Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review by Yaoguang Guo, Sihan Hu, Sihan Hu, Shiman Luo, Lang Tu, Yao Tang, Fang Zeng, Fang Zeng, Fang Zeng

“…Improvements were also noted in neurological deficit scores [MD = −0.59, 95%CI (−0.92, −0.27), p < 0.05] and modified Neurological Severity Scores (mNSS) [MD = -5.68, 95%CI (−7.41, −3.95), p < 0.05], highlighting functional recovery. While the analysis showed no significant effect on caspase-3 densities [MD = −0.39, 95%CI (−0.79, 0.02), p > 0.05], a notable increase in Bcl-2 densities suggested an anti-apoptotic mechanism [MD = −0.73, 95%CI (−1.68, 0.21), p > 0.05]. …”
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Effects of Dexmedetomidine as an Adjuvant in Preoperative Ultrasound-Guided Internal Branch of Superior Laryngeal Nerve Block on Postoperative Sore Throat and Hemodynamics in Patie... by Chen Z, Zhang L, Lu G, Zhang Y, Zhao D, Zhao S, Zhang H, Jin Y, Zhao X, Jin Y

“…In this first randomized controlled trial to date, we aimed to investigate the effects of US-guided iSLNB, with or without perineural dexmedetomidine, on the incidence and severity of POST following DLTs.Methods: A total of 159 patients were randomly assigned to three groups: control, bilateral US-guided iSLNB (2 mL 0.20% ropivacaine + 1 mL saline on each side), and bilateral US-guided iSLNB combined with perineural dexmedetomidine group (2 mL 0.20% ropivacaine + 1 mL 0.5 μg·kg− 1 dexmedetomidine on each side). …”
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The Main Directions of Improving the Methodology for the Application of Advanced Information and Communication Technologies in the Statistical Activities of the Republic of Uzbekis... by I. E. Zhukovskaya

“…The scientific article presents the main directions of improving the methodology for the application of advanced information and communication technologies in the statistical activities of the Republic of Uzbekistan in the context of the formation of a digital economy, in particular with the aim of achieving maximum reliability and efficiency in collecting and processing statistical data, as well as the openness and quality of information when receiving consolidated indicators for various user requests, an analysis of the functionality of information systems and technologies used in the statistical field was carried out, a methodology for the provision of modern state interactive services to end users was developed on the basis of the implementation of a digital analytical platform, mechanisms for improving the quality of state statistical reporting based on the use of web service technologies were proposed, scientific approaches to the integration of statistical activities with other ministries and departments in the in the context of the digitalization of the economy are expressed.The author concludes that the digital economy changes all spheres of life in modern society, contributes to the formation of a new management paradigm, methods and means based on the strengthening of the role of science as a leading productive force generating more and more new knowledge, leading to new trends in the improvement of managerial processes, solving problems of information compatibility of various software and technological complexes, which, in turn, contributes to the processes of globalization and improvement of the social sphere of the national economy, which are manifested not only in the growth of production indicators, but also in the improvement of the quality of life of the country's population.The article shows that a comprehensive analysis, statistical data on the development of innovative processes in the economy allow us to note that innovations based on the use of the advanced ICT contribute to improving the technical and technological basis of production processes, optimizing management processes, and developing human capital. …”
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A systematic review and meta-analysis of acupuncture's impact on hemiplegic gait recovery after stroke by Zheng Sun, Haitian Sun, Kuang Yu, Zilong Zhu, Yiren Lin, Ke Sun, Jianbin Zhang

“…Objective: This systematic review aims to evaluate the efficacy and safety of acupuncture in alleviating gait disturbances in post-stroke hemiplegia, focusing on various gait parameters. …”
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Multi-omic biomarkers associated with multiple sclerosis: from Mendelian randomization to drug prediction by Wei Yang, chenglin Liu, Zhenhua Li, Miao Cui

“…This approach allowed us to explore the functions of key genes and the mechanisms of co-morbidity associated with the disease. …”
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Development of an <i>in vitro</i> model to study the role of disulfide bonds in the largest extracellular domain of the sodium-dependent phosphate transporter NaPi2b in OVCAR-8 ova... by V. S. Skripova, D. A. Firsova, A. V. Kilunov, L. F. Bulatova, M. A. Poputsky, R. G. Kiyamova

