Transcriptomic Profiles for Elucidating Response of Bladder Intracavitary Hyperthermic Perfusion Chemotherapy in High‐Risk Nonmuscular Invasive Bladder Cancer by Zhicheng Huang, Tianhui Zhang, Jinghua Pan, Guihao Zhang, Linjun Jiang, Huiming Jiang, Pei Wan, Ying Peng, Wenchao Zou, Qinghua Liu, Nanhui Chen

“…However, the molecular mechanisms underlying the response to HIPEC remain poorly understood. This study aimed to elucidate the transcriptomic profiles associated with the response to HIPEC in NMIBC patients. …”
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Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis by Ricardo Félix Morais, José Maria Sousa, Cemal Koba, Leon Andres, Tiago Jesus, Inês Baldeiras, Tiago Gil Oliveira, Isabel Santana

“…In AD, precuneus and inferior parietal lobules atrophy aligns with dopaminergic and GABAergic receptors, potentially impacting memory and executive functions. In bvFTD, medial orbitofrontal and temporal atrophy, is linked to mu-opioid receptor impairment, possibly contributing to behavioral symptoms. …”
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Development and Validation of a Tool to Assess Pain in Preverbal and Non-verbal Children with Cerebral Palsy: Cerebral Palsy Faces Pain Scale (CPFPS) by Chidozie Emmanuel Mbada, Emmanuel Odunayo Fashote, Taofeek Oluwole Awotidebe, Oluwatosin Eunice Olorunmoteni, Atitlola Adebambo, Adekola B. Ademoyegun, Ademola O. Sonuga, Clara Fatoye, Tadesse Gebrye, Francis Fatoye

“…Background: Cerebral palsy (CP) is the most common neurodisability in children. This study aimed to develop and validate a faces pain scale for preverbal and non-verbal children (PvNv) with CP in Nigeria.Methods: Twelve paediatric practitioners and three verbal adults with CP participated in a three-round modified Delphi study on scale development and validation of the CPFPS. …”
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Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation by Sarah Ingrid Pinto Santos, Santiago José Ortiz-Peñuela, Alessandro de Paula Filho, Ana Laura Midori Rossi Tomiyama, Lilian de Oliveira Coser, Juliano Coelho da Silveira, Daniele dos Santos Martins, Adriano Polican Ciena, Alexandre Leite Rodrigues de Oliveira, Carlos Eduardo Ambrósio

“…Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by autoimmune destruction of the myelin sheath, leading to irreversible and progressive functional deficits in patients. Pre-clinical studies involving the use of neural stem cells (NSCs) have already demonstrated their potential in neuronal regeneration and remyelination. …”
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Evaluation of stripe rust resistance and analysis of resistance genes in wheat genotypes from Pakistan and Southwest China by Sakina Abbas, Sakina Abbas, Yunfang Li, Jing Lu, Jianming Hu, Jianming Hu, Xinnuo Zhang, Xinnuo Zhang, Xue Lv, Armghan Shahzad, Donghui Ao, Maryam Abbas, Yu Wu, Lei Zhang, Muhammad Fayyaz

“…We utilized previously published functional and linked molecular markers to detect 13 major stripe rust resistance genes: Yr5, Yr9, Yr10, Yr15, Yr17, Yr18, Yr26, Yr29, Yr30, Yr36, Yr48, Yr65, and YrSp. …”
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Recovery of Bacteroides thetaiotaomicron ameliorates hepatic steatosis in experimental alcohol-related liver disease by Moris Sangineto, Christoph Grander, Felix Grabherr, Lisa Mayr, Barbara Enrich, Julian Schwärzler, Marcello Dallio, Vidyasagar Naik Bukke, Archana Moola, Antonio Moschetta, Timon E. Adolph, Carlo Sabbà, Gaetano Serviddio, Herbert Tilg

