Knowledge domain and emerging trends in post-stroke cognitive impairment: a bibliometric analysis by Heyu Zhang, Yanwei Li, Luqian Zhan, Jingfang Long, Jianing Shen, Jiahui Chen, Jiajing Qian, Zhiming Pan, Xue Wu, Zhen Wang, Zhen Wang, Wenjun Wu, Guiqian Huang, Guiqian Huang

“…The journal Stroke had the strongest international influence in this field. Keywords such as “functional connectivity,” “tool,” “systematic review,” and “meta-analysis” have been revealed to have momentous impact on PSCI in recent years. …”
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Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): protocol for a multicentre randomised placebo-controlled triple-blind trial by Mohsen Sadatsafavi, Megan E Jensen, Francine M Ducharme, Nathalie Alos, Geneviève Mailhot, Benoît Mâsse, John H White, Ali Khamessan, Sze Man Tse, Reza Alizadehfar, Dirk E Bock, Patrick Daigneault, Chantal Lemire, Connie Yang, Dhenuka Radhakrishnan

“…Secondary outcomes include number of laboratory-confirmed viral URTIs, exacerbation duration and severity, parent functional status, healthcare use, treatment deintensification, cost and safety.Ethics and dissemination This study has received ethical approval from all sites. …”
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Socioeconomic status and lifestyle as factors of multimorbidity among older adults in China: results from the China Health and Retirement Longitudinal Survey by Wei Gong, Wei Gong, Wei Gong, Xiaoxiao Hu, Huimin Cui, Huimin Cui, Yuxin Zhao, Yuxin Zhao, Hong Lin, Hong Lin, Hong Lin, Peng Sun, Peng Sun, Jianjun Yang, Jianjun Yang

“…These findings offered empirical and theoretical support for early risk stratification and targeted public health interventions aimed at mitigating multimorbidity in aging populations.…”
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Screening of biomarkers for diagnosing chronic kidney disease and heart failure with preserved ejection fraction through bioinformatics analysis by Can Hou, Jiayi Xu, Min Zhou, Junyu Huo, Xiaofei Wang, Wanying Jiang, Tong Su, Hui Wang, Fang Jia

“…The R software package “limma” was employed to conduct differential expression analysis. Functional annotation was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). …”
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The mSQUASH is a feasible and valid measurement tool to uniformly assess daily physical activity in patients with rheumatic diseases by Suzanne Arends, Anneke Spoorenberg, Hendrika Bootsma, Kornelis S M van der Geest, Davy Paap, Lianne Gensler, Karina de Leeuw, Yvonne M van der Kraan, Ellen Thovmasyan, Noa Ausma, Helene Kokol, Marlies Carbo, Stan C Kieskamp

“…Fair correlations were found between mSQUASH and Axial Spondyloarthritis Disease Activity Score (ρ=−0.31), Bath Ankylosing Spondylitis Functional Index (ρ=−0.37) and Assessment of SpondyloArthritis International Society-Health Index (ρ=−0.30). …”
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Critical care services in Bagmati province of Nepal: A cross sectional survey [version 4; peer review: 4 approved, 2 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Background This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a focus on access, infrastructure, human resources, and intensive care unit (ICU) services. …”
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Initial experience of laparoendoscopic single-site radical prostatectomy with a novel purpose-built robotic system by Zheng Wang, Chao Zhang, Chengwu Xiao, Yang Wang, Yu Fang, Baohua Zhu, Shouyan Tang, Xiaofeng Wu, Hong Xu, Yi Zhou, Lingfen Wu, Zhenjie Wu, Bo Yang, Yi He, Yi Liu, Linhui Wang

“…The demographic and baseline data, surgical, oncological, and functional outcomes as well as follow-up data were recorded. …”
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The Needle in the Haystack: Uncovering the First Whale Shark (Rhincodon typus) Aggregation in the Coral Sea by Ingo B. Miller, Richard Fitzpatrick, Kátya G. Abrantes, Bradley Norman, Simon J. Pierce, Mark V. Erdmann, Lisa A. Hoopes, Christine Dudgeon, Matthew D. Dunbabin, Alistair D. M. Dove, Robin J. Beaman, Samantha D. Reynolds, Christopher Rohner, Samuel M. Williams, David Paton, Sonny Lewis, Adam Barnett

