Health-Related Quality of Life and Fatigue in Children with Pompe Disease by Linda E. Scheffers, Karolijn Dulfer, PhD, Charlotte Lanser, Maarten Mackenbach, MD, Ans T. van der Ploeg, MD, PhD, Johanna M.P. van den Hout, MD, PhD, Linda E. van den Berg, MD, PhD

“…Objective: Pompe disease is an inheritable metabolic myopathy caused by the deficiency of the lysosomal enzyme acid-⍺-glucosidase. The aim of this study was to investigate self-reported and parent-reported health related quality of life (HR-QOL) and fatigue in children with Pompe disease. …”
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Effects of dietary crude protein on antioxidant activity, immunocompetence and the structural properties of the rumen in tibetan sheep (Ovis aries), as determined by transcriptomic... by Zhenling Wu, Fengshuo Zhang, Quyangangmao Su, Qiurong Ji, Kaina Zhu, Tingli He, Xuan Chen, Yu Zhang, Jiacheng Gan, Wei Gao, Xianhua Zhang, Geerli Saren, Shengzhen Hou, Linsheng Gui

“…In conclusion, an 11.58% crude protein diet enhanced papillary development and antioxidant activity in Tibetan sheep, likely by modulating the expression of functional genes.…”
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Predictors for quantitative flow ratio loss in patients with de novo coronary artery disease treated with drug-coated balloons by Yunhui Zhu, Tianli Hu, Qianqian Bian, Yufei Chen, Tianping Zhou, Jing Li, Guosheng Fu, Wenbin Zhang, Xulin Hong

“…The aim of this study was to explore the factors affecting QFR loss in patients with de novo lesion after DCB-angioplasty. …”
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Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study by Misbah Unnisa, Mahya Faghih, Asbjørn Mohr Drewes, Vikesh K. Singh, Dhiraj Yadav, Rupjyoti Talukdar, Søren Schou Olesen, Anna Evans Phillips

“…Background and Aims: Chronic pancreatitis (CP) is a disease that is present in multiple different geographic populations and is treated similarly around the world. …”
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Barriers and facilitators to maternal death surveillance and response at a busy urban National Referral Hospital in Uganda [version 2; peer review: 2 approved] by Jolly Beyeza-Kashesya, Dan K.Kaye, Joseph Rujumba, Noah Kiwanuka, Moses Mukuru, Imelda Namagembe, Annettee Nakimuli, Josaphat Byamugisha, Ashley Moffett

“…Major facilitators were involving all health workers in the MDSR process, eliminate blame, strengthen leadership, implement recommendations from MDSR and functionalize lower health facilities (especially Health Centre -IVs). …”
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Markers of Inflammation and Hypofibrinolysis Are Associated with Cognitive Dysfunction and Motor Performances in Atrial Fibrillation Patients on Oral Anticoagulant Therapy: Insight... by Francesco Alfano, Francesca Cesari, Anna Maria Gori, Martina Berteotti, Emilia Salvadori, Betti Giusti, Alessia Bertelli, Filippo Fratini, Angela Rogolino, Benedetta Formelli, Francesca Pescini, Enrico Fainardi, Eleonora Barucci, Giulia Salti, Arianna Cavaliere, Andrea Ginestroni, Rossella Marcucci, Anna Poggesi

“…Population studies have also suggested an association between AF and cognitive impairment and dementia. The aim of this study is therefore to assess, in a population of AF patients on oral anticoagulant therapy, the association between circulating biomarkers involved in the pathogenesis of AF and the cognitive and motor performances of the enrolled patients. …”
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Extraction of fermentable sugars and phenolic compounds from Colombian cashew (Anacardium occidentale) nut shells using subcritical water technology: Response surface methodology a... by Luis J. Cruz-Reina, Jader Rodríguez-Cortina, Fabrice Vaillant, Israel Herrera-Orozco, Chiara Carazzone, Rocío Sierra

