Identification and validation of a lenvatinib resistance-related prognostic signature in HCC, in which PFKFB4 contributes to tumor progression and lenvatinib resistance by Jinfeng Wang, Jianfei Shi, Lili Mi, Ning Li, Xin Han, Man Zhao, Xiaoling Duan, Guangjie Han, Jiaojiao Hou, Fei Yin

“…Mutation signatures, therapeutic response, functional enrichment, and immune profile analyses were performed in the two groups. …”
Get full text

Platelets in preeclampsia: an observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape by Gashaw Garedew Woldeamanuel, Kenean Getaneh Tlaye, Xueqin Wang, Long Nguyen-Hoang, Qiongjie Zhou, Yinan Wang, Bo Wah Leung, Yao Wang, Liona C. Poon, Chi Chiu Wang

“…RNA-seq analysis revealed a total of 20, 618 and 1819 transcripts in the peripheral blood, placental villous and decidua of preeclamptic women, respectively. Functional analysis revealed that the PI3K-Akt and Wnt signalling pathways were significantly enriched in the placental villous and decidua of preeclamptic patients, respectively. …”
Get full text

The Effect of Ceftriaxone on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study by Şeyma Özsoy, Zeynep Kasap Acungil

“…Ceftriaxone is a β-lactam antibiotic that increases EAAT-2 expression and functional activity. This study aims to investigate the effects of ceftriaxone on penicillin- induced epileptiform activity by using electrocorticography (ECoG) in anesthetized rats.Method: In this study, 35 Wistar male rats were used. …”
Get full text

Kinesiophobia and associated factors among people with musculoskeletal disorders in Ethiopia: a multicenter cross-sectional study by Yazachew Mekonnen, Moges Gashaw, Yohannes Abich, Mihret Dejen Takele, Samuel Teferi Chanie, Dechasa Imiru Wayessa, Sisay Deme, Alemu Kassaw Kibret

“…Abstract Introduction Kinesiophobia has a major health impact on patients with Musculoskeletal disorders (MSDs) in their functional and physical activities, which leads to poor outcomes, loss of motivation, loss of mobility, and decreased quality of life. …”
Get full text

HBx mutant-regulated RPL13AP25 mediates suboptimal virological response to entecavir and HCC progression by Yang-Hsiang Lin, Ming-Wei Lai, Yu-De Chu, Kwang-Huei Lin, Chao-Wei Hsu, Rong-Nan Chien, Po-Heng Chuang, Chih-Lang Lin, Chau-Ting Yeh

“…Hepatitis B virus X (HBx) gene was sequenced from entecavir-treated patients who developed hepatocellular carcinoma (HCC). Functional assays were conducted using Transwell assays, MTT assays, and xenograft model. …”
Get full text

Avoidant/Restrictive Food Intake Disorder in Adult Patients with Gastrointestinal Diseases: A Concept Analysis Using Evolutionary Approach by Che Y, Li S, Hu X, Hu H, Zhang C, He C

“…Consequences involved nutritional/psychological consequences, poor overall health, complex disease management, and reduced quality of life.Conclusion: We found that avoidant/restrictive food intake disorder in the context of gastrointestinal diseases is a state of disordered eating characterized by food exclusion and selectivity, which may progress into a disorder when its impact on physical or psychological functioning exceeds adaptive threshold. This study clarifies the concept, and the findings provide a basis for developing assessment tools, guiding dietary management, and informing the implementation of targeted interventions in GI patients.Keywords: concept analysis, avoidant/restrictive food intake disorder, adult, gastrointestinal diseases, eating disorders…”
Get full text

Dietary protein re-alimentation following restriction improves protein deposition via changing amino acid metabolism and transcriptional profiling of muscle tissue in growing beef... by Jiaqi Wang, Chun Shen, Guangyong Zhao, Mark D. Hanigan, Mengmeng Li

“…This study aimed to develop a compensatory growth model using growing beef cattle by changing dietary protein and to investigate the underlying mechanisms of compensatory protein deposition in muscle tissue. …”
Get full text

Predictive potential of cardiovascular risk factors and their associations with arterial stiffness in people of European and Korean ethnic groups by T. A. Brodskaya, V. A. Nevzorova, K. I. Shakhgeldyan, B. I. Geltser, D. A. Vrazhnov, Yu. V. Kistenev

“…Aim. To compare the effect of cardiovascular risk factors on aortic stiffness in people of European and East Asian ethnic groups.Material and methods. …”
Get full text

App-based daily self-measurement of impedance in cochlear implant users by Sarah Vormelcher, Sarah Vormelcher, Cornelia Batsoulis, Daniel Kley, Michael Mair, Andreas Büchner

“…IntroductionImpedance telemetry measurements in cochlear implant (CI) recipients are commonly used to assess CI electrode functionality and provide valuable insights into inner ear conditions. …”
Get full text

Cognitive-Discursive Study of Migration Discourse (Based on English-Language Media Texts) by N. V. Stepanova