“…ABSTRACT Aggregations are key events, supporting critical ecological and biological functions in many species. For highly mobile and elusive species, aggregations often provide the only feasible opportunities for research. …”
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Investigating Czech society’s expectations for forest recreation by Ratna Chrismiari Purwestri, Miroslav Hájek, Petra Palátová, Meryem Tahri, Diana Carolina Huertas-Bernal, Stephen Awuni, Stephen Awuni, Sri Murniani Angelina Letsoin, Sri Murniani Angelina Letsoin, Fajar Rahmawan, Miroslava Hochmalová, Vilém Jarský, Marcel Riedl, Roman Dudík

“…As part of the cultural services, recreational functions contribute aesthetic value and opportunities for various sports and leisure activities. …”
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Effects of Sacubitril/Valsartan on Exercise Capacity in Patients with Heart Failure with Reduced Ejection Fraction and the Role of Percentage of Delayed Enhancement Measured by Car... by Cinzia Nugara, Francesco Giallauria, Giuseppe Vitale, Silvia Sarullo, Giovanni Gentile, Francesco Clemenza, Annamaria Lo Voi, Antonino Zarcone, Elio Venturini, Gabriella Iannuzzo, Andrew JS Coats, Filippo M Sarullo

“…Conclusion: Sacubitril/valsartan improves cardiopulmonary functional capacity in HFrEF patients. The presence of myocardial fibrosis on cardiac magnetic resonance is a predictor of response to therapy.…”
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Amphiphilic Bioactives of Freshwater Aquatic Plants <i>Nelumbo nucifera</i> (Indian Lotus) and <i>Lemna</i> sp. with Antioxidant, Anti-Inflammatory and Antithrombotic Activities: I... by Marina Seferli, Melina Lefkaki, Vasileios Manousakis, Anna Ofrydopoulou, Katie Shiels, Sushanta Kumar Saha, Grigorios Krey, Nikolaos Kamidis, Nikolaos Stamatis, Chryssa Anastasiadou, Alexandros Tsoupras

“…<b>Conclusions:</b> These findings suggest that <i>N. nucifera</i> and <i>Lemna</i> sp. are promising sources of bioactive compounds with potential applications in functional foods, cosmetics, and pharmaceuticals targeting inflammation- and thrombosis-related chronic diseases. …”
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General anesthesia is an independent predictor for worse maternal outcome in pregnant pulmonary arterial hypertension patients without cardiac shunt but not for those with shunt by Weida Lu, Min Li, Fuqing Ji, Hua Feng, Liangyi Qie, Guo Li, Qiushang Ji, Mingying Ling, Fan Jiang, Xiaopei Cui

“…Both World Health Organization functional class (WHO-FC) III/IV and general anesthesia were predictors for gravidae without shunt, whereas only WHO-FC III/IV was a predictor for gravidae with shunt. …”
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Leveraging the enrichment analysis from a genome-wide association study against epilepsy—focusing on the role of tryptophan catabolites pathway in patients with drug-resistant epil... by Alice Y. W. Chang, Alice Y. W. Chang, Chin-Wei Huang, Ping-Lin Tsai, Chun-An Liang, Chun-An Liang, Wei Chen Liao, Tzu-Fun Fu, Tzu-Fun Fu, Hui Hua Chang, Hui Hua Chang, Hui Hua Chang, Hui Hua Chang

“…Moreover, we investigated the potential role of molecular signature profiles, as exemplified by tryptophan catabolites (TRYCATs), in DRE patients.MethodsWe used data from the Taiwan Biobank to perform a GWAS and identified enrichment pathways through the functional database Reactome. To validate the results, we enrolled community-dwelling controls and DRE patients. …”
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Identification of SNPs and Candidate Genes Associated with Growth Using GWAS and Transcriptome Analysis in Portuguese Oyster (<i>Magallana angulata</i>) by Jingyi Xie, Yue Ning, Yi Han, Caiyuan Su, Xiaoyan Zhou, Qisheng Wu, Xiang Guo, Jianfei Qi, Hui Ge, Yizou Ke, Mingyi Cai

