CITA GO-ON study. A community based multidomain lifestyle intervention to prevent cognitive decline. Protocol design and recruitment process by Mikel Tainta, Mikel Tainta, Mikel Tainta, Mikel Tainta, Mirian Ecay-Torres, Myriam Barandiaran, Myriam Barandiaran, Myriam Barandiaran, Ainara Estanga, Carolina López, Miren Altuna, Miren Altuna, Ane Iriondo, Jon Saldias, Maite Garcia-Sebastian, Marta Cañada, Maria de Arriba, Imanol Reparaz-Escudero, Mikel L. Sáez de Asteasu, Mikel L. Sáez de Asteasu, Mikel Izquierdo, Mikel Izquierdo, Nekane Balluerka, Arantxa Gorostiaga, Naia Ros, Goretti Soroa, Jara Domper, Jara Domper, Lucia Gayoso, Lucia Gayoso, Maria Arrizabalaga-Lopez, Usune Etxeberria, Usune Etxeberria, Maria Ines Torres, Elena Alberdi, Elena Alberdi, Estibaliz Capetillo-Zarate, Estibaliz Capetillo-Zarate, Estibaliz Capetillo-Zarate, Maider Mateo-Abad, Itziar Vergara, Javier Mar, Pablo Martinez-Lage

“…The secondary outcomes measure cost-effectiveness, quality of life, and functional abilities. Blood samples and brain imaging will also be collected to evaluate the effects of the intervention on brain structure and plasma biomarkers.ResultsRecruitment has been completed with 1051 participants selected (mean age (standard deviation, SD) of 69.65 (6.36), 58,50 % female, and mean CAIDE (SD) of 7.62 (1.427). …”
Get full text

Upregulation of interferon-γ response genes in monocytes and T cells identified by single-cell transcriptomics in patients with anti-citrullinated peptide antibody-positive early r... by Bong-Ki Hong, Sungyong You, Jung Gon Kim, Jung Gon Kim, Minhyung Kim, Naeun Lee, Kijun Lee, Kijun Lee, In-Pyo Baek, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju, Wan-Uk Kim, Wan-Uk Kim, Ho-Youn Kim

“…Additionally, we conducted single-cell RNA sequencing of CD45+ cells from peripheral blood samples to analyze and compare the distribution and functional characteristics of the cell subsets based on the ACPA status.ResultsSerum concentrations of interferon-γ (IFN-γ) and interleukin (IL)-12 were higher in ACPA+ eRA than in ACPA- eRA. …”
Get full text

In-silico proteomic analysis of the role of IL-4 and IL-10 in IVD degeneration: Protein-protein interaction networks for candidate prioritisation by Paola Bermudez-Lekerika, Francesco Gualdi, Christine L. Le Maitre, Janet Piñero, Baldomero Oliva, Benjamin Gantenbein

“…Protein-protein interaction (PPI) networks provide a static map of functional protein interactions, which when combined with algorithms, can prioritize key protein candidates which experimental studies cannot capture. …”
Get full text

Histology and Immunohistochemistry of Adipose Tissue: A Scoping Review on Staining Methods and Their Informative Value by Tom Schimanski, Rafael Loucas, Marios Loucas, Oliver Felthaus, Vanessa Brébant, Silvan Klein, Alexandra Anker, Konstantin Frank, Andreas Siegmund, Andrea Pagani, Sebastian Geis, Sophia Theresa Diesch, Andreas Eigenberger, Lukas Prantl

“…Background: Histological and immunohistochemical analyses of adipose tissue are essential for evaluating the quality and functionality of lipoaspirates in regenerative medicine and fat grafting procedures. …”
Get full text

Effects of different dietary zinc sources on growth performance, muscle texture, and intestinal immunity in Mandarin Fish (Siniperca chuatsi) by Xiaolu Yan, Lingcheng Pan, Zhigang Deng, Yabin Wu, Dianchao Gu, Lei Yan, Yushuang Chen, Da Zhou, Fubao Wang, Min Zhao, Li Luo

“…Overall, amino acid-chelated zinc outperforms zinc sulfate in promoting growth, improving muscle quality, antioxidant and immune functions, and enhancing intestinal health, with Zn-Met (2:1) having the best effects.…”
Get full text

Comparison of the effect of iguratimod and hydroxychloroquine on regulatory B cells in the treatment of primary Sjögren’s syndrome by Jin-Mei Zou, Li Yang, Jia-Ang Luo, Yan Ren, Si-Yin Li, Yu Zhang, Jian-Ling Dong, Dai-Hua Deng, Yuan-Piao Ni, Min Li, Xiao-Shuang Yin, Jing Yang

