Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer by Xinya Jia, Qiang Zhang, Zhe Wang, Jianliang Cao, Anran Song, Chao Lan, Yuepeng Hu

“…Notably, GSTA4 expression was significantly reduced in PC tissues, and higher GSTA4 levels were linked to a favorable prognosis. In vitro functional analyses demonstrated that GSTA4 overexpression markedly inhibited PC cell proliferation and migration.ConclusionThe GSH metabolism-associated prognostic signature developed in this study effectively identifies high-risk patients with PC. …”
Get full text

Nomogram prediction of molecular characteristics in WHO grade 3–4 diffuse gliomas based on fractal analysis and VASARI features by Changyou Long, Dan Xu, Wenbo Sun, Weiqiang Liang, Jie Zhou, Shen Gui, Huan Li, Haibo Xu

Get full text

Carbohydrate metabolism parameters in angina patients treated with metoprolol and its combination with trimetazidine by E. V. Bochkareva, O. V. Aleksandrovich, P. Yu. Bardybakhin, E. K. Butina, N. G. Kucheryavaya, I. N. Ozerova, V. A. Metelskaya

“…In total, 28 men aged 46-68 years, with Functional Class (FC) II-III stable angina, positive exercise stress test (EST), and no prior β-AB therapy were examined. …”
Get full text

Defining Public Health Transformation: A Scoping Review by Violet Phooko, Kuhlula Maluleke, Sebueng Ramatsokotla, Thato Serite, Kabelo Kgarosi, Funeka Sokudela, Tivani Mashamba‐Thompson

“…ABSTRACT Public health transformation aims to instigate enduring changes in healthcare services, staff roles and patient involvement, fostering heightened satisfaction among patients and staff while bolstering financial sustainability. …”
Get full text

Effect of Controlled Hypotension by Esmolol Versus Remifentanil on Cerebral Oxygen Saturation in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Clinical Trial by Demet Altun, Serkan Ünsal, Levent Aydemir, Hakan Kara, Özlem Turhan, Ali Emre Çamcı

“…Objective: In this prospective, single blind-randomized study, we aimed to investigate the effect of controlled hypotension by esmolol vs. remifentanil on cerebral oxygen saturation (rSO2) by near-infrared spectroscopy (NIRS) in patients undergoing functional endoscopic sinus surgery (FESS).Material and Methods: One hundred fifty patients undergoing elective FESS under controlled hypotension were evaluated for study inclusion. …”
Get full text

Attitude of Healthcare Providers Towards Care of People with Disabilities, in Hail Region, Saudi Arabia by Saleh KA, Alrubaiee GG, Alqalah TAH, Almoliky MA, Alrashedi H, Alkubati SA, Ahmed WA

“…Khalil A Saleh,1 Gamil Ghaleb Alrubaiee,2 Talal Ali Hussein Alqalah,3 Mokhtar Abdu Almoliky,4 Habib Alrashedi,5 Sameer A Alkubati,6 Waled AM Ahmed7 1Department of Medical Surgical, College of Nursing, University of Ha’il, Hail, Saudi Arabia; 2Department of Community Health, College of Nursing, University of Ha’il, Hail, Saudi Arabia, and Department of Community Health and Nutrition, Al-Razi University, Sana’a, Yemen; 3Department of Medical Surgical Nursing, College of Nursing, University of Ha’il, Ha’il, Saudi Arabia and Nursing Division, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen; 4Medical Surgical Nursing Department; College of Nursing, University of Ha’il, Hail, Saudi Arabia, and Nursing Department; Faculty of Medicine and Health Sciences; Taiz University, Taiz, Yemen; 5Medical-Surgical Nursing Department, University of Hai’l, Hail, Saudi Arabia; 6Department of Medical Surgical Nursing, College of Nursing, University of Hail, Hail City, Saudi Arabia, and Department of Nursing, Faculty of Medicine and Health Sciences, Hodeida University, Hodeida, Yemen; 7Community Health Nursing Department, Faculty of Nursing, Al-Baha University, Al-Baha, Saudi ArabiaCorrespondence: Khalil A Saleh; Waled AM Ahmed, Email dr.khalil.aden@gmail.com; wahmed@bu.edu.saBackground: Disability, whether congenital or acquired, poses significant challenges that affect individuals’ physical, mental, psychological, and social functioning. This study aimed to examine the attitudes of healthcare providers in Hai’l City towards people with disabilities.Methods: A cross-sectional design was used, involving 321 healthcare providers from the Hai’l region, employing the Scale of Attitudes towards Disabled Persons (SADP) for data collection. …”
Get full text

