Gender differences in clinical and prescribing characteristics of biologic and targeted synthetic drugs in naïve patients with rheumatoid arthritis: Data from BIOBADASER III regist... by Paloma Vela-Casasempere, Lucía Otero-Varela, Silvia Gómez Sabater, Rocío Caño Alameda, Cristina Campos Fernández, Jerusalén Calvo-Gutiérrez, Yanira Pérez-Vera, Sara Manrique Arija, Sagrario Bustabad, Javier Manero Ruiz, María Dolores Ruiz Montesino, Lucía Ruíz Gutiérrez, Antonio Mera Varela, Manuel José Moreno Ramos, Fernando Sánchez-Alonso, Isabel Castrejón

“…Disease characteristics differ between genders in terms of comorbidities, extra-articular manifestations, quality of life, disease activity and functional scores. There is a possibility that RA may be managed differently depending on gender: under-treated due to professional bias when prescribing advanced therapies, or over-treated due to overestimation of disease activity. …”
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Neutrophil Extracellular Trap Formation Suppressed by Ro 106-9920 Enhances Diabetic Wound Healing by Blocking NLRP3 Inflammasome Activation by Hua Li, Lihua Xu, Jingying Chen, Huijuan Huang, Feiteng Liang, Shuxiao Li, Fuda Huang, Junyu Guo

“…However, potential therapeutic agents remain underexplored. Our present study aimed to explore the effects of Ro 106-9920, a specific nuclear factor kappa B (NF-κB) inhibitor, on diabetic wound healing and to elucidate the underlying mechanisms. …”
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Structural and morphological features of microcrystalline сellulose from industrial hemp hurd by L. O. Barybina, T. V. Tkachenko, O. O. Haidai, V. S. Sokol, B. V. Korinenko, D. S. Kamenskyh, Y. V. Sheludko, V. A. Povazhny, V. A. Bohatyrenko, S. V. Ruban, V. O. Yevdokymenko

“…The FTIR spectrum of the sample shows typical functional groups corresponding to MCC. There are two distinct mass loss steps in thermograms (TGA). …”
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Efficacy and safety of combination therapy with lenvatinib and pembrolizumab in elderly patients with advanced endometrial cancer by M. V. Volkonskiy, A. A. Akopyan, T. A. Zhelezkova, R. S. Zhikhorev, E. P. Krasnorutskaya, N. R. Abidova, T. A. Makarkina, M. O. Skorina, V. M. Filippova, I. A. Luev, Yu. V. Vasilyeva, G. D. Malina, L. P. Veshkina, B. L. Nersesyan

“…Additional studies are required to evaluate the efficacy and safety of the combination therapy of lenvatinib and pembrolizumab in patients with a more severe functional status.…”
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A consortium of seven commensal bacteria promotes gut microbiota recovery and strengthens ecological barrier against vancomycin-resistant enterococci by Alan Jan, Perrine Bayle, Nacer Mohellibi, Clara Lemoine, Frédéric Pepke, Fabienne Béguet-Crespel, Isabelle Jouanin, Marie Tremblay-Franco, Béatrice Laroche, Pascale Serror, Lionel Rigottier-Gois

“…Uncovering the actors and mechanisms reducing the intestinal colonisation by VRE is essential to control infection. We aimed to identify commensal bacteria that interfere with VRE gut colonisation or act as an ecological barrier. …”
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Diagnostic Effectiveness of Transforming Growth Factor Beta 1 in Assessing the Risk of Developing Graft Dysfunction in Liver Recipient Children by R. M. Kurabekova, O. M. Tsiroulnikova, I. E. Pashkova, A. G. Olefirenko, O. E. Gichkun, L. V. Makarova, R. A. Monakhov, P. O. Shevchenko

“…Transforming growth factor beta 1 (TGF-β1) is a pleiotropic cytokine with a profibrogenic and immunosuppressive effect that can have a definite effect on the liver transplant functioning.Aim. To determine the diagnostic efficacy of TGF-β1 in blood when assessing the risk of developing graft dysfunction in liver recipient children. …”
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Features of hydration of the composite system based on methyl silica AM-1 and dispersed Amanita muscaria mushrooms by T. V. Krupska, A. M. Datsiuk, M. I. Terebinska, S. O. Tellis, N. V. Vitiuk, I. V. Laguta, Qiliang Wei, Jinju Zheng, Weiyou Yang, V. V. Turov

