The CD4/CD8 ratio is associated with T lymphocyte functions in long-term virally suppressed patients with HIV by Qing Xiao, Fengting Yu, Liting Yan, Xiaojie Lao, Xuelei Liang, Hongxin Zhao, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yao Liu, Fujie Zhang

“…The activation and proliferation phenotypes, mitochondrial functions, and inflammatory indexes of CD4+ T cells and CD8+ T cells were measured, and correlations between the CD4/CD8 ratio and T cell functions were analyzed. …”
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Prediction of Abnormal Functional Performance in Chronic Obstructive Pulmonary Disease Using Respiratory Models: A Pilot Study by Ribeiro CO, Lopes AJ, de Melo PL

“…Caroline Oliveira Ribeiro,1,* Agnaldo José Lopes,2,* Pedro Lopes de Melo1,3,* 1Biomedical Instrumentation Laboratory - Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil; 2Pulmonary Function Laboratory, State University of Rio de Janeiro, Rio de Janeiro, Brazil; 3BioVasc Research Laboratory - Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil*These authors contributed equally to this workCorrespondence: Pedro Lopes de Melo, Email plopes@uerj.brIntroduction: The contribution of respiratory models to understanding and predicting functional capacity abnormalities in chronic obstructive pulmonary disease (COPD) has not yet been investigated.Purpose: The aims of this study were: (1) To investigate the associations between the extended Resistance-Inertance-Compliance (eRIC) and the fractional-order (FrOr) models with changes in Glittre-ADL and handgrip tests and; (2) To evaluate the accuracy of these models in predicting abnormal functional capacity in COPD.Patients and Methods: The study was carried out in a group of 40 adults with COPD and a control group of 40 healthy individuals, both evaluated by respiratory oscillometry, spirometry, Glittre-ADL test and handgrip test. eRIC and fractional order models were also used to quantify biomechanical changes and obtain physiological information. …”
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The Synthetic Cannabinoids ADB-FUBINACA Modulate Mitochondrial Function and Dynamics at Biologically Relevant Concentrations During In Vitro Neurodifferentiation by R.F. Malheiro, H. Carmo, F. Carvalho, J.P. Silva

“…Interestingly, the influence of mitochondria on cellular homeostatic responses has emerged as a central regulator of neural stem cell fate. Thus, here we aimed to evaluate the effects of this SC on mitochondrial function and dynamics during in vitro neurodifferentiation. …”
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Effect of streptococcal arginine deiminase on the function of CD4⁺ and CD8⁺T lymphocytes by E. A. Starikova, J. T. Mammedova, A. Ozhiganova, A. M. Lebedeva, T. A. Leveshko, L. A. Burova, I. V. Kudryavtsev

“…Arginine metabolism plays an important role in regulating the functions of immune cells in mammals. Pathogenic microbes use the mechanism of arginine depletion to suppress the immune response during infection. …”
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Stepwise Total Hip Arthroplasty with Lateral and Posterolateral Approaches: Intraoperative Imaging, Fixation Strategy, and Early Functional Outcomes by Roland Fazakas, Laura Ioana Bondar, Csongor Toth, Brigitte Osser, Iosif Ilia, Gabriel Roberto Marconi, Victor Niculescu, Ramona Nicoleta Suciu, Liviu Gavrila-Ardelean, Alexandru Pop

“…Cemented implants allowed for immediate full weight-bearing and were preferred in elderly patients with poor bone quality, while uncemented components were used in younger patients with good bone density, requiring a delayed weight-bearing protocol. Functional scores improved in both groups between six weeks and six months. …”
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Functional Monitoring of Patients With Knee Osteoarthritis Based on Multidimensional Wearable Plantar Pressure Features: Cross-Sectional Study by Junan Xie, Shilin Li, Zhen Song, Lin Shu, Qing Zeng, Guozhi Huang, Yihuan Lin

