The DEXA-CORT trial: study protocol of a randomised placebo-controlled trial of hydrocortisone in patients with brain tumour on the prevention of neuropsychiatric adverse effects c... by Elisabeth F C van Rossum, Amir H Zamanipoor Najafabadi, Wouter A Moojen, Nienke R Biermasz, Wouter R van Furth, Onno C Meijer, Clemens M F Dirven, Anne-Sophie C A M Koning, Djaina D Satoer, Christiaan H Vinkers, Rishi D S Nandoe Tewarie, Alberto M Pereira

“…Secondary outcomes are neuropsychiatric symptoms, quality of sleep, health-related quality of life and neurocognitive functioning at several time points postoperatively. …”
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Machine learning-based prediction model for lung ischemia-reperfusion injury: insights from disulfidptosis-related genes by Yanpeng Zhang, Yanpeng Zhang, Yanpeng Zhang, Jingyang Sun, Jingyang Sun, Jingyang Sun, Yihan Lin, Yihan Lin, Yihan Lin, Rongxuan Jiang, Rongxuan Jiang, Rongxuan Jiang, Niuniu Dong, Niuniu Dong, Niuniu Dong, Huanhuan Dong, Huanhuan Dong, Huanhuan Dong, Peng Li, Peng Li, Peng Li, Jinteng Feng, Jinteng Feng, Jinteng Feng, Zijiang Zhu, Guangjian Zhang, Guangjian Zhang, Guangjian Zhang

“…Differential expressed analysis and functional enrichment analysis were conducted to identify key genes associated with lung transplant IRI. …”
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Genome-Wide Analysis of the EIN3/EIL Transcription Factors in <i>Osmanthus fragrans</i> and Their Stress Response to Azacytidine (AZA) and Ethylene (ETH) Treatment by Dou Pan, Chun Xu, Wanlu Ma, Xinyi Zhu, Qiangjun Yu, Yingting Zhang, Jie Yang, Xiangling Zeng, Xuan Cai, Jingjing Zou

“…Strikingly, <i>OfEIL7</i> exhibited dual regulatory roles, correlating strongly with natural flowering progression, AZA-induced demethylation, and ETH responses. Functional divergence was observed in petal senescence, with <i>OfEIL2–5</i> and <i>OfEIL7–9</i> showing stage-specific and tissue-specific expression patterns. …”
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CRISPR/Cas9-mediated simultaneous targeting of GmP34 and its homologs produces T-DNA-free soybean mutants with reduced allergenic potential by Dongwon Baek, Byung Jun Jin, Mi Suk Park, Ye Jin Cha, Tae Hee Han, Ye Na Jang, Su Bin Kim, Sang In Shim, Jong-Il Chung, Hyun Jin Chun, Min Chul Kim, Min Chul Kim, Min Chul Kim

“…Gene expression profiling revealed similar expression patterns of all three genes during seed maturation, indicating potential functional redundancy. Two multiplex CRISPR/Cas9 constructs were designed to simultaneously target GmP34/GmP34h1 and GmP34/GmP34h1/GmP34h2 genes, respectively. …”
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Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice by Dilpreet Kour, Dilpreet Kour, Parul Khajuria, Parul Khajuria, Kuhu Sharma, Kuhu Sharma, Alpa Sharma, Alpa Sharma, Ankita Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, P. Ramajayan, P. Ramajayan, Sanghapal D. Sawant, Sanghapal D. Sawant, Sanghapal D. Sawant, Utpal Nandi, Utpal Nandi, Zabeer Ahmed, Zabeer Ahmed, Ajay Kumar, Ajay Kumar

“…Background and AimAlzheimer’s disease (AD) progresses with Aβ plaque deposition and neuroinflammation. …”
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The outcomes of salvage robotic radical prostatectomy following radiation versus focal therapy: Does the primary treatment modality matter? by Alireza Ghoreifi, Lorenzo Storino Ramacciotti, Masatomo Kaneko, Luis G. Medina, Giovanni E. Cacciamani, Shiran Konganige, Manju Aron, Sarmad Sadeghi, Hossein Jadvar, Hooman Djaladat, Rene Sotelo, Mihir M. Desai, Inderbir S. Gill, Monish Aron, Andre Luis Abreu

