Deciphering the role of SEMA4A/MAPK signaling in sepsis: insights from Mendelian randomization, transcriptomic, single-cell sequencing analyses, and vitro experiments by Meng-Qin Pei, Yan-Ling Lin, Li-Ming Xu, Yu-Shen Yang, Zhen-Dong Sun, Ya-Fen Zeng, Gui-Dan Wang, He-Fan He, Li-Ying Yu, Li-Ying Yu

“…BackgroundSepsis is a condition with high mortality and multiple organ dysfunction, undergoing complex pathogenesis and limited treatment options. This study aims to uncover new therapeutic targets for sepsisMethodsThree independent transcriptomic datasets from sepsis patients in the GEO database were utilized. …”
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Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial by Hannah Berg, Timothy J. McDermott, Rayus Kuplicki, Hung-Wen Yeh, Wesley K. Thompson, Ryan Smith, Elisabeth Akeman, Namik Kirlic, Ashley Clausen, Mallory Cannon, Evan White, Christopher R. Martell, Kate B. Wolitzky-Taylor, Michelle G. Craske, James L. Abelson, Martin P. Paulus, Robin L. Aupperle

“…Abstract Treatments for generalized anxiety disorder (GAD) often aim to address maladaptive approach-avoidance behavior patterns. …”
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Questions and answers on iron deficiency treatment selection and the use of intravenous iron in routine clinical practice by Toby Richards, Christian Breymann, Matthew J. Brookes, Stefan Lindgren, Iain C. Macdougall, Lawrence P. McMahon, Malcolm G. Munro, Elizabeta Nemeth, Giuseppe M. C. Rosano, Ingolf Schiefke, Günter Weiss

“…Modern intravenous iron preparations can facilitate rapid iron repletion in one or two doses, both for absolute iron deficiency and, in the presence of inflammation, functional iron deficiency, where oral iron therapy is ineffective or has not worked. …”
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State-of-the-art: Insights from the Ross RegistryCentral Message by Buntaro Fujita, MD, Anas Aboud, MD, Hans-Hinrich Sievers, MD, Stephan Ensminger, MD, DPhil

“…The Ross procedure uses the autologous pulmonary valve as an aortic valve substitute and aims to improve valve durability while avoiding anticoagulation and therefore achieve a sustained long-term result with regard to survival, valve functionality, and quality of life. …”
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Bioinformatics-driven exploration of key genes and mechanisms underlying oxidative stress in traumatic brain injury by Bin Ren, Jifang Liang, Leifang Yang, Xiaocong Wei, Min Guo, Hong Li

“…Machine learning analysis highlighted AKR1C2, QDPR, CYP3A5, CNTF, and PNPT1 as key genes with diagnostic potential (AUC > 0.6). Functional analysis revealed significant involvement of these genes in immune processes and metabolic regulation. …”
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3D printed cacao-based formulations as nutrient carriers for immune system enhancement by Rachel L. Milliken, Aikaterini Dedeloudi, Emily Vong, Robyn Irwin, Sune K. Andersen, Matthew P. Wylie, Dimitrios A. Lamprou

“…LH at a 10% concentration emerged as the optimal formulation, demonstrating balanced structural properties and effective miscibility with VitD3.This study highlights how raw Greek honey produced without chemical miticides, has the potential to enhance the functionality and palatability of 3D-printed health supplements. …”
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Sex differences in the association between atherogenic index of plasma and progression from normoglycemia to prediabetes: evidence from a 5-year large-scale retrospective cohort st... by Chufu Yang, Qiying Chen, Weiyan Li, Chuang Gao, Yong Han, Jiaqian Zhu

“…The Cox proportional hazards regression model assessed the association between AIP and the risk of progression from normoglycemia to pre-DM, with restricted cubic splines functions used to assess non-linear relationships. …”
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Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population by Tasnova Tasnim, Mir Md Abdullah Al-Mamun, Noor Ahmed Nahid, Md Reazul Islam, Mohd Nazmul Hasan Apu, Most Umme Bushra, Sikder Nahidul Islam Rabbi, Zabun Nahar, Jakir Ahmed Chowdhury, Maizbha Uddin Ahmed, Mohammad Safiqul Islam, Abul Hasnat

“…Lung cancer is one of the most frequently occurring cancers throughout the world as well as in Bangladesh. This study aimed to correlate the prognostic and/or predictive value of functional polymorphisms in SULT1A1 (rs9282861) and XRCC1 (rs25487) genes and lung cancer risk in Bangladeshi population. …”
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Assessing the Antioxidant, Hepatoprotective, and Iron-Chelating Potential of <i>Perilla frutescens</i> Seed by Sirichatnach Pakdeepromma, Komsak Pintha, Payungsak Tantipaiboonwong, Chonthida Thephinlap, Maitree Suttajit, Sawaruj Kaowinn, Napapan Kangwan, Wanwisa Suwannaloet, Kanjana Pangjit

“…While current pharmaceutical drugs for iron chelation have limitations, the search for natural herbs with iron-chelating properties is crucial. This study aimed to explore the various biological functions of the <i>Perilla frutescens</i> seed, regarding antioxidant activity and hepatoprotective and iron-chelating properties. …”
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A Narrative Review in Hip Surgery: Key Findings from a Leading Orthopedic Journal in 2022–2023 by Nikolai Ramadanov, Maximilian Voss, Robert Prill, Jonathan Lettner, Aleksandra Królikowska, Krzysztof Korolczuk, Roland Becker

