Analysis of treatment patterns and persistence on branded and generic medications in major depressive disorder using retrospective claims data by Solem CT, Shelbaya A, Wan Y, Deshpande CG, Alvir J, Pappadopulos E

“…., Global Health Outcomes, New York, NY, 3Epidemiology Department of Mailman’s School of Public Health, Columbia University Mailman School of Public Health, New York, NY, USA Background: In major depressive disorder (MDD), treatment persistence is critical to optimize symptom remission, functional recovery, and health care costs. Desvenlafaxine tends to have fewer drug interactions and better tolerability than other MDD drugs; however, its use has not been assessed in the real world.Objective: The aim of the present study is to compare medication persistence and concomitant MDD drug use with branded desvenlafaxine (Pristiq®) compared with antidepressant drug groups classified as 1) branded selective serotonin reuptake inhibitors (SSRIs; ie, escitalopram [Lexapro™]) and selective serotonin–norepinephrine reuptake inhibitors (SNRIs; ie, venlafaxine [Effexor®], duloxetine [Cymbalta®]) and 2) generic SSRIs/SNRIs (ie, escitalopram, citalopram, venlafaxine, fluvoxamine, fluoxetine, sertraline, paroxetine, and duloxetine).Patients and methods: MDD patients (ICD-9-CM codes 296.2, 296.3), with ≥2 prescription fills for study drugs and 12-month preindex continuous enrollment from the MarketScan Commercial Claims and Encounters Database (2009–2013), were included. …”
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GAN-enhanced deep learning for improved Alzheimer's disease classification and longitudinal brain change analysis by Purushottam Pandey, Surbhi Bhatia Khan, Surbhi Bhatia Khan, Surbhi Bhatia Khan, Jyoti Pruthi, Eid Albalawi, Ali Algarni, Ahlam Almusharraf

“…Alzheimer's disease (AD) is commonly defined by a progressive decline in cognitive functions and memory. Early detection is crucial to mitigate the devastating impacts of AD, which can significantly impair a person's quality of life. …”
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Copula Approximate Bayesian Computation Using Distribution Random Forests by George Karabatsos

“…Ongoing modern computational advancements continue to make it easier to collect increasingly large and complex datasets, which can often only be realistically analyzed using models defined by intractable likelihood functions. This <i>Stats</i> invited feature article introduces and provides an extensive simulation study of a new approximate Bayesian computation (ABC) framework for estimating the posterior distribution and the maximum likelihood estimate (MLE) of the parameters of models defined by intractable likelihoods, that unifies and extends previous ABC methods proposed separately. …”
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Effectiveness of Virtual Reality Exposure Therapy for Postoperative Rehabilitation Following Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis by Sebastián Eustaquio Martín Pérez, Carmen Pérez Canosa, Iván Pérez Aguiar, Alexandra Marina Medina Rodríguez, Isidro Miguel Martín Pérez

“…Virtual reality exposure therapy has emerged as a potentially beneficial adjunct to traditional rehabilitation, offering immersive, interactive environments that may aid in pain relief, balance, proprioception, and functional recovery. This meta-analysis aimed to evaluate the efficacy of VRET compared to conventional rehabilitation for postoperative cruciate ligament reconstruction, focusing on outcomes in pain, balance, proprioception, and the knee flexion range of motion. …”
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Immunophenotype and metabolism are linked in peripheral blood neutrophils from patients with kidney cancer by A. A. Savchenko, A. G. Borisov, I. V. Kudryavtsev, I. I. Gvozdev, A. V. Moshev

“…The aim of the present study was to analyze the relationships between expression of activation and adhesion receptors on peripheral blood neutrophils, and intracellular activity of some neutrophil enzymes in patients with kidney cancer (KC). …”
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Serotonin blood level study, anxiety-depressive states indicators and patients life quality after laparoscopic treatment of gastroesophageal reflux disease by Ye. I. Haidarzhi

“…The dynamics of serotonin levels correspond to the dynamics of the patients number with signs of anxiety and depression before and after surgery in the main group, as well as the improvement in the psychological state of patients after surgery compared to preoperative data on the scales of the “psychological component” of SF-36 health questionnaire: Vitality (VT), Social Functioning (SF), Role-Emotional (RE), Mental Health (MH). …”
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Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation by Yazhe Ma, Youcheng Wang, Yuanjia Ke, Yuanjia Ke, Yuanjia Ke, Qingyan Zhao, Qingyan Zhao, Qingyan Zhao, Jie Fan, Yang Chen

“…Co-expression and WGCNA analyses identified lactylation- and immune-associated gene modules in AF. Functional enrichment analysis highlighted immune-related pathways such as T cell activation and neutrophil degranulation. …”
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Combining Machine Learning With Real-World Data to Identify Gaps in Clinical Practice Guidelines: Feasibility Study Using the Prospective German Stroke Registry and the National Ac... by Sandrine Müller, Susanne Diekmann, Markus Wenzel, Horst Karl Hahn, Johannes Tuennerhoff, Ulrike Ernemann, Florian Hennersdorf, Max Westphal, Sven Poli

“…Identifying such gaps would augment CPGs but is challenging when using traditional methods. ObjectiveThis study aims to leverage real-world data coupled with machine learning (ML) techniques to systematically identify and quantify gaps in German thrombolysis-in-stroke guidelines. …”
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Environmental Life Cycle Assessment of Healthcare Waste Valorisation Alternatives by Zlaugotne Beate, Zandberga Anda, Gusca Julija, Kalnins Silvija Nora