“…The resulting hydrochar comprised lignin (58.82 ± 3.44 %) and structural carbohydrates (approximately 40 %), showing thermal stability up to 200 °C, OH functional groups on its surface, and a textured morphology under microscopy. …”
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Home-based self-administered transcranial direct current stimulation for women affected by primary dysmenorrhoea in Northeastern Brazil: a protocol study by Thiago Anderson Brito De Araújo, Edson Silva-Filho, Rodrigo Pegado, Tatiana Camila de Lima Alves da Silva, Yvinna Tamiris Rodrigues, Paloma Cristina Alves de Oliveira, Ervinas Bernatavicius, Alexander Anthony Cook, Emilè Radytè, Maria Thereza Micussi

“…In this sense, strategies focused on the central nervous system are important to re-establish normal functioning. Home-based self-administered transcranial direct current stimulation (tDCS) emerges as a strategy to modulate dysfunctional brain areas and improve the symptoms. …”
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Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior by Elena Martin-Garcia, Laura Domingo-Rodriguez, Beat Lutz, Rafael Maldonado, Inigo Ruiz de Azua

“…Methods: We applied a genetic strategy to reconstitute cannabinoid type-1 receptor (CB1) expression at functional levels specifically in CaMKII+ neurons (CaMKII-CB1-RS) and adipocytes (Ati-CB1-RS), respectively, in a CB1 deficient background. …”
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Relaxin mimetic in pulmonary hypertension associated with left heart disease: Design and rationale of Re‐PHIRE by Marcin Ufnal, Kathleen Connolly, Marcus Millegard, Elena Surkova, Marco Guazzi, Diana Bonderman, Justin Ezekowitz, Finn Gustafsson, Michał Ciurzyński, Raquel López Vilella, Tariq Ahmad, Roy Gardner, Pavel Jansa, Sandra vanWijk, Koichiro Kinugawa, Erik Björklund, Zhi‐Cheng Jing, Stephan Rosenkranz

“…AZD3427 is a functionally selective, long‐acting mimetic of relaxin, a hormone that has the potential to induce vasodilation and prevent fibrosis. …”
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Proteomics signatures associated with hip arthropathy in ankylosing spondylitis by Xianghui Wen, Xianghui Wen, Linkai Fang, Zena Chen, Dong Liu, Shenghui Wen, Jinwei Li, Qiuxia Li, Qiujing Wei, Shuangyan Cao, Peng Zhang, Jieruo Gu, Jieruo Gu

“…While persistent inflammation is a hallmark of AS, the molecular mechanisms driving hip involvement remain poorly characterized. This study aimed to identify and validate protein biomarkers associated with hip arthropathy progression in AS through integrated proteomic and functional analyses.MethodsLiquid chromatography-mass spectrometry (LC–MS/MS) was employed to screen for differentially abundant proteins (DAPs) in hip joint tissues from 30 AS patients and 14 non-AS controls. …”
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Antioxidant activities of sea buckthorn polysaccharides and their potential application in cosmetic industry by Hao Wang, Na Cheng, Qingyuan Wu, Danjiao Fang, Faiz-Ur Rahman, Huifang Hao, Yongmin Zhang

“…Conclusion: These results showed that sea buckthorn polysaccharide has certain antioxidant activity; therefore, sea buckthorn polysaccharide has a strong potential to be applied in antioxidant and anti-aging functional cosmetics.…”
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Tumor-derived exosomal lncRNA SNHG4 promotes triple-negative breast cancer progression by targeting XPO5 by Zhi-Wen Wang, Zhi-Wen Wang, Hou-Sheng Yang, Hong-Shan Guo, Yue-Ying Li, Jin-Yun Zhong, Shu Jiang, Jia-Peng Li, Zhong-Yi Yang, Chuan-Yi Zhou, Jun Wang, Xing-Hua Liao, Lei Mao

