The first generic tirzepatide GP30931: physicochemical and biological similarity to the reference drug by I. A. Lugovik, A. V. Babina, S. S. Arutyunyan, D. О. Ermolaeva, V. B. Saparova, T. N. Kobeleva, P. G. Zaikin, A. D. Mikushina, A. S. Bukatin, I. E. Eliseev, B. Ts. Zajchik, Y. S. Keruchenko, I. S. Ohrimenko, E. V. Bocharov, A. Kh. Taldaev, V. A. Lushpa, I. E. Makarenko, R. V. Drai

“…Impurity profiles were analyzed using size-exclusion and reversed-phase HPLC. Functional activity was determined in cellular tests for activation of calcium currents through GLP-1 and GIP receptors with an assessment of the half-maximal effective concentration (EC50); equivalence was confirmed by the two-sided test (TOST, 90 % confidence interval).Results and discussion. …”
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Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity by Shiyang Chen, Shaohua Chen, Qingyang Kang, Fangzheng Lin, Fangzheng Lin, Fangzheng Lin, Shuting Zheng, Xixi Liu, Chunhong Guo, Chunhong Guo, Yongjin Li, Yongjin Li, Dingkun Lin, Dingkun Lin, Xiaolong Zeng

“…However, further research is needed to explore the clinical functional effects of knee laxity.…”
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Strain elastography for detecting advanced Fontan-associated liver disease: a retrospective study by Koji Imoto, Takeshi Goya, Yuki Azuma, Tomonobu Hioki, Tomomi Aoyagi, Hazumu Nagata, Akiko Nishizaki, Takamori Kakino, Ayako Ishikita, Kenichiro Yamamura, Ichiro Sakamoto, Masatake Tanaka, Kohtaro Abe, Yoshihiro Ogawa

“…Abstract Background The Fontan procedure has improved the prognosis of patients with a functional single ventricle; however, late complications—including Fontan-associated liver disease (FALD)—have surfaced as clinical concerns. …”
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Microbial diversity and composition in the gut microbiome of patients during systemic inflammatory response syndrome: can we use gut bacteria as potential biomarkers to characteriz... by Rafaela Ramalho Guerra, Rafaela Ramalho Guerra, Rafaela Ramalho Guerra, Patricia da Silva Fernandes, Otávio von Ameln Lovison, Otávio von Ameln Lovison, Giovanna de Ross Forni, Giovanna de Ross Forni, Gabriel Silva de Oliveira, Luana Cristina Viana, Dariane Castro Pereira, William Latosinski Matos, William Latosinski Matos, Miriane Melo Silveira Moretti, Fabiana Zempulski Volpato, Luciana Giordani, Luciana Giordani, Patricia Orlandi Barth, Patricia Orlandi Barth, Tarsila Vieceli, Diego Rodrigues Falci, Márcio Manozzo Boniatti, Afonso Luís Barth, Afonso Luís Barth, Afonso Luís Barth, Andreza Francisco Martins, Andreza Francisco Martins, Andreza Francisco Martins, Andreza Francisco Martins

“…In sepsis, the loss of taxa involved in key metabolic functions, as short-chain fatty acid production, reflects dysbiosis and may contribute to worse outcomes. …”
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Elevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum by Digital Chromoendoscopy and Magnification Colonoscopy in Patients with Spondyloarthrit... by Juliette De Avila, Cristian Flórez-Sarmiento, Viviana Parra-Izquierdo, Wilson Bautista-Molano, Magaly Chamorro-Melo, Adriana Beltrán-Ostos, Diego Alejandro Jaimes, Valery Khoury, Lorena Chila-Moreno, Alejandro Ramos-Casallas, Juan Manuel Bello-Gualtero, Jaiber Gutiérrez, Cesar Pacheco-Tena, Philippe Selim Chalem Choueka, Consuelo Romero-Sánchez

“…Objective: This study aimed to establish a correlation between fecal calprotectin levels (FC) and intestinal inflammation in patients with spondyloarthritis without inflammatory bowel disease. …”
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Radiomic features of PET/CT imaging of large B cell lymphoma lesions predicts CAR T cell therapy efficacy by Yoganand Balagurunathan, Zhouping Wei, Jin Qi, Zachary Thompson, Erin Dean, Erin Dean, Hong Lu, Hong Lu, Saran Vardhanabhuti, Salvatore Corallo, Jung W. Choi, Jenny J. Kim, Mike Mattie, Michael Jain, Frederick L. Locke