“…ObjectivesThis study aimed to evaluate the efficacy of iguratimod (IGU) and hydroxychloroquine (HCQ) in the treatment of primary Sjögren’s syndrome (pSS).MethodsThis was a randomised controlled study. …”
Get full text

Local cerebral neurofilament light chain during acute stage is associated with clinical outcomes in stroke patients receiving endovascular thrombectomy by Kunxin Lin, Youliang Wang, Wenlong Zhao, Yiru Zheng, Xiaohua Sun, Ling Fang, Ying Fu, Ning Wang, Qianqian Lin

“…Abstract Background Prediction of stroke outcomes is challenging due to limited predictive properties of clinical and radiological variables. We aimed to investigate whether local cerebral neurofilament light chain (NfL) could provide additional prognostic value. …”
Get full text

Spatiotemporal analysis of Anopheles gambiae larval sites and malaria transmission in Djilakh, Central Senegal by Assane Ndiaye, Camille Morlighem, Aminata Niang Diène, Moussa Kane, Abdoulaye Diallo, Fassiatou Tairou, Mohamed Abderemane Nourdine, Pape Cheikh Sarr, Lassana Konaté, Ousmane Faye, Oumar Gaye, El Hadji Amadou Niang, Catherine Linard, Ousmane Sy

“…The correlation between malaria morbidity and functioning breeding sites varied throughout the rainy season, depending on the size and stability of the existing breeding sites. …”
Get full text

The Combination of Curcumae Radix and Syzygium Aromaticum Extracts Mitigates Benign Prostatic Hyperplasia through Anti-Proliferative and Anti-Inflammatory Effects by Geum Hwa Lee, Yu Seob Shin, Ji Hyun Kim, Da hee Shim, Hwa Young Lee, Luo Zhao, Mohammad Mamun Ur Rashid, Hwang Eui Cho, Jong Jin Lee, Min Kyoung Kim, Do Sung Kim, Hyun Jun Park, Han Jung Chae

“…However, a few natural functional foods has been conclusively proven to cure or prevent symptoms of BPH. …”

Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction by Yiming Chen, Baochao Fan, Jingchun Zeng, Yutian Zou, Chenyang Tao, Chen Chen, Peiming Zhang, Jian Liang, Fangfang Qi, Hailin Tang, Liming Lu

“…Our findings revealed that acupuncture may activate the defense response to viruses, with altered immune cell functions in classical monocytes correlating with clinical responses to reduced methadone doses. …”
Get full text

Chemical Composition, Free Radicals and Pathogenic Microbes in the Extract Derived from <i>Dictyota dichotoma</i>: In Silico and In Vitro Approaches by Fouad Oumassi, Khalid Chebbac, Naouar Ben Ali, Soundouss Kaabi, Zineb Nejjar El Ansari, Amira Metouekel, Azeddin El Barnossi, Abdelfattah El Moussaoui, Mohamed Chebaibi, Loubna Bounab, Ibrahim Mssillou, Abdelaaty Abdelaziz Shahat, Brahim El Bouzdoudi, Mohammed L’bachir El Kbiach

“…Marine algae are renowned for their health benefits due to the presence of functional bioactive compounds. In this context, this study aims to valorize the extract of a seaweed, <i>Dictyota dichotoma</i> (<i>D. dichotoma</i>), through phytochemical characterization using liquid chromatography–mass spectrometry (HPLC-MS), as well as in vitro and in silico evaluation of its biological activities (antioxidant and antimicrobial). …”
Get full text

RNA-Seq Analysis of Mouse Hepatocytes AML12 Exposed to Neodymium Nitrate by Ning Wang, Jing Leng, Yaxin Han, Gonghua Tao, Jingqiu Sun, Cheng Dong, Kelei Qian, Xiuli Chang, Ping Xiao, Xinyu Hong

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to explore the functions and pathways associated with differentially expressed genes (DEGs). …”
Get full text

Acute cannabis intoxication among the paediatric population by Ginevra Malta, Giuseppe Davide Albano, Gianluca Lavanco, Anna Brancato, Carla Cannizzaro, Antonina Argo, Simona Contorno, Fulvio Plescia, Stefania Zerbo

“…By providing a comprehensive overview, it aims to inform future research, guide policymaking, and enhance clinical and toxicological practice in addressing this growing public health concern. …”
Get full text

Salidroside inhibits melanin synthesis and melanoma growth via mTOR and PI3K/Akt pathways by Qi Ouyang, Qi Ouyang, Shengye Tian, Shengye Tian, Hengyu Zhou, Hengyu Zhou, Ying Mao, Xiang Li, Feng Yan, Feng Yan, Ailong Liu, Ailong Liu, Xiang Hu, Changqiao You, Changqiao You, Jun He