“…Isolation and purification of transmembrane proteins, including NaPi2b, for structural and functional studies is difficult, therefore it is necessary to develop an in vitro model to study the formation of disulfide bonds in the ECD region of the NaPi2b transporter and their role in ensuring the availability of the cryptic MX35 epitope and transporter activity in living cells.Aim. …”
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Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers by Wentong Li, Yiyi Zhang, Chuanhong Li, Mingyang Jiang, Dong Wang, Luomeng Chao, Luomeng Chao, Luomeng Chao, Yuxia Yang

“…Immune microenvironment analysis was conducted using CIBERSORT, while single-cell transcriptomics was analyzed within the Seurat framework.ResultsA total of 897 DEGs were identified, with functional enrichment analysis revealing significant involvement in T cell activation (p=2.84×10-3), neuroactive ligand-receptor interaction (p=6.01×10-4), and osteoclast differentiation (NES=2.83). …”
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ANATOMICAL AND GENETIC PREDISPOSITION FOR CARIES IN PERMANENT DENTITION. REVIEW by K.A. Udaltsova, E.O. Pisarenko

“…They identified 23 modules comprising of 53 genes. Functional analyses of these 53 genes revealed three major clusters: cytokine network relevant genes, matrix metalloproteinases (MMPs) family, and transforming growth factor-beta (TGF-β) family, all of which have been previously implicated to play important roles in tooth development and carious lesions. …”
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The effect of chloroquine on cervical cancer via the PI3K/AKT/MDM2 pathway by Dandan Xu, Chenyang Hou, Jianliang Chang, Shuaibo Yang, Zhicong Yang, Zelong Yuan, Jingqi Li, Shuqin Liu, Yaqun Liu, Yingpeng Su, Peng Gao, Xiaojuan Liu

“…Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to predict the underlying biological functions and mechanisms involved in the anti-colorectal cancer effects of CQ. …”
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Pemanfaatan Fuzzy Logic dan Hill Climbing untuk Optimasi Pengelolaan Tempat Pengolahan Sampah Reduce-Reuse-Recycle (TPS 3R) pada Dinas Lingkungan Hidup (DLH) DKI Jakarta by Ramadana Arbi, Meinarini Catur Utami, Qurrotul Aini

“…The 3R TPS is still functionally not maximum way to be used as inadequate facilities such as quality degradation on organic counter, and there is no mechanical separation place and its room. …”
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AI in Home Care—Evaluation of Large Language Models for Future Training of Informal Caregivers: Observational Comparative Case Study by Clara Pérez-Esteve, Mercedes Guilabert, Valerie Matarredona, Einav Srulovici, Susanna Tella, Reinhard Strametz, José Joaquín Mira

“… BackgroundThe aging population presents an accomplishment for society but also poses significant challenges for governments, health care systems, and caregivers. Elevated rates of functional limitations among older adults, primarily caused by chronic conditions, necessitate adequate and safe care, including in-home settings. …”
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Exploring Autophagy-Related Gene Expression in Hepatocellular Carcinoma via TCGA, GEPIA2, and HPA Databases: Implications for Prognosis by Gu X, Chen Y, Hu X, Li Y, Zhu R, Li H, Yuan Z, Wang Y

“…RT-qPCR analysis further confirmed significant upregulation of mRNA expression levels of randomly selected BAG3, EIF2AK2, KIF5B, and RAB24 in HCC cell lines, consistent with the bioinformatics analysis findings.Conclusion: This study showed that the 41 obtained ARGs, such as ATG16L1, ATG4B, BAG3, KIF5B, MAPK1, RAB24, and SOGA1, these findings suggest that ARGs may serve as prognostic biomarkers for HCC, warranting further validation in clinical cohorts and functional studies.Keywords: hepatocellular carcinoma, bioinformatics, autophagy, prognostic markers, TCGA…”
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Efficient in vitro regeneration and genetic fidelity analysis of shea tree (Vitellaria paradoxa Gaertn) using ISSR markers by Affi Jean Paul Attikora, Souleymane Silué, Mongomaké Kone, Napkalo Silue, Yves Kwibuka, Saraka Didier Martial Yao, Caroline De Clerck, Sok Lay Him, Nafan Diarrassouba, Taofic Alabi, Ludivine Lassois

