Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway by Yan Li, Hong Wang, Xiaoyang Li, Yuan He, Huiquan Liu, Dong Han, Ting Mei, Yixuan Li, Zilong Xu, Xiaoying Wei, Jianguo Wang, Peijie Zhou, Yuwen Wang, Ziye Li, Junhao Ning, Anlin Wang, Jingjing Cheng, Dong Qian

“…PGAM5 anchors at mitochondria and regulates mitochondria functions. We aim to explore whether the regulation of tumor-intrinsic PGAM5 on mitochondria affects tumor-infiltrating immune cells in the microenvironment and whether tumor-intrinsic PGAM5 can be a therapeutic target to enhance the immunotherapy efficacy of hepatocellular carcinoma (HCC).Methods We analyzed the correlation of PGAM5 expression and immune cells infiltration using Gene Expression Omnibus (GEO) and The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) data sets based on cibersort algorithm and tumor-tissue arrays from two independent cohorts. …”
Get full text

The efficacy, safety and clinical feasibility of a percutaneous atrial septal shunt device for pulmonary arterial hypertension: a single-center cohort study by Mingfei Li, Dandan Chen, Jianing Fan, Dan Tian, Lei Zhang, Xiaochun Zhang, Shasha Chen, Yuan Zhang, Wenzhi Pan, Lihua Guan, Daxin Zhou, Junbo Ge

“…Seven patients’ New York Heart Association (NYHA) functional classification improved from grade III to grade II. …”
Get full text

Measure selection for an electronic patient-reported outcome (ePRO) system for CAR T-cell therapy patients: a modified Delphi consensus studyResearch in context by Sarah E. Hughes, Foram Khatsuria, Christel McMullan, Karen L. Shaw, Anita Walker, Francesca Kinsella, David Burns, Olalekan L. Aiyegbusi, Elin Haf Davies, John Ansell, Evelyn Chakera, Charles Craddock, Alastair Denniston, Rebecca Lloyd, Paul Ferguson, Ronjon Chakraverty, Melanie Calvert

“…These measures, EQ5D-5L, measuring HRQoL, and Functional Assessment of Chronic Illness Therapy–Item GP5 (FACT-GP5), single-item global indicator of cancer treatment tolerability, will be included in the ePRO system. …”
Get full text

Geographic variation in secondary metabolites contents and their relationship with soil mineral elements in Pleuropterus multiflorum Thunb. from different regions by Yaling Yang, Siman Wang, Ruibin Bai, Feng Xiong, Yan Jin, Hanwei Liu, Ziyi Wang, Chengyuan Yang, Yi Yu, Apu Chowdhury, Chuanzhi Kang, Jian Yang, Lanping Guo

“…Objective. This study aimed to investigate the variations in the distribution of active components in HSW across diverse planting regions and their relationship with soil mineral elements. …”
Get full text

Impaired response inhibition to negative emotional stimuli in depressed adolescents with non-suicidal self-injury: a neurophysiological perspective by Lin Zhao, Su Hong, Xinyu Peng, Xiaoqing He, Jinhui Hu, Lingli Ma, Xinyi Liu, Wanqing Tao, Ran Chen, Zhenghao Jiang, Chenyu Zhang, Jing Liao, Jiaojiao Xiang, Qi Zeng, Linqi Dai, Qi Zhang, Wo Wang, Li Kuang

“…Moreover, depressed adolescents with NSSI showed significant event-related synchronization (ERS) in the Delta and Theta bands of FCz electrode from 0 to 0.6 seconds, and event-related desynchronization (ERD) in the Theta and Alpha bands of Pz electrode from 0.2 to 1.2 seconds, collectively reflecting functional processes associated with response inhibition.ConclusionsDepressed adolescents with NSSI showed increased P3d amplitudes, enhanced Delta/Theta ERS, and heightened Theta/Alpha ERD when receiving negative emotional stimuli, suggesting that depressed adolescents with NSSI have impaired response inhibition, which may contribute to the development of NSSI.…”
Get full text

In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies by Nicola Normanno, Fabiana Tatangelo, Piera Maiolino, Stefania Scala, Caterina Ieranò, Dario Righelli, Crescenzo D'Alterio, Maria Napolitano, Luigi Portella, Giuseppina Rea, Federica Auletta, Sara Santagata, Anna Maria Trotta, Giuseppe Guardascione, Federica Liotti, Nella Prevete, Antonio Luciano, Antonio Barbieri, Annabella Di Mauro, Cristin Roma, Riziero Esposito Abate, Roberto Pacelli, Rosa Marina Melillo

