Research on NS1 Proteins of Group 2 Tembusu Virus Inhibiting the Production of Duck Type Ⅰ IFN by Yunzhen HUANG, Junqin ZHANG, Linlin LI, Jiawen DONG, Yong XIANG, Ming LIAO, Minhua SUN

“…Further studies revealed that the TMUV-JM NS1 inhibited the expression of type Ⅰ IFN via targeting TBK1, and the NS1 255-352 aa was the functional region of the inhibitory effect. It was found that TMUV-JM NS1 did not interact with TBK1 directly, but reduced the phosphorylation level of TBK1 indirectly, thereby suppressed the expression of type Ⅰ IFN.…”
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Patient Reported Outcome Measures in cancer care: a hybrid effectiveness-Implementation trial to optimise Symptom control and health service Experience (PROMISE)–protocol for a ran... by David Wyld, Afaf Girgis, Elizabeth Miller, Penelope M Webb, Gunter Hartel, Karen Martin, Rahul Ladwa, Melissa Eastgate, Suzanne O’Brien, Sabe Sabesan, Raymond J Chan, Amy Brown, Robert Mason, Mark B Pinkham, Bena Brown, Louisa G Collins, Fiona Crawford Williams, Kerrie Doupain, Vicki Fennelly, Peter McGuire, Rebecca Packer, Jasotha Sanmugarajah, Georgia Slapp, Doreen Tapsall, Jeanie White, Laurelie R Wishart

“…The primary outcomes are unplanned hospital presentations and physical/functional well-being at 6 months. We hypothesise that, compared with usual care, patients randomised to use an ePROM tool will have fewer unplanned hospital presentations, report better health-related quality of life and greater satisfaction with their care and that the ePROM tool will be cost-effective. …”
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Arabic validation and cross-cultural adaptation of climate anxiety scale by Shymaa Mamdouh Mohamed Abdu, Assem Gebreal, Safar Abadi Alsaleem, Moath S. Aljohani, Suzan Abdel-Rahman, Mohamed Fakhry Hussein, Nada Ibrahim, Iffat Elbarazi, Samah Hussein, Omar Shamma, Ahmed Elsayed said Noureldin, Ramy Mohamed Ghazy

“…Model reliability coefficient omega (omega/omega S) for general factor, functional domain, and cognitive domain were 0.94, 0.92, and 0.89, respectively, suggesting a satisfactory fit threshold. …”
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Matrix stiffness-dependent PD-L2 deficiency improves SMYD3/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC by Shunxi Wang, Xiaoxue Yuan, Zetao Yang, Xuan Zhang, Zhiling Xu, Li Yang, Xian Yang, Wei Zhou, Wanqian Liu

“…Objectives: This research aimed to explore how extracellular matrix stiffness affects ferroptosis and its treatment efficacy in HCC. …”
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Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmaco... by Jiacheng Shen, Jiacheng Shen, Jiacheng Shen, Yuxuan Fang, Yuxuan Fang, Nan Xu, Nan Xu, Hongyi Chen, Hongyi Chen, Miao Zhu, Miao Zhu, Dan Li, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Yanqing Liu, Haibo Wang, Haibo Wang, Guoqing Li, Guoqing Li

“…TPL can enter RhoA, Rock1, and Rock2 target protein binding domains with stable binding activities, and may cause conformational changes of Rock1 related to molecular functions.ConclusionTPL inhibits RA-FLS in motility by regulating actin cytoskeleton remodeling through action on the RhoA/Rho-associated kinase signaling pathway.…”
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Fecal microbiota is more stable during degradation and more diverse for ex situ cheetahs in Namibia compared to the USA by Morgan A. Maly, Morgan A. Maly, Morgan A. Maly, Morgan A. Maly, Reade B. Roberts, Mia M. Keady, Anne Schmidt-Küntzel, Meagan Maxwell, Laurie Marker, Matthew Breen, Carly R. Muletz-Wolz, Adrienne E. Crosier

“…We also found few differences in predictive functions of the fecal microbiota between the populations, where only one disease-related pathway was higher in the USA samples. …”
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Psychometric property of the Japanese version of self-efficacy for managing chronic disease scale in individuals with chronic diseases by Megumi Hazumi, Mayumi Kataoka, Ayako Nakashita, Kentaro Usuda, Michi Miyake, Chiaki Kamikawa, Daisuke Nishi, Naoaki Kuroda