“…At the first stage of the study, articles were considered at the text level with the identification of lexical, syntactic and stylistic aspects of the functioning of the discourse. At the second stage (discourse as a discursive practice), examples of intertextuality were investigated, including the depth layer of intertext – cognitive one. …”
Get full text

Insomnia prehabilitation in newly diagnosed breast cancer patients: Protocol for a pilot, multicentre, randomised controlled trial comparing nurse delivered sleep restriction thera... by Leanne Fleming, Solveiga Zibaite, Simon D Kyle, Kathleen Boyd, Vivien Green, James Mansell, Beatrix Elsberger, David Young

“…<h4>Introduction</h4>Insomnia is a prevalent sleep disorder that negatively impacts daytime functioning and quality of life. Breast cancer patients report higher rates of insomnia and more circadian disruption than other cancer groups. …”
Get full text

CYTOKINES AS PREDICTORS OF INTESTINAL METAPLASIA OF STOMACH by L. V. Matveeva

“…An increase in IL-6, EPO, IL-18, VEGF, IFNα were also common, thus indicative for changed functional activity of cytokines due to microbial contamination of gastric mucosa, tissue hypoxia with activation of angiogenesis, confirming a transition of intestinal metaplasia to gastric carcinogenesis. …”
Get full text

Identification of a Novel Subtype of Ocular Hypertensive Eyes with the Lowest Risk of Progression Under Treatment by Asma Poursoroush, Vida Abedi, Xiaoqin Huang, Jiang Li, Alireza Vafaei Sadr, Amy L. de Jongh Curry, Louis R. Pasquale, Michael V. Boland, Chris A. Johnson, Siamak Yousefi

Get full text

AGE-RELATED CHANGES IN HEART RATE VARIABILITY AND THEIR RELATION WITH LEUCOCYTE TELOMERE LENGTH by L. I. Streltsova, О. N. Tkacheva, E. V. Plokhova, D. U. Akasheva, I. D. Strajesko, E. N. Dudinskaya, S. А. Boytsov

“…Aim. To assess the  relation of age-depended changes  in heart  rate variability (HRV) with telomere  length.  …”
Get full text

Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and p... by Shrinjana Dhar, Pritha Bhattacharjee

“…It uses a comprehensive bioinformatics methodology to depict pathways and functionality enrichment, allowing for cost-effective risk prediction and management. …”
Get full text

Engineering of covalent organic framework (COF) via mono-doping and co-doping for the detection of CO2 gas pollutant by John A. Agwupuye, Ekere Nwachukwu Romanus, Janefrances Ngozi Ihedioha, Ismail O. Amodu, Bassey O. Ekpong, Destiny E. Charlie, Fehintola E. Umo, Modestar Chinecherem Agwupuye, Muhammad Zeeshan

“…In this work, the detection of CO2 gas on newly modified covalent organic framework (COF) surface was investigated using density functional theory (DFT). All computational calculations were performed using the DFT/ωB97XD/6–311 + +g(d,p)/def2svp/LANL2DZ computational method. …”
Get full text

The Effectiveness of Therapeutic Exercise Interventions With Virtual Reality on Balance and Walking Among Persons With Chronic Stroke: Systematic Review, Meta-Analysis, and Meta-Re... by Maria Krohn, Aki Rintala, Jaakko Immonen, Tuulikki Sjögren

“…We evaluated the Berg Balance Scale score, Functional Reach Test performance, Activities-specific Balance Confidence Scale score, Six-minute Walk Test, Two-minute Walk Test, 10-meter Walk Test results, and cadence (outcome measures). …”
Get full text

Violence against healthcare professionals: perspective of local focal points in the south of Portugal by Maria Otília Zangão, Isaura Serra, Dulce Cruz, Maria da Luz Barros, Anabela Coelho, Maria Antónia Chora, Carolina Santos, Laurência Gemito

“…,departments, services, offices or functional units) on violence against health professionals in the Alentejo region. …”
Get full text

Extending the Three-Dimensional Culture of Adipocytes Through Surface Coatings by Sheetal Chowdhury, Komal Beeton, Zacchaeus Wallace, Maggie Moore, Gene L. Bidwell, Amol V. Janorkar

“…SDS gel electrophoresis, FTIR spectroscopy, and turbidimetry analyses revealed that ELP was conjugated with RGD without much alteration in the molecular weight, functional groups present, and transition temperature of ELP. …”
Get full text

Upregulation of 15-Hydroxyprostaglandin Dehydrogenase by Celecoxib to Reduce Pain After Laparoendoscopic Single-Site Surgery (POPCORN Trial): A Randomized Controlled Trial by Kyung Hee Han, Sunwoo Park, Seungmee Lee, Jiyeon Ham, Whasun Lim, Gwonhwa Song, Hee Seung Kim

“…These exploratory findings warrant confirmation in larger trials with functional validation of HPGD expression (ClinicalTrials.gov, NCT03391570).…”
Get full text