“…Background/Objectives: Orthopedic hip surgery has undergone advances driven by innovations in surgical techniques and improved patient care protocols. The aim was to synthesize and appraise all studies relevant to hip surgery published in Knee Surgery, Sports Traumatology, Arthroscopy (KSSTA) in 2022–2023. …”
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Predictive Modeling of soil salinity integrating remote sensing and soil variables: An ensembled deep learning approach by Sana Arshad, Jamil Hasan Kazmi, Endre Harsányi, Farheen Nazli, Waseem Hassan, Saima Shaikh, Main Al-Dalahmeh, Safwan Mohammed

“…From this perspective, the current research aimed to predict soil electrical conductivity (EC) from remote sensing and soil data using advanced deep learning (DL) architectures. …”
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Does the surgeon’s learning curve impact pentafecta outcomes in radical prostatectomy? a systematic review and meta-analysis by Jose Arnaldo Shiomi Da Cruz, Breno Cordeiro Porto, Bruno Damico Terada, Felipe Giraldo Alvarez Gonçalves, Soraya Hussein Orra, Juan Victor Nabhan Martinez, Carlo Camargo Passerotti, Rodrigo A. S. Sardenberg, Kenneth Nunes Tavares De Almeida, Everson Luiz De Almeida Artifon, Jose Pinhata Otoch

“…Our analysis suggests that reaching a threshold of 100 cases may be necessary to consistently attain optimal functional and perioperative results.…”
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The comparative analysis of the effectiveness of stimulation of liver regeneration by bone marrow cells and total RNA of these cells by Z. Z. Gonikova, A. O. Nikolskaya, L. A. Kirsanova, M. Yu. Shagidulin, N. A. Onishchenko, V. I. Sevastianov

“…Extensive liver resection (ELR), performed in a number of surgical operations, refers to a critical injury, which necessitates the improvement of methods of therapy of acute post-resection liver failure.Aim: to compare the effectiveness of stimulation of regenerative processes in the liver residue after ELR (60–70%) by intraperitoneal administration of lysed aspirate bone marrow cells (BMCs) and total RNA (tRNA) isolated from BMCs.Materials and methods. …”
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Correlation study of LINC02609 and SNHG17 as prognostic biomarkers of kidney renal clear cell carcinoma and therapeutic sensitivity based on public data and In Vitro analysis by Chaoqun Xing, Weiwei Zou, Yangqin Li, Ti Zhang, Fan Yao, Zhi-Yong Yao, Xiao-Liang Xing

“…The response to immunotherapy and the sensitivity to chemotherapy drugs were analyzed through the Tumor Immune Dysfunction and Exclusion (TIDE) database and the Genomics of Drug Sensitivity in Cancer2 (GDSC2) database. Functional validation of LINC02609 was conducted in renal carcinoma A498 cells using siRNA-mediated knockdown.ResultsLINC02609 and SNHG17 were significantly upregulated in KIRC tissues and independently associated with poor overall survival. …”
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Beyond inflammation: the molecular basis of bone remodeling in axial spondyloarthritis and psoriatic arthritis by Giuseppe Lopalco, Andrea Cito, Florenzo Iannone, Torsten Diekhoff, Denis Poddubnyy, Denis Poddubnyy, Fabian Proft

“…Axial spondyloarthritis (axSpA), a subset of SpA, predominantly involves the sacroiliac joints and spine, often progressing to ankylosis, severe disability, and functional impairment. Psoriatic arthritis (PsA), another SpA subtype, is characterized by a heterogeneous phenotype that includes peripheral arthritis, enthesitis, and axial involvement, frequently associated with psoriasis. …”
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Feedback of patient-reported outcomes to healthcare professionals for comparing health service performance: a scoping review by Dominique A Cadilhac, Shaun L Hancock, Olivia F Ryan, Violet Marion, Sharon Kramer, Paulette Kelly, Sibilah Breen

“…Objective Patient-reported outcomes (PROs) provide self-reported patient assessments of their quality of life, daily functioning, and symptom severity after experiencing an illness and having contact with the health system. …”
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Arsenic trioxide regulates DYNAP through hsa-mir-573 and inhibits the proliferation of laryngeal cancer by Yanru Ren, Xiao Yang, Yang Hui, Weiyao Chen, Yi Cheng, Ning Zhang, Tao Liu, Xinxin Yang, Xiaoyu Li

“…Arsenic trioxide (ATO), a drug well-known for treating acute promyelocytic leukemia, has shown potential antitumor effects in several solid tumors. This study aimed to investigate the role of ATO on LSCC proliferation and its underlying molecular mechanisms. …”
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Classification of management tools in small business organizations for developing a sales funnel by E. R. Tolstova, L. V. Silakova

“…The classification of programs and services that will automate the company’s sales funnel, taking into account the price of the product and its functionality, the combination of which will be optimal for small businesses, is proposed. …”
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The current status of nano-hydrogel preparations for osteochondral repair: Systematic Review by Abebe Feyissa Amhare, Abebe Feyissa Amhare, Lichun Qiao, Huan Deng, Jinyan Lin, Jun Wang, Wei Wang, Jing Han

“…Future work should focus on long-term validation, functional outcome measures, and development of smart, adaptive materials to support clinical translation.…”
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Single‐cell transcriptomic atlas of different endometriosis indicating that an interaction between endometriosis‐associated mesothelial cells (EAMCs) and ectopic stromal cells may... by Shengdi Hou, Jing Zhang, Zhiqiang Zhang, Hong Qu, Shuhong Li, Ying Jiang, Chongdong Liu

“…In this study, we employed single‐cell RNA sequencing (scRNA‐seq) to profile the transcriptome of each type using surgical biopsy samples obtained from six patients. We aimed to explore and elucidate the variations among these different types of endometriosis. …”
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