Prevalence and Mortality of Heart Failure Stages in a Free‐Living Older Adult Population: Data From the Brazilian Longitudinal Study of Adult Health by Altair I. Heidemann, Angela B. S. Santos, Marcio S. Bittencourt, Antonio L. P. Ribeiro, Luis E. Rohde, Paulo A. Lotufo, Bruce B. Duncan, Murilo Foppa

“…There are scarce data on HF staging from longitudinal studies in Latin America. This study aimed to determine the prevalence and mortality of HF stages in a Brazilian adult cohort of participants 60 years old and over. …”
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Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain’s reward center by Tien S. Dong, Michelle Guan, Emeran A. Mayer, Jean Stains, Cathy Liu, Priten Vora, Jonathan P. Jacobs, Venu Lagishetty, Lin Chang, Robert L. Barry, Arpana Gupta

“…Whole brain resting state functional MRI was acquired, and connectivity and brain network properties were calculated. …”
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Insights into the human cDNA: A descriptive study using library screening in yeast by Zina Alaswad, Nayera E. Attallah, Basma Aboalazm, Eman S. Elmeslhy, Asmaa S. Mekawy, Fatma A. Afify, Hesham K. Mahrous, Ashrakat Abdalla, Mai A. Rahmoon, Ahmed A. Mohamed, Ahmed H. Shata, Rana H. Mansour, Fareed Aboul-ela, Mohamed Elhadidy, Biola M. Javierre, Sherif F. El-Khamisy, Menattallah Elserafy

“…The utilization of human cDNA libraries in yeast genetic screens is an approach that has been used to identify novel gene functions and/or genetic and physical interaction partners through forward genetics using yeast two-hybrid (Y2H) and classical cDNA library screens. …”
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Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy by Anna K. Tobiasch, Georg F. Lehner, Clemens Feistritzer, Andreas Peer, Birgit Zassler, Viktoria M. Neumair, Sebastian J. Klein, Michael Joannidis

“…Only EV-associated and functionally active TF and not TF antigen levels showed a predictive potential regarding DIC. …”
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Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions by Aikaterini Sakagianni, Christina Koufopoulou, Petros Koufopoulos, Sofia Kalantzi, Nikolaos Theodorakis, Maria Nikolaou, Evgenia Paxinou, Dimitris Kalles, Vassilios S. Verykios, Pavlos Myrianthefs, Georgios Feretzakis

“…These techniques were applied to identify clusters based on gene length and distribution according to resistance class, offering insights into the resistance genes’ structural and functional properties. Data preprocessing, such as filtering and normalization, was conducted prior to applying machine learning methods to ensure consistency and accuracy. …”
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IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression by Hui Wang, Hui Wang, Jirui Li, Yinghai Wang, Yang Chen, Yang Chen, Weifeng Zhang, Xinyan Pan, Xinyan Pan, Chanjuan Su, Ziteng Li, Li Wang, Li Wang, Jiang Gu, Jiang Gu

“…Tertiary lymphoid structures (TLS) in the TME have important immune-related functions. This study aims to analyze the distribution characteristics of IgG4-expressing cells, regulatory T cells (Tregs), and M2-type macrophages as well as to elucidate the relationship between IgG4 and the polarization of M2 macrophages within TLS in esophageal cancer.ObjectTo elucidate the distribution of IgG4, Treg cells, and M2 macrophages in TLS and to assess the impact of IgG4 on macrophage polarization.MethodsEsophageal cancer tissue were analyzed with multiplex immunofluorescence to determine the spatial distribution and density of B cells, T cells, and their subtypes. …”
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Coping styles and quality of life in oral cancer patients undergoing radical resection and free flap reconstruction by Kento Kaminogo, Satoshi Yamaguchi, Tatsuya Tokura, Hiroyuki Kimura, Shinichi Kishi, Noriyuki Yamamoto, Norio Ozaki, Hideharu Hibi

“…Objective: Oral cancer is associated with functional impairment and changes in appearance due to disease progression and/or treatment. …”
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Robotic assisted anatrophic nephrotomy “oyster-pearl extraction technique” for deep and centrally located endophytic renal mass by Mahendra Pal, Amandeep Arora, Ankit Misra, Ajit Gujela, Uday Chandankhede, Manoj Tummala, Sugam Godse, Ganesh Bakshi, Santosh Menon, Gagan Prakash

