Effects of a novel non-pharmacological intervention based on respiratory biofeedback, neurofeedback and median nerve stimulation to treat children with ADHD by Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Anayali Estudillo-Guerra, Lna Ali, Diana Martinez, Roberto Hornero, Roberto Hornero, Leon Morales-Quezada

“…IntroductionAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition that affects cognitive, academic, behavioral, emotional, and social functioning, primarily in children. Despite its high prevalence, current pharmacological treatments are not effective in 30% of cases and show poor long-term adherence. …”
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Synergistic effects of PAR2 and TrkA exacerbate visceral hypersensitivity induced by chronic pancreatitis in rats by Zhiyun Liu, Jiao Zhu, Qianbo Chen, Kunming Tao, Kai Wei, Xiaodan Wu, Haibo Qiu, Zhijie Lu

“…Finally, we demonstrated the functional interaction between PAR2 and TrkA by whole-cell patch clamp recordings. …”
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A novel optimized silver nitrate staining method for visualizing the osteocyte lacuno-canalicular system by Jinlian Wu, Jinlian Wu, Chunchun Xue, Qiang Li, Hongjin Wu, Jie Zhang, Chenglong Wang, Weiwei Dai, Libo Wang

“…By offering a more accurate and comprehensive analysis of the LCS across species, this approach has the potential to advance research on osteocyte morphogenesis, as well as the functional and evolutionary adaptations of the osteocyte LCS across different taxa.…”
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Cerebral blood flow based on 3D-ASL technology in the early detection of mild cognitive impairment in type 2 diabetic patients: a pilot study by Tingzhou Hou, Yijie Wang, Hanwen Xu, Hanwen Xu, Zhenyu Shu, Xiaodong He, Xiaohong Wu

“…Spearman’s correlation analysis showed that CBF in the temporal, parietal, occipital, and hippocampal regions was significantly and positively correlated with MoCA scores (P < 0.05), with temporal and parietal CBF also significantly and positively correlated with MMSE scores (P < 0.05).ConclusionsCBF, based on 3D-ASL measurements, especially in the hippocampus, is a promising functional marker for identifying MCI in patients with T2DM.…”
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BRD4 silencing attenuates hemin-induced neuronal ferroptosis and inflammation via the H3K27ac–ATF3 axis in an in vitro model of cerebral hemorrhage by Jing Yi, Hua Tang, Siwei Que, Tao Zheng, Hu Zeng, Xiaoming Xie, Hua Chen

“…Abstract Background Intracerebral hemorrhage (ICH), a subtype of hemorrhagic stroke, is associated with high morbidity and mortality. This study aimed to investigate the role and underlying mechanism of bromodomain and extraterminal domain protein 4 (BRD4) in neural injury following ICH. …”
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Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metaboli... by Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta

“…Owing to the presence of multiple enzymatic domains, LRRK2 has been associated with a diverse set of cellular functions and signaling pathways. It also has several pathological mutant-variants, and their incidences show ethnicity biases and drug-response differences with expression in dopaminergic-neurons and astrocytes. …”
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C5aR1 blockade reshapes immunosuppressive tumor microenvironment and synergizes with immune checkpoint blockade therapy in high-grade serous ovarian cancer by Chen Zhang, Kankan Cao, Moran Yang, Yiying Wang, Mengdi He, Jiaqi Lu, Yan Huang, Guodong Zhang, Haiou Liu

“…The complement C5a/C5aR1 axis contributes to the programming of the immunosuppressive phenotype of TAMs in solid tumors and represents a promising immunomodulatory target for treating HGSCs. Here, we aimed to identify the relevance of C5aR1 in prognosis, immune microenvironment, and immunotherapy response in HGSCs. …”
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Association between dietary patterns and anemia in older adults: the 2015 China adults chronic diseases and nutrition surveillance by Pengfei Wang, Qiya Guo, Xue Cheng, Wen Zhao, Hongyun Fang, Lahong Ju, Xiaoli Xu, Xiaoqi Wei, Weiyi Gong, Lei Hua, Jiaxi Li, Xingxing Wu, Li He