“…However, how salidroside achieves its anti-melanoma effect in melanoma by regulating PI3K/Akt/mTOR remains poorly understood. This study aimed to explore the effect of salidroside on PI3K/Akt/mTOR in melanoma, which plays a role in regulating melanogenesis.MethodsNetwork pharmacology was predicted that salidroside may exert an anti-melanoma effect through modulating melanin synthesis functions and signaling pathways. …”
Get full text

A comparison of floating catchment area parameters with applications to a dataset of clinics enrolled in a statewide child and adolescent psychiatric consultation program by Jocelyn Hunyadi, Jocelyn Hunyadi, Lara S. Savas, Kehe Zhang, Kehe Zhang, Jeanette E. Deason, Ryan Ramphul, Melissa F. Peskin, Erica L. Frost, Cici Bauer, Cici Bauer

“…Using the 2SFCA method, we further compared accessibility patterns across two kernel density distance decay functions for 10 catchment area specifications.ResultsAs expected, spatial accessibility measures, such as the spatial accessibility ratio (SPAR), are sensitive to input parameters, particularly the catchment area. …”
Get full text

Immunoadsorption study Mainz in adults with post-COVID syndrome (IAMPOCO)—a single-blinded sham-controlled crossover trial to evaluate the effect of immunoadsorption on post-COVID... by Marco Stortz, Pascal Klimpke, Andreas Kommer, Philipp Gründer, Livia Steenken, Christian Dresel, Daniel Kraus, Irene Schmidtmann, Arndt Weinmann, Julia Weinmann-Menke

“…By using a crossover design and including a sham treatment arm, the study aims to compare the effects of immunoadsorption and sham therapy within the same patients. …”
Get full text

Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study by Michael Jöbges, Melanie Tempfli, Melanie Tempfli, Christoph Kohl, Christoph Herrmann, Stefan Kelm, Alexa Kupferschmitt, Alexa Kupferschmitt, Alexa Kupferschmitt, Ida Montanari, Nike Walter, Gerhard Suetfels, Thomas Loew, Volker Köllner, Volker Köllner, Thilo Hinterberger

“…Various measures were employed, including the fatigue scale for motor functioning and cognition (FSMC), the Test Battery for Attention (TAP) and the Montreal Cognitive Assessment (MoCA).ResultsOut of the 1,086 recruited participants, a total of N = 701 participants were included in the main data analysis. …”
Get full text

Extension for Community Healthcare Outcomes-Palliative Care in Africa and Quality of Life, Symptoms, Patient Experience, and Caregiver Distress Among Patients With Cancer by Sriram Yennurajalingam, Olaitan Soyannwo, John Weru, Edwina Beryl VND Addo Opare-Lokko, Henriette Burger, Esther Nafulah, Oladayo Aikomo, Adeniyi Adenipekun, Irene Botchway, Mary Ocansey, Jayita Deodhar, Jianliang Dai, Clark R. Andersen, Joseph Anthony Arthur, Aline Rozman de Moraes, Penny A. Stanton, Eduardo Bruera, Suresh Reddy

“…PURPOSEIn this study, we aimed to evaluate the association between the Extension for Community Healthcare Outcomes-Palliative Care (ECHO-PC; ECHO Model–Based comprehensive educational and telementoring intervention) for health care professionals (HCPs) and change in patient-reported quality-of-life (QOL; Functional Assessment of Cancer Therapy-General [FACT-G]) among patients with advanced cancer. …”
Get full text

Design, Manufacture, and Performance Testing of a Water Hammer Pump with Five Different Air Chambers by Marco Fidel Romero Zárate, Héctor Flores-Breceda, Juan Arredondo-Valdez, Urbano Luna-Maldonado, Wilgince Apollon, Alejandro Isabel Luna-Maldonado

“…Specifically, this research aimed to evaluate the impact of air chamber design on pump performance. …”
Get full text

Vocal biomarkers in heart failure—design, rationale and baseline characteristics of the AHF-Voice study by Fabian Kerwagen, Fabian Kerwagen, Maximilian Bauser, Magdalena Baur, Fabian Kraus, Caroline Morbach, Caroline Morbach, Rüdiger Pryss, Kristen Rak, Stefan Frantz, Stefan Frantz, Michael Weber, Julia Hoxha, Stefan Störk, Stefan Störk

“…A total of 131 patients were enrolled between April 2023 and November 2024: their mean age was 75 years (SD 10), 31% were women, 86% were in NYHA functional class III or IV, and 38% presented with de novo heart failure. …”
Get full text