A novel founder variant in BEST1 gene causing autosomal recessive bestrophinopathy by Nagham Maher Elbagoury, Caroline Atef Tawfik, Asmaa Fawzy Abdel-Aleem, Heba Mahmoud Fathy, Dina Nabil Baddar, Mona Lotfi Essawi

“…The pathogenicity of the variants was tested using different in silico functional analysis tools. Results The clinical examination and investigations confirmed the ARB phenotype. …”
Get full text

Prevention of Dry Eye Syndrome Before Phacoemulsification of Cataracts in Patients with a History of Cosmetic Procedures in the Periorbital Area by А. V. Trubilin, E. G. Poluninа, V. N. Trubilin, V. S. Zakatianskii

“…This group of patients is recommended to undergo a set of therapeutic physiotherapeutic procedures — eyelid hygiene + massage in the periorbital area, aimed at restoring the functional activity of the meibomian glands and increasing the stability of the tear film, which reduces the incidence of severe dry eye syndrome and inflammation in the postoperative period after cataract phacoemulsification by 19.89%.…”
Get full text

Integrated analysis and experimental validation reveal the prognostic and immunological features associated with coagulation in hepatocellular carcinoma by Guangzhen Qu, Kun Liu, Weiyu Xu, Dongming Li

“…Consequently, our research aims to uncover how CAGs affect the prognosis and immune microenvironments of HCC. …”
Get full text

STUDY ON THE APPLICATION OF FLY ASH IN ROAD AND AIRPORT CONSTRUCTION by Oleksandr Vasylovych Stepanchuk, Yang Shilin, Valentyna Valentynivna Hrabovchak

“…Fly ash positively affects the physical and mechanical properties of the concrete, making it a functional additive in the production of heavy-duty concrete. …”
Get full text

Preparation and characterization of bovine dental pulp-derived extracellular matrix hydrogel for regenerative endodontic applications: an in vitro study by Hisham Elnawam, Abdelrahman Thabet, Ahmed Mobarak, Amr Abdallah, Rania Elbackly

“…Conclusions Both P-ECM and P-ECM + HA retained their bioactive properties demonstrating a potential role as functionalized scaffolds for regenerative endodontic procedures.…”
Get full text

Proposing a New Classification for Managing Prostaglandin-Induced Enophthalmos in Glaucoma Patients by Ferraro V, Gaeta A, Barone G, Confalonieri F, Tredici C, Vinciguerra P, Di Maria A

“…This classification system may serve as a clinical tool in patients with persistent or advanced PAPS who seek cosmetic correction or relief from functional symptoms.Keywords: prostaglandin-associated periorbitopathy syndrome, prostaglandin-induced enophthalmos, calcium hydroxyapatite, autologous fat grafting, glaucoma therapy complications, classification system, enophtalmos, orbital changes in glaucoma…”
Get full text

Insomnia, pruritus, and constipation in hemodialysis patients: a cross-sectional study by Jing Zhu, Bifei Wang

“…Constipation was diagnosed according to the Rome IV criteria for functional gastrointestinal disorders. Additional clinical and laboratory parameters were collected for comprehensive analysis. …”
Get full text

A novel -mutated human induced pluripotent stem cell model for understanding -mutated tumors by Katsuhito Watanabe, Takashi Nakamura, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma

“…We then analyzed the functionality of this induced pluripotent stem cell model and differentiated epithelial cells. …”
Get full text

An ensemble strategy for piRNA identification through hybrid moment-based feature modeling by Mansoor Ahmed Rasheed, Tamim Alkhalifah, Fahad Alturise, Yaser Daanial Khan

“…Abstract This study aims to enhance the accuracy of predicting transposon-derived piRNAs through the development of a novel computational method namely TranspoPred. …”
Get full text

Anxiety-depressive disorders in patients with coronary artery disease with borderline coronary artery stenosis and visceral obesity by D. A. Yakhontov, Yu. O. Ostanina, O. V. Dunicheva, T. G. Tsibina, N. A. Kokoulina, V. L. Lukinov

“…Aim. To assess the prevalence of anxiety-depressive disorders in pa­tients with coronary artery disease (CAD) with borderline coronary artery (CA) stenosis and visceral obesity.Material and methods. …”
Get full text

Sanitary, hygienic, and welfare aspects of keeping Pomeranian Spitz in a breeding private kennel by N. Yu. Krempa, O. V. Kozenko, B. V. Gutyj, S. S. Popadiuk, M. A. Ivakhiv

