Immune checkpoint changes correlate with the progression and prognosis of amyotrophic lateral sclerosis by Sheng Chen, Chunzuan Xu, Changyun Liu, Jiaqi Li, Shupei Ke, Yingqian Lu, Yali Huang, Jialin Chen, Feifei Lin, Huapin Huang, Zhangyu Zou

“…ALS patients exhibiting a greater percentage of PD-1 in CD4+ T cells showed accelerated functional decline. Serum analyses identified four elevated soluble checkpoints in ALS versus both HCs and Mimics (sPD-1/sBTLA/sCTLA-4/sCD27, p < 0.05), with sCD28/TIM-3 showing higher in ALS than in Mimics, and sGITR/sCD137/sIDO/sCD80/sLAG3/sPD-L2 elevating in ALS compared to HCs. …”
Get full text

Distinct phenotypes of salivaricin-producing Ligilactobacillus salivarius isolated from the gastrointestinal tract of broiler chickens and laying hens by A.G. Elnar, Y.J. Jang, B.G. Eum, M.H. Kang, G.W. Hwang, D.Y. Kil, G.B. Kim

“…Ligilactobacillus salivarius harbors bacteriocin genes in its repA-type megaplasmid, specifically salivaricin P (salP), a class IIb bacteriocin. This study aimed to differentiate 25 salP-positive Lig. salivarius strains isolated from the gastrointestinal tract (GIT) of broilers and laying hens. …”
Get full text

Performance exploration of multi-gene panels of alopecia areata susceptibility and drug-binding targets by Hongye Liu, Yang Li, Ling Ren, Xiaofeng Yang, Shuo Zhang, Hongmei Bi, Hongxia He, Jingyu Ren, Xiaoqing Lang, Shuping Guo

“…The functions of these genes in biological processes were analyzed to identify special multi-gene panels that may play crucial roles in AA. …”
Get full text

Lithium Chloride Effect on Mortality and Neurological Deficits in the Model of Ischemic Stroke in Rats by O. A. Grebenchikov, R. A. Cherpakov, A. K. Evseyev, A. V. Ershov, A. N. Kuzovlev, P. A. Lonchinsky, S. S. Petrikov, A. K. Shabanov

“…Recent experimental studies have shown pronounced neurocardio-nephroprotective properties of lithium salts.Aim of study. To evaluate the effect of lithium chloride on the lethality and severity of cognitive and neurological deficits in the modeling of ischemic stroke in rats.Materials and methods. …”
Get full text

Sewage sludge-derived biochar modified with MgCl2: Used as adsorbent material for phosphorus removal from aqueous medium by Valber Georgio de Oliveira Duarte, Jader Alves Ferreira, Denise Eulálio, Guilherme Max Dias Ferreira, Vera Regina Leopoldo Constantino, Gustavo Franco de Castro, Jairo Tronto

“…The P adsorption isotherm followed the Langmuir model, with a maximum adsorption capacity of 176 mg·g⁻1 after 48 h. Magnesium-functionalized biochar produced from SS has a high capacity for P removal from an aqueous medium, which represents a promising alternative for applying this material as a P fertilizer.…”
Get full text

Parathyroid Carcinoma: An Up-to-Date Retrospective Multicentric Analysis by Francesco Quaglino, Luca Manfrino, Luca Cestino, Massimo Giusti, Enrico Mazza, Alessandro Piovesan, Nicola Palestini, Corrado Lauro, Elena Castellano

“…PC is equally gender distributed, and the average patients’ age is in the fifth decade of life. It is usually functioning, with greater biochemical activity and multiple symptoms. …”
Get full text

Prognostic Factors and Talaporfin Sodium Concentration in Photodynamic Therapy for Recurrent Grade 4 Glioma by Mikoto Onodera, Shuji Kitahara, Yasuto Sato, Takakazu Kawamata, Yoshihiro Muragaki, Ken Masamune

“…<b>Background:</b> Although extensive resection improves the prognosis of gliomas, it risks impairing critical brain functions. Photodynamic therapy (PDT) utilizing talaporfin sodium (TS) targets tumor cells upon light activation. …”
Get full text

Prognostic importance of the Controlling Nutritional Status (CONUT) score in patients undergoing cardiac resynchronisation therapy by Yasuo Okumura, Yukitoshi Ikeya, Yuki Saito, Toshiko Nakai, Rikitake Kogawa, Naoto Otsuka, Yuji Wakamatsu, Sayaka Kurokawa, Kimie Ohkubo, Koichi Nagashima

“…Aims Malnutrition is common and associated with worse clinical outcomes in patients with heart failure (HF). …”
Get full text

Health status biomarkers and hemato-biochemical indices in Nile tilápia by Lorena Bavia, Ana Paula da Silva, Milena Carvalho Carneiro, Melyssa Kmecick, Roberta Pozzan, Juan Esquivel-Muelbert, Lourdes Isaac, Maritana Mela Prodocimo

“…Because of this, establishing baseline reference parameters for this healthy animal is extremely valuable for comparison. Thus, our aim is to establish reference values for Nile tilapia for comparative purposes for: (i) functional activation of the alternative pathway of the complement system (ACH50), (ii) some serum biochemical parameters of liver, kidney and muscle tissue integrity, and (iii) hematological profile of Nile tilapia under controlled conditions. …”
Get full text

Acceptability of veggie bread among Lebanese adults by Asma Chanbour, Hussein F. Hassan, Dima Kreidieh, Salma Khazaal, Tareq Osaili, Tareq Osaili, Khaled El Omari, Khaled El Omari, Nada El Darra

