Silicon-enriched meat consumption mitigates brain cortex damage associated with diabetic dyslipidemia in a late-stage type 2 diabetes mellitus rat model by Rocío Redondo-Castillejo, Luis Apaza Ticona, Adrián Macho-González, Aránzazu Bocanegra, Alba Garcimartín, Marina Hernández-Martín, Anastasia Parfenova, Sara Bastida, Luis García-García, M. Elvira López-Oliva, Francisco J. Sánchez-Muniz, Juana Benedí

“…This study demonstrates for the first time that silicon, provided as a functional dietary ingredient of meat-products, exhibited a capacity to partially counteract brain cortex metabolic damage caused by T2DM.…”
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Inhibition of carbohydrate digestive enzymes by a complementary essential oil blend: in silico and mixture design approaches by El Hassania Loukili, Mouhcine Fadil, Amal Elrherabi, Mohammed Er-rajy, Mohamed Taibi, Khalil Azzaoui, Khalil Azzaoui, Rachid Salghi, Rachid Sabbahi, Mohammed M. Alanazi, Larbi Rhazi, Aleksandar Széchenyi, Aleksandar Széchenyi, Mohamed Siaj, Belkheir Hammouti

“…Additionally, density functional theory (DFT) calculations and molecular docking simulations were conducted to assess the key metabolites' electronic properties and interaction potential with target enzymes.ResultsGC-MS analysis identified 32 metabolites in P. graveolens, with citronellol (18.67%), eucalyptol (13.30%), and 2-octen-1-ol (8.12%) as major components. …”
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Effect of adjunctive intraoral balance appliance in the usual care of patients with chronic temporomandibular joint disorders using Korean medicine in South Korea: study protocol f... by Jae-Heung Cho, Hyungsuk Kim, Woo-Chul Shin, Se yun Kim, Whisung Cho, Jaehyun Park, Won-Seok Chung, Mi-yeon Song

“…Secondary outcomes will include overall functional assessment of the TMJ using several scales, as well as evaluations of quality of life, patient satisfaction and AEs.The recruitment started on 18 July 2024, and 37 patients were included as of 8 July 2025.Ethics and dissemination Ethical approval is obtained from the Kyung Hee University Korean Medicine Hospital Institutional Review Board (IRB number: KOMCIRB 2023-06-001). …”
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Resveratrol promotes cholesterol efflux from dendritic cells and controls costimulation and T-cell activation in high-fat and lipopolysaccharide-driven atherosclerotic mice by Linhui Zhang, Haixia Wang, Zishan Wang, Jianyi Xu, Mengyuan Wang, Wenxin Wang, Qiongshan He, Yun Yu, Dongping Yuan, Guirong Bu, Runze Qiu, Jun Long

“…This study aimed to explore the roles of RES in cholesterol metabolism and inflammatory behaviors of DCs in the context of AS. …”
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Clinical and Ultrasound Evaluation of Hemiplegic Shoulder Pain in Stroke Patients: A Longitudinal Observational Study Starting in the First Hours After Stroke by Filippo Cotellessa, William Campanella, Luca Puce, Maria Cesarina May, Marta Ponzano, Riccardo Picasso, Matteo Mordeglia, Davide Subbrero, Ester Cecchella, Laura Mori, Davide Sassos, Massimo Del Sette, Matteo Formica, Carlo Trompetto

“…This longitudinal study aimed to investigate the clinical and ultrasound characteristics of HSP emerging within the first 72 h (T0) post-stroke, with follow-ups at one month (T1) and three months (T2). …”
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Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4+ T Cells by Michal Holub, Alžběta Stráníková, Ondřej Beran, Simona Arientová, Oldřich Bartoš, Kateřina Kondelková, Stanislav Plíšek, Pavel Chalupa

“…Chronic hepatitis C (CHC) is associated with altered cell-mediated immune response. Objective. The aim of the study was to characterize functional alterations in CD4+ T cell subsets and myeloid-derived suppressor cells (MDSCs) during chronic hepatitis C virus (HCV) infection. …”
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Rheumatoid Arthritis Real-world Cohort Study in China (ReALSA): protocol for a multicentre prospective, longitudinal cohort study by Long Zhang, Ying Yang, Lie Dai, Yingying Zhu, Jian-Zi Lin, Ze-Hong Yang, Qian-Hua Li, Zhi-Ming Ouyang, Hai-Jun Liu, Yao-Wei Zou, Kui-Min Yang, Li-Juan Yang, Ying-Qian Mo, Jian-Da Ma