Correlations between expression levels of genes encoding multifunctional YB-1 protein, inflammatory cytokines and multidrug resistance P-gp protein in surgical material from patien... by M. V. Erokhina, E. N. Pavlova, E. A. Scherbakova, E. Yu. Rybalkina, L. N. Lepekha, R. V. Tarasov, E. K. Tarasova

“…We suggest that the YB-1 protein can potentially have different functions: (1) being a participant in tuberculous inflammation via the cytokine expression; (2) modulating the P-gp activity and changing the pharmacokinetics of anti-tuberculosis drugs, thus requiring future studies.…”
Get full text

Deficit irrigation and biostimulation preconditioning to improve drought resistance in melon by Susana Zapata-García, Abdelmalek Temnani, Pablo Berríos, Pedro J. Espinosa, Claudia Monllor, Alejandro Pérez-Pastor

“…Therefore, the incorporation of plant biostimulation is proposed as a sustainable strategy to increase water productivity and enhance functional fruit quality.…”
Get full text

New Indicators of Myocardial Work in Healthy Individuals by V. E. Oleynikov, A. V. Babina, V. A. Galimskaya, A. V. Golubeva, K. N. Makarova, N. A. Donetskaya

“…Aim. To study in healthy individuals the gender and age characteristics of left ventricular (LV) myocardial work indicators, their correlations with global LV deformity indicators and echocardiographic parameters characterizing LV systolic and diastolic functions.Materials and methods. 70 Healthy individuals (n=70; 34 men and 36 women; aged 39.3±8.9 years) were included in the study. …”
Get full text

The Effect of Self-Esteem on Mobile Phone Addiction Among College Students: Sequential Mediating Effects of Online Upward Social Comparison and Social Anxiety by Zhang P, Wang M, Ding L, Liu J, Yuan Y, Zhang J, Feng S, Liu Y

“…This study aims to examine the relationship between self-esteem and mobile phone addiction in Chinese college students, exploring the chain mediation effects of online upward social comparison and social anxiety.Participants and Methods: A cross-sectional study was conducted using an offline questionnaire survey with 789 Chinese college students, employing convenience sampling in Shaanxi Province, China. …”
Get full text

Contrasting diversity and temporal patterns in leaf and root microbiome of two nearby temperate Zostera marina meadows by E. Teira, A. Díaz-Alonso, E. Fernández, M. Pérez-Lorenzo, E. Delgadillo-Nuño, C. Mendoza-Segura, J. Severino P. Ibánhez, P. Beca-Carretero

“…Abstract Background The Zostera marina microbiome plays a crucial role in meadow functioning and resilience. We aim at testing if the microbial communities of Z. marina leaves and roots exhibit distinct diversity and succession patterns associated to distinct environmental conditions and anthropogenic pressures. …”
Get full text

Antimicrobial peptides (AMPs) of lizards: a first comprehensive characterization of beta-defensins, ovo-defensins and cathelicidins from Podarcis lilfordi and closely related Lacer... by Katherin Otalora, Jessica Gómez-Garrido, Laura Baldo

“…The observed instances of peptide identity or similarity, along with the putative maintenance of specific polymorphisms across species, provide a basis for investigating the potential functional equivalence of these peptides among lizards and underscore the need for population-level studies of allele intraspecific diversity.…”
Get full text