“…In melanoma, liver, and thyroid cancer cells, intrinsic PD-1 signaling activates oncogenic functions, while in lung cancer cells, it has a tumor suppressor effect. …”
Get full text

Outcomes of transcatheter aortic valve replacement in younger low-risk patients: a comprehensive meta-analysis of efficacy and safety by António Rocha de Almeida, António Rocha de Almeida, António Rocha de Almeida, Maria Rita Lima, Maria Rita Lima, Daniel A. Gomes, Renato Fernandes, Eduardo Infante Oliveira, Eduardo Infante Oliveira, Pedro Araújo Gonçalves, Pedro Araújo Gonçalves, Rui Campante Teles, Rui Campante Teles, Manuel de Sousa Almeida, Manuel de Sousa Almeida, Lino Patrício

“…Background and aimsSevere aortic stenosis (AS) was traditionally managed with surgical aortic valve replacement (SAVR). …”
Get full text

Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using s... by Zhaorui Cheng, Xiangyu Yang, Yi Ren, Huimin Wang, Qi Zhang, Sailing Lin, Wenhao Wu, Xiaolu Yang, Jiahan Zheng, Xinzhu Liu, Xin Tao, Xiaoyong Chen, Yuxin Qian, Xiushen Li

“…This study aims to investigate these mechanisms using single-cell RNA sequencing data. …”
Get full text

Inflammatory profiling and immune cell infiltration in dysthyroid optic neuropathy: insights from bulk RNA sequencing by Qintao Ma, Yuanping Hai, Yongbo Duan, Genfeng Yu, Cheng Song, ShengAi Huang, Anqi Huang, Yan Zhu, Yongzhi Shen, Zimeng Huang, Xiao Wang, Lan Liu, Thomas Efferth, Huiyu Guo, Yi Wang, Yi Wang, Jie Shen

“…ROC analysis and single-gene GSEA were used to evaluate the diagnostic potential and functional relevance of core genes. Inflammatory-Related Differential Genes (IRDGS) were identified and preliminarily validated using Quantitative Real-Time PCR.ResultsDifferential gene expression analysis revealed 176 and 202 significantly upregulated genes in DON vs. non-DON and DON vs. …”
Get full text

Incidence and outcoMes of MInor stroke and high-risk traNsient ischEmic attack in NordicTus. IMMINENT study by M.E. Ramos-Araque, M. Castellanos, L. Naya Rios, E. López-Cancio, J. Molina Gil, J. Marta-Moreno, H. Tejada-Meza, M. Temprano Fernández, C. Antón González, D. Vidal de Francisco, J. Tejada-García, J.L. Maciñeiras Montero, P. Vicente Alba, J.M. García-Sánchez, B. Aguilera Irazabal, M. Martínez-Zabaleta, I.N. Diez, A. Pinedo Brochado, I. Azkune Calle, M.M. Freijo, A. Moreno-Estebanez, E. Palacio-Portilla, L. Manrique Arregui, M. Rodríguez-Yáñez, M. Santamaría-Cadavid, J.J. Timiraos-Fernández, Y. Herrero Infante, J. Trejo-Gabriel-Galán, A. Echavarria-Iñiguez, C. Tejero-Juste, J. Rodríguez Montolio, F. Julián-Villaverde, M. Moreno García, L. López-Mesonero, L. Redondo-Robles, N. Aymerich, J. Korroza, J.F. Arenillas

“…Follow-up was performed at 30 and 90 days. Functional prognosis was assessed with the modified Rankin scale score (mRS). …”
Get full text

Interest groups in Lithuania: dynamics of development and characteristics of institutionalization by Alvidas Lukošaitis

“…On the other - it implies functional inclusion of the interest groups into the decision-making process. …”
Get full text

Designing the outsourcing model in central government organizations by Mahnaz Moradi, Morteza Ghasemi, Maryam Majidi, Gholamreza Amjadi

“…Outsourcing is related to the transfer of a complete functional department of the business or some activities of a functional department and keeping the rest of the activities of that department internally. …”
Get full text

