Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung ade... by Yi-Feng Ren, Qiong Ma, Xiao Zeng, Chun-Xia Huang, Jia-Li Ren, Fang Li, Jia-Jing Tong, Jia-Wei He, Yang Zhong, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Heng-Zhou Lai, Ping Xiao, Xiang Zhuang, Peng Wu, Li-Ting You, Wei Shi, Xi Fu, Chuan Zheng, Feng-Ming You

“…Conclusions Our findings offer a potential therapeutic strategy to maintain a dynamic balance within the TME and improve the immunotherapy efficacy by modulating the relative proportions and functional states of CXCL9 + TAMs and TREM2 + TAMs.…”
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Synergistic induction of PGE2 by oral pathogens and TNF promotes gingival fibroblast-driven stromal-immune cross-talk in periodontitis by Elwira Nieboga, Aureliusz Schuster, Dominika M. Drapala, Mariia Melnykova, Aleksander Gut, Weronika Lipska, Mateusz Kwitniewski, Marcin Migaczewski, Marta Czesnikiewicz-Guzik, Tomasz Kaczmarzyk, Jan Potempa, Aleksander M. Grabiec

“…In periodontitis, oral pathogens penetrate the epithelial barrier and aggravate ongoing gingival inflammation by promoting the production of inflammatory mediators, such as prostaglandin E2 (PGE2). This study aimed to investigate the functional consequences of the interplay between oral pathogens and a pro-inflammatory environment in the activation of the PGE2 pathway in primary human gingival fibroblasts (GFs). …”
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TLS and immune cell profiling: immunomodulatory effects of immunochemotherapy on tumor microenvironment in resectable stage III NSCLC by Chaopin Yang, Chaopin Yang, Jinqi You, Jinqi You, Yizhi Wang, Yizhi Wang, Si Chen, Si Chen, Yan Tang, Yan Tang, Hao Chen, Hao Chen, Haoran Zhong, Ruyue Song, Hao Long, Hao Long, Tong Xiang, Ze-Rui Zhao, Ze-Rui Zhao, Jianchuan Xia, Jianchuan Xia

“…Post-immunochemotherapy, CD8+ T cells increase, but CD38+CD8+ T cells show reduced functionality. These findings highlight the complex immune dynamics and their implications for NSCLC treatment.…”
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Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways by Liya Liu, Liya Liu, Liya Liu, Ying Cheng, Ying Cheng, Guosheng Lin, Guosheng Lin, Huifang Zheng, Huifang Zheng, Xinran Zhang, Xinran Zhang, Peilin Zhao, Peilin Zhao, Meixuan Guo, Meixuan Guo, Qihong Liu, Qihong Liu, Wenyi Fang, Wenyi Fang, Wenrong Wang, Wenrong Wang, Anjum Jafri, Aling Shen, Aling Shen, Xiao Ke, Xiao Ke, Youqin Chen

“…Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used for functional exploration. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to validate RNA-seq analysis results. …”
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A Prospective Pilot Study for Prognosis of Cardiac Resynchronization Therapy Super-Response Using Electrical and Mechanical Dyssynchrony Assessment in Patients with Heart Failure a... by Tariel Atabekov, Andrey Smorgon, Anna Mishkina, Sergey Krivolapov, Svetlana Sazonova, Mikhail Khlynin, Roman Batalov, Sergey Popov

“…The study prospectively included patients with HF, classified as New York Heart Association (NYHA) functional class (FC) II–III in sinus rhythm with Strauss LBBB criteria and reduced left ventricular ejection fraction (LVEF). …”
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Association between transcranial direct current stimulation and disability and quality of life in individuals with Parkinsonism: cross-sectional study by Ravi Shankar Reddy, Ravi Shankar Reddy, Jaya Shanker Tedla, Jaya Shanker Tedla, Irshad Ahmad, Venkata Nagaraj Kakaraparthi, Snehil Dixit, Kumar Gular, Paul Silvian Samuel, Suhail Mansour Aljehani, Feras Ahmed Alarabi

“…Transcranial direct current stimulation (tDCS) has shown promise in improving motor and cognitive functions when combined with physical therapy. This study aimed to explore the association between tDCS exposure and disability levels, as well as its impact on self-reported QoL in individuals with Parkinsonism undergoing physical therapy.MethodsThis cross-sectional study enrolled 51 participants diagnosed with Parkinsonism from a tertiary care hospital’s neurology outpatient clinic. …”
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Galectin-3 in the blood serum of patients with bone tumors by N. E. Kushlinskii, O. V. Kovaleva, P. L. Prishchep, N. N. Zybina, V. Jurisic, A. A. Alferov, Yu. B. Kuzmin, I. O. Goryacheva, I. N. Kuznetsov, I. V. Bulytcheva, S. R. Varfolomeeva, E. A. Sushentsov, E. S. Gershtein, D. V. Rogozhin, O. O. Yanushevich, I. S. Stilidi

