Redha Taiar, José Alexandre Bachur, Luiza Torres-Nunes, Bruno Bessa Monteiro-Oliveira, Eliane de Oliveira Guedes-Aguiar, Ana Carolina Coelho-Oliveira, Vanessa Amaral Mendonça, Ana Cristina Rodrigues Lacerda, Anelise Sonza, Adérito Seixas, Mario Bernardo-Filho, Danúbia da Cunha de Sá-Caputo

“…<b>Objective</b>: This systematic review aims to summarize the scientific evidence on the impact of physical exercise on body composition and functionality in individuals with COPD. …”
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Resting-state functional magnetic resonance imaging and tryptophan hydroxylase-2 methylation interaction in major depressive disorder by Zhi Xu, Tingting Tan, Yan Jiang, Haiping Tang, Bingwei Chen, Wenji Chen, Yonggui Yuan

“…In our previous study, we demonstrated that DNA methylation of Tryptophan Hydroxylase-2 (TPH2) is related to the occurrence of MDD. The present study aimed to identify the interaction of the functional activities of brain regions identified as regions of interest (RoI) in MDD with TPH2 gene methylation to explore their relationship. …”
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