Multi-omics analyses reveal altered gut microbial thiamine production in obesity by Yu Xia, Yu Xia, Longya Lu, Lulu Wang, Yanyan Qiu, Xingyin Liu, Weihong Ge, Weihong Ge, Weihong Ge

“…Integrated analysis indicated that thiamine deficiency was positively associated with the depletion of thiamine auxotrophic bacteria in the obese microbiome. Functional analysis revealed that KOs content for enzymes involved in the microbial production of thiamine were significantly lower in obesity, including tRNA uracil 4-sulfurtransferase (ThiI, PWilcoxon = 0.001) and nucleoside-triphosphatase (NTPCR, PWilcoxon = 0.006), both of which were positively associated with fecal thiamine.ConclusionOur study highlights the impairment of microbial thiamine production and its broad associations with gut microbiota dysbiosis and obesity-related phenotypes. …”
Get full text

Analysis and Identification of Therapeutic Targets for Neuronal Regeneration After Ischemic Stroke by Xiao‐Li Min, Li Guo, Zhenyu Wang, Lei Zhao, Chenglong Shi, Xiaoyong Liu, Zhen Wang, Fei‐Fei Shang, Jiaping Wang

“…To identify the key genes, functional enrichment and Protein–Protein Interaction (PPI) network analysis were conducted. …”
Get full text

Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation by Asmaa M. Gaber, Adel Abdel-Moneim, Eman S. Abdel-Reheim, Gamal Allam, Manal Abdul-Hamid, Ahmed Hosni, Ahmed Hosni

“…Despite HSD and LT4 effectively alleviating the THs profile, only HSD offered substantial protection from hypothyroidism-associated cardiac inflammation and injury through its potent impact on the transcriptional miRNAs level and Nrf2/NF-κB protein expression (key regulators of the redox biomarkers and the inflammatory mediators).ConclusionHSD provides dual thyroprotective and cardioprotective effects that enhance THs bioavailability and functionality in the cardiovascular system.…”
Get full text

Molecular characterization of heavy metal-tolerant bacteria and their potential for bioremediation and plant growth promotion by Saira Abbas, Saira Abbas, Sobia Zulfiqar, Muhammad Arshad, Nauman Khalid, Nauman Khalid, Amjad Hussain, Amjad Hussain, Iftikhar Ahmed

“…IntroductionHeavy metal pollution adversely affects soil health by disrupting the microbial community structure and functions. The current study aimed to isolate and characterize heavy metal-tolerant bacterial strains and evaluate their potential for soil bioremediation and promoting agricultural sustainability.MethodsA total of 68 bacterial strains were isolated from industrial discharge-contaminated sites and screened for their maximum tolerance limits (MTL) against Cr, Cu, Pb, As, and Cd. …”
Get full text

Grip Strength, Fall Efficacy, and Balance Confidence as Associated Factors with Fall Risk in Middle-Aged and Older Adults Living in the Community by Priscila Marconcin, Estela São Martinho, Joana Serpa, Samuel Honório, Vânia Loureiro, Marcelo de Maio Nascimento, Fábio Flôres, Vanessa Santos

“…Background: Falls are a major public health concern among older adults, often resulting in injury, functional decline, and reduced quality of life. While handgrip strength (HGS), fall efficacy, and balance confidence have individually been associated with fall risk, their combined predictive value is still underexplored, particularly in physically active older adults. …”
Get full text

Clinical significance of assessing ADAMTS-13 and von Willebrand factor level in COVID-19 convalescent pregnant women by N. R. Gashimova, K. N. Grigoreva, V. O. Bitsadze, L. L. Pankratyeva, J. Kh. Khizroeva, M. V. Tretyakova, Ya. M. Shammut, E. Iu. Iupatov, V. I. Tsibizova, J.-K. Gris, D. V. Blinov, A. D. Makatsariya

“…The ADAMTS-13/vWF ratio determines the pathway functioning, the risk of microcirculation disorders and clinical complications.…”
Get full text

