CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1 by Valerio Taverniti, Laura Meiss-Heydmann, Cloé Gadenne, Hannah Vanrusselt, Dieudonné Buh Kum, Fabio Giannone, Patrick Pessaux, Catherine Schuster, Thomas F. Baumert, Yannick Debing, Eloi R. Verrier

“…Background & Aims: Chronic HBV infection is the leading cause of liver disease and of hepatocellular carcinoma. …”
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Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina by Sol A. Cataldo, Andrea Micciulli, Laura Margulis, Melina Cibeyra, Sabrina Defeo, Silvina G. Horovitz, Analía Martino, Raul Melano, Milagros Mena, Francisco Parisi, Diego Santoro, Florencia Sarmiento, Martin A. Belzunce

“…Neuroimaging studies have identified structural alterations in brain regions linked to cognitive functions. However, most of these studies have focused on patients within months of their initial infection. …”
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Device‐therapy in chronic heart failure: Cardiac contractility modulation versus cardiac resynchronization therapy by Goekhan Yuecel, Leo Gaasch, Abbass Kodeih, Svetlana Hetjens, Babak Yazdani, Stefan Pfleger, Daniel Duerschmied, William T. Abraham, Ibrahim Akin, Juergen Kuschyk

“…Conclusions Chronic heart failure patients could experience comparable 12‐month improvements in functional status and ventricular reverse remodelling, with appropriately implanted CCMs and CRT‐Ds. …”
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Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…Screening tests for cognitive impairment (MMSE) and functional status (ADL, IADL) were performed. BPSD were evaluated with the Neuropsychiatric Inventory (NPI). …”
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Prognostic and immunological implications of cathepsin Z overexpression in prostate cancer by Junyue Tao, Junyue Tao, Junyue Tao, Yiding Chen, Yiding Chen, Yiding Chen, Xiaokang Bian, Xiaokang Bian, Xiaokang Bian, Tingting Cai, Tingting Cai, Tingting Cai, Changhao Song, Changhao Song, Changhao Song, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang, Zongyao Hao, Zongyao Hao, Zongyao Hao, Jialing Meng, Jialing Meng, Jialing Meng, Qintao Ge, Qintao Ge, Jun Zhou, Jun Zhou, Jun Zhou

“…Nevertheless, its specific role in prostate cancer (PCa) remains insufficiently understood. This study aimed to investigate the expression profile of CTSZ in PCa and evaluate its prognostic significance.MethodsThree independent cohorts, including TCGA-PRAD, MSKCC, and a real-world AHMU-PC cohort were enrolled in this study. …”
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Baseline assessments of research capacity, capability and culture in UK local authorities: reflections from evaluators embedded in Health Determinants Research Collaborations by Lauren Bell, Rachel Chapman, Charlotte Ashton, Claire Batey, Jack Brazier, Elizabeth Castle, Arundeep Chaggar, Julian Elston, Faye Esat, Hannah Goldwyn Simpkins, Leonard Ho, Cath Quinn, Jessica Sheringham, Demelza Smeeth, Irene Stylianou, Simon Twite, James Woodall, Beck Taylor

“…Where measured, collaborations were functioning well, with recommendations to enhance communication. …”
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Children’s Headache Through Drawings: A Narrative Review and a Portrait Gallery by Floriana Ferro, Caterina Gaspari, Giulia Manfrè, Federica Cernigliaro, Daniela D’Agnano, Ruben Panzica, Edvige Correnti, Maria Rosita Ruta, Francesca Marchese, Renata Pitino, Mariarita Capizzi, Giuseppe Santangelo, Antonella Versace, Vittorio Sciruicchio, Vincenzo Raieli

“…Headache represents one of the most prevalent and disabling conditions in the pediatric population, with significant repercussions on mental and psychological well-being, as well as on academic achievement and social functioning, ultimately leading to a marked reduction in quality of life. …”
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RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch by Yuefang Liu, Shujun Gao, Zhanghui Li, Lei Yin, Shiyao Ge, Yangjing Zhao, Hui Wang, Bing Wan, Qixiang Shao

“…The results of in vitro studies declared that rhIL-11 promoted differentiation of BM cells into M-MDSCs phenotypically and functionally via activating STAT3 signaling, which was cross-regulated by the mTORC1. …”
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Objectively measured activity behaviours using the ActivPAL accelerometer following robotic and manually performed total knee arthroplasty: a feasibility study from a randomized co... by Nick D. Clement, Bola Ajekigbe, Jayasree Ramaskandhan, Steven Galloway, Karen Smith, David J. Weir, David J. Deehan