“…At the same time, it performs several functions at once: mechanically separates particles of biomaterial from each other, which prevents them from caking and becoming infected with fungal spores; transforms interfacial water into a clustered state (radius of water clusters 1–50 nm), which is characterized by excess free energy, and due to air microbubbles, does not allow rapid desorption of biologically active substances into the aqueous environment. …”
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Predictors of long-term outcome of patients with schizophrenia in Africa: systematic review and meta-analysis by Mulualem Kelebie, Setegn Fentahun, Gebresilassie Tadesse, Girum Nakie, Girmaw medfu, Birtukan Fasil, Gidey Rtbey, Mulu Muche, Melese Gobezie, Abenet Alazar, Mamaru Melkam, Getasew Kibralew

“…Longitudinal studies have provided profound insights into the trajectory of schizophrenia, elucidating its progression, clinical phenotype, functional impairments, treatment responsiveness, and key prognostic determinants. …”
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Chronic Tic Disorders in Youth: Clinical Phenotypes and Response to Pharmacological Treatment with Aripiprazole by Francesca Falcone, Stefano Berloffa, Gianluca Sesso, Antonio Narzisi, Elena Valente, Valentina Viglione, Gabriele Masi, Annarita Milone, Pamela Fantozzi

“…Conclusions: Comorbid neurodevelopmental disorders, such as ADHD or ASD, result in worse emotional and behavioral functioning in patients with tic disorders. ADHD–ASD interaction may be linked to more internalizing symptoms and autistic behaviors. …”
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RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer by Songliu Hu, Ning Zhan, Jian Li, Liqun Wang, Yiyan Liu, Ke Jin, Yixuan Wang, Juxuan Zhang, Yiyang Chen, Yang Bai, Yichong Wang, Lishuang Qi, Shilong Liu

“…The long non-coding RNA CBR3-AS1 mediates radioresistance in NSCLC, yet the underlying molecular mechanism is unclear. This study aims to explore whether and how N6-methyladenosine (m6A) modification regulates CBR3-AS1 expression and promotes NSCLC radioresistance. …”
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Optimizing health-related quality of life assessments for stroke survivors: a validation study of psychometric properties for the Vietnamese version of stroke impact scale 3.0 by Thao Thi Phuong Nguyen, Thao Thi Phuong Nguyen, Hai Bui Hoang, Hai Bui Hoang, Huyen Thi Thanh Vu, Huyen Thi Thanh Vu, Seung Won Lee, Seung Won Lee, Seung Won Lee, Seung Won Lee

“…BackgroundEnsuring lifelong health among aging populations necessitates comprehensive assessments of functional recovery and quality of life, particularly for vulnerable groups such as older adult stroke survivors. …”
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Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study by Huijing Shao, Chang Xu, Haoran Wang, Nan Lu, Hang Gu, Caihong Zhang, Lirong Li, Qianqian Sun, Rui Guan, Beibei Xuan

“…Cross-trait pleiotropic analysis identified shared loci and genes, while functional annotation and tissue-specific analysis revealed relevant biological pathways and tissues. …”
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Three-Leaf-Clover Thyroid and Minimally Invasive Trans-Cervical Synchronous Thyroidectomy and Ectopic Mediastinal Thyroid Tissue Removal: Does the Age of the Patient Count amid a M... by Claudiu Nistor, Mihai-Lucian Ciobica, Oana-Claudia Sima, Anca-Pati Cucu, Mihai Costachescu, Adrian Ciuche, Lucian-George Eftimie, Dana Terzea, Mara Carsote

“…This innovative surgical procedure offers the advantage of avoiding a sternotomy incision which has clear functional and aesthetic implications, while the video-assisted approach allows optimal visualization of the mediastinal anatomy and safe vascular sealing under visual control, without the risk of a major hemorrhage.…”
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A machine learning-based risk prediction model for diabetic oral ulceration by Wang Xiaoling, Wang BingQian, Zhu Zhenqi, Li Wen, Gu Shuyan, Chen Hanbei, Xin Feng, Chenglong Yang, Jutang li, Guoyao Tang, Jie Wei