Eating "rubbish"? Exploring the herbal secrets of "Laji-He," a traditional herbal rice snack from southern China by Renchuan Hu, Qianyun Wang, Zhongxin Duan, Yunan Hu, Kedao Lai, Xiaohui Cai, Ya Peng, Binsheng Luo

“…Conclusions Laji-He is a traditional functional snack, with the plants used in its preparation serving as both food and medicine. …”
Get full text

Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective by Xinhua Peng, Xinhua Peng, Rongrong Zhu, Ke Zhang, Jianghong Ji, Chuanguo Lv, Feng Feng, Feng Feng

“…AimMalignant cerebral edema (MCE) is a life-threatening complication of acute brain injuries, with mortality rates exceeding 80% in the absence of treatment. …”
Get full text

Comparative analysis of centrally mediated and inflammatory pain experiences amongst patients diagnosed with rheumatoid arthritis: A multimethods study by Zoe Rutter‐Locher, Tom Esterine, Ruth Williams, Leonie S. Taams, Kirsty Bannister, Bruce W. Kirkham, Heidi Lempp

“…Importantly, both groups revealed the substantial psychological, functional and social impacts of their pain, highlighting the often ‘invisible’ and misunderstood nature of their symptoms. …”
Get full text

Research on fusion neutron energy spectrum measurement using a Bonner sphere spectrometer based on a 4H-SiC detector by ZHANG Mingqiang, ZHONG Guoqiang, HUANG Juan, CHANG Jiafeng, DU Qin, CHEN Chuankai, LU Yang, CHEN Le

“…Subsequently, the experimental results were normalized with the neutron flux monitoring results of the fission ionization chamber (ZZ3) on the EAST device and combined with the neutron response functions obtained from the Monte Carlo simulation for each moderated sphere. …”
Get full text

Enhancing neurological disease diagnostics: fusion of deep transfer learning with optimization algorithm for acute brain stroke prediction using facial images by Fadwa Alrowais, Mohammed Alqahtani, Jahangir Khan, Achraf Ben Miled, Da’ad Albalawneh, Abdulwhab Alkharashi, Samah Al Zanin, Radwa Marzouk

“…The proposed ENDDFTL-ABSPFI method aims to enhance brain stroke detection and classification models using facial imaging. …”
Get full text

Are Activity Restrictions Necessary After Total Hip Arthroplasty: A Systematic Review by Sagar Telang, BS, Amir Human Hoveidaei, MD, MSc, Cory K. Mayfield, MD, Jay R. Lieberman, MD, Michael A. Mont, MD, Nathanael D. Heckmann, MD

“…This systematic review aims to assess whether the liberalization of postoperative activity restrictions following THA impacts implant survivorship, return to sport, patient satisfaction, and functional health outcomes. …”
Get full text

Invasive shrub (Lantana camara L.) alters the tree diversity and ecosystem-level carbon pools in tropical forests of Central India by Parvaiz Ahmad Lone, Subashree Kothandaraman, Subashree Kothandaraman, Javid Ahmad Dar, Javid Ahmad Dar, Khalid Rehman Hakeem, Mohammed Latif Khan

“…Tropical forests, known for their biodiversity and carbon (C) richness, face significant threats from biological invasions that disrupt structural and functional processes. Lantana camara (Family: Verbenaceae) is an invasive shrub that has spread across several Indian landscapes. …”
Get full text

Elevated mir‐141 in obesity: Insights into the interplay with sirtuin 1 and non‐alcoholic fatty liver disease by Nikta Dadkhah Nikroo, Habib Jafarinejad, Zeynab Yousefi, Zohreh Abdolvahabi, Mojtaba Malek, Pejman Mortazavi, Abdolreza Pazouki, Somayeh Mokhber, Mitra Nourbakhsh

“…The aim of this research was to evaluate the levels of miR‐141 and its relationship with SIRT1 and NAFLD. …”
Get full text

