The Adjunctive Efficacy of Fuzheng Huayu Tablet on Portal Hypertension with HBV Related Cirrhosis: A Protocol for a Multicenter Randomized Controlled Trial by Li Z, Guo Y, Huang J, Lv J, Liu C

“…The secondary outcomes included grades of gastroesophageal varices (GEV), liver stiffness measurement, and liver functions. The safety of the testing medicines was also observed.Discussion: Through a multi-center, controlled clinical trial, with the main endpoints of liver decompensated events, we aim to evaluate the clinical efficacy and safety of anti-fibrotic product FZHY on PH in patients with HBV-caused cirrhosis.Trial Registration: Clinical Trials.gov, ID: NCT 02945956/02945982. …”
Get full text

Exploring the Anti-depression Mechanism of Polygonatum ordoratum Based on GEO Database Combined with Network Pharmacology and Molecular Docking Technology by Zhenxu JIANG, Chaoxing WANG, Yuliang WANG, Hong ZHAO, Yu SHEN, Shiqing SUN, Yongzhe MA, Mingming SONG, Yu ZHANG

“…Objective: This study aims to identify the potential targets and signaling pathways of the rhizome of Polygonatum odoratum (Yuzhu in traditional Chinese medicine) in the treatment of depression, through bioinformatics and network pharmacology, and to preliminarily explore its efficacy through PC12 cell experiments. …”
Get full text

The relationship between the composite dietary antioxidant index and rheumatoid arthritis risk in American adults: the mediating role of BMI by Tao Gao, Zhi-Yu Chen, Tao Li, Jian-Dong Tang, Xu Lin, Hai-Gang Hu, Sheng-Yu Wan, Chao Wu

“…Weighted multivariate logistic regression models, restricted cubic spline (RCS) functions, and subgroup analyses were employed to examine the association between CDAI levels and RA in American adults. …”
Get full text

Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis by Lijuan Feng, Kaiyong Bai, Limeng He, Hao Wang, Wei Zhang

“…Subsequently, the potential mechanisms of these biomarkers in RA were further explored using gene set enrichment analysis (GSEA), subcellular localization, chromosome localization, immune infiltration, functional analysis, molecular regulatory networks, drug prediction, and molecular docking. …”
Get full text

Effects of Dan Shen (Salvia miltiorrhiza) on blood pressure management in hypertensive patients: a randomized controlled trial by Pan Li, Zonghua Jiang, Linfei Dong, Shifeng Wang, Jiangli Qi, Longhong Zhu

“…QoL, assessed via SF-36, improved significantly, particularly in vitality (+20.9) and physical functioning (+18.6). Adverse events (AEs) were mild to moderate, mainly gastrointestinal discomfort and dizziness, and did not result in dropout. …”
Get full text

How do health problems affect the quality and everyday life of patients with endometriomas? by K. Chmaj-Wierzchowska, M. Wojciechowska, I. Parda, K. Plagens-Rotman, P. Rzymski, M. Wilczak

“…Introduction: The quality of human life is a subjective value and it largely depends on mental health, personality traits, preferences, and value system. This study aimed to discuss the incidence of health problems in patients with benign changes of reproductive organs (due to changes in the adnexa with the characteristics of endometrial cysts - endometriomas and other gynecological diseases, i.e. uterine myomas, other benign ovarian tumors), and influence of these problems with the daily functioning of the surveyed women. …”
Get full text

Partial replacement of high-fibre forages with corn silage across the lactation cycle: effects on methane emission, rumen fermentation and efficiency in dairy cows by M. Eslamizad, M. Schmicke, H. Sauerwein, B. Kuhla

“…After calving, cows with a divergent breeding value for functional herd life were equally allocated to a lactation diet containing forage (66% of DM) of either low (LCS; 31.1% DM) or high corn silage (HCS; 37.7% DM) proportion. …”
Get full text

Analyzing special needs reports for children: sociodemographic trends, diagnoses, and support areas over five years (2019–2024) by Semih Canpolat, Mehmet Emin Parlak, Esra Kurt Canpolat, Erdogan Oz

“…When the areas of Specific Learning Disabilities (SLD) were analyzed, it was determined that the highest rate was in the area of rehabilitation/early support (intervention) requirement to support cognitive functions with 43.1%. When the special needs levels were analyzed according to the disease areas, the highest rate was found in 13 areas except for the Nephrology area and Genitourinary System-Surgery Area was SCRN. …”
Get full text

Content of CD4⁺T cell subpopulations in predicting the efficacy of biological therapy for psoriasis in children by D. G. Kuptsova, T. V. Radigina, O. V. Kurbatova, A. I. Materikin, R. V. Epishev, L. A. Opryatin, A. A. Khotko, N. N. Murashkin, S. V. Petrichuk

“…The aim of the study was to evaluate the content of T helper subpopulations in prognosis of effectiveness of biologics in children with psoriasis. …”
Get full text

Algorithm for selecting predictors and prognosis of atrial fibrillation in patients with coronary artery disease after coronary artery bypass grafting by B. I. Geltser, K. I. Shakhgeldyan, V. Yu. Rublev, B. O. Shcheglov, E. A. Kokarev

