Molecular mechanisms of dose-dependent regulation of hepatic lipid metabolism by BaP through modulation of AhR binding to XRE1 or XRE3 by Mengdi Zhang, Mengdi Zhang, Xiaoli Lv, Xiaoli Lv, Chaojie Wang, Chaojie Wang, Lei Wang, Lei Wang, Han Wang, Han Wang, Xue Wang, Xue Wang, Yulu Du, Yulu Du, Jun Li, Jun Li, Jun Li, Xiuli Han, Xiuli Han, Xiuli Han, Lei Fan, Lei Fan, Yuxia Hu, Yuxia Hu, Yuxia Hu, Tuya Bai, Tuya Bai, Weizhong Huangfu, Fuhou Chang, Fuhou Chang

“…Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon and a potent environmental pollutant, has been implicated in the dysregulation of lipid metabolism and metabolic diseases, warranting investigation into its effects on liver functions, particularly regarding fibroblast growth factor 21 (FGF21) mediated pathways. …”
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Absolute Configuration and Chiroptical Properties of Flexible Drug Avapritinib by Ya-Dong Yang, Chen Zhao, Liang-Peng Li, Yi-Xin Lv, Bei-Bei Yang, Xin Li, Ru Wang, Li Li

“…Conformational analysis and density functional theory (DFT) calculations correlated experimental spectra with theoretical predictions, facilitating definitive configurational assignment. …”
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A comprehensive bioinformatics analysis of pathways and biomarkers shared between type 2 diabetes mellitus and chronic obstructive pulmonary disease by Tingting Hu, Xiaomei Duan, Jiale Gao, Zheng Li, Dan Xu, Jing Jing, Fengsen Li, Jianbing Ding, Li Ma, Min Jiang, Jing Wang

“…BackgroundT2DM and COPD are prevalent and high-burden diseases which are closely related, with poor patient outcomes. In this study, we aimed to identify common diagnostic markers for T2DM and COPD and their therapeutic potential.MethodsMicroarray data from the GEO database were analyzed to identify DEGs, whereas WGCNA, co-differential gene analyses were employed to identify co-expression modules and DEGs functions. …”
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Frailty and Upper Gastrointestinal Surgery: Initial Findings from Thailand’s First Surgical Frailty Study by Gritin Gonggetyai, Nathawadi Techalertsuwan, Chawisa Nampoolsuksan, Thammawat Parakonthun, Jirawat Swangsri, Asada Methasate, Arunotai Siriussawakul, Onuma Chaiwat, Varalak Srinonprasert

“…Frail patients were significantly older and had poorer functional status and nutritional risk. Frail patients also underwent fewer resection procedures (61.1% vs 84.2%, p=0.001). …”
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Composite Flours Based on Black Lentil Seeds and Sprouts with Nutritional, Phytochemical and Rheological Impact on Bakery/Pastry Products by Christine (Neagu) Dragomir, Sylvestre Dossa, Călin Jianu, Ileana Cocan, Isidora Radulov, Adina Berbecea, Florina Radu, Ersilia Alexa

“…This paper aimed to study the nutritional, phytochemical and rheological properties of some composite flours based on wheat flour (WF) mixed with non-germinated (LF) and sprouted lentil flour (SLF), in order to fortify the wheat flour and to obtain functional bakery/pastry products. …”
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Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding by Luiz Ladeira, Anouk Verhoeven, Jonas van Ertvelde, Jian Jiang, Alessio Gamba, Julen Sanz-Serrano, Tamara Vanhaecke, Harm J. Heusinkveld, Ramiro Jover, Mathieu Vinken, Liesbet Geris, Liesbet Geris, Liesbet Geris, Bernard Staumont

“…AimsIn silico methods provide a resourceful toolbox for new approach methodologies (NAMs). …”
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Impacts of phosphate-solubilizing bacterium strain MWP-1 on vegetation growth, soil characteristics, and microbial communities in the Muli coal mining area, China by Yanru Wu, Yanru Wu, Wenquan Yang, Jiancun Kou, Jiancun Kou, Qinyao Li, Jiaqing Liu, Lu Chi, Yangcan Zhang, Qian Liu, Yanghua Yu