“…Due to diversity of cancer, the functional role of galectin-3 is rather controversial; however, for many types of neoplasms, the marker acts as a tumor growth promoter.Aim. …”
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Distinct 5-methylcytosine profiles of LncRNA in breast cancer brain metastasis by Song Wang, Jianran Guo, Xinmiao Xian, Min Li, Anqi Zhang, Yujiao Liu, Yifei Zhang, Shen Chen, Guohao Gu, Xuehua Zhang, Dong Yan, Meng An, Li Pan, Bo Fu

“…Although 5-methylcytosine (m5C) has been identified as an important regulatory modifier, its distribution in BCBM is not well understood. This study aimed to investigate the distribution of m5C in BCBM. …”
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Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell r... by Victoria Jennings, Alan Melcher, Fiona Errington-Mais, Victoria Roulstone, Kevin J Harrington, Galabina Bozhanova, Shane Foo, Martin McLaughlin, Malin Pedersen, John Bell, Pablo Nenclares, Joan Kyula, Lizzie Appleton, Edward Armstrong, Masahiro Ono, Matthew K L Chiu, Anton Patrikeev, Nitya Mohan, Julia Hoebart, Emmanuel Patin

“…Finally, combination MG1 and programmed cell death protein-1 antibody (αPD-1) therapy was investigated in advanced 4434 tumors.Results MG1 effectively supported priming of functional cytotoxic T cells (CTLs) against tumor-associated antigens as well as virus-derived peptides, as assessed using peptide recall and T2 killing assays, respectively. …”
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Optical and electron microscopy imaging of model circulating tumour cells by Марина Оленчук, Григорій Монастирський, Олена Гнатюк, А. Бойзен, Ч. Чжан, Галина Солянік, Денис Колесник, Сергій Карахім, Галина Довбешко

“…Objectives: This study aimed to visualize Lewis lung carcinoma (LLC) cells cultured under de-adhesive conditions using various microscopy techniques for their characterization and to examine the cancer cells' structure and functionality. …”
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Hepatocellular carcinoma hosts cholinergic neural cells and tumoral hepatocytes harboring targetable muscarinic receptors by Charlotte A. Hernandez, Claire Verzeroli, Armando Andres Roca Suarez, Abud-José Farca-Luna, Laurie Tonon, Roger Esteban-Fabró, Roser Pinyol, Marie-Laure Plissonnier, Ievgeniia Chicherova, Anaëlle Dubois, Pascale Bellaud, Marine Seffals, Bruno Turlin, Alain Fautrel, Gabriel Ichim, Michel Rivoire, Guillaume Passot, Zuzana Macek-Jilkova, Thomas Decaens, Alain Viari, Barbara Testoni, Sandra Rebouissou, Josep M. Llovet, Fabien Zoulim, Romain Parent

“…Background & Aims: Owing to unexplained interpatient variation and treatment failure in hepatocellular carcinoma (HCC), novel therapeutic approaches remain an urgent clinical need. …”
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White Matter Magnetic Resonance Diffusion Measures in Multiple Sclerosis with Overactive Bladder by Xixi Yang, Martina D. Liechti, Baris Kanber, Carole H. Sudre, Gloria Castellazzi, Jiaying Zhang, Marios C. Yiannakas, Gwen Gonzales, Ferran Prados, Ahmed T. Toosy, Claudia A. M. Gandini Wheeler-Kingshott, Jalesh N. Panicker

“…Conclusions: This study identified that lesions affecting different WM tracts in MS can result in OAB symptoms and demonstrated the role of the WM in the neural control of LUT functions. By using DTI, the association between OAB symptom severity and WM changes were identified, adding knowledge to the current LUT working model. …”
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Neoadjuvant sintilimab and chemotherapy followed by transoral surgery for HPV-positive resectable oropharyngeal cancer: a single-arm, two-centre, phase 2 trialResearch in context by Shida Yan, Xing Zhang, Fengjiao Li, Ankui Yang, Hui Li, Wanming Hu, Qiaohong Lin, Xiyuan Li, Mingyuan Du, Jingtao Chen, Guodong Man, Jianwei Zhang, Xuemei Fang, Li Ning, Shiting Zhang, Lili Han, Yanmei Ma, Jun Wang, Shuwei Chen, Ming Song

“…Interpretation: Neoadjuvant immunochemotherapy and sequential transoral surgery, including TORS, appears to be a feasible strategy that yields favorable oncologic and functional outcomes for patients with resectable HPV+OPSCC. …”
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Neurobiomechanical Characterization of Feedforward Phase of Gait Initiation in Chronic Stroke: A Linear and Non-Linear Approach by Marta Freitas, Pedro Fonseca, Leonel Alves, Liliana Pinho, Sandra Silva, Vânia Figueira, José Félix, Francisco Pinho, João Paulo Vilas-Boas, Augusta Silva