Genome Selection and Genome-Wide Association Analyses for Litter Size Traits in Large White Pigs by Yifeng Hong, Xiaoyan He, Dan Wu, Jian Ye, Yuxing Zhang, Zhenfang Wu, Cheng Tan

“…(1) Background: Litter size traits are critical for pig breeding efficiency but pose challenges due to low heritability and sex-limited influences. This study aimed to elucidate the genetic architecture and identify candidate genes for these traits in Large White pigs using genomic selection (GS) and genome-wide association analyses (GWAS). (2) Methods: This study utilized phenotypic data from nine litter size traits in Large White sows. …”
Get full text

Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant... by Zhongqiang Fan, Zhao Wang, Hui Zhang, Hao Zhang, Rui Zhao, Shimiao Zhu, Xiaoqiang Liu

“…Abstract Background Dendritic cells (DCs) derived extracellular vesicles represent a promising vehicle for the activation of adaptive immunity, demonstrating significant potential in the development of cancer nanovaccines. The aim of this study was to evaluate the antitumor efficacy of a functional DCs-derived extracellular vesicles in castration-resistant prostate cancer. …”
Get full text

Mental health literacy among Jordanian nurses: a cross-sectional study and scale validation by Walid Al-Qerem, Anan Jarab, Judith Eberhardt, Fawaz Alasmari, Alaa Hammad, Amani Moh’d Ibrahim Alfarajat, Sarah Abu Hour, Lujain Al-sa’di, Rama AlKhateeb, Walaa Ashran

“…Rasch analysis confirmed proper item hierarchy and no significant gender-based differential item functioning. Cronbach’s α values exceeded 0.70 across all factors, supporting the scale’s reliability. …”
Get full text

Association of Forced Vital Capacity with the Developmental Gene NCOR2. by Cosetta Minelli, Charlotte H Dean, Matthew Hind, Alexessander Couto Alves, André F S Amaral, Valerie Siroux, Ville Huikari, María Soler Artigas, David M Evans, Daan W Loth, Yohan Bossé, Dirkje S Postma, Don Sin, John Thompson, Florence Demenais, John Henderson, SpiroMeta consortium, CHARGE consortium, Emmanuelle Bouzigon, Deborah Jarvis, Marjo-Riitta Järvelin, Peter Burney

“…Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes.…”
Get full text

Single-staged Surgical Correction of Kyphotic Deformity due to Dorsal Spinal Tuberculosis in Pediatric Patients: Outcome Analysis by Mageswaran Shanmugavelu, Makesh Ram Sriraghavan, Prabhu Aloy, Poornima Kumararaja, Sai Vinay Bharadwaj Namala

“…Results: All six cases had good radiological and functional outcomes in terms of kyphotic correction and neurological recovery. …”
Get full text

A theory-based analysis of the implementation of online asynchronous telemedicine platforms into primary care practices using Normalisation Process Theory by Cara Leighton, Natalie Joseph-Williams, Annavittoria Porter, Adrian Edwards, Alison Cooper

“…Widespread implementation of online platforms in primary care practices can be supported by policy-makers through consistent guidelines to improve platforms’ content, functionality and compatibility with clinical systems to try to enable improvements in practice. …”
Get full text

AI in Medical Questionnaires: Innovations, Diagnosis, and Implications by Xuexing Luo, Yiyuan Li, Jing Xu, Zhong Zheng, Fangtian Ying, Guanghui Huang

“… This systematic review aimed to explore the current applications, potential benefits, and issues of artificial intelligence (AI) in medical questionnaires, focusing on its role in 3 main functions: assessment, development, and prediction. …”
Get full text

Relationship between placental autophagy and inflammasome activities with morbidity of extremely preterm infants by Burak Deliloğlu, Funda Tüzün, Anıl Aysal, Nuray Duman, Hasan Özkan, Erdener Özer

“…The placenta is the major regulatory element of the in-utero environment, and alterations in placental cellular functions in infection, inflammation, and hypoxemia lead to adverse preterm birth outcomes. …”
Get full text