“…Perioperative findings and functional/oncologic outcomes were compared in RT versus FT groups. …”
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Identification and validation of efferocytosis-related biomarkers for the diagnosis of metabolic dysfunction-associated steatohepatitis based on bioinformatics analysis and machine... by Chenghui Cao, Chenghui Cao, Wenwu Liu, Xin Guo, Shuwei Weng, Yang Chen, Yonghong Luo, Shuai Wang, Botao Zhu, Botao Zhu, Yuxuan Liu, Yuxuan Liu, Daoquan Peng

“…This analysis was followed by a series of in-depth investigations, including protein–protein interaction (PPI), correlation analysis, and functional enrichment analysis, to uncover the molecular interactions and pathways at play. …”
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Micro-electrical discharge coating of AlCoCrFeNi high entropy alloy on MgAz31B to enhance the corrosion and wear resistance by Rashi Tyagi, B.D.Y. Sunil, Monty Kumar, Harish Bishwakarma, Kuldeep K. Saxena, Rakesh Chandrashekar, Jabir Ali, Lakshita Sehgal, A. Anitha Lakshmi

“…The present research aims to enhance the performance of magnesium alloy (MgAZ31b) in corrosive environments by utilizing high entropy alloy (HEA) coatings, specifically focusing on AlCoCrFeNi. …”
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The effects of parenting styles on eating concerns in patients with eating disorders: the mediating role of self-compassion by Jingjing Yang, Jinyan Wu, Linlin Zhu, Chao Chen, JinRui Zhou, Lei Yang, Xueni Li, Yunai Su, Qingmei Kong, Tianmei Si

“…Consequently, the present study aims to investigate the relationship between parenting styles and eating concerns, along with the mediating role of self-compassion. …”
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Polymorphisms of <i>TXK</i> and <i>PLCE1</i> Genes and Their Correlation Analysis with Growth Traits in Ashidan Yaks by Juanxiang Zhang, Xita Zha, Guowu Yang, Xiaoming Ma, Yongfu La, Xiaoyun Wu, Xian Guo, Min Chu, Pengjia Bao, Ping Yan, Chunnian Liang

“…Phospholipase C epsilon 1 (<i>PLCE1</i>), a membrane-associated enzyme, is of paramount importance for the differentiation of myoblasts and the normal functioning of muscle tissue. In recent years, both of these genes have been reported to be associated with the economic traits of animals. …”
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Changes in pancreatic levodopa uptake in patients with obesity and new-onset type 2 diabetes: an 18F-FDOPA PET-CT study by Yeongkeun Kwon, Yeongkeun Kwon, Yeongkeun Kwon, Hanseok Yoon, Jane Ha, Hyeon-seong Lee, Kisoo Pahk, Hyunwoo Kwon, Sungeun Kim, Sungsoo Park, Sungsoo Park, Sungsoo Park

“…All patients’ lifestyle modification was conducted prior to 18F-FDOPA PET-CT, and plasma samples were collected to confirm changes in amino acid metabolites.ResultsPancreatic levodopa uptake increased in obese patients with insulin resistance, whereas it decreased in obese patients with new-onset type 2 diabetes [standardized uptake value (SUV) mean in participants with normal weight, 2.6 ± 0.7; SUVmean in patients with obesity, 3.6 ± 0.1; SUVmean in patients with obesity and new-onset type 2 diabetes, 2.6 ± 0.1, P = 0.02].ConclusionsThis suggested that the alterations in the functional capacity of pancreatic beta cells to take up circulating levodopa are potentially linked to the insulin resistance and the pathogenesis of type 2 diabetes. …”
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Do Progressive Intensities of Transcranial Direct Current Stimulation with and Without 40 Hz Binaural Beats Change Pre-Frontal Cortex Hemodynamics? A Randomized Controlled Trial by Maria de Cassia Gomes Souza Macedo, Kariny Realino do Rosário Ferreira, Paula Almeida Meira, Arthur Ferreira Esquírio, Michelle Cristina Sales Almeida Barbosa, Gabriela Lopes Gama, Alexandre Wesley Carvalho Barbosa