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Antimutagenic and anticoagulant therapeutic effects of Ag/Ag2O nanoparticles from Olea europaea leaf extract: mitigating metribuzin-induced hepato-and nephrotoxicity by Manel Azzi, Manel Azzi, Ibtissam Laib, Abderrhmane Bouafia, Abderrhmane Bouafia, Ifriqya Medila, Ifriqya Medila, Ali Tliba, Salah Eddine Laouini, Salah Eddine Laouini, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum

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Can Endothelin-1 Help Address the Diagnostic and Prognostic Challenges in Multimorbid Acute Heart Failure Patients? by Bianca-Ana Dmour, Minerva Codruta Badescu, Cristina Tuchiluș, Corina Maria Cianga, Daniela Constantinescu, Nicoleta Dima, Ștefania Teodora Duca, Awad Dmour, Alexandru Dan Costache, Maria-Ruxandra Cepoi, Adrian Crișan, Sabina Andreea Leancă, Cătălin Loghin, Ionela-Lăcrămioara Șerban, Irina Iuliana Costache-Enache

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Multidisciplinary, multicenter consensus for the care of patients affected with Sturge–Weber syndrome by May El Hachem, Andrea Diociaiuti, Angela Galeotti, Francesca Grussu, Elena Gusson, Alessandro Ferretti, Carlo Efisio Marras, Davide Vecchio, Simona Cappelletti, Mariasavina Severino, Carlo Gandolfo, Simone Reali, Rosa Longo, Carmen D’Amore, Lodovica Gariazzo, Federica Marraffa, Marta Luisa Ciofi Degli Atti, Maria Margherita Mancardi, and the Sturge-Weber Syndrome Multidisciplinary Group

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Evaluating Factors Affecting Interior Architectural Space Quality to Enhance Spatial Resilience and Human Productivity: An Application of Maslow’s Hierarchy of Needs by Moharam Ghahremani Drvish, Farhang Mozafar, Ceyed bagher Hoseini, Fateme Mahdizadeye seraj

“…<p style="text-align: left;"><strong>Abstract</strong></p> <p style="text-align: left;">The aim of the current research is to investigate the relationship between the architectural quality of the interior organizational space and spatial resilience and its impact on employee productivity. …”
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Deciphering key nano-bio interface descriptors to predict nanoparticle-induced lung fibrosis by Jiayu Cao, Yuhui Yang, Xi Liu, Yang Huang, Qianqian Xie, Aliaksei Kadushkin, Mikhail Nedelko, Di Wu, Noel J. Aquilina, Xuehua Li, Xiaoming Cai, Ruibin Li

“…Results The nano-bio interactions induced diverse changes in the 4 characteristics of MeONPs and had variable effects on the 14 cellular functions, which were quantitatively evaluated in chemico and in vitro. …”
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Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells by Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu

“…We investigated the biological functions of JAG2 in immune evasion using in vitro co‐culture systems, flow cytometry, tumor‐bearing mouse models, and PDTOs. …”
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Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages by Antonio Sica, Marta Di Martile, Valentina Farini, Francesca Maria Consonni, Daniela Trisciuoglio, Marianna Desideri, Elisabetta Valentini, Simona D'Aguanno, Maria Grazia Tupone, Simonetta Buglioni, Cristiana Ercolani, Enzo Gallo, Bruno Amadio, Irene Terrenato, Maria Laura Foddai, Donatella Del Bufalo

“…Our previous studies have demonstrated that bcl-2 affects melanoma progression and regulates the tumor microenvironment. The aim of this study was to evaluate whether bcl-2 expression in melanoma cells could influence tumor-promoting functions of tumor-associated macrophages, a major constituent of the tumor microenvironment that affects anticancer immunity favoring tumor progression.Methods THP-1 monocytic cells, monocyte-derived macrophages and melanoma cells expressing different levels of bcl-2 protein were used. …”
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