“…By combining GWAS and comparative transcriptome analysis, a total of seven candidate genes were identified, with biological functions related to growth inhibition, stress response, cell cycle regulation, and immune defense. …”
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Inhaled Nitric Oxide ReDuce postoperatIve pulmoNAry complicaTions in patiEnts with recent COVID-19 infection (INORDINATE): protocol for a randomised controlled trial by Hui Zhang, Xiaomei Wang, Xue Yang, Ziyu Zheng, Gang Luo, Qianqian Fan, Huang Nie, Baobao Gao, Lini Wang, Chong Lei, Shuxiu Wang, Bingqing Zhao, Hailong Dong

“…Accumulating evidence suggests that nitric oxide (NO) inhalation might be effective in treating COVID-19. NO functions in COVID-19 by promoting vasodilation, anticoagulation, anti-inflammatory and antiviral effects. …”
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Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone l... by Jumi Kim, Jumi Kim, Jiseon Ha, Jiseon Ha, Chanho Song, Chanho Song, Muhammad Azhar Sajjad, Muhammad Azhar Sajjad, Fadia Kalsoom, Hyeonjoong Kwon, Hyeonjoong Kwon, Jaewoo Park, Sun Park, Sun Park, Kyongmin Kim, Kyongmin Kim

“…AGK2 suppresses HBV replication through direct antiviral actions, and by epigenetic modulation of cccDNA, indicating that using AGK2 to target SIRT2 and associated epigenetic regulators shows promise as a functional cure for chronic hepatitis B.…”
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Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised... by Nigel Garrett, Sharana Mahomed, Edmund Capparelli, Cheryl Baxter, Nonhlanhla Yende Zuma, Tanuja Gengiah, Derseree Archary, Penny Moore, Natasha Samsunder, Dan H Barouch, John Mascola, Julie Ledgerwood, Lynn Morris, Salim Abdool Karim

“…The purpose of this trial is to provide safety, pharmacokinetic (PK) and functional activity data of VRC07-523LS and PGT121 when administered subcutaneously (SC) to young South African women. …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…Histological analyses of the brain revealed delayed accumulation of activated astrocytes contributing to the preservation of the neural microenvironment by reducing neuroinflammation.The extent of FTY-related disease improvement was sex-dependent. Motor functions and body weight improved mostly in female mice with sustained estrogen levels, whereas males had to compensate for the ongoing, disease-related testis atrophy and the loss of androgen production.Our study underscores the beneficial therapeutic effects of FTY on HD involving endogenous steroid hormones and their important anabolic effects. …”
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Impact of aging on alanine aminotransferase levels and frailty in chronic kidney disease patients: laboratory-based cross-sectional study in Northwest Ethiopia by Melaku Mekonnen Agidew, Anemut Tilahun Mulu, Awgichew Behaile Teklemariam, Misganaw Asmamaw Mengstie, Addisu Melake, Edgeit Abebe Zewde, Zelalem Tilahun Muche, Samuel Berihun Dagnew, Nega Dagnew Baye, Bezawit Adane, Muluken Walle, Girma Derso

“…BackgroundChronic kidney disease (CKD) is a non-communicable progressive condition that leads to a gradual decline in kidney functions, resulting in different complications. Serum alanine aminotransferase (ALT) is an important biomarker for diagnosing liver comorbidities. …”
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Evaluation of a patient decision aid for opportunistic salpingectomy and salpingectomy as sterilization method to prevent ovarian cancer by Malou E. Gelderblom, Charlotte Fisch, Jurgen M. J. Piek, Laura A. M. vanLieshout, Justine Briet, Lauren Bullens, Sjors F. P. J. Coppus, Inge Ebisch, Alexandra A. vanGinkel, Rafli van deLaar, Natascha deLange, Marloes Maassen, Huy Ngo, Angele L. M. Oei, Brenda Pijlman, Brigitte Slangen, Regina The, Dineke Smedts, Caroline Vos, Joanna IntHout, Joanne A. deHullu, Rosella P. M. G. Hermens

“…Main reasons for choosing opportunistic salpingectomy were the risk‐reducing effect of ovarian cancer (N = 311; 90%) and the lack of functionality of the fallopian tubes after childbearing (N = 320; 92%). …”
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