“…The outcomes of interest include RA disease outcomes (including disease activity, functional and radiographic indicators) and RA-related complications/comorbidities (eg, sarcopenia, CVD, malignancies and specific infection).Ethics and dissemination Ethical approval has been approved by the Medical Ethics Committee of Sun Yat-sen Memorial Hospital, Sun Yat-sen University (ID: SYSKY-2023-1235-01); the Affiliated Panyu Central Hospital of Guangzhou Medical University (ID: PYRC-2024-214-01); and ShenShan Medical center, Memorial Hospital of Sun Yat-sen University (ID: 2024-SSKY-118-01). …”
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Prognostic value of myocardial bridging versus non-obstructive CAD: a long-term follow-up study by Zengfa Huang, Beibei Cao, Yang Yang, Yi Ding, Xinyu Du, Wanpeng Wang, Mei Li, Zuoqin Li, Xi Wang, Xu Zhao, Xiang Wang

“…Abstract We aim to investigate if myocardial bridging (MB) provides predictive value beyond its association with non-obstructive coronary artery disease (CAD) burden in a long-term follow-up and multicenter study. …”
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Pecan-medicinal crops intercropping improved soil fertility and promoted interactions between soil microorganisms and metabolites by Ruyuan Wang, Chenyang Liu, Xuesong Bie, Yan Dai, Xu Feng, Ren Wang, Ming Wang, Shu Xu, Yu Chen

“…In addition, the result of metabolomic analysis showed that intercropping promoted the synthesis of functional compounds, such as trehalose and ethanolamine, which enhanced plant disease resistance in bulk soils. …”
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The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis by Erik Hellbacher, Erik Hellbacher, Vincent van Hoef, Alina Johansson, Ann Knight, Ann Knight, Iva Gunnarsson, Iva Gunnarsson, Annette Bruchfeld, Annette Bruchfeld, Per Eriksson, Sophie Ohlsson, Solbritt Rantapää-Dahlqvist, Johanna Dahlqvist, Johanna Dahlqvist

“…MMP-1, MMP-9, HGF, and OSM were uniquely upregulated in PR3-AAV, while TNF, TNF-R1/R2, TNFRSF14, and TNFRSF9 were prominent in MPO-AAV. Functional enrichment analyses underscored STAT3 signaling in PR3-AAV and TNF signaling in MPO-AAV.ConclusionsThis study identifies distinct and shared signaling pathways in PR3-AAV and MPO-AAV, highlighting STAT3 and TNF pathways as potential subtype-specific mechanisms. …”
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Thiacloprid Exposure Induces Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis in the Liver of Mauremys reevesii by Shuqin Lin, Yunjuan Xiao, Siyu Li, Liyan Tang, Haitao Shi, Meiling Hong, Li Ding

“…Transcriptome analysis revealed that genes significantly associated with the elimination of superoxide radicals, organelle inner membrane functions, peroxiredoxin activity, and apoptotic pathways were abundantly expressed in the high‐concentration THI group. …”
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Colo‐Protective Effects of Pentoxifylline Alone or in Combination With Mesalamine in Colitis Through Sphingosine Kinase 1/Sphingosine 1 Phosphate, and Zonula Occuldin 1 Pathways: N... by Fatemah A. Alherz, Mahmoud S. Abdallah, Esraa M. Mosalam, Mostafa M. Bahaa, Thanaa A. Elmasry, Mohamad A. El‐Gammal, Walaa A. Negm, AyaIbrahim Elberri, Nora Elshorbagi, Hend E. Abo Mansour, Amir O. Hamouda, Muhammed M. Salahuddin, Mohamed Yasser, Mamdouh Eldesoqui, Sarah Alrubia, Amsha S. Alsegiani, Eman El‐Khateeb, Mohamed Kh. ElMahdy, Eman Wahsh