“…The top five features contributing to the model’s predictions were the current number of oral ulcers, diminished oral functional capacity, number of decayed or missing teeth, possession of health insurance (commercial), and Low-Density Lipoprotein (LDL-C), accounting for 57.32% of the total importance. …”
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Genome mining identifies a diversity of natural product biosynthetic capacity in human respiratory Corynebacterium strains by Ashley L. Cunningham, Ilya Y. Zhbannikov, Rachel Myers, Tommy H. Tran, Wei Gao, Katherine P. Lemon, Jhoanna N. Aquino, Jillian H. Hurst, Joon Won Yoon, Patrick C. Seed, Matthew S. Kelly

“…This genomic study investigated the diversity and capacity for natural product synthesis within these species, as indicated by their biosynthetic gene clusters (BGCs). We aimed to map and quantify the BGC diversity in a contemporary collection of Corynebacterium strains, representative of their prevalence in the respiratory microbiota, and to elucidate intra- and interspecies variation in BGC content. …”
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Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension by M. A. Manukyan, A. Yu. Falkovskaya, V. F. Mordovin, I. V. Zyubanova, V. A. Lichikaki, E. I. Solonskaya, A. A. Vtorushina, S. A. Khunkhinova, I. A. Skomkina, V. V. Rudenko, T. Yu. Rebrova, E. F. Muslimova, S. A. Afanasyev

“…Aim. To assess the functional state of the sympathetic nervous system according to β-adrenergic reactivity of erythrocyte membranes (EM) in patients with refractory (rfHTN) and resistant hypertension (rHTN) in relation to target organ damage.Material and methods. …”
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Ultrasound-guided coracobrachialis plane musculocutaneous nerve block for perioperative analgesia in pediatric Gartland type III supracondylar humerus fracture: a prospective pilot... by Tianyi Gao, Zhuorun Song, Shunyi Lu, Nan Song, Wentao Yu, Huilin Yang, Jun Zou, Qian Wang, Jun Ge

“…Hospital stays remained comparable [1.60 ± 0.66 (days) vs. 1.56 ± 0.67 (days), p = 0.98].ConclusionCora-MNB proves to be a safe and effective approach for anesthesia in pediatric SHF cases, offering superior analgesic outcomes, reduced NSAIDs usage, improved shoulder functionality, and high satisfaction levels without extending the hospital stay. …”
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Efficacy and tolerability of pharmacological interventions for schizophrenia non-responsive to prior treatment: a systematic review and network meta-analysisResearch in context by Myrto Samara, Andreas S. Lappas, Elisavet Pinioti, Eleni Glarou, Iwo Fober, Christos Christogiannis, Spyridon Siafis, Nikos Christodoulou, Bartosz Helfer, Dimitris Mavridis, Stefan Leucht

“…This systematic review and network meta-analysis (NMA) aimed to compare the efficacy and tolerability of all available pharmacotherapy options. …”
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Isolation andfunctional characterization of HO-hMSCs as NK-supportive cells derived from hematopoietic organoids by TANG Shili, LIN Bixuan, HUANG Enxia, HE Ying, XUE Yuan, ZHANG Yonggang

“…However, existing xenogeneic feeder cells or tumor-derived genetically modified feeder cells pose risks of residual immunogenicity and malignant transformation, limiting clinical use. This study aims to develop a humanized mesenchymal-like stromal cell (hematopoietic organoid-derived human mesenchymal stromal cells, HO-hMSCs) derived from iPSC-based hematopoietic organoids, and elucidate its mechanisms of NK-supportive activity to enable a safe, efficient platform for clinical-grade NK cell production. …”
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<i>PD-L1</i> and <i>PD-L2</i> gene expression in human glioblastoma cells resistant to chemo- and radiotherapy by A. A. Pinevich, N. L. Vartanyan, L. N. Kiseleva, I. I. Bode, I. Yu. Krutetskaya, A. V. Kartashev, V. E. Makarov, T. E. Poneza, I. V. Smirnov, M. P. Samoilovich

“…Membrane molecules PD-L1 and PD-L2, ligands of T lymphocytes PD1 receptor, perform immunoregulatory functions. Their binding to the receptor leads to inhibition of proliferation, reduction of cytokine production, cytotoxic response, and apoptosis of T lymphocytes. …”
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