“…Aims: To assess whether it was feasible to objectively measure activity behaviour between robotic arm-assisted (raTKA) and manually performed (mTKA) total knee arthroplasty using the ActivPAL accelerometer. …”
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Identification of hub genes and prediction of the ceRNA network in adult sepsis by Kangyi Xue, Kan Wu, Haoxian Luo, Haihua Luo, Zhaoqian Zhong, Fen Li, Lei Li, Li Chen

“…It carries a high risk of morbidity and mortality, and its pathogenesis has yet to be fully elucidated. The main aim of this study was to identify prognostic hub genes for sepsis and to predict a competitive endogenous RNA (ceRNA) network that regulates the hub genes. …”
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Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway by Ang Li, Ang Li, Ang Li, Man Luo, Xiyao Liu, Hongjiao Wu, Hongjiao Wu, Hongjiao Wu, Xiaoguang Liu, Zhi Zhang, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang

“…Functional enrichment analyses were performed to compare molecular features between low and high TLR3 expression groups using gene set variation analysis (GSVA). …”
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New Minimally Invasive Method for Treating Posterior Pelvic Ring Fractures: Biomechanical Validation and Clinical Application of Sacroiliac Joint Locking Plate by Liang Jin, Xiaorui Hao, Zhenzhu Zhang, Qiaoli Zhang, Shuxin Zhang, Fei Zhou, Shuirong Yang, Weijie Zheng, Xiaohui Xiong, Wanchen Gong, Yukun Wang, Xiaojie Chen, Jiexin Huang

“…Clinically, postoperative pain scores decreased to 1.9 ± 0.9 after SJP surgery, which was a significant reduction compared with the preoperative score of 9.1 ± 1.1. Functional prognosis scores improved from 36.1 ± 11.5 preoperatively to 88.4 ± 14.2, showing a marked improvement. …”
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Gut dysbiosis is associated with difficult-to-treat rheumatoid arthritis by Patricia Ruiz-Limón, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Natalia Mena-Vázquez, Natalia Mena-Vázquez, Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Arkaitz Mucientes, Arkaitz Mucientes, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Rocío Redondo-Rodriguez, Rocío Redondo-Rodriguez, Laura Cano-García, Laura Cano-García, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…The gut microbiota was analyzed using 16S rRNA gene sequencing; bioinformatics analysis was performed using QIIME2, and its functionality was inferred through PICRUSt. We recorded data on clinical findings, inflammation, and cytokines. …”
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Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models by Chuanbin Chen, Qingmin Chen, Shenghai Liu, Guoxi Li, Jiawei Zhao, Jingting Huang, Tianyi Ye, Xinting Yang, Zigui Huang, Zhen Wang, Fuhai He, Mingjian Qin, Chenyan Long, Binzhe Tang, Yongqi Huang, Weizhong Tang, Jungang Liu, Xiaoliang Huang

“…Abstract Objective This study aims to explore the differences in composition, abundance, and biological functions of the gut microbiota between colorectal cancer (CRC) patients with peripheral nerve invasion (PNI) and those without peripheral nerve invasion (NPNI). …”
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COMPARATIVE ANALYSIS OF QUALITY OF LIFE AFTER THORACIC ENDOVASCULAR AORTIC REPAIR AND OPTIMAL MEDICAL THERAPY IN PATIENTS WITH UNCOMPLICATED TYPE B AORTIC DISSECTION by Anna Yu. Shkandala, Oleh V. Zelenchuk, Serhii M. Furkalo, Borys M. Todurov, Andrii V. Khokhlov, Nataliia O. Yashchenko, Serhii M. Sudakevych

“…Thoracic endovascular aortic repair (TEVAR) is considered a minimally invasive intervention, but the impact of this intervention on quality of life has not yet been fully evaluated. Aim. To analyze patient quality of life and compare outcomes between patients treated with TEVAR in combination with optimal medical therapy versus optimal medical therapy alone. …”
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Insights into De Quervain’s Tenosynovitis as an Unintended Consequence of Problematic Smartphone Usage: A Cross-sectional Observational Study by Aswin Sugumaran, Dilip Kumar Naidu, Madhan Raju, Sabari Vaasan Lakshmikanthan, S Karthikeyan, Kevin Dhas, Vamsi Krishna, Praveen Raja