“…The market situation regarding the breeding of decorative dogs of the Pomeranian breed and providing consumers with appropriate services in this field of activity dictate the rules and create the conditions of competition between market participants, which encourages improvement, development, and constant monitoring of it in terms of novelties and needs that provide opportunities for comfortable care and decent maintenance of pupils. The work aimed to analyze the impact of sanitary and hygienic factors and ensuring healthy housing conditions on the functional state of the body and mental health of Pomeranian Spitz dogs in the conditions of the private breeding kennel Fluffy Luxury Pom in the suburbs of Lviv. …”
Get full text

Cellpose as a reliable method for single-cell segmentation of autofluorescence microscopy images by Jeremiah M. Riendeau, Amani A. Gillette, Emmanuel Contreras Guzman, Mario Costa Cruz, Aleksander Kralovec, Shirsa Udgata, Alexa Schmitz, Dustin A. Deming, Beth A. Cimini, Melissa C. Skala

“…Overall, the Cellpose ATM provides a fast, reliable, reproducible, and accurate method to segment single cells in autofluorescence microscopy images such that functional changes in cells are accurately captured in both 2D and 3D culture.…”
Get full text

THE KARDIOKANON STUDY: A WAY TO SETTLE THE SUBJECT OF CLINICAL EQUIVALENCE OF GENERIC AND ORIGINAL DRUGS by S. Yu. Martsevich, N. P. Kutishenko, M. L. Ginzburg, G. V. Matyushin, V. V. Skibitskiy, L. A. Sokolova, A. V. Deev

“…Aim. To compare two therapies based on the use of original or generic drugs in patients with stable ischemic heart disease (IHD). …”
Get full text

Dynamics of free radical processes in the oral fluid of patients with chronic recurrent aphthous stomatitis at the first stage of therapy by O. V. Tarasova, A. V. Shumsky, O. N. Pavlova, O. N. Gulenko

“…In order to achieve the set objective we had to solve the following tasks: to evaluate the functional activity of free radical processes in the oral liquid of patients with CPAS on the background of antiseptics (chlorhexidine, octenisept, furacilin, myramistine) and anaesthetic (Camistad gel) application for 7 days.Materials and Methods. …”
Get full text

Study of the psychometric properties of the HLS-EU-12 questionnaire in rural Bangladesh. by Fakir M Amirul Islam

“…The analysis was focused on differential item functioning (DIF) across gender and age, targeting, multidimensionality, response dependency, and item categorization.…”
Get full text

Premenstrual dysphoric disorder—an undervalued diagnosis? A cross-sectional study in Hungarian women by Boglárka Pataki, Bianka Luca Kiss, Sára Kálmán, Ildikó Kovács

“…Background: Premenstrual dysphoric disorder (PMDD) is a common but underdiagnosed mental health problem among women of reproductive age, which complicates women's daily lives with the presence of severe psychological symptoms altering everyday functioning. This study aimed to assess the prevalence of probable PMDD, the anxio-depressive symptom severity, and well-being in women affected by PMDD across the menstrual cycle. …”
Get full text

METHODS FOR THE TRAINING OF FUTURE IT SPECIALISTS IN STRATEGIC AND TACTICAL ACTIVITIES IN BUSINESS ORGANIZATIONS by Lavrentieva Olena, Krupskyi Oleksandr

“…The purpose of the article is to review and analyse the features of strategic and tactical activities in the functioning of IT specialists in a business organization, as well as the study of methodological foundations of the formation of tactical and strategic competence in future IT specialists, which will allow them to implement various measures of strategic planning and project work successfully. …”
Get full text

A clinical investigation of extracranial metastases in 17 cases of intracranial solitary fibrous tumors by Chao Wang, Jiang Li, Gang Li, Da-Yun Feng, Ying-Xi Wu, Jun-Ting Li, Di Yang, Jia-Hua Zhou

“…Mortality was attributed to functional failure of vital organs, tumor burden, systemic failure, or cachexia. …”
Get full text

Association of vascular stiffness and geriatric syndromes in hypertensive elderly patients by A. V. Luzina, N. K. Runikhina, O. N. Tkacheva, Yu. V. Kotovskaya

“…A comprehensive geriatric assessment was performed with functional and neuropsychological tests to identify geriatric syndromes. …”
Get full text

Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease by Wenjun Wang, Lanxiang Wu, Chao Ouyang, Tao Huang

“…Subsequently, a nomogram was developed to forecast the likelihood of developing COPD. In addition, functional enrichment analysis, immune infiltration, molecular regulatory network, and drug prediction were carried out. …”
Get full text