“…Incorporating vegetables as functional ingredients has gained interest in enhancing its nutritional profile. …”
Get full text

Longitudinal Evaluation of Vitamin D, Parathyroid Hormone, Antimicrobial Peptides, and Immunomodulatory Genes in Hospitalized Foals by Ahmed M. Kamr, Celine Bartish, Jamie Summers, Julia Horton, Laura D. Hostnik, Kindra Orr, Nimet Browne, Katarzyna A. Dembek, Caroline Saliba, Diego E. Gomez, Ramiro E. Toribio

“…Conclusions and Clinical Importance Decreased vitamin D metabolite concentrations and decreased antimicrobial peptide concentrations suggest that vitamin D has important immunomodulatory functions in newborn foals.…”
Get full text

The ADAMTS2 metalloproteinase inhibits tumor growth by regulating the innate immune system by Loïc Joannes, Laura Dupont, Louis Stock, Esther Arpigny, Pascale Hubert, Marie Ancion, Margaux Luyckx, Joan Abinet, Wen Peng, Didier Calaldo, Agnes Noel, Thomas Marichal, Michael Herfs, Christophe Deroanne, Alain Colige

“…As these properties are likely to alter tumor progression, we aimed to assess the overall impact of ADAMTS2 on cancer development. …”
Get full text

Structural brain network organization in children with prenatal alcohol exposure by Xiaoyun Liang, Claire E. Kelly, Chun-Hung Yeh, Thijs Dhollander, Stephen Hearps, Peter J. Anderson, Deanne K. Thompson

“…Complex structural network analyses can provide insight into the neurobiological underpinnings of these functions, as they may be sensitive for characterizing the effects of PAE on the brain. …”
Get full text

Effect of alternating salinity stress on the gut microbiota of razor clam Sinonovacula constricta by Yi Yuan, Qunqun Jiang, Qinggang Xue, Qinggang Xue, Zhihua Lin, Zhihua Lin, Wenfang Dai, Wenfang Dai

“…The former two groups were used as the control, and the latter two groups aimed to investigate the effect of alternating salinity stress on clam growth and gut microbiota by 16S rRNA gene amplicon sequencing.ResultsAlternating salinity stress caused faster and higher mortality compared with the two control groups, and disrupted the gut microbiota including altered α-diversity, composition and structure. …”
Get full text

Research on screening key proteins related to the pathogenesis of sepsis associated encephalopathy based on DIA proteomics technology by Wu Shuhui, Hu Hongjie, Lu Yuru, Zhu Wei

“…Objective To explore the key proteins in plasma of patients with sepsis associated encephalopathy (SAE) through data-independent acquisition(DIA) quantitative proteomics and machine learning techniques, with the aim of guiding research on SAE pathogenesis and aiding early diagnosis. …”
Get full text

Mild and reversible nephrotoxicity following repeated administration of damnacanthal in nude mice by Noppanan Kotsaouppara, Thunyatorn Yimsoo, Worapapar Treesuppharat, Jeeraphong Thanongsaksrikul, Potjanee Srimanote

“…This study, therefore, aims to assess the renal toxicity of 20 mg/kg damnacanthal (DAM20) in nude mice following three, seven and 14 repeated administrations. …”
Get full text

Immunomodulatory and anticancer effects of moringa polyherbal infusions: potentials for preventive and therapeutic use by Wamidh H. Talib, Wamidh H. Talib, Hadeel Shaher Al Junaidi, Heba K. Alshaeri, Moudi M. Alasmari, Moudi M. Alasmari, Rawan W. Hadi, Ahmad Riyad Alsayed, Douglas Law

“…The Nitro Blue Tetrazolium Assay and Neutral Red Method were used to assess the effects of each extract on macrophage phagocytic and pinocytosis functions. Lymphocyte proliferation was also tested.ResultsThe anti-proliferative activity of Moringa-saffron showed the strongest anti-proliferative effect on T47-D and EMT6/P, with IC50 values of 1.14 ± 0.05 and 1.65 ± 0.27 mg/ml, respectively. …”
Get full text

Enhanced neurological anomaly detection in MRI images using deep convolutional neural networks by Ahmed Mateen Buttar, Zubair Shaheen, Abdu H. Gumaei, Mogeeb A. A. Mosleh, Mogeeb A. A. Mosleh, Indrajeet Gupta, Samah M. Alzanin, Muhammad Azeem Akbar

“…The model employs Rectified Linear Unit (ReLU) activation functions, the Adam optimizer, and a random search strategy to fine-tune hyper-parameters like learning rate, batch size, and the number of neurons in fully connected layers. …”
Get full text

Comparative analysis of regenerative activity of bone marrow cells and total RNA extracted from them in chronic fibrosing liver disease by Z. Z. Gonikova, A. O. Nikolskaya, L. A. Kirsanova, M. Yu. Shagidulin, N. A. Onishchenko, V. I. Sevastyanov

“…It was revealed that normalization of functional liver parameters in all groups were ahead of restoration of the histological structure of the liver. …”
Get full text

Influence of rough micro-threaded and laser micro-textured implant-neck on peri-implant tissues: A systematic review by Wayel Mohammed Huraib, Fawaz Pullishery, Thamer Abdulmohshin Al-Ghalib, Adham Abdulmajeed Tash Niyazi, Haitham Binhuraib, Mahmoud El Homossany, Malak Saeed Bamigdad

“…Background and objective: This systematic review aimed to explore clinical outcomes of marginal or crestal bone level (MBL) and soft tissue status around implants, following the placement of rough micro-threaded/laser-microtextured surface (LMS) implants. …”
Get full text