“…Background: Although accurately assessing self-efficacy for self-management is crucial in chronic illness care, important, there is a scarcity of validated psychometric properties in Japan. This study aimed to validate a Japanese version of the Self-Efficacy for Managing Chronic Disease (SEMCD-J) scale. …”
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Citizen Science to Raise Antimicrobial Resistance Awareness in the Community: The MicroMundo Project in Spain and Portugal by Jessica Gil‐Serna, Patricia Antunes, Susana Campoy, Ángeles Cid, Antonio Cobo‐Molinos, Paulo Durão, Carmen Fajardo, Belén Fouz, Ana R. Freitas, Filipa Grosso, Piet W. J. deGroot, Trinidad deMiguel, Bruno González Zorn, Belén Hinojosa, Maria João Leão, Montserrat Llagostera, Rosa deLlanos, Ainhoa Lucía, Sergi Maicas, Irma Marín, Magdalena Martínez‐Cañamero, Carla Miranda, José Manuel Molina‐Guijarro, Diego A. Moreno, María de losLlanos Palop, María José Pérez‐Álvarez, Pedro M. Pereira, María Teresa Pérez‐Gracia, Sandra Quinteira, Carmen Rioboo, Beatriz Robredo, José María Rodríguez‐Calleja, Rafael R. de laHaba, Sandra Sánchez, Manuel Sánchez Angulo, Cristina Sánchez‐Porro, Félix J. Sangari, Beatriz Santos, Eduarda Silveira, Begonya Vicedo, Víctor J. Cid, all members of MicroMundo Teams in Spain and Portugal

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Diagnosis and treatment of synthetic mid-urethral sling complications by Helen E. O’Connell, Christopher K. Harding, Gaurav Khatri, Phyllis Glanc, Eric Bautrant, Sarah Love-Jones, Karen Ward, Henry H. Yao, Ventia Hoe, Charlotte Korte, Nicolle Germano, Sanjeevan Kalavampara, Sherif Mourad, Hashim Hashim

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Comparative Assessment of Lower Urinary Tract Infections in Hospitalized Adults from Western Romania: A Retrospective Cohort with Microbiological Analysis by Adela Benea, Mirela Turaiche, Ovidiu Rosca, Elena Hogea, Madalina-Ianca Suba, Norberth-Istvan Varga, Uday Shree Akkala Shetty, Daniel Porav-Hodade, Ileana Enatescu, Adrian Cosmin Ilie, Ciprian Rachieru, Daniel-Florin Lighezan, Oana Silvana Sarau, Cristian Andrei Sarau

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Dietary pattern and nutritional assessment in a cohort of mothers identified by neonatal screening for cobalamin deficiency in offspring: an Italian single center experience by Martina Tosi, Martina Tosi, Veronica Maria Tagi, Veronica Maria Tagi, Alice Colombo, Alessandra Cecchini, Marianna Zobele, Chiara Montanari, Chiara Montanari, Simona Ferraro, Alessandra Bosetti, Eleonora Bonaventura, Eleonora Bonaventura, Fabio Bruschi, Fabio Bruschi, Diego De Zan, Giulia Fiore, Giulia Fiore, Cristina Cereda, Cristina Cereda, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti, Elvira Verduci, Elvira Verduci

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Penerapan Importance Performance Analysis (IPA) pada Evaluasi Keberlanjutan Penggunaan e-filing untuk Pelaporan Pajak Perorangan by Imelda Saluza, Dewi Sartika

“…As a result, further research is needed, namely IPA, which aims to identify the variables that need to be changed in the long-term usage of e-filing. …”
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Rehabilitation effect on psycho-emotional well-being in women with surgically treated vulvar cancer: a randomised controlled trial by Blinov V. Dmitry, Antonina G. Solopova, Elena V. Gameeva, Nazim G. Badalov, Vsevolod N. Galkin, Mikhail A. Eremushkin, Alexandra M. Stepanova, Alexander E. Ivanov, Olga S. Gridasova

“…Aim. to evaluate the effectiveness of rehabilitation programs in relation to the psycho-emotional sphere during 36 months following surgical treatment of early-stage VC. …”
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Clinical, electromyographic, and biophysical characterization of the rare Nav1.4 channel mutation SCN4A L1436P by François Charles Wang, François Charles Wang, Olivier Bouquiaux, Olivier Bouquiaux, Isabelle Lievens, Bernard Lakaye, Laura Vandries, Margaux Poleur, Samira Abdou Ide, Nurcan Inci, Vincent Seutin