“…Recycling iHCW has environmental and economic benefits and by valorising iHCW, it would be possible to reduce the amount of landfilled waste and use it as a resource. The aim of the research is to understand the environmental consequences and potential benefits of treated iHCW valorisation scenarios through the ‘gate-to-gate’ (from iHCW generation at medical facilities to end-of-life or recovery) life cycle assessment framework and to compare it with the existing practice – landfilling with functional unit 1 ton of treated iHCW and using ReCiPe 2016 (Midpoint, Hierarchist perspective) method. …”
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Analysis of Students’ Motivation Formation to Study Physics in Modern Conditions by E. L. Kazakova, E. V. Moshkina, O. V. Sergeeva, E. V. Tikhomirova

“…The survey itself and survey data analysis were conducted using the functional features of the e-learning platform Blackboard Learn. …”
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Evaluation of the Relationship between the Pulp and Periapical Lesions with Controlled Type Type 2 Diabetes in Patients Referred to the Dental Clinic: A Radiographic Evaluation by Abbas Mesgarani, Alireza Sedighi, Ozra Akha, Abolfazl Hosseinnataj, Ali Golmohammadi, Maede Salehi

“…Background and Purpose: Diabetes Mellitus is a group of complex, multi-system metabolic disorders that alter many functions of the immune system and are associated with delayed recovery and a reduced immune response. …”
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Reconfigured metabolism brain network in asymptomatic Creutzfeldt-Jakob disease by Yu Kong, Zhongyun Chen, Jing Zhang, Yihao Wang, Min Chu, Haitian Nan, Yue Cui, Deming Jiang, Liyong Wu

“…Background: Investigating brain metabolic networks is crucial for understanding the pathogenesis and functional alterations in Creutzfeldt-Jakob disease (CJD). …”
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Galectin-3: role in the formation of various hemodynamic phenotypes of heart failure and interaction with some neurohumoral factors by A. K. Kurbonov, A. G. Gadaev, N. M. Nurillaeva, M. M. Ernazarov, D. O. Nasretdenova

“…Aim. To study the interaction of serum galectin-3 (Gal-3) with fibrogenic factors, cardiac remodeling, as well as parameters of central hemodynamics in various hemodynamic phenotypes of heart failure (HF).Material and methods. …”
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Association of Mobile Stroke Unit Care and Spending, Utilization, and Death in New York City by Dhruv Khullar, Babak B. Navi, Saad Mir, Matthew E. Fink, Luisa Tinapay, Glenn Asaeda, Rainu Kaushal, Eshani Pareek, Amelia M. Bond

“…Background Transport by mobile stroke units (MSUs), which provide access to computed tomography scanning and intravenous blood pressure medications and thrombolytics, reduces time to treatment and may improve short‐term functional outcomes for patients with acute stroke. …”
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Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia by Zhang X, Li Z, Li R, Wang X, Liu H, Du X, Gao Y, Liu S, Xu Y

“…The expression patterns of this axis in the prefrontal cortex were consistent with those observed in peripheral blood samples from clinical patients.Conclusion: This study identified a specific multi-molecular axis in early-onset schizophrenia, wherein hsa-circ-0000713 functioned as a sponge to reduce the inhibitory effects of hsa-miR-370-3p on ANK3 and MGLL. …”
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Quantitative and structural features of the SMN1 and SMN2 genes in patients with spinal muscular atrophy 5q by A. I. Vlasenko, V. D. Nazarov, S. V. Lapin, A. V. Mazing, E. A. Surkova, T. V. Blinova, T. M. Alekseeva

“…The clinical picture of the disease is heterogeneous and varies depending on the age of onset and the ability to perform motor functions. Several genetic and molecular modifiers have been identified that are thought to influence the severity of SMA. …”
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Sistem Informasi Geografis Pemetaan Data Terpadu Kesejahteraan Sosial di Kabupaten Garut by Dede Kurniadi, Asri Mulyani, Marshal Firmansyah, Nia Abania

“…In addition to this, the results of the BlackBox testing assessment show that the test results have met all the results expected by users on functional requirements, with these results expected to make it easier for the public to find information and check the registered status in DTKS, one of which is through the data search feature based on NIK (Citizenship Identification Number). …”
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Exploring the Ethical Challenges of Conversational AI in Mental Health Care: Scoping Review by Mehrdad Rahsepar Meadi, Tomas Sillekens, Suzanne Metselaar, Anton van Balkom, Justin Bernstein, Neeltje Batelaan

“…We included articles discussing the ethical challenges of CAI functioning in the role of a therapist for individuals with mental health issues. …”
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Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized control... by Chenhui Wang, Mengwei Yan, Yuru Li, Lei Han, Hongqian Wang, Shufeng Jia, Xingchen Liu, Yang Liu, Fan Wu, Baoguo Wang

“…No significant differences were observed between both groups at week 12 in CST, TUG, SF-36 scores, EARS scores, or the incidence of adverse events.ConclusionAlthough clinical significance was not achieved, H2-O2 inhalation alleviated KOA symptoms and enhanced functional activity in elderly patients undergoing the HBE program during the initial 2 weeks. …”
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Negative Correlation Between Fractional Anisotropy on Diffusion Tensor Imaging and Neck Disability Index in Cervical Spondylotic Radiculopathy After Percutaneous Cervical Nucleopla... by Fan N, Li T, Lu X, Ma X, Yang L, Du P, Zang L, Yuan S

“…Similarly, no significant correlations were observed between ADC values and NDI scores pre- and postoperatively.Conclusion: DTI is an imaging method that helps identify the clinical functional status of patients with CSR after PCN. The FA value can be used as a potential predictor of patient prognosis and are strongly negatively correlated with NDI scores. …”
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