Purification, Structural Characterization, and Immunomodulatory Activity of an Exopolysaccharide from <i>Acetilactobacillus jinshanensis</i> BJ01 in <i>Baijiu</i> Fermentation Grai... by Tian Tian, Bo Wan, Ying Xiong, Han Wang, Yuanyuan An, Ruijie Gao, Pulin Liu, Mingchun Zhang, Lihong Miao, Weifang Liao

“…This study aims to identify the chemical structure and immunomodulatory activity of exopolysaccharides (EPSs) from <i>Acetilactobacillus jinshanensis</i> BJ01 and suggest its potential applications in the pharmaceutical field and as functional food additives. …”
Get full text

Association between polymorphisms of <i>IL33</i> and <i>IL37</i> and atopic dermatitis by O. A. Svitich, O. Yu. Olisova, M. B. Potapova, E. A. Meremianina, N. D. Rasskazova, E. A. Belokopytova, A. A. Solodkova, A. A. Murzina, I. B. Semenova, A. G. Upatova

“…The IL-1 family includes the recently discovered IL-33 and IL-37, and their role in the pathogenesis of AD has been actively studied. IL-33 functions as an alarmin that can induce IL-31 production, thereby leading to skin barrier impairment, pruritus and scratching. …”
Get full text

Exploring ENPP5 as a diagnostic biomarker for sepsis: a comprehensive bioinformatics analysis by Jiamin Gao, Yanjun Li, Jinping Huang, Cailing Wei, Jieling Chen, Aichun Huang, Ningmei Liu, Yibo Lu, Shixiong Yang

“…Abstract Background The rising mortality rates in sepsis highlight the current lack of reliable therapeutic biomarkers. This study aims to identify markers associated with biological functions to offer new strategies for sepsis diagnosis. …”
Get full text

Characterization and Specific Detection of <i>Lactobacillus paracasei</i>-Derived Extracellular Vesicles Using Anti-p40-Modified Au Thin Film by Kyeongmin Lee, Eun-Gyung Cho, Youngbo Choi, Yunsik Kim, Jin Hee Lee, Surin Hong

“…However, methods for specific detection and quantitative evaluation of Lp-EVs are still limited. This study aims to develop a surface plasmon resonance (SPR)-based sensor system for the precise and selective detection of Lp-EVs. …”
Get full text

Decreased Endothelin-1 bioavailability impairs aggressiveness of gallbladder cancer cells by Jetzabel Vidal-Vidal, David Brown-Brown, Nelson Quilaqueo-Millaqueo, Gaspar Peña-Münzenmayer, Carlos Spichiger, Claudia Quezada-Monrás, Flavio Salazar-Onfray, Julio C. Tapia, Ignacio Niechi

“…Treatment also decreased the expression of EMT and stemness markers CD44 and Vimentin. Functionally, rNEP reduced cell migration, invasion, and colony formation, while SM19712 affected migration and colony formation. …”
Get full text

Integrating artificial intelligence in community-based diabetes care programmes: enhancing inclusiveness, diversity, equity and accessibility a realist review protocol by Valeria E Rac, Joanna Bielecki, Samah Hassan, Sarah Ibrahim, Aleksandra Stanimirovic, Suja Mathew, Ryan Hooey, James Marshall Bowen

“…Synthesis will employ realist logic, analysing relationships between contexts (eg, organisational capacity), mechanisms (eg, AI functionalities) and outcomes (eg, reduced disparities).Ethics and dissemination Ethics approval is not required for conducting this realist review. …”
Get full text

Features of the cytokine profile in the structures of chorion and placenta in premature termination of pregnancy by A. A. Zhyvetska-Denysova, I. I. Vorobiova, N. Ya. Skrypchenko, V. B. Tkachenko

“…Inflammation plays a leading role in the development of preterm birth. Structural and functional changes in the placenta against the background of inflammation make up the morphological substrate of chronic placental dysfunction, which, in a case of decompensation, triggers the process of preterm birth. …”
Get full text

Integrating geographic information systems into veterinary education within the one health framework: an interdisciplinary approach by Antonio Contreras, Víctor Cuevas, Jorge Rivera-Gomis, Jorge Rivera-Gomis, Antonio Sánchez, Pelayo Acevedo, Joaquin Vicente

“…This gap limits the ability of veterinary students to effectively utilize spatial data in their future professional practice.MethodsTo address this educational shortfall, we implemented a teaching innovation project at the University of Murcia, aimed at incorporating GIS training into veterinary education. …”
Get full text

Change in mental health service utilization from pre- to post-COVID-19 period in the United States by Md Rezaul Kader, Mohammod Mahmudur Rahman, Piali Dey Bristi, Foyez Ahmmed

“…Objectives: This study aimed to explore the change in mental health service utilization before and after the COVID-19 pandemic as well as determine the association of various sociodemographic characteristics and comorbidities on the utilization pattern. …”
Get full text

Characterization and prognostic of CD8 + TIM3 + CD101 + T cells in glioblastoma multiforme by Hong-Liang Wang, Sai Li, Chun-Chun Ma, Xiang-Hu Zheng, Hao-Yuan Wu, Chen-Xi Chang, Zhi-Hao Yang, Jia-Wei Wang, Fa-Ming Pan, Bing Zhao