“…Principal component (PC) analysis was performed to reduce the dimensionality in feature-based functional categories: size (n=38), shape (n=9), and texture (n=259). …”
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HYPERTENSIVE HEART DISEASE IN COVERT ARTERIAL HYPERTENSION OF A LARGE FACTORY EMPLOYEE by A. N. Britov, E. M. Platonova, M. I. Smirnova, V. M. Gorbunov, V. P. Shapovalova, V. M. Ryzhov, S. V. Olishevko, N. A. Eliseeva, T. V. Ryzhova, Ya. N. Koshelyavskaya, A. D. Deev

“…Aim. To study structural and functional changes of myocardium, that are explained as the signs of hypertensive heart disease (HHD), in covert arterial hypertension (CAH) at the workplace of a large factory employee using echocardiography (EchoCG). …”
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Deciphering the tumor ecosystem dynamics undergoing immunochemotherapy therapy across multiple cancer types unveils the immunosuppressive role of S100A4 in fibroblasts by promoting... by Bo Yang, Bo Yang, Ruiji Chen, Ruiji Chen, Mali Zu, Jie Yao, Hong Ren, Hong Ren, Yingxue Lin, Yingxue Lin, Bo Zhang, Tianjiao Ji, Yang Liu

“…Cell-cell communication analysis, Meta-Programs (MPs) via non-negative matrix factorization, and functional enrichment were performed. Immunohistochemistry (IHC) and Western blot validated S100A4 expression and PD-L1 induction in vitro.ResultsWe constructed a single-cell map across cancer types and systematically characterized dynamic changes in tumor cells and diverse microenvironmental cell populations following neoadjuvant therapy, along with thier gene expression and pathway alterations. …”
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Objective measurement methods for the evaluation of socket comfort in patients with transfemoral amputation: a systematic review by Lisa Marie Tiesler, Lisa Marie Tiesler, Melanie Edel, Melanie Edel, Fangxing Wang, Fangxing Wang, Philipp Pieroh, Welf-Guntram Drossel, Welf-Guntram Drossel, Alina Carabello, Alina Carabello, Daniel Zipplies, Christoph-Eckhard Heyde, Stefan Schleifenbaum, Stefan Schleifenbaum, Stefan Schleifenbaum

“…Addressing these challenges will enable the development of reliable tools for assessing socket-limb interface quality, especially prosthetic fit and comfort, and drive progress in improving prosthetic functionality and patient outcomes.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42023405042, identifier, CRD42023405042…”
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Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension by Rebecca L. Harper, Xin Zhou, David P. Marciano, Aiqin Cao, Lingli Wang, Guibin Chen, Mir S. Adil, Wenyu Zhou, Peter Maguire, Shanthi Deivanayagam, Quan Yu, Vignesh Viswanathan, Dan Yang, Marcy Martin, Sarasa Isobe, Shoichiro Otsuki, Jordan Burgess, Audrey Inglis, Devon Kelley, Patricia A. del Rosario, Andrew Hsi, Francois Haddad, Roham T. Zamanian, Manfred Boehm, Michael P. Snyder, Marlene Rabinovitch

“…These changes are linked to intrinsic functional abnormalities that contribute to the monocytes’ increased propensity to invade the pulmonary circulation.…”
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Unveiling Palmitoyl Thymidine Derivatives as Antimicrobial/Antiviral Inhibitors: Synthesis, Molecular Docking, Dynamic Simulations, ADMET, and Assessment of Protein–Ligand Interact... by Sarkar M. A. Kawsar, Samiah Hamad Al-mijalli, Gassoumi Bouzid, Emad M. Abdallah, Noimul H. Siddiquee, Mohammed A. Hosen, Mabrouk Horchani, Houcine Ghalla, Hichem B. Jannet, Yuki Fujii, Yasuhiro Ozeki