“…The hemodynamic effect was assessed using a functional near-infrared intracranial spectroscope (fNIRS) positioned on the left supraorbital region (Fp1). …”
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Risk for ocular hypertension progression to early glaucoma: A predictive model and key predictors by Shaofen Huang, Man Luo, Guitong Ye, Zhenlan Yang, Lingling Liao, Nina Wu, Yingting Zhu, Xing Liu, Yehong Zhuo, Hui Xiao

“…Background: Ocular hypertension (OHT) is the most significant risk factor for glaucoma. We aimed to develop a model for predicting OHT progression to early glaucoma and to identify key predictors. …”
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion by Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva M. Garrido‐Martín, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador, José Luis Solórzano, M. Teresa Muñoz, Patricia Cozar, Patricia Plaza, Rocío Suárez, Marta Jiménez, Roberto Moreno, Arantxa Rosado, Pablo Gámez, Ricardo García‐Luján, Jon Zugazagoitia, E. Alejandro Sweet‐Cordero, Mariano Barbacid, Amancio Carnero, Irene Ferrer, Luis Paz‐Ares

“…IL‐11's multifaceted impact on both tumour cells and the tumour microenvironment underscores its potential as a therapeutic target in LUAD. This study aims to unravel the involvement of IL‐11 in LUAD progression and its influence on the tumour microenvironment. …”
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Valorization of resistant starch from acorns as a new ingredient for chocolate milk puddings by Luís M.G. Castro, Sérgio C. Sousa, Manuela Machado, Elisabete M.C. Alexandre, Jorge A. Saraiva, Manuela Pintado

“…Aim: Despite being a fruit rich in resistant starch, acorns remain undervalued. …”
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Dietary Chinese herbal formula supplementation improves yolk fatty acid profile in aged laying hens by Zhihua Li, Chengwen Meng, Md. Abul Kalam Azad, Wencao Lin, Jue Gui, Yadong Cui, Wei Lan, Qinghua He, Xiangfeng Kong

“…Chinese herbal formula (CHF) has the potential to improve the performance of aged laying hens through integrated regulation of various physiological functions. The present study aimed to investigate the effects of dietary CHF supplementation on the yolk fatty acid profile in aged laying hens. …”
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A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease by Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang

“…We have identified subsets of astrocytes and analyzed their functions. The differentiation trajectory of astrocyte subtypes was explored using Monocle2. …”
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Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in MiceSummary by Kensuke Hamada, Yuki Nakanishi, Yu Muta, Mayuki Omatsu, Kosuke Iwane, Munehiro Ikeda, Jiayu Chen, Yoko Masui, Naoki Aoyama, Nobukazu Agatsuma, Go Yamakawa, Takahiro Utsumi, Hiroki Kitamoto, Makoto Okabe, Yoshiro Itatani, Takumi Adachi, Koubun Yasuda, Shuji Yamamoto, Akihisa Fukuda, Etsushi Kuroda, Masaki Ohmuraya, Kazutaka Obama, Seiichi Hirota, Hiroki Ikeuchi, Kenji Nakanishi, Hiroshi Seno

“…Background &amp; Aims: Retinoblastoma-binding protein 9 (RBBP9) was initially reported as cell cycle regulator via RB/E2F. …”
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Elevated prolactin levels before endometrial transformation negatively impact reproductive outcomes in frozen embryo transfer cycles under hormone replacement therapy by Yaxin Wang, Fei Sheng, Li Cao, Jiaying Ni, Meishan Wang, Yan Yang, Jiating Wang, Jingyi Lu, Jian Zhou, Hongfang Shao

“…Abstract Introduction Prolactin (PRL) plays a key role in the regulation of reproductive functions. However, its impact on outcomes in infertility women undergoing assisted reproductive technology remains unclear. …”
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Incidence, Risk and Trends of Multiple Primary Cancers in Patients With Colorectal Cancer: Evidence From the South Australian Cancer Registry by Mulugeta Melku, Oliver G. Best, Jean M. Winter, Lauren A. Thurgood, Muktar Ahmed, Ganessan Kichenadasse, Murthy Mittinty, Molla M. Wassie, Erin L. Symonds

“…The incidence of MPCs was assessed using cumulative incidence functions, and age‐standardised rates were estimated. …”
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