“…In addition, MWP-1 also significantly improved the diversity of soil bacterial and fungal communities (p < 0.05), and changed their functions. It also significantly altered the relative abundance of genes regulating phosphorus absorption and transport, inorganic phosphorus dissolution and organic phosphorus mineralization in the bacterial community (p < 0.05). …”
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Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy by Hongyan Li, Rong Gan, Jiadi Liu, Duling Xu, Qiyue Zhang, Haidong Tian, Huijun Guo, Haijun Wang, Zhimin Wang, Xianwu Zeng

“…Peptide-conjugated PEGlated liposomes containing Dox (peptide-Lipo@Dox) were prepared for radionuclide and drug delivery. Glioma cell functions were determined based on cell cycle and viability, apoptosis, cell invasion and migration, and colony-formation assays. …”
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Dissection of the genetic basis and molecular mechanism of ovule number per ovary in oilseed rape (Brassica napus L.) by Muslim Qadir, Muslim Qadir, Muslim Qadir, Xinyi Lin, Farhan Nabi, Kishore Kumar Ashok, Xue-Rong Zhou, Qingbin Sun, Peiman Shi, Xinfa Wang, Jiaqin Shi, Hanzhong Wang

“…Ovule number per ovary (ONPO) determines the maximum potential of seed number per fruit that is a direct component of seed yield in crops. This study aimed to dissect the genetic basis and molecular mechanism of ONPO using a newly developed doubled haploid (DH) population in oilseed rape. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Few items demonstrated differential item functioning concerning variables such as age, sex, and education. …”
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MYOCARDIAL PERFUSION ASSESSMENT IN FORECASTING EFFECT OF CORONARY ANGIOPLASTY IN PATIENTS WITH ISCHEMIC CHRONIC HEART FAILURE by A. B. Mironkov, V. V. Chestukhin, F. A. Blyakhman, T. F. Shklyar, E. N. Ostroumov, Е. D. Kotina, S. A. Sakhovsky, E. T. Asoev, B. L. Mironkov

“…Aim. To define influence of the left ventricle (LV) perfusion defects on the clinical status dynamics after coronary angioplasty in patients with the expressed myocardium dysfunction of ischemic etiology. …”
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Increased long-term central memory T cells in patients with retreatment pulmonary tuberculosis by Xin Yao, Xin Yao, Haomin Cai, Jianxia Chen, Fangyong Yu, Xiaocui Wu, Yarong Shi, Yarong Shi, Yang Hu, Yuyan Xu, Qinghua Xu, Zhonghua Liu, Zhonghua Liu

“…Nevertheless, the specific functions and changes of T lymphocyte subsets in retreatment tuberculosis remain poorly understand. …”
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Menstrual blood and ritual beliefs: a qualitative study on menstrual health and hygiene practices among senior high school girls in Volta Region, Ghana by Sitsofe Gbogbo, Israel Wuresah, Wisdom Axame, Priscilla Klutse, Emmanuel Gbogbo, Robert Kokou Dowou, Sarah Odi Mantey, Sarah Abena Yeome Ayitey, Ishmael Boateng, Paramount Eli Nelson, Nuworza Kugbey, Victor Christian Korley Doku, Julie Hennegan, Frank E. Baiden, Fred N. Binka

“…Additionally, water and hygiene facilities were mostly inadequate, with many girls relying on poorly maintained pit latrines and non-functional flushing toilets. Conclusion The study found a mismatch between what girls say they do with menstrual waste and what actually happens in schools. …”
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The effect of dual inflammation on the acute phase clinical outcomes of schizophrenia patients with comorbid COVID-19 by Jiahui Zhu, Jiamin Shao, Peng Wang, Yuan Liu, Gangming Cheng, Qi Zhou, Zhuoran Li, Jiayi Li, Mingqia Wang, Zhuokai Zhang, Xuan Dong, Chuan Shi