“…Aim. To develop an algorithm for selecting predictors and prognosis of atrial fibrillation (AF) in patients with coronary artery disease (CAD) after coronary artery bypass grafting (CABG).Material and methods. …”
Get full text

Analysing length of stay disparities in inpatient forensic psychiatric care: a cross-sectional study in Czechia by Marek Páv, Ondřej Vaníček, Jiří Závora, Jaroslav Pekara, Michaela Zahrádka-Kȍhlerová, Simona Papežová, Martin Anders

“…Abstract Background Length of stay (LoS) is a critical parameter of inpatient forensic treatment functioning. Inpatient forensic LoS in Czechia varies across hospitals with the number of patients per 100,000 inhabitants and the treatment duration. …”
Get full text

A Digital Mental Health Solution to Improve Social, Emotional, and Learning Skills for Youth: Protocol for an Efficacy and Usability Study by Kayla V Taylor, Laurent Garchitorena, Carolina Scaramutti-Gladfelter, Mykayla Wyrick, Katherine B Grill, Azizi A Seixas

“…Following this, in phase 2, school administrators and teachers undergo intensive training sessions on Neolth’s functionalities and intervention processes as well as understand barriers and facilitators of implementing a digital mental health program at their respective schools. …”
Get full text

The Outcomes of Delayed Revascularization in Lower Extremity Vascular Injury: A Retrospective Cohort Study by Chai KS, Faisham WI, Wan-Sulaiman WA, Rosli MA, Mat-Saad AZ, Jusoh MH, Paiman M, Halim AS

“…Introduction: There is no consensus yet whether delayed limb salvage procedures with an “ischemic time” of more than 6 hours are worthwhile, as these repairs are often complicated by reperfusion injury. Our study aims to determine the outcomes of delayed revascularization to validate our current treatment approach and assess areas for future improvement. …”
Get full text

The impact of urbanization on land use land cover change using geographic information system and remote sensing: a case of Mizan Aman City Southwest Ethiopia by Addis Bikis, Muluye Engdaw, Digvijay Pandey, Binay Kumar Pandey

“…Deforestation for urban functions, including timber production, construction materials, and firewood, adversely affects the environment. …”
Get full text

Impact of periprocedural factors on revascularization success and good clinical outcomes in anterior circulation stroke patients treated with mechanical thrombectomy by M. Kurminas, A. Berūkštis, N. Misonis, A. E. Tamošiūnas, D. Jatužis

“…The primary outcome was functional independence after 90 days (modified Rankin scale 0-2). …”
Get full text

Enhancing selective itaconic acid synthesis in Yarrowia lipolytica through targeted metabolite transport reprogramming by Cosetta Ciliberti, Zbigniew Lazar, Kacper Szymański, Evgeniya Yuzbasheva, Tigran Yuzbashev, Ivan Laptev, Luigi Palmieri, Isabella Pisano, Gennaro Agrimi

“…For the first time, complete gene set of the itaconate biosynthetic pathways from both fungal species were functionally expressed and compared in a yeast system with a similar genetic background. …”
Get full text

CITED2 Mediates Metabolic Reprogramming in Renal Tubular Epithelial Cells via the AKT Signaling Pathway to Induce Sepsis-Associated Acute Kidney Injury by Deng R, Yang H, Zhong W, Zhou J, Huang G, Zeng K

“…CITED2 silencing and overexpression were employed to elucidate its regulatory role, focusing on the AKT signaling pathway.Results: S-AKI causes structural and functional kidney damage, aggravated inflammatory responses, and dysregulated glucose metabolism, accompanied by increased expression of CITED2. …”
Get full text

ANALISIS STAKEHOLDERS DALAM PENGEMBANGAN PROGRAM DIKLAT DI BALAI DIKLAT APARATUR KEMENTERIAN KELAUTAN DAN PERIKANAN STAKEHOLDERS ANALYSIS IN DEVELOPMENT OF TRAINING PROGRAM ON TRAI... by Yudistira Adi Nugroho

“…One of the contributing factors is the development of training programs in both technical training and functional training have not been fully implemented. …”
Get full text

Vasoreactive testing prevalence and characteristics in patients with idiopathic pulmonary arterial hypertension by Goncharova Natalia, Kirill Lapshin, Aelita Berezina, Irina Zlobina, Anton Ryzhkov, Zhaneta Matakaeva, Elizaveta Andreeva, Olga Moiseeva

“…INTRODUCTION: The choice of treatment strategy in patients with idiopathic pulmonary arterial hypertension (IPAH)/HPAH/DPAH (Hereditary pulmonary arterial hypertension/ Drug-induced pulmonary arterial hypertension) II-III functional class (FC) (WHO) based on an acute vasoreactive testing result (VRT). …”
Get full text

Soil enzyme activities and health indicator characteristics in furrow‐irrigated and flooded rice production systems by Aziz Ahmed, Jim J. Wang, Manoch Kongchum, Dustin L. Harrell, Nutifafa Adotey, Md Ali Haider, Lewis Gaston, Changyoon Jeong

“…Despite FIR's growing adoption, its impacts on soil biological functioning and nutrient cycling remain poorly understood, limiting the ability to optimize management practices for this emerging system. …”
Get full text