“…ObjectiveThrough wearable gait analysis technology, we aim to obtain abundant gait information based on machine learning techniques to develop a simple, rapid, effective, and patient-friendly functional assessment model for the KOA rehabilitation process to provide long-term remote monitoring, which is conducive to reducing the burden of social health care system. …”
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Impact of Lysine to Methionine Ratios on Antioxidant Capacity and Immune Function in the Rumen of Tibetan Sheep: An RNA‐Seq Analysis by Fengshuo Zhang, Quyangangmao Su, Zhanhong Gao, Zhenling Wu, Qiurong Ji, Tingli He, Kaina Zhu, Xuan Chen, Yu Zhang, Shengzhen Hou, Linsheng Gui

“…However, the formulation of an ideal amino acid (AA) composition is crucial for better protein utilization by livestock. This study aimed to investigate the effects of different lysine to methionine ratios on the antioxidant capacity and immune function of the rumen in Tibetan sheep. …”
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426 Developing a Molecular Toolkit to define NEK functions in triple-negative breast cancer (TNBC) biology by Julia Boehling, Jack R. Elliot, Elizabeth C. Martin, Bridgette M. Collins-Burow, David H. Drewry, Van T. Hoang, Sean Lee, Matthew E. Burow

“…Objectives/Goals: The never in mitosis kinase (NEK) family regulates vital processes, namely cell cycle progression, but their potential as therapeutic targets in TNBC has not been fully explored. Our studies aim to develop a toolkit to investigate the functional roles of NEKs in pathologies including carcinogenesis. …”
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Rehabilitation Impact of Vivifrail Exercise Program Type C on the Cognitive Function of Pre-Frail Elderly People in the Community by Sri Soenarti, Dwi Indriani Lestari, Muhammad Barlian Nugroho, Harien Lestari, Tita Hariyanti

“…This study aimed to determine the effect of the Vivifrail Exercise Program Type C on the cognitive function of pre-frail elderly people. …”
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Cardiac Performance by Echocardiography, Cardiovascular Biomarker, Kidney Function, and Venous Oxygen Saturation as Mortality Predictors of Septic Shock by Pudjo Rahasto, BUdhi Setianto, Ina S Timan, Suhendro Suhendro, Lugyanti Sukrisman, Renan Sukamawan, Mondastri K Sudaryo, Peter Kabo

“…Our study may provide greater knowledge and understanding on pathophysiology of cardiovascular disorder in patients with septic shock. This study aimed to evaluate the roles of echocardiography, cardiovascular biomarkers, venous oxygen saturation and renal function as predictors of mortality rate in patients with septic shock. …”
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Metabolic, Microvascular, and Structural Predictors of Long-Term Functional Changes Evaluated by Multifocal Electroretinogram in Type 1 Diabetes by Mariacristina Parravano, Serena Fragiotta, Eliana Costanzo, Fabiana Picconi, Paola Giorno, Daniele De Geronimo, Daniela Giannini, Monica Varano, Vincenzo Parisi, Lucia Ziccardi

“…Background: This study aimed to analyze the potential pathogenic connection between metabolic factors, photoreceptor cell rearrangements, retinal microvascular perfusion, and functional parameters through multifocal electroretinography (mfERG) in type 1 diabetes mellitus (DM1). …”
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Association between insecticide exposomics and cognitive function in older adults: an observational study based on NHANES 2011–2014 by Mengfan Zhang, Xiaofang Guo, Yuanjun Chen, Xinghua Liu, Xingdong Lin

“…ObjectiveThis study aims to investigate the association between exposure to insecticide exposomics and cognitive function, among adults aged 60 and above.MethodsWe employed a multi-stage probability sampling method to analyze data derived from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2014. …”
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Feasibility and preliminary efficacy of an online home-based functional exercise program for Parkinson's disease: a pilot study by Hyungwoo Lee, Hunyoung Ha, Heehyun Shin, Byungjun Park, Nyeonju Kang, Kiwon Park, Ryul Kim, Kyeongho Byun