“…Conclusion: Robotic-assisted ‘Oyster-pearl extraction technique’ via anatrophic nephrotomy offers a promising approach to manage centrally endophytic renal masses in patients with or without comorbidities with preservation of functional renal parenchyma, swift post-operative recovery along with accepted oncological outcome.…”
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The impact of indoor and outdoor exercise programs on anthropometric, body composition, metabolic status, cardiovascular response, and neuromuscular capacity in individuals with In... by Miguel Jacinto, Rui Matos, Diogo Monteiro, Raul Antunes, André Caseiro, Beatriz Gomes, Maria João Campos, José Pedro Ferreira

“… The increase in overweight and obesity among individuals with Intellectual and Developmental Disabilities (IDD) also increases the deterioration of functionality and the risk of developing chronic diseases. …”
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A genome-wide association study of adults with community-acquired pneumonia by Eva Suarez-Pajes, Itahisa Marcelino-Rodriguez, Elisa Hernández Brito, Silvia Gonzalez-Barbuzano, Melody Ramirez-Falcon, Eva Tosco-Herrera, Luis A. Rubio-Rodríguez, María Luisa Briones, Olga Rajas, Luis Borderías, Jose Ferreres, Antoni Payeras, Leonardo Lorente, Javier Aspa, Jose M. Lorenzo Salazar, José Manuel Valencia-Gallardo, Nieves Carbonell, Jorge L. Freixinet, Felipe Rodríguez de Castro, Jordi Solé Violán, Carlos Flores, Carlos Rodríguez-Gallego

“…Subsequently, we prioritized genes and likely causal variants based on Bayesian fine mapping and functional evidence. Imputation and association of classical HLA alleles and amino acids were also conducted. …”
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Inhibitory Effects of Genistein on Vascular Smooth Muscle Cell Proliferation Induced by Ox-LDL: Role of BKCa Channels by Bing Bai, Nanjuan Lu, Wei Zhang, Jinghan Lin, Tingting Zhao, Shanshan Zhou, Elona Khasanova, Liming Zhang

“…Large-conductance calcium-activated potassium (BKCa) channels are the primary type of potassium channels in VSMCs, which regulate various biological functions of VSMCs. However, whether genistein exerts an antiproliferation effect on Ox-LDL-stimulated VSMCs remains unclear. …”
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Integrating multi-omics techniques and in vitro experiments reveals that GLRX3 regulates the immune microenvironment and promotes hepatocellular carcinoma cell proliferation and in... by Yang Li, Yuan Chen, Yuan Chen, Yang Zhang, Yunsheng Fang, Yunsheng Fang, Ling Wu, Ying Zhao, Danqiong Wang, Xiaoyuan Qiao

“…By cell communication analysis as well as GO and KEGG enrichment analysis, we determined the functional role of iron metabolism in different cell types. …”
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Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension by Claudia Desireé Norzagaray-Valenzuela, Claudia Desireé Norzagaray-Valenzuela, Marco Antonio Valdez-Flores, Josue Camberos-Barraza, Josue Camberos-Barraza, Alberto Kousuke De la Herrán-Arita, Juan Fidel Osuna-Ramos, Javier Magaña-Gómez, Carla Angulo-Rojo, Alma Marlene Guadrón-Llanos, Katia Aviña-Padilla, Loranda Calderón-Zamora

“…Functional enrichment analyses were conducted to elucidate biological processes associated with disease-specific modules.ResultsWe identified distinct regulatory modules: ME3 in T2DM, enriched in metabolic stress response, intracellular trafficking, and inflammation, and ME7 in HTN, enriched in immune response and vascular remodeling. …”
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Prevalence and clinical significance of loneliness in older patients admitted to acute hospital wards by Gloria Brombo, Paola Guindani, Dario Pedrini, Giovanni Lorenzo Squintani, Barbara Carrieri, Massimiliano Fedecostante, Giuseppina Dell’Aquila, Flaminia Lucchini, Andrea Ungar, Enrico Mossello, Antonio Cherubini, Giovanni Zuliani