“…DEGs were identified, and cell trajectories were constructed using Seurat, Monocle 2, and CellChat packages. Functional enrichment analysis was conducted with clusterProfiler, and a prognostic model was developed. …”
Get full text

Evaluation of enhanced pain management programs for patients undergoing surgery for severe knee osteoarthritis: a retrospective study by Peng Liu, Jiabing Li, Weimin Liang, Xiao Yang, Jiang Hu, Chongxin Huang, Ji Zhou

“…Complication rates were lower in Group C (22.03%) compared to Group A (46.61%) and Group B (26.45%) (p < 0.05).Conclusion Optimized perioperative analgesic protocols are associated with improved pain control, enhanced functional recovery, and reduced complication rates in knee osteoarthritis surgery. …”
Get full text

Metastasis of Squamous Cell Carcinoma of the Larynx to the Right Adrenal Gland—A Case Report by Eliza Działach, Michał Simlot, Karolina Osowiecka, Elżbieta Nowara, Jarosław Markowski, Mateusz Grajek

“…Imaging studies provided detailed insights into the lesion’s size, metabolic activity, and non-functional status. Despite comprehensive efforts, the tumor was deemed unresectable, highlighting the aggressive nature of the disease and the limitations of current therapeutic modalities. …”
Get full text

The greener, the richer, the happier?——Spatial distribution and coupling analysis of urban green space and residents’ emotion based on social media data by Zexun Li, Lihui Hu, Alin Lin, Jiarui Chen, Yue Xu

“…And has introduced policies such as urban regeneration and low-carbon community construction, which are aimed at upgrading urban quality and improving the well-being of the people. …”
Get full text

Evaluation of Efficacy and Safety of Etanercept and Etanercept + Methotrexate Therapy in Patients with Juvenile Idiopathic Arthritis without Systemic Manifestations by T. M. Bzarova, Ye. I. Alekseeva, S. I. Valieva, R. V. Denisova, K. B. Isaeva, Ye. G. Chistyakova, A. M. Chomakhidze, T. V. Sleptsova, A. N. Fetisova, O. L. Lomakina, M. A. Soloshenko

“…As early as 1 month after the first etanercept injection, clinical and laboratory parameters of disease activity significantly decreased in 83 and 77% and functional ability of joints improved in 87 and 74% of patients treated with TNF- inhibitor and its combination with methotrexate. …”
Get full text

Comparisons of the QLICP-HN and FACT-H&N instruments for measuring quality of life in patients with head and neck cancer by Fan Shen, Fan Shen, Wenhua Chi, Xizi Yang, Gaofeng Li, Jianfeng Tan, Chonghua Wan

“…BackgroundTwo head and neck cancer quality-of-life(QoL) measurement tools, the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&amp;N) and the Quality of Life Instruments for Cancer Patients-Head and Neck Cancer (QLICP-HN), are widely used in China, but several researchers tend to be confused about which QoL measurement tool to choose before conducting QoL measurements. …”
Get full text

The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress by Kunbin Li, Liming Lu, Xianli Yao, Zhiyuan Wu, Pingge Sun, Xiaopeng Wen, Xiaoxing Li, Kai Wang, Xiran Yin

“…The upregulation of Nrf2, a primary orchestrator of the oxidative stress response, has beneficial effects in SCII. Here, we aimed to uncover a SCII-related transcription factor that is able to elevate Nrf2 expression. …”
Get full text

Value of the 6 min walk test in detecting cardiopulmonary involvement in patients with systemic sclerosis by Sytske Anne Bergstra, Oliver Distler, Cosimo Bruni, Jeska De Vries-Bouwstra, Tom WJ Huizinga, Suzana Jordan, Saad Ahmed, Jacopo Ciaffi, Maarten Ninaber, Sophie I E Liem, Eva M Hoekstra, A A Schouffoer, D Ueckert, Hubert Vliegen

“…The 6 min walk test (6MWT) is widely used to assess functional capacity, but its ability to detect incident CPI remains uncertain. …”
Get full text

Glycometabolism change during Burkholderia pseudomallei infection in RAW264.7 cells by proteomic analysis by Xuexia Li, Yingfei Zeng, Shengnan Guo, Chen Chen, Lin Liu, Qianfeng Xia

“…The interaction of B. pseudomallei with its host is complicated, and cellular response to B. pseudomallei infection is still largely unknown. In this study, we aimed to determine host-cell responses to B. pseudomallei at the proteomics level. …”
Get full text

Changes in the structure and properties of graphene oxide surfaces during reduction and modification by M. T. Kartel, K. V. Voitko, Y. Grebelna, S. V. Zhuravskyi, K. Ivanenko, T. V. Kulyk, S. M. Makhno, Yu. I. Sementsov

“… The aim of the current study was to find changes in the structure and state of the surface of graphene oxide (GO) under the conditions of its reduction and modification by hetero atoms of nitrogen and amino acids. …”
Get full text

Innovative integration of automated breast volume scan and ultrasound elastography for enhanced differentiation of benign and malignant breast lesions by Lamei Zhang, Yao Peng, Yang He, Zixian Wei, Ling Gan, Jiaqi Zhang

“…Furthermore, ultrasound elastography (UE) provides complementary functional information by assessing tissue stiffness, aiding in the differentiation between benign and malignant breast lesions. …”
Get full text