“…BackgroundParkinson's disease (PD) leads to motor and non-motor impairments, contributing to sarcopenia and reduced functional independence. While functional strength exercises can help manage these symptoms, adherence remains challenging, particularly in home-based setting.ObjectiveThis pilot exercise intervention study aimed to evaluate the feasibility and efficacy of an 8-week Online Home-Based Exercise Program (OHEP), which provides easy-to-follow functional strength exercises for PD patients, enabling them perform these exercises safely and effectively at home.MethodsFifteen patients with early-stage PD (Hoehn and Yahr Stage 1–2) participated in an 8-week exercise intervention, consisting of a 2-week in-person training followed by a 6-week online home-based exercise session using Zoom. …”
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Functional Recovery After Hip Arthroplasty with a Minimal Invasive or Classical Approach Eight Years After Intervention by Mirela Vuckovic, Lana Ruzic, Karlo Tudor, Tomislav Prpic, Zdravko Jotanovic, Silvije Segulja, Andrica Lekic, Ksenija Bazdaric

“…<b>Background:</b> The aim of this study was to investigate differences in functional recovery eight years after total hip arthroplasty in patients who underwent hip joint surgery using two different approaches: the classic lateral approach and the anterolateral minimally invasive surgical approach. …”
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Effects of cardamonin on the growth performance, intestinal barrier function and intestinal microbiota of Danzhou chickens under heat stress by Haoran Jiang, Liguang Shi, Tanjie Deng, Guanyu Hou, Wenjuan Xun

“…ABSTRACT: The aim of this study was to investigate the effects of cardamonin (CDN) on the growth performance, intestinal mucosal barrier function and intestinal microbiota of Danzhou chickens under heat stress. …”
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Progressive iron overload in middle-aged mice impairs olfactory function, triggers lipid oxidation and induces apoptosis by Lin Deng, Lin Deng, Lin Deng, Qihui Luo, Qihui Luo, Yucong Liu, Yucong Liu, Yao Wang, Yao Wang, Zongliang Xiong, Zongliang Xiong, Hongping Wang, Lu Zhao, Lanlan Jia, Lanlan Jia, Riyi Shi, Chao Huang, Chao Huang, Zhengli Chen, Zhengli Chen

“…IntroductionThis study aims to investigate the progressive impact of chronic iron overload on the olfactory bulb, a region significantly affected in early neurodegenerative diseases like Parkinson’s and Alzheimer’s. …”
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Low birth weight associations with cardiac structure and function in adults after arterial switch for transposition of the great arteries by Art Schuermans, Béatrice Santens, Jef Van den Eynde, Xander Jacquemyn, Roel L.F. Van der Palen, Michael C. Honigberg, Alexander Van De Bruaene, Piet Claus, Jan Bogaert, Werner Budts

“…Background and aims: The objective of this study was to assess the associations of birth weight with cardiac structure and function in adults with dextro-transposition of the great arteries (D-TGA) who underwent the arterial switch operation (ASO). …”
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Lung function may recover after coal mine fire smoke exposure: a longitudinal cohort study by David Brown, Tyler Lane, Michael J Abramson, Bruce R Thompson, Caroline X Gao, Jillian Ikin, Brigitte Borg, Nicolette R Holt, Catherine L Smith, Annie Makar, Thomas McCrabb, Mikayla Thomas, Kris Nilsen

“…For post-bronchodilator reactance and area under the curve, a negative impact of PM2.5 in round 1 showed signs of recovery in round 2 (both p&lt;0.001).Conclusion In this novel study evaluating long-term respiratory outcomes after medium-duration high concentration PM2.5 exposure, the attenuated associations between exposure and respiratory function may indicate some recovery in lung function. …”
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Association between the proportionality of functional mitral regurgitation and survival after mitral valve operationCentral MessagePerspective by Makoto Mori, MD, PhD, Christina Waldron, BS, Sigurdur Ragnarsson, MD, Soh Hosoba, MD, PhD, Mina Zaky, MD, Dustin Lieu, MD, Markus Krane, MD, Arnar Geirsson, MD

“…Objective: The concept of proportionate and disproportionate functional mitral regurgitation suggests that transcatheter edge-to-edge mitral repair may benefit patients with a smaller left ventricle relative to a higher regurgitant burden. …”
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Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function by Inssaf Berkiks, Inssaf Berkiks, Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Blessing Moses, Blessing Moses, Tiroyaone Brombacher, Tiroyaone Brombacher, Frank Brombacher, Frank Brombacher

“…One of the major consequences of schistosomiasis is its impact on brain function, and despite its severity, the underlying mechanism(s) remain inadequately understood, highlighting a knowledge gap in the disease. …”
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