Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria by Shan Jiang, Xiling Chen, Lan Ma, Qihao Guo, Lan Luo, Yuehui Wang, Xuan Qu, Jiaojiao Li, Liping An, Wei Huang, Yonghua Wu, Hongyu Zhang, Cuntai Zhang, Yun Fan, Songbai Zheng, Jian Cao, Xiaohong Liu

“…Objectives: In this study, we aimed to explore the impact of nutrition therapy on clinical outcomes for patients classified according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. …”
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Construction and validation of a necroptosis-related lncRNA signature for predicting the prognosis of gastrointestinal cancer patients by Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Chi Feng, Chi Feng, Chi Feng, Chi Feng, Jiehua Wu, Jiehua Wu, Jiehua Wu, Jiehua Wu, Xing Sun, Xing Sun, Xing Sun, Xing Sun, Pengfei Zhu, Pengfei Zhu, Pengfei Zhu, Pengfei Zhu, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng

“…The robustness of the score was further supported by cluster analysis, and the biological functions of the selected lncRNAs were experimentally validated through phenotypic assays.ResultsWe constructed a prognostic signature comprising five necroptosis-related lncRNAs, referred to as the Necro-lnc score. …”
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Shared and specific competing endogenous RNAs network mining in four digestive system tumors by Yulai Tang, Aamir Fahira, Siying Lin, Yiming Shao, Zunnan Huang

“…The ceRNA networks were constructed using the miRcode and ENCORI databases. Functional enrichment analysis and prognostic RNA screening were performed with ConsensusPathDB and univariate Cox regression analysis. …”
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Virtual reality solution to promote adapted physical activity in older adults: outcomes from VR2Care project exploratory study by Vincenzo De Luca, Malak Qbilat, Alessandra Cuomo, Antonio Bianco, Francesca Cesaroni, Chiara Lanari, Ad van Berlo, Telma Mota, Lucia Pannese, Michael Brandstötter, Matthieu Arendse, Vania Mota, Willeke van Staalduinen, Hugo Paredes, Guido Iaccarino, Guido Iaccarino, Maddalena Illario

“…Virtual reality (VR) and serious games (SG) are promising tools to improve physical and cognitive functioning. As part of the VR2Care project activities, four pilot sites explored the capabilities of the VR environment in a remote psychomotor training with SG and a hybrid approach with local groups of older adults performing physical activity.ObjectiveThe present study aimed to explore and measure the impact on older adults’ quality of life and physical activity of using VR2Care solution and the level of usability, satisfaction and acceptance.MethodsThe study is a mixed method study, using qualitative and quantitative surveys to evaluate quality of life and physical activity of older users, and usability, satisfaction and acceptance of the solution. …”
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Cost evaluation of acute ischemic stroke in Latin America: a multicentric studyResearch in context by Luiza Borba Dittrich, Ana Paula Beck da Silva Etges, Joana Siqueira de Souza, Miriam Allein Zago Marcolino, Eva Rocha, Pablo Amaya, Miguel A. Barboza, Andrés Gaye Saavedra, Gonzalo Pérez Hornos, Carlos Abanto, Ana Lucía Castillo-Soto, Natalia Llanos-Leyton, Virginia Pujol Lereis, María Soledad Rodriguez Pérez, Matías Alet, Victor Navia, Solange Lopez, Antonio Arauz, Fabiola Serrano, Bruna Chwal, Leonardo Augusto Carbonera, Raul Gomes Nogueira, Gustavo Saposnik, Carisi Anne Polanczyk, Sheila Cristina Ouriques Martins, Ana Cláudia de Souza

“…The mean cost per patient was I$ 12,203 (SD I$ 15,055), with 49% achieving a favourable functional outcome. Compared to medical treatment alone, MT incurred costs 3.1 times higher, with an incremental cost of I$ 20,418 per patient (p < 0.0001). …”
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Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells by Hao-Cheng Gu, Ling-Fang Wang, Yu-Wei Zhang, You-Qiong Zhuo, Zhou-Hang Zhang, Xing-Yu Wei, Quan-Wen Liu, Ke-Yu Deng, Hong-Bo Xin