“…Pain intensity was assessed using the VAS, while functional disability was measured using the quick DASH and PRWE questionnaires. …”
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Protocol of the pilot study to test and evaluate the iCARE tool: a machine learning-based e-platform tool to make health prognoses and support decision-making for the care of older... by John P Hirdes, Hao Luo, Davide L Vetrano, Graziano Onder, Jonathan Chen, Violetta Kijowska, Katarzyna Szczerbińska, Johanna Edgren, Amaia Calderón-Larrañaga, George Heckman, Ron MC Herings, Johanna de Almeida Mello, Anja Declercq, Mark Hoogendoorn, Caitlin McArthur, Mari Aaltonen, Yi Chai, Karlijn J Joling, Micaela Jantzi, Rosa Liperoti, Melissa Northwood, Ilona Barańska, Agata Stodolska, Hein P J van Hout, Margaret Saari, Luca Mariotti, Emiel O Hoogendijk, Luke Turcotte, Louk Smalbil, Elizabeth P Howard, John N Morris, Daniela Fialová, Eline CM Kooijmans, Riikka-Leena Leskelä, Jokke Häsä, Georg Ruppe, Carmen Angioletti, Olena Antonenko, Shireen Aziz, Gustavo Betini, Jovana Brkič, Roberto Da Cas, Daniel Da Cunha Leme, Lu Dai, Cecilia Damiano, Natalia Drapała, Bonaventure Egbujie, Collin JC Exmann, Harriet Finne-Soveri, Charlene France, Tiziana Grisetti, Ira Haavisto, Sophie Hogeveen, Paweł Jagielski, Laurian Jongejan, Jet E Klunder, Ingrid Kummer, Anna Lukačišinová, Matti Mäkelä, Krista Mathias, Amanda Mofina, Reem Mulla, Mikko Nuutinen, Sandra Ochwat, Paula Pennanen, Jitka Pokladníková, Bregtje Proost, Ahmer Raza, Emanuele Rocco Villani, Jindra Reissigová, Erez Schachter, Katarzyna Sekulak, Chi-Ling Joanna Sinn, Andrea Vokálová, Adrianna Ziuziakowska, Mari Lahelma, Anna-Maria Hiltunen, Anna Salminen, Mor Alon, Collin Exmann, Wiebe Boorsma, Johanna de Almeida Mello, Hein PJ van Hout

“…Introduction The provision of optimal care for older adults with complex chronic conditions (CCCs) poses significant challenges due to the interplay of multiple medical, pharmacological, functional and psychosocial factors. To address these challenges, the I-CARE4OLD project, funded by the EU-Horizon 2020 programme, developed an advanced clinical decision support tool—the iCARE tool—leveraging large longitudinal data from millions of home care and nursing home recipients across eight countries. …”
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Multi-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling by Walid Mottawea, Basit Yousuf, Salma Sultan, Tamer Ahmed, JuDong Yeo, Nico Hüttmann, Yingxi Li, Nour Elhouda Bouhlel, Hebatoallah Hassan, Xu Zhang, Zoran Minic, Riadh Hammami

“…Furthermore, MEVs were able to traverse the intestinal barriers and reach distal organs, including the brain, thereby potentially influencing brain functionality and contributing to mental and behavior.…”
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Identification of novel molecular subtypes and construction of a prognostic signature via multi-omics analysis and machine learning in lung adenocarcinoma by Ke Ma, Jie Xu, Jie Xu, Congyue Wang, Congyue Wang, Xu Cao, Xu Cao, Wenjie Yu, Jingjing Xi, Xuan Zhang, Jiamin Zhan, Yang Liu, Aoyang Yu, Aoyang Yu, Shuhan Liu, Yanhua Liu, Yanhua Liu, Chong Chen, Chong Chen, Xiaoli Mai, Xiaoli Mai

“…We further confirmed the effects of ANLN knockdown and the expression of a domain-negative anillin protein (dnANLN) via western blotting, cell proliferation assays, flow cytometry, and transwell migration assays in vitro.ResultsOur analysis revealed that the novel molecular subtypes exhibited differences in prognoses, biological functions, and immune infiltration profiles in LUAD. …”
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Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway by Kyonghwan Choe, Muhammad Ali, Roy Lardenoije, Renzo J.M. Riemens, Ehsan Pishva, Horst Bickel, Siegfried Weyerer, Per Hoffmann, Michael Pentzek, Steffi Riedel-Heller, Birgitt Wiese, Martin Scherer, Michael Wagner, Diego Mastroeni, Paul D. Coleman, Alfredo Ramirez, Inez H.G.B. Ramakers, Frans R.J. Verhey, Bart P.F. Rutten, Gunter Kenis, Daniel L.A. van den Hove

“…However, no studies to date have systematically explored changes in the TRP pathway at both transcriptional and epigenetic levels. This study aimed to investigate transcriptomic, DNA methylomic (5mC) and hydroxymethylomic (5hmC) changes within genes involved in the TRP and nicotinamide adenine dinucleotide (NAD) pathways in AD, using three independent cohorts. …”
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