“…Objective: Loneliness represents a risk factor for morbidity and mortality. We aimed to evaluate the prevalence of loneliness among hospitalized older patients, and its association with baseline characteristics and clinical post-discharge outcomes. …”
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Prevalence of Anxiety and Depressive Disorders in a Sample of Moscow Residents: Comparison of the GAD-7 and HADS Results with a Clinical Assessment by Valeriya I. Savenkova, Yana A. Zorkina, Alexandra G. Ochneva, Angelina I. Zeltzer, Darya A. Ryabinina, Anna M. Tsurina, Elizaveta A. Golubeva, Anna S. Goncharova, Irina V. Alekseenko, George P. Kostyuk, Anna Yu. Morozova

“…Detecting a disorder at an early stage can prevent the development of severe disorders and preserve the patient’s functioning ability. Simple and reliable screening tools based on self-completion of questionnaires can be used for this purpose. …”
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Nutrition and Antioxidant Potential of Three Cauliflower (Brassica oleracea L. Var. Botrytis) Cultivars Cultivated in Southern Part of Bangladesh by Mousumi Jahan Sumi, Sharmin Akter Serity, Tusar Kanti Roy, Keya Akter, Shishir Rasul, Mostofa Jaman Depro, Md. Masum Abdullah, Md. Nesar Uddin

“…The findings highlight the potential of Carotena and Valentena for health-conscious consumers seeking nutrient-rich, antioxidant benefits in functional meals.…”
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Network Pharmacology Approaches to Myocardial Infarction Reperfusion Injury: Exploring Mechanisms, Pathophysiology, and Novel Therapies by Joy Das, Ashok Kumar Sah, Ranjay Kumar Choudhary, Rabab H. Elshaikh, Utpal Bhui, Shreya Chowdhury, Anass M. Abbas, Manar G. Shalabi, Nadeem Ahmad Siddique, Raji Rubayyi Alshammari, Navjyot Trivedi, Khoula Salim Ali Buwaiqi, Said Al Ghenaimi, Pranav Kumar Prabhakar

“…Post-reperfusion recovery is further complicated by structural and functional abnormalities such as microvascular obstruction, endothelial dysfunction, and myocardial stunning. …”
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Surgical management and postoperative outcomes of orbital cavernous malformations: A systematic literature review by the EANS skull base section by Edoardo Agosti, Vittorio Ricciuti, Giorgio Mantovani, Giorgia De Rosa, Pier Paolo Panciani, Marco Maria Fontanella, Cesare Zoia, Moncef Berhouma, Michaël Bruneau, Luigi Maria Cavallo, Jan Frederick Cornelius, Sebastien Froelich, Emmanuel Jouanneau, Diego Mazzatenta, Torstein R. Meling, Mahmoud Messerer, Dimitris Paraskevopoulos, Pierre-Hugues Roche, HenryWS. Schroeder, Marcos Tatagiba, Idoya Zazpe, Roy Thomas Daniel

“…Complications were infrequent: visual acuity worsening (3.9 %), diplopia (2.4 %), and enophthalmos (1.7 %). Functional outcomes improved significantly, particularly visual acuity (65.1 %) and proptosis (61.6 %). …”
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Impact of the Use of 2-Phospho-L Ascorbic Acid in the Production of Engineered Stromal Tissue for Regenerative Medicine by David Brownell, Laurence Carignan, Reza Alavi, Christophe Caneparo, Maxime Labroy, Todd Galbraith, Stéphane Chabaud, François Berthod, Laure Gibot, François Bordeleau, Stéphane Bolduc

“…However, AA is chemically unstable in culture, with a half-life of 24 h, requiring freshly prepared AA with each change of medium. This study aims to demonstrate the functional equivalence of 2-phospho-L-ascorbate (2PAA), a stable form of AA, for tissue reconstruction. …”
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Enhanced glucose metabolism mediated by CD147 is associated with 18F‐FDG PET/CT imaging in lung adenocarcinoma by Yufan Zhang, Jianjing Liu, Yunchuan Sun, Xiaozhou Yu, Jian Wang, Dong Dai, Yanjia Zhu, Xiuyu Song, Lei Zhu, Xiaofeng Li, Wengui Xu

“…Reprogrammed glycolytic metabolism is a hallmark of cancer cells and significantly affects several cellular functions. In the current study, we aimed to investigate cluster of differentiation 147 (CD147)‐mediated glucose metabolic regulation in LUAD and its association with 18F‐FDG PET/CT imaging. …”
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