“…Postural control arises from the complex interplay of stability, adaptability, and dynamic adjustments, which are disrupted post-stroke, emphasizing the importance of examining these mechanisms during functional tasks. This study aimed to analyze the complexity and variability of postural control in post-stroke individuals during the feedforward phase of gait initiation. …”
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Molecular analysis of three DNA mismatch repair protein variants in Chinese families with suspected Lynch syndrome by Juyi Li, Haichun Ni, Peng Cheng, Yujia Peng, Lei Liu, Xiangyang Wang, Wei Cheng, Hengfei Li, Xiufang Wang, Hongfeng Zhang, Jifa Hu, Aiping Deng, Wei Cai, Wei Cai

“…PurposeThis study aimed to examine pathogenic variations in three families clinically diagnosed with suspected Lynch syndrome (LS).MethodsThree probands clinically diagnosed suspected LS were subjected to immunohistochemical analysis of DNA mismatch repair (MMR) protein. …”
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The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis by Xiaoxi Fan, Zhenfeng Cheng, Ruiyin Shao, Keke Ye, Xudong Chen, Xueli Cai, Shanshan Dai, Zhixuan Tang, Si Shi, Wenyuan Zheng, Weijian Huang, Jibo Han, Bozhi Ye

“…Mechanistically, GI‐Y2 directly interacts with the Arg10 residue of GSDMD and reduces the membrane binding of GSDMD‐N. Functionally, we revealed that GI‐Y2 inhibits the formation of atherosclerotic plaques by targeting GSDMD. …”
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Supporting African communities to increase resilience and mental health of kids with developmental disabilities and their caregivers using the World Health Organization’s Caregiver... by Melissa Washington-Nortey, Vibian Angwenyi, Mekdes Demissie, Eva Mwangome, Tigist Eshetu, Hanna Negussie, Kimberley Goldsmith, Andrew Healey, Merga Feyasa, Girmay Medhin, Amanuel Belay, Temesgen Azmeraw, Medhanit Getachew, Rahel Birhane, Carophine Nasambu, Tsegereda Haile Kifle, Angela Kairu, Beatrice Mkubwa, Fikirte Girma, Rehana Abdurahman, Ruth Tsigebrhan, Liya Tesfaye, Leonard Mbonani, Nadine Seward, Tony Charman, Andrew Pickles, Erica Salomone, Chiara Servili, Edwine Barasa, Charles R. Newton, Charlotte Hanlon, Amina Abubakar, Rosa A. Hoekstra

“…Participants in the control arm will receive the intervention after completing follow-up assessments. We aim to recruit 544 child-caregiver dyads, evenly distributed across the two arms and countries. …”
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Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of a... by Jia-Xin Li, Jia-Xin Li, Shi-Yu Tan, Li-Qi Li, Yu-Hong Zheng, Lin Zhao, Hui-Rong Zhu, Hai-Lang He, Yan-Yu Zhang, Run-Ze Li, Tian-Yu Bao, Yi-Zhong Zhang, Xiao-Man Yang, Hao Zhang, Hui-Hui Chen, Bo-Wen Wu, Xin Lin, Xiao-Sheng Lin, Xiao-Sheng Lin, Yin Cheng Lin, Xin-Bing Sui, Ying Xie, Xian-Mei Zhou, Pei-Yu Yan

“…In terms of immune regulation, tricin increased the numbers of CD8+ T lymphocytes and the levels of the functional cytokines TNFα, IFNγ, and Granzyme B. Tricin also increased the numbers of B lymphocytes and disrupted the PD-1/PD-L1 pathway. …”
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Gut microbiota, immune cell, colorectal cancer association mediators: a Mendelian randomization study by Yuegang Li, Meng Zhuang, Shiwen Mei, Gang Hu, Jinzhu Zhang, Wenlong Qiu, Xishan Wang, Jianqiang Tang

“…Therefore, in this study, we aimed to unravel the interactions between the gut microbiota, immune cells, and colorectal cancer. …”
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Right-restricting measures implemented by Public Health Surveillance services during the COVID-19 pandemic: a systematic review protocol by Tiago Correia, Marcelo Dayrell Vivas, Larissa Bragagnolo, Igor Antônio Lourenço da Silva, Fernando Tureck, Reinaldo Santos, Samara Kielmann, Debora do Carmo, Camila Avarca, Franciele da Silva, Mariana Paes, Luis Fernando Nogueira Tofani, Arthur Chioro

“…Considering the various measures that may have been adopted, the following categories of analysis will be used: (i) Public Health Surveillance as a field, (ii) the various specific areas of Health Surveillance, (iii) law enforcement, (iv) right-restricting measures and consent, (v) interactions between right-restricting measures and routine Public Health Surveillance functions, (vi) differences between countries and (vii) Health Surveillance lessons learnt from the COVID-19 pandemic. …”
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