Propofol orchestrates long non-coding RNAs in MCF7 cells, unraveling new avenues for breast cancer intervention by Cigir Biray Avci, Tuba Gokdogan Edgunlu, Tugba Suzek, Neslihan Pinar Ozates, Bakiye Goker Bagca, Aysegul Demirtas Bilgic, Cilem Ozdemir, Bakiye Ugur

“…The study used qRT-PCR to analyze cancer-related lncRNA expressions following propofol treatment; this was supported by RNA-RNA interaction predictions and in silico functional analysis using selected datasets and the R cluster Profiler GSEABase package. …”
Get full text

Nanobiosensors for revolutionizing parasitic infections diagnosis: a critical review to improve global health with an update on future challenges prospect by Soheil Sadr, Ashkan Hajjafari, Alireza Sazmand, Cinzia Santucciu, Giovanna Masala, Mahdi Soroushianfar, Shakiba Nazemian, Abbas Rahdar, Sadanand Pandey, Moez Guettari, Hassan Borji

“…Nanobiosensors can utilize diverse nanomaterials such as gold nanoparticles (AuNPs) for the detection of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) in Plasmodium, carbon nanotubes (CNTs) functionalized with anti-EgAgB antibodies for Echinococcus, and QDs labeled with DNA probes for the detection of Leishmania kDNA. …”
Get full text

Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis by Kornelius Schulze, Tim Daniel Rose, Lorenz Adlung, Manuela Peschka, Francesca Pagani, Joao Gorgulho, Thorben W. Fründt, Ismail Labgaa, Philipp K. Haber, Carolin Zimpel, Darko Castven, Arndt Weinmann, Teresa Garzia-Lezana, Moritz Waldmann, Thomas Renné, Hannah Voß, Manuela Moritz, Dorian Orlikowski, Hartmut Schlüter, Jan Baumbach, Myron Schwartz, Ansgar W. Lohse, Samuel Huber, Bruno Sangro, Rocio I.R. Macias, Laura Izquierdo-Sanchez, Jesus M. Banales, Henning Wege, Jens U. Marquardt, Augusto Villanueva, Josch Konstantin Pauling, Johann von Felden

“…Background & Aims: Actionable candidates of hepatocarcinogenesis remain elusive, and tools for early detection are suboptimal. …”
Get full text

Plasma volume status predicting clinical outcomes in patients undergoing transcatheter edge‐to‐edge mitral valve repair by Ai Kagase, Masanori Yamamoto, Takahiro Tokuda, Ryotaku Kawahata, Hiroto Nishio, Tetsuro Shimura, Ryo Yamaguchi, Mitsuru Sago, Yuki Izumi, Mike Saji, Masahiko Asami, Yusuke Enta, Masaki Nakashima, Shinichi Shirai, Masaki Izumo, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Toru Naganuma, Hiroki Bouta, Yohei Ohno, Masahiro Yamawaki, Hiroshi Ueno, Kazuki Mizutani, Daisuke Hachinohe, Toshiaki Otsuka, Shunsuke Kubo, Kentaro Hayashida, OCEAN‐Mitral Investigators

“…This study aimed to evaluate the prognostic significance of PVS in these patients. …”
Get full text

The Elephant Ethogram: a library of African elephant behaviour by Joyce Poole, Petter Granli

“…One example is the work of Nishida et al. (1999) on chimpanzees, Pan troglodytes, which aims to provide an exhaustive list of behaviours. …”
Get full text

Effects of parietal iTBS on resting-state effective connectivity within the frontoparietal network in patients with schizophrenia: An fMRI study by Li Li, Lina Wang, Han Wu, Bing Li, Weigang Pan, Wenqing Jin, Wen Wang, Yanping Ren, Chaomeng Liu, Xin Ma

“…Therefore, this pilot fMRI study aimed to examine the efficacy of parietal iTBS in ameliorating WM impairments and explore its influence on the resting-state effective connectivity within the frontoparietal network in patients with SZ. …”
Get full text