“…Morphological, histological, and functional alternations were examined using multiple approaches. …”
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Lnc MSTRG 4701.7 targets miR-1786/RORa to competitively regulate proliferation and apoptosis in chicken follicular granulosa cells by Chang Ma, Chang Ma, Hengsong Wu, Hengsong Wu, Chunchi Yan, Chunchi Yan, Simushi Liswaniso, Simushi Liswaniso, Xue Sun, Xue Sun, Ning Qin, Ning Qin, Rifu Xu, Rifu Xu

“…RORa was also identified as a functional target of miR-1786 in GCs, and as a competitive endogenous RNA, MSTRG.4701.7 regulated RORa expression by sponging miR-1786, thereby playing a regulatory role in GCs. …”
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Contribution of Human Resources for Health competence and skill mix on compliance with healthcare quality standards among Primary Healthcare Facilities in Tanzania: evidence from d... by Syabo M. Mwaisengela, Patricia A. Materu, Chrisogone J. German, Issa I. Mmbaga, Danny J. Temba, Raymond R. Kiwesa, Martin S. Mapunda, Erick S. Kinyenje, Nathanael Sirili, Pankras W. Luoga, Simon P. Ernest, Joseph M. Burra, Joseph C. Hokororo, Godfrey Kacholi, Ntuli A. Kapologwe, Mackfallen G. Anasel, Claud J. Kumalija, Michael Habtu, Grace E. Saguti, Janeth S. Masuma, Talhiya A. Yahya, Eliudi S. Eliakimu

“…Inadequate numbers with poor skill mix compromise health system functioning that negatively affect delivery of quality healthcare services. …”
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Identification and validation of DNA methylation-driven gene OSR1 as a novel tumor suppressor for the diagnosis and prognosis of breast cancer by Jian Xu, Biao Yang, Ling Cheng, Chen Gan, Runze Huang, Anlong Li, Han Ge, Longyu Hu, Meiwen Ling, Xinyi Zheng, Bao Zhao, Mingjun Zhang, Huaidong Cheng, Huaidong Cheng

“…Low OSR1 expression was significantly associated with M stage, HER2 status, PAM50 subtypes, and histological classification, and linked to poorer overall survival outcomes. Functional enrichment implicated OSR1 in pathways related to peptide hormone secretion, peptide transport, metal ion response, and forebrain development. …”
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Prediction role of a novel biomarker ST2 in risk assessment of adverse cardiovascular events in chronic heart failure with preserved and intermediate ejection fraction after myocar... by E. V. Grakova, A. T. Teplyakov, K. V. Kopieva, Sh. D. Akhmedov, O. N. Ogurkova, M. V. Soldatenko

“…Totally, 87 patients included (72 males) with CHD and CHF I-III functional class by NYHA with ejection fraction of the left ventricle (LVEF) 63 [55; 65]%, mean age 63 [57; 69] y.o. …”
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Effects of feeding enriched-olive cake on milk quality, metabolic response, and rumen fermentation and microbial composition in mid-lactating Holstein cows by A. Amato, L. Liotta, C. Cavallo, C. L. Randazzo, A. Pino, S. Bonacci, M. Frisina, A. Procopio, F. Litrenta, V. Floridia, A. R. Di Rosa, M. Oteri, E. Trevisi, V. Lopreiato

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Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…Specifically, the study aims to address three critical questions: Do unmanned ships possess characteristics that preclude their insurability? …”
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Impact of extraction methods on the properties of Carica papaya pseudostem fibers from Cameroon used as reinforcement in biocomposites by Jean Aimé Mono, Sandrine Emvoutou Ndongo, Odette Thérèse Adegono Assiene, Armel Mewoli, Rachelle Appolince Nguefack Assona, Richard Hervé Bitete, Giresse Ulrich Defo Tatchum, Claude Takoumbe