“…We aimed to investigate the role of Bt in the genesis of ethanol-induced liver steatosis. …”
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Mono and combination therapies in pulmonary arterial hypertension patients with comorbidities: A COMPERA analysis by Dirk Skowasch, Christine Pausch, Doerte Huscher, David Pittrow, Judith Wede, Fabian Kreimendahl, Stephan Rosenkranz, Stephan Beckmann, Matthias Held, Ekkehard Grünig, H. Ardeschir Ghofrani, Hans Klose, Andris Skride, Michael Halank, Stefan Stadler, Marion Delcroix, Anton Vonk‐Noordegraaf, Ralf Ewert, Grzegorz Kopec, Marius M. Hoeper, Karen M. Olsson

“…Abstract Aims Pulmonary arterial hypertension (PAH) is often diagnosed in elderly patients with comorbidities. …”
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Gut microbiome and metabolome characteristics of patients with cholesterol gallstones suggest the preventive potential of prebiotics by Ye Liu, Hexin Li, Tianhan Sun, Gaoyuan Sun, Boyue Jiang, Meilan Liu, Qing Wang, Tong Li, Jianfu Cao, Li Zhao, Fei Xiao, Fangqing Zhao, Hongyuan Cui

“…Supplementing with FOS could serve as a potential approach for managing CGS by altering the composition and functionality of gut microbiota.…”
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Biomarker identification for rheumatoid arthritis with inadequate response to DMARD and TNF therapies using multidimensional analyses by Leyuan Li, Hui Guo, Weijin Zhang, Xi Xiang, Jun Chi, Mengmeng Zhang, Jiali Chen, Zhimin Wang, Liping Dai

“…However, the molecular mechanism of RA with insensitive to medicine remains insufficient. Thus, this study aims to identify the biomarkers of RA patients with inadequate responses (IR) toward disease-modifying antirheumatic drug (DMARD) and antitumor necrosis factor (TNF) therapies, using multidimensional analyses. …”
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Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and gut health markers in patients with irritable bowel syndrome—A randomized, doubl... by Adrianna Wierzbicka, Adrianna Wierzbicka, Barbara Khaidakov, Oliwia Zakerska-Banaszak, Paulina Andrzejewska, Alina Baturo, Paulina Kowalczyk, Krzysztof Lemke, Agnieszka Dobrowolska, Marzena Skrzypczak-Zielinska, Dorota Mankowska-Wierzbicka

“…IntroductionIrritable bowel syndrome (IBS) is the most prevalent functional bowel disorder impacting around 5%−10% of the general population worldwide. …”
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Mapping outcomes for recovery of consciousness in studies from 1986 to 2020: a scoping review protocol by Monica Steiner, Elizabeth Burns, Trudy Mallinson, Joshua Rosenow, Jennifer Weaver, Alison Cogan, Parie Bhandari, Erica Jacobs, Ariana Pape, Chantal Nguyen, Ann Guernon, Tom Harrod, Theresa Bender Pape, Marilyn Pacheco, Catherine Burress Kestner, Kelsey Watters, Elizabeth Yost, Henk Eilander, Berno Overbeek, Sophie Leeds, Kelly Krese, Haylee Winden, Mary Philbin, Stefani Cleaver, Vanessa Silva, Konner Nelson, André Lindsey, Angela Hartman, Kristen Maisano, Erika Cooley, Jessica Rudin Portnoff, Bailey Widener, Sarah Hollingsworth, Coty Wardwell, Julianne Angel, Ladan Hakima, Jennifer Nebel, Bint-e Zainab Awan

“…We will chart the data by applying the WHO International Classification of Functioning, Disability and Health Framework to identify the content areas of clinical outcome assessments. …”
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Immunogenic Activity of Secreted Protein-Based Compounds Staphylococcus aureus № 6 by I. M. Gruber, E. A. Astashkina, O. V. Lebedinskaya, N. B. Egorova, M. V. Kiselevsky, F. V. Donenko, N. E. Yastrebova, O. M. Ignatova, E. A. Kurbatova, L. S. Cherkasova

“…Difficulties in the therapy of infection, caused by S. aureus, depends on the resistance of staphylococci to antibiotics, proceeding to chronicity of the diseases and the development on that background the depression of innate immunity functions and decreasing of the host resistance to the infection. …”
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Differences in virulence and drug resistance between Clostridioides difficile ST37 and ST1 isolates by Zirou Ouyang, Jing Yang, Huimin Zhang, Min Zhao, Huimin Yang, Jiafeng Zhao, Yaxuan Yang, Cuixin Qiang, Zhirong Li, Pu Qin, Weigang Wang, Yanan Niu, Jianhong Zhao