“…This study aimed to analysis the dietary patterns in older adults aged 60 and above in China and their association with anemia. …”
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SAFETY OF CANNED MILK AS AN INTEGRATED CRITERION OF THEIR TECHNOLOGY EFFECTIVENESS. RUSSIAN EXPERIENCE by S. N. Turovskaya, A. G. Galstyan, A. N. Petrov, I. A. Radaeva, E. E. Illarionovа, V. K. Semipyatniy, S. A. Khurshudyan

“…Significant potential lies in the research of thermodynamic characteristics, functional and technological indicators of dairy products and further implementation of the obtained data, as system criteria of the technological operations rationality definition, the validity of production schemes, and the evaluation of product quality. …”
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The influence of microwave-assisted osmotic dehydration in coconut meat preservation technique by Mahfujul Alam, Mipahur Jannat, Nayon Datta, Mir Meahadi Hasan, Asraful Alam, Md. Ashrafuzzaman Zahid, Md. Shakir Moazzem, Mohammad Mainuddin Molla, Mrityunjoy Biswas

“…The findings are essential for producers, processors, and consumers looking to optimize the quality and functionality of coconut meat when utilized for multiple purposes.…”
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Integrated machine learning and single-cell RNA sequencing reveal COL4A2 and CXCL6 as oxidative stress-associated biomarkers in periodontitis by Siyu Sun, Siyu Sun, Jing Ren, Jing Ren, Xiujuan Zeng, Yanbin Chen, Qianbing Zhou, Junying Yang, Shan Chen

“…Key genes linked to oxidative stress in periodontitis were identified through a comprehensive analytical approach, including differential expression analysis, weighted gene co-expression network analysis (WGCNA), gene set enrichment analysis (GSEA), and functional enrichment analyses (GO and KEGG). Machine learning algorithms were subsequently employed to refine the selection of key genes. …”
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Comparing modified light bulb with multiple drilling methods in treating non-traumatic femoral head osteonecrosis: A cohort study by Ali Parsa, Hamid Dolatabadi, Saeid Esmaeilian, Seyed Ali Moshtaghioon, Neda Mirzaei, Omid Shahpari, Elham Rahmanipour, Mohammad Ghorbani

“…Objective: This study aims to evaluate and compare the clinical and radiological results of the multiple drilling (MD) technique with the Modified Light Bulb (MLB) method for treating pre-collapse stage osteonecrosis of the femoral head (ONFH). …”
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Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Ener... by Maria D’Elia, Carmen Marino, Rita Celano, Enza Napolitano, Chiara Colarusso, Rosalinda Sorrentino, Anna Maria D’Ursi, Luca Rastrelli

“…Objectives: The aim of this study was to evaluate the impact of a novel antioxidant formulation (RE:PAIR, RP-25) containing CoQ10, alpha-lipoic acid, and Chaga extract on mitochondrial dysfunction and oxidative stress. …”
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Identification and characterization of Sr59-mediated stem rust resistance in a novel wheat-rye translocation T2BL·2BS-2RL by Mahboobeh Yazdani, Matthew N. Rouse, Prabin Bajgain, Tatiana V. Danilova, Ivan Motsnyi, Brian J. Steffenson, Mehran Patpour, Mahbubjon Rahmatov

“…Four NLR genes were identified on the 2R chromosome, with Chr2R_NLR_60 being tightly linked to the Sr59 resistance gene. In-silico functional enrichment analysis of the translocated 2RL region (25,681,915 bp) identified 223 genes, with seven candidate genes associated with plant disease resistance and three linked to agronomic performance, contributing to oxidative stress response, protein kinase activity, and cellular homeostasis. …”
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Technology features of decellularization of human liver fragments as tissue-specific fine-grained matrix for cell-engineering liver construction by E. A. Nemets, L. A. Kirsanova, Ju. B. Basok, M. Ju. Schagidulin, E. A. Volkova, S. T. Metelsky, V. I. Sevastianov