“…IntroductionOur aims were to provide an integrated clinical and biophysical characterization of the rare variant NM_000334.4(SCN4A) c.4307T>C (p.Leu1436Pro; L1436P), affecting the skeletal muscle sodium channel Nav1.4, and to compare its functional consequences with both wild-type (WT) channels and the well-established pathogenic variant p.Arg1448His (R1448H).MethodsWe retrospectively analyzed nine unrelated patients carrying the heterozygous L1436P variant. …”
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Phenol solutions recovery as water pollutants with eugenol cross-linked diallyl phthalate using supported liquid membrane by A.A. Kiswandono, N. Ningsih, A.V. Sindiani, Rinawati ., H.I. Qudus

“…This study seeks to mitigate phenol waste by employing an 8 percent copolymer of eugenol and diallyl phthalate through the supported liquid membrane method. Furthermore, it aims to assess the effectiveness of phenol transport and separation using this membrane technique. …”
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Altered Expression of Cell Cycle Regulators and Factors Released by Aged Cells in Skeletal Muscle of Patients with Bone Fragility: A Pilot Study on the Potential Role of SIRT1 in M... by Angela Falvino, Roberto Bonanni, Beatrice Gasperini, Ida Cariati, Angela Chiavoghilefu, Amarildo Smakaj, Virginia Veronica Visconti, Annalisa Botta, Riccardo Iundusi, Elena Gasbarra, Virginia Tancredi, Umberto Tarantino

“…<b>Background/Objectives</b>: Cellular aging represents a crucial element in the progression of musculoskeletal diseases, contributing to muscle atrophy, functional decline, and alterations in bone turnover, which promote fragility fractures. …”
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Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration by Yichen Hu, Qinghua Zou, Yanbo Sun, Weiming Li, Zhaochuan Yin, Yuanpei Zhao, Kaiwen Shi, Hongyuan Liu, Jiahui Wang

“…Subsequently, the biological functions of the differentially expressed genes (DEGs) were explored through DEGs analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and Gene Ontology (GO) analysis. …”
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Advances in insect chromosome evolution(昆虫染色体进化研究进展) by 陆月琪(LU Yueqi), 陈曦(CHEN Xi), 李飞(LI Fei)

“…In the section on structural variations, we highlighted types of rearrangements such as inversions and translocations, specifically discussing their roles in restricting recombination or linking adaptive gene complexes, and summarized recent advances in understanding their contributions to speciation and functional innovation. This review aims to emphasize the potential value of chromosome evolution mechanisms in agricultural pest management and the development of beneficial insect resources, offering valuable reference and technical inspiration for both basic research on insect chromosome biology and applied research on pest control strategies. . …”
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Exosomal miR-6126 as a novel therapeutic target for overcoming resistance of anti-cancer effect in hepatocellular carcinoma by Hyemin Hwang, Jimin Kim, Tae-Hun Kim, Yeonju Han, Dayoung Choi, Sua Cho, Seunghwan Kim, Sanghee Park, Taehyun Park, Filippo Piccinini, Won Jong Rhee, Jae-Chul Pyun, Misu Lee

“…Among these, miR-6126 was significantly downregulated in Huh7RS cells compared to Huh7S cells. Functional studies using 2-dimensional (D) and 3D cell culture systems revealed that miR-6126 overexpression reduced sorafenib resistance in Huh7RS cells, while its inhibition increased resistance in Huh7 cells. miR-6126 downregulated key proteins involved in cancer stem cell maintenance, such as CD44 and HK2. …”
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Efficiency of Therapeutic Use and Mechanisms of Therapeutic Effect of "Essentuki" and "Narzan" Mineral Waters in Various Diseases: a Review by Tatiana V. Konchugova, Tatiana V. Apkhanova, Tatyana V. Marfina, Detelina B. Kulchitskaya, Larisa A. Marchenkova, Valeriia A. Vasileva, Maxim Yu. Yakovlev, Olga M. Musaeva

“…Drinking of natural medicinal mineral waters is the basis of spa treatment for patients with digestive diseases and metabolic disorders. AIM. To search for and analyze the results of scientific studies devoted to studying the mechanisms of action of drinking mineral waters of the Essentuki group, as well as the effectiveness of using “Essentuki-4”, “Essentuki-17”, “Narzan” mineral waters in various gastroenterological diseases, metabolic diseases and urinary system. …”
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