“…Although C. difficile ST37 only produces a functional toxin B, it causes disease as severe as that caused by hypervirulent ST1. …”
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ICP-Based Mapping and Localization System for AGV with 2D LiDAR by Felype de L. Silva, Eisenhawer de M. Fernandes, Péricles R. Barros, Levi da C. Pimentel, Felipe C. Pimenta, Antonio G. B. de Lima, João M. P. Q. Delgado

“…This work presents the development of a functional real-time SLAM system designed to enhance the perception capabilities of an Automated Guided Vehicle (AGV) using only a 2D LiDAR sensor. …”
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Photoacoustic imaging for monitoring radiotherapy treatment response in head and neck tumors by Niklas Holzwarth, Zoe Rachel, Jan-Hinrich Nölke, Melanie Schellenberg, Lukas Bauer, Nicholas Schreck, Christoph J. Bender, Kris K. Dreher, Sebastian Regnery, Katharina Weusthof, Manuel Wiesenfarth, Annette Kopp-Schneider, Jürgen Debus, Alexander Seitel, Sebastian Adeberg, Lena Maier-Hein, Thomas Held

“…PAI leverages the photoacoustic effect in order to non-invasively recover functional tissue properties in depths of up to several centimeters. …”
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The protective role and mechanism of ginkgolide B in regulating mTOR signalling pathway involved in Manganese-induced apoptosis and autophagy in N27 cells by Liyu Su, Shunyu Xiang, Huan Mao, Jiayu Fu, Hongwei Ding, Feng Wang, Lan Zhao, Jianwei Bai, Yuyan Cen, Deyu Zhu, Meng Deng, Yan Li

“…Ginkgolide B (GB) is a diterpenoid compound found in the leaves of the traditional Chinese medicine plant Ginkgo biloba, which has been shown to have a variety of pharmacological functions. However, the role of GB in Manganese(Mn)-induced apoptosis and autophagy in neuronal cells remains poorly understood. …”
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Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma by Fanjie Meng, Hao Li, Ruoyi Jin, Airong Yang, Hao Luo, Xiao Li, Peiyu Wang, Yaxing Zhao, Olga Chervova, Kaicheng Tang, Sida Cheng, Bin Hu, Yun Li, Jianpeng Sheng, Fan Yang, David Carbone, Kezhong Chen, Jun Wang

“…Abstract Background Lung adenocarcinoma (LUAD) with lymph node (LN) metastasis is linked to poor prognosis, yet the underlying mechanisms remain largely undefined. This study aimed to elucidate the immunogenomic landscape associated with LN metastasis in LUAD. …”
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IncRNA IPAN antagonizes RIG-I/TRIM25-mediated degradation of influenza A virus PB1 to promote viral replication by Tingting Sun, Shumin Chen, Rui Zhou, Saisai Guo, Yilu Ye, Jingyi Qiu, Xiaoyu Li, Shan Cen, Jing Wang

“…The productive infection of influenza A virus (IAV) requires the functional involvement of host long noncoding ribonucleic acids (lncRNAs). …”
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Comparative response mechanisms of two cultivars of Musa paradisiaca L. to Fusarium oxysporum f.sp. cubense infection by Yajie Duan, Yajie Duan, Zhiwei Jia, Zhiwei Lu, Huigang Hu, Rulin Zhan

“…With the aim of enhancing plants’ ability to respond to pathogenic fungi, this study focuses on disease resistance genes. …”
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A20 negatively regulates necroptosis-induced microglia/macrophages polarization and mediates cerebral ischemic tolerance via inhibiting the ubiquitination of RIP3 by Meiqian Qiu, Wenhao Zhang, Jiahua Dai, Weiwen Sun, Meijing Lai, Shiyi Tang, En Xu, Yuping Ning, Lixuan Zhan

“…Also, a novel mechanism by which HPC functions in cerebral ischemic tolerance is elucidated.…”
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