Spatial Analysis of the Relationship between Ecological Factors and Housing Prices in Tehran by Atefeh Kolyaei, Tahir Prizadi, Habibollah Fasihi

“…Consequently, these factors play a crucial role in determining real estate values. This research aimed to explore the extent to which spatial variations in residential property prices in Tehran were affected by ecological factors. …”
Get full text

Non-pharmacological interventions for temporomandibular disorders: A systematic review and meta-analysis by Qiu-yi CHEN, Quan MIAO, Fei-yu FU, Ying LIN, Chen-xi ZENG, Pei-yue PENG, Yi-xin ZHANG, Lu LIU, Bin LI

“…Objective: This study aimed to evaluate the clinical efficacy of non-pharmacological interventions for TMDs, focusing on their impact on pain relief, jaw mobility, and functional improvement. …”
Get full text

GRAPHIC NOVEL TRANSLATION: SEMIOTIC AND MULTIMODAL PERSPECTIVE by Anna V. Khodorenko.

“…Maus is the first graphic novel dealing with Holocaust theme aimed at the adult audience. According to the definition of the graphic novel, Maus is seen to share discursive mechanisms with visual narrative instruments, embedded in multimodal phenomena. …”
Get full text

Real-world experience with the diagnosis of bile acid malabsorption (BAM) using serum 7-alpha-C4 and 48-hour stool bile acids by G. Mendoza-Domínguez, Z.M. Garrido-Santos, C. Lau, R. Balbuena, A.D. Santana-Vargas, M. Schmulson-Wasserman

“…Introduction and aims: Bile acid malabsorption (BAM) is responsible for 30% of cases of diarrhea-predominant irritable bowel syndrome (IBS-D) or functional diarrhea and 63.5% of cases of diarrhea following cholecystectomy. 75SeHCAT is the gold standard diagnostic method but is unavailable in Mexico. …”
Get full text

Flow-Cytometric Quantification of Urine Kidney Epithelial Cells Specifically Reflects Tubular Damage in Acute Kidney Diseases by Leonie Wagner, Jacob Kujat, Valerie Langhans, Luka Prskalo, Diana Metzke, Emil Grothgar, Paul Freund, Nina Goerlich, Hannah Brand, Sara Timm, Matthias Ochs, Andreas Grützkau, Sabine Baumgart, Christopher M. Skopnik, Adrian Schreiber, Falk Hiepe, Gabriela Riemekasten, Philipp Enghard, Jan Klocke

Get full text

Is performing the Kasai portoenterostomy in the neonatal period associated with a better prognosis? A single-center, retrospective cohort study from China by Chuanping Xie, Peize Wang, Dingding Wang, Yuyan Jin, Shuangshuang Li, Yong Zhao, Junmin Liao, Yanan Zhang, Kaiyun Hua, Yichao Gu, Jingbin Du, Yongwei Chen, Dayan Sun, Guojun Zhang, Jinshi Huang

Get full text

Healthcare workers' knowledge and attitudes regarding artificial intelligence adoption in healthcare: A cross-sectional study by Moustaq Karim Khan Rony, Khadiza Akter, Latifun Nesa, Md Tawhidul Islam, Fateha Tuj Johra, Fazila Akter, Muhammad Join Uddin, Jeni Begum, Md. Abdun Noor, Sumon Ahmad, Sabren Mukta Tanha, Most. Tahmina Khatun, Shuvashish Das Bala, Mst. Rina Parvin

Get full text

Preparasi Karbon Aktif Sekam Padi dan Serbuk Gergaji Kayu Jati melalui Proses Refluks sebagai Adsorben Larutan Multi Ion Fe(II)/Cu(II) by Cucun Alep Riyanto, Yohanes Ariesto, Fidelis Tertius Aluh Christyawardana, Yehez Kiel Sandy Pradana, Nicho Vernanda Wina Puspita, Iga Permata Sari, Jose D Michael Yonggulemba, Marturia Ester Tumbelaka, Sarawinda Hutagalung, Fuady Hanief, Wawan Rustyawan

“…The results showed that the RHAC and TSAC had O-H, C–H stretching, C≡C, C=C/C=O, C-H, and P=O functional groups with the dominance of C (~53%wt) and O (~48.1%wt) elements. …”
Get full text