“…Intracolonic AA induced marked functional, biochemical, and inflammatory damage to colonic tissue. …”
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Anthocyanin Degradation Drives Heat-Induced Petal Fading in <i>Chrysanthemum morifolium</i> at Full Bloom: A Multi-Omics Analysis by Ge Zhao, Yanan Li, Jialin Peng, Xiuge Li, Wenhao Xia, Yuhe Tian, Yukun Li, Lijie Zhou

“…These findings provide new insights into the metabolic regulation of anthocyanins in chrysanthemums under heat stress and offer potential strategies for maintaining flower color quality during summer production, highlighting key candidate genes (<i>CmPRX</i>s and <i>CmOMT1</i>) for future functional validation and breeding efforts aimed at improving heat tolerance and color stability.…”
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Critical care services in Bagmati province of Nepal: A cross sectional survey [version 3; peer review: 3 approved, 1 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Background This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a focus on access, infrastructure, human resources, and intensive care unit (ICU) services. …”
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2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment by Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang

“…Conclusion: MT-ND3 is a crucial target for improving diabetic cognitive dysfunction, and 2-HIBA can directly bind to the MT-ND3 protein to alleviate the functional impairment of the mitochondrial respiratory chain in mice to treat DCI.…”
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Equine Adipose-Derived Mesenchymal Stromal Cells Release Extracellular Vesicles Enclosing Different Subsets of Small RNAs by Stefano Capomaccio, Katia Cappelli, Cinzia Bazzucchi, Mauro Coletti, Rodolfo Gialletti, Franco Moriconi, Fabrizio Passamonti, Marco Pepe, Stefano Petrini, Samanta Mecocci, Maurizio Silvestrelli, Luisa Pascucci

“…In this study, we investigated small RNA content of EVs produced by e-AdMSC with the aim of speculating on their possible biological role. …”
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Comparative analysis of endometrial, vaginal, and gut microbiota in patients with and without adenomyosis by Marta Valdés‐Bango, Meritxell Gracia, Elisa Rubio, Andrea Vergara, Climent Casals‐Pascual, Cristina Ros, Mariona Rius, Maria Ángeles Martínez‐Zamora, Eduard Mension, Lara Quintas, Francisco Carmona

“…In this context, the hypothesis that alterations in the microbiota may be involved in the pathogenesis of adenomyosis, by affecting the epigenetic, immunologic, and biochemical functions of the host, has recently been postulated. …”
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LRP6 regulates growth in Litopenaeus vannamei via the Wnt/β-catenin signaling pathway by Sheng Wang, Xiaodi Wang, Hao Yang, Xuanzheng Di, Haoyang Li, Bin Yin, Ziwei Liu, Chaozheng Li, Jianguo He

“…Multiple sequence alignments and phylogenetic analyses indicated that LvLRP6 belongs to the invertebrate LRP6 family and has conserved phosphorylation sites with those of LRP6 in other species. Functional investigations via RNAi technology revealed that silencing LvLRP6 via dsRNA injection resulted in a significant reduction in shrimp growth, as indicated by lower weight gain than that in the control group. …”
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Enhanced expression of ten‐eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P‐glycoprotein expression by Chuanxu Wang, Hua Ye, Lei Zhang, Yayu Cheng, Shifeng Xu, Ping Zhang, Zijie Zhang, Jimin Bai, Fangkang Meng, Lin Zhong, Guangjun Shi, Hao Li

“…Abstract Increasing evidence revealed that ten‐eleven translocation 1 (TET1) plays an important role in tumorigenesis and chemoresistance, but its functions in gemcitabine resistance in cholangiocarcinoma (CCA) remain unknown. …”
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The comprehensive transcriptomic atlas of porcine immune tissues and the peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genes by Qingyao Zhao, Jiahao Wang, Fuping Ma, Quanzhen Chen, Huatao Liu, Jinyan Yang, Siqian Chen, Yongjie Tang, Siyuan Mi, Lulu Wang, Xini Wang, Guohong Liu, Kai Xing, Ying Yu, Chuduan Wang

“…By integrating different epigenetic genomics datasets, we identified several core immune genes and their causal variants, including IFI44, IFIT5, EIF2AK2 and others, which are closely related to immune development and response. Functional validation studies reveal that the IFI44 gene acts as a negative regulator of the antiviral response; its inhibition effect significantly reduced Poly(I:C)-induced cell necrosis, while enhancing apoptosis to combat viral infections. …”
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