“…One of the problems when you create a bioengineered liver, as an alternative to transplantation of the donor liver in the treatment of end-stage liver failure, is the matrix, able to temporarily perform the functions of the natural extracellular matrix (ECM) and provide the necessary conditions to maintain the viability of the liver cells. …”
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Rationale and design of Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined with Endovascular Treatment in ACute Ischaemic StrokE (RETRACE II): a randomised double-... by Yongjun Wang, Zixiao Li, Hao Wang, Wenhuo Chen, Xinsheng Han, Wenjie Wang, Lingling Ding, Tingyu Yi, Gaocai Zhang

“…Background While endovascular therapy (EVT) remains the primary treatment for acute ischaemic stroke (AIS) management, persistent functional deficits in patients with successful recanalisation underscore the necessity for complementary neuroprotective strategies.Aim To investigate the safety and efficacy of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) as a potential adjunctive neuroprotective intervention following EVT in AIS patients.Design The Low-Frequency REpetitive TRanscranial Magnetic Stimulation Combined with Endovascular Treatment in ACute Ischaemic StrokE (RETRACE-II) trial is a phase II, multicentre, prospective, randomised, double-blind, sham-controlled pilot study. 60 successfully recanalised AIS patients with anterior circulation occlusion were equally randomised (1:1) to active LF-rTMS or sham intervention. …”
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Identification and validation of immune and diagnostic biomarkers for interstitial cystitis/painful bladder syndrome by integrating bioinformatics and machine-learning by Tao Zhou, Can Zhu, Wei Zhang, Qiongfang Wu, Mingqiang Deng, Zhiwei Jiang, Longfei Peng, Hao Geng, Zhouting Tuo, Zhouting Tuo, Ci Zou

“…The expression and biological functions of key genes in IC/BPS were further validated through in vitro experiments.ResultsA total of 87 DEGs were identified, comprising 43 up-regulated and 44 down-regulated genes. …”
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A peer-support lifestyle intervention for preventing type 2 diabetes in India: A cluster-randomized controlled trial of the Kerala Diabetes Prevention Program. by Kavumpurathu R Thankappan, Thirunavukkarasu Sathish, Robyn J Tapp, Jonathan E Shaw, Mojtaba Lotfaliany, Rory Wolfe, Pilvikki Absetz, Elezebeth Mathews, Zahra Aziz, Emily D Williams, Edwin B Fisher, Paul Z Zimmet, Ajay Mahal, Sajitha Balachandran, Fabrizio D'Esposito, Priyanka Sajeev, Emma Thomas, Brian Oldenburg

“…However, there were significant improvements in some cardiovascular risk factors and physical functioning score of the HRQoL scale.<h4>Trial registration</h4>Australia and New Zealand Clinical Trials Registry ACTRN12611000262909.…”
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APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion by Ziwen Li, Min Li, Sinuo Sun, Yu Bin, Suwei Zuo, Ronghua Huo, Jiayin Song, Gang Xue, Xu Lin, Jingfang Wu

“…However, whether APOE promotes PTC progression through ferroptosis modulation remains unclear. This study aims to investigate the ferroptosis-related mechanisms through which APOE facilitates cell invasion, migration, and macrophage polarization in PTC. …”
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SH3GL1‐activated FTH1 inhibits ferroptosis and confers doxorubicin resistance in diffuse large B‐cell lymphoma by Zi‐Wen Duan, Wei‐Ting Wang, Yan Wang, Rong Wang, Wei Hua, Chun‐Yu Shang, Rui Gao, Hao‐Rui Shen, Yue Li, Jia‐Zhu Wu, Hua Yin, Li Wang, Jian‐Yong Li, Wei Xu, Jin‐Hua Liang

“…This approach combined high‐throughput sequencing technologies, such as Deep‐DIA and LC‐MS, with functional validation techniques, including CRISPR/Cas9 gene editing, xenograft models, and molecular pathway analyses. …”
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