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Assessment of The Potential Interference and Conflict of Artificial Intelligence With Human Rights and Citizenship: Challenges and Solutions by Hossein Khazaei, Mojtaba Hemmati

“…Determining legal responsibilities for the actions and functions of AI systems is complex. Traditional legal systems assign responsibility based on intention and action. …”
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Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism by Qianjiao Zhao, Qianjiao Zhao, Qianjiao Zhao, Yueting Zhong, Yueting Zhong, Yueting Zhong, Zheng Li, Zheng Li, Zheng Li, Jia Tang, Jia Tang, Jia Tang, Chao Pi, Chao Pi, Wenwu Zheng, Peng Shi, Ying Zuo, Jun Jiang, Yan Yang, Shifeng Chu, Yumeng Wei, Ling Zhao, Ling Zhao, Ling Zhao

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Cholangiocarcinoma-derived secreted products and growth arrest-specific 2-like 3 enhance migratory and invasive abilities of fibroblasts by Natnicha Paungpan, Kulthida Vaeteewoottacharn, Paweena Dana, Saowaluk Saisomboon, Sittiruk Roytrakul, Wiphawi Hipkaeo, Yada Polsan, Kanlayanee Sawanyawisuth, Sukanya Luang, Worachart Lert-itthiporn, Vor Luvira, Chawalit Pairojkul, Yaovalux Chamgramol, Sopit Wongkham, Seiji Okada

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STAGER checklist: Standardized testing and assessment guidelines for evaluating generative artificial intelligence reliability by Jinghong Chen, Lingxuan Zhu, Weiming Mou, Anqi Lin, Dongqiang Zeng, Chang Qi, Zaoqu Liu, Aimin Jiang, Bufu Tang, Wenjie Shi, Ulf D. Kahlert, Jianguo Zhou, Shipeng Guo, Xiaofan Lu, Xu Sun, Trunghieu Ngo, Zhongji Pu, Baolei Jia, Che Ok Jeon, Yongbin He, Haiyang Wu, Shuqin Gu, Wisit Cheungpasitporn, Haojie Huang, Weipu Mao, Shixiang Wang, Xin Chen, Loïc Cabannes, Gerald Sng Gui Ren, Iain S. Whitaker, Stephen Ali, Quan Cheng, Kai Miao, Shuofeng Yuan, Peng Luo

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Analyzing Worn-Out Texture Regeneration from Urban Branding Perspective Using Structural Equation Modeling (SEM) (Case Study: Worn-Out Texture of Shahr-e-Kord) by Dvood Mahdavi, Ali Mohammadi Gojani, Waliullah Nazari

“…The present study aimed to model the impact of urban regeneration on the branding of Shahr-e-Kord's dilapidated urban fabric. …”
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Cannabidiol as a treatment for patients who are clinically at high risk of developing psychosis: learnings from the CANTOP-RCT by Sagnik Bhattacharyya, Cathy Davies, Ben Carter, Philip McGuire, Michael Brammer, Paolo Fusar-Poli, Matthew Broome, Stuart Watson, Jesus Perez, Alison Yung

“…We received funding to test this in a large clinical trial comparing cannabidiol to placebo (a sugar pill with no active ingredient). We aimed to study 300 clinical high-risk state patients. …”
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From the WHO framework to integrated senior health and wellness hub program: an implementation journey by Xiaoting Huang, Xiaoting Huang, Hao Yi Tan, Hao Yi Tan, Hao Yi Tan, Pei Ling Er, Amber Wong, Si Qi Lim, Joshua Kuan Tan, Wan Qi Yee, Xiaohui Xin, Lian Leng Low

“…IntroductionAs global populations age, ensuring older adults maintain functional ability and wellbeing is a critical public health priority. …”
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