“…The antifungal activity was evaluated based on mycelial growth inhibition. Density functional theory (DFT) calculations were employed to investigate the electronic and structural properties, including the global reactivity, frontier molecular orbital (FMO), natural bond orbital (NBO), and molecular electrostatic potential (MEP). …”
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Reactive oxygen species responsive double-locked liposome collaborative photodynamic therapy for reducing electrical conduction recurrence after radiofrequency catheter ablation by Ying Zhuge, Gonghao Li, Mingyue Sun, Jiajia Zhang, Jiafeng Zou, Feng Gao, Fang Wang

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Integrating CT radiomics and clinical data with machine learning to predict fibrosis progression in coalworker pneumoconiosis by Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Xiaobing Li, Qian Li, Qian Li, Qian Li, Qian Li, Xinyi Xie, Wei Wang, Xuemei Li, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Tingqiang Zhang, Li Zhang, Li Zhang, Li Zhang, Li Zhang, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Yongsheng Liu, Li Wang, Li Wang, Li Wang, Li Wang, Wutao Xie

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T-2 toxin-induced spatial learning and memory impairment in mice via the gut-brain axis and the intervening effects of resveratrol by Sheng-Quan Su, Gui-Yuan Xiong, Chun-Yan Yao, Xiao-Ling Liu, Yin-Yin Xia, Jin-Yun Long, Xiu-Kuan Li, Liang-Mei Wang, Long Yi, Wu-Wei Xu, Wu-Qiang Lu, Qian-Qian Li, Ting Hu, Hao Liu, Ke-Xue Wang, Peng Luo, Tong-Jian Cai

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Revealing the potential therapeutic mechanism of Lonicerae Japonicae Flos in Alzheimer’s disease: a computational biology approach by Qin Xiang, Qin Xiang, Qin Xiang, Qin Xiang, Yu Xiang, Yao Liu, Yongjun Chen, Qi He, Taolin Chen, Liang Tang, Liang Tang, Binsheng He, Jianming Li

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INVESTIGATION OF THE OPTICAL BONE DENSITY OF THE ALVEOLAR PROCESSES IN THE AREA OF DEFECTS OF DENTITION by S.A. German

“…To obtain a stable functioning implantation system, it is necessary to clearly define the amount of bone tissue to reveal the bone quality of the alveolar division of the jaw. …”
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SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: Time-to-Event Analysis of a Hospital-Based Cohort Study of Pregnant Women in Rio de Janeiro, Brazil by Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhaes de Oliveira, Larissa Rangel Mageste, Karin Nielsen-Saines, Patricia Brasil

“…Hospital-based studies of pregnant women and their neonates provide valuable insights within the field of perinatal health research. The aim of this study was to evaluate the effect of SARS-CoV-2 infection on maternal and perinatal outcomes among hospitalized pregnant women in Rio de Janeiro during the COVID-19 pandemic. …”
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Investigation of the efficiency of different reprocessing methods on disposable laryngeal masks contaminated with HBV DNA by Gökahmetoğlu, Günhan, Renders, Duygu Perçin, Gökahmetoğlu, Selma, Biçer, Cihangir, Aksu, Recep, Çevik, Şerife

“…After the decontamination procedures, the functioning control of the LM was controlled.Results: The HBV DNA level in the simulated saliva samples was 100,000 IU/mL (lg 5). …”
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A novel stemness-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity of clear cell renal cell carcinoma by Jia Liu, Lin Yao, Yong Yang, Jinchao Ma, Ruijian You, Ziyi Yu, Peng Du

“…Enrichment analysis was performed to explore the potential functions of SRmRNAs. Multiple machine learning algorithms were employed to construct a prognostic signature. …”
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Spectrum of mutations and their phenotypic manifestations in children and adults with long QT syndrome by N. N. Chakova, S. M. Komissarova, E. A. Zasim, T. V. Dolmatovich, E. S. Rebeko, S. S. Niyazova, E. V. Zaklyazminskaya, L. I. Plashchinskaya, M. V. Dudko

“…Aim. To determine the spectrum of mutations in the genes responsible for the long QT syndrome (LQTS) and study their phenotypic manifestations in patients with LQTS in different age groups.Materials and methods. …”
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