“…RNA-seq results were supported by bioinformatics analysis and Western blot analysis. Functional assays including in vivo tumor formation, Colony formation Assay, Scratch migration and transwell assays were performed to study exosomes related phenomena and mechanism.ResultsSerum-derived exosomes from patients with TNBC can induce TNBC progression in vitro and in vivo. lncRNA SNHG4 was most significantly up-regulated in exosomes, and overexpression of lncRNA SNHG4 significantly promoted the proliferation and migration of TNBC cells. …”
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Identification of gastroenteropancreatic neuroendocrine tumor patients with high liver tumor burden based on clinicopathological features by Nuerailaguli Jumai, Luohai Chen, Xiaoxuan Lin, Qiao He, Man Liu, Yuan Lin, Yanji Luo, Yu Wang, Min-hu Chen, Xiangsong Zhang, Zhirong Zeng, Ning Zhang

“…Abstract Background Metastatic liver tumor burden (LTB) is a prognostic factor affecting the survival of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), but evaluation of the LTB usually depends on radiologic and functional imaging. This study aimed to develop a clinical model based on easily accessible clinicopathological markers to predict LTB level in GEP-NET patients. …”
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Bindarit attenuates neuroinflammation after subarachnoid hemorrhage by regulating the CCL2/CCR2/NF-κB pathway by Yanting Yao, Qiaowei Wu, Kaikun Yuan, Pei Wu, Chao Xu, Zhiyong Ji, Weishi Xu, Hongli Yu, Anyu Xu, Yanchen Liu, Huaizhang Shi

“…Bindarit improved neurological functions and reduced neuroinflammation by regulating the CCL2/CCR2/NF-κB pathway in early brain injury after SAH.…”
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Supramolecular nanofibers of natural asiaticoside for self-supporting gelation and enhanced transdermal delivery by Xixi Hu, Shuang Tian, Jiao Wang, Weixi Luo, Jiangli Yao, Rui Zhu, Yiyuan Dai, Hongyun Li, Yuhua Ma, Chen Liu, Wenping Wang

“…The hydrogel’s dual functionality (pH-responsive gelation and enhanced permeation) offers a sustainable platform for the transdermal delivery of hydrophobic phytochemicals, bridging phytochemistry and nanobiotechnology. …”
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Healing through faith: Meeting a chaplain coupled with biblical readings could produce lymphocyte changes that correlate with brain activity (HEALING study) [version 5; peer review... by András Béres, Csaba Aranyi, Miklós Emri, Éva Perpékné Papp, Edit Hörcsik, Márta Kuti, Ferenc Tomanek, Ferenc Nagy, Dániel Fajtai, Pál Bödecs, Péter Szabó, Eszter Vinczen, Bettina Bakos, Renáta Sillinger, Eszter Gál, Hajnalka Kisdeákné, Ágnes Petőfalviné, Dániel Kovács, Gergely Bíró, Tamás Németh, Judit Fodor, Imre Repa, Erzsébet Papp, Antal Szilágyi, Zoltán Szalai, György Nagyéri, Marianna Kiss-Merki

“…A subgroup of the visited patients was subjected to functional magnetic resonance imaging (fMRI), during which they listened to an audiotape of readings of the same biblical passage (n = 21). …”
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Placental markers of miscarriage by A. A. Zhyvetska-Denysova, I. I. Vorobiova, N. Ya. Skrypchenko, S. M. Tolkach, S. M. Razdaibedin, Yu. M. Bondarenko

“…The markers of inflammation and premature labor are structural and functional changes of placenta in combination with moderate expression of TNF-α in syncytium, high expression of NK-CD56 in villous stroma, high expression of CD45/T200/LCA in the decidual membrane.…”
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Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis by Hui Lian, Kai Xu, Airu Chang, Yaxuan Wang, Shuaichen Ma, Lianhui Cheng, Wenyu Zhao, Cong Xia, Lan Wang, Guoying Yu

“…This study aimed to investigate the role of PTPN21 in lung fibrosis. …”
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Predictive biomarkers for cardiometabolic risk in postmenopausal women: insights into visfatin, adropin, and adiponectin by Anna Maria Cybulska, Daria Schneider-Matyka, Ireneusz Walaszek, Mariusz Panczyk, Dorota Ćwiek, Anna Lubkowska, Elżbieta Grochans, Kamila Rachubińska, Katarzyna Malewicz, Mariusz Chabowski, Mariusz Chabowski

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