“…Then clinical symptoms, cognitive performance, and functional assessments were conducted at recruitment. …”
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Study protocol of “From Science 2 School”—prevalence of sports and physical exercise linked to omnivorous, vegetarian and vegan, diets among Austrian secondary schools by Katharina C. Wirnitzer, Katharina C. Wirnitzer, Katharina C. Wirnitzer, Derrick R. Tanous, Derrick R. Tanous, Mohamad Motevalli, Mohamad Motevalli, Georg Göbel, Gerold Wirnitzer, Clemens Drenowatz, Gerhard Ruedl, Armando Cocca, Werner Kirschner

“…Therefore, this multidisciplinary study aims to survey and scale health behaviors with a special focus on the prevalence of traditional and vegetarian diets in connection with PA levels among Austrian pupils (10–19 years), teachers and principals in secondary education levels I and II. …”
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Pulmonary arterial hypertension with cardiopulmonary comorbidities: is it a unique phenotype? by Meng Zhang, Xueran Guo, Wei Guo, Yan Wang, Yao Xiao, Jiancheng Han, Ye Li, Tingting Man, Jie Li, Yong Chen, Shengchen Duan, Wenmei Zhang, Hui Li, Ao Yin, Jiafei Peng, Chunrong An, Wanmu Xie, Qian Gao, Shuai Zhang, Yunxia Zhang, Zhenguo Zhai, Jun Wan

“…Conclusion PAH patients with cardiopulmonary comorbidities represent a unique phenotype, with different clinical manifestation and treatment responses from typical PAH and inconsistencies between hemodynamics and functional status from baseline to follow-up.…”
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Understanding facilitators and barriers to adherence in home-based pulmonary rehabilitation for chronic obstructive pulmonary disease patients using the Health Belief Model: a qual... by Qiuxuan Zeng, Wenli Chen, Siyi Xu, Xu Yang, Dandan Xue, Yuhang Peng, Xiaohong Lin, Yingwen Yu, Huixin Huang, Ping Huang, Min Dong, Jiaying Li

“…Newly identified facilitators included physical limitations and fatigue, emotional distress, perceived ineffectiveness, time constraints, caregiving responsibilities, lack of support, cost, poor exercise conditions, reduced medical dependence, self-awareness of functional decline, attention-seeking behaviors, environmental cues, mental resilience, and religious beliefs. …”
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Clinical Predictors of Cognitive Impairment in a Cohort of Patients with Older Age Bipolar Disorder by Camilla Elefante, Giulio Emilio Brancati, Maria Francesca Beatino, Benedetta Francesca Nerli, Giulia D’Alessandro, Chiara Fustini, Daniela Marro, Gabriele Pistolesi, Filippo Baldacci, Roberto Ceravolo, Lorenzo Lattanzi

“…This cross-sectional study aims to identify the clinical features associated with cognitive impairment in OABD. …”
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A scoping review of financial decision-making measures in midlife and beyond: results from the advancing reliable measurement in cognitive aging and decision-making ability (ARMCAD... by Emily H. Ho, Berivan Ece, Patricia Bucko, Tatiana Karpouzian-Rogers, Sarah Pila, Zahra Hosseinian, Yasmin Hussein, S. Duke Han, Peter A. Lichtenberg, Aaron C. Lim, Aaron C. Lim, Sandra Weintraub, Sandra Weintraub, Richard C. Gershon

“…BackgroundCognitive decline in older adults affects key functions such as memory, concentration, planning, reasoning, and decision-making (DM). …”
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Molecular mechanism and biological pathway of high-expressed RAD51 in regulating cell adhesion and potentially affecting oral squamous cell carcinoma by Yu-Xing Tang, Yu-Yan Pang, Yan Cui, Guo-Jiao Wu, Lin-Qing Huang, Chang-Zhan Zhou, Bin Li, Qi Li, Bang-Teng Chi, Rong-Quan He, Di-Yuan Qin, Jian-Di Li, Gang Chen, Dong-Ming Li, Yi-Wu Dang

“…However, its multi-platform expression patterns and functional role in cell adhesion within the context of OSCC have not yet been comprehensively validated. …”
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