Efficacy and safety of Shenxiong-Xinmaikang Decoction in patients with stable angina pectoris: a real-world prospective observational study by Yanchen Dong, Yanchen Dong, Yanchen Dong, Kaojuan Zeng, Yongzhen Liang, Yongzhen Liang, Guoping Xie, Donghui Liang, Donghui Liang

“…However, robust clinical evidence supporting its efficacy and safety is lacking. This study aimed to evaluate the real-world effectiveness and safety of SXXMKD as an adjunct to standard therapy for SAP.MethodsThis was a prospective, single-center, real-world observational study conducted between 2019 and 2023, enrolling 219 SAP patients (Registry: ChiCTR2100052872). …”
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Detection of Myocardial Deformation Patterns and Prognostic Value of Routine Echocardiographic Parameters in Patients with Cardiac Sarcoidosis Versus Extracardiac Sarcoidosis: Syst... by Hritvik Jain, Maryam Shahzad, Muhammad Usman, Anil KC, Jagjot Singh, Jyoti Jain, Ramez M. Odat, Aman Goyal, Faizan Ahmed, Raheel Ahmed

“…Speckle-tracking echocardiography has emerged as a promising tool for detecting subclinical myocardial dysfunction, which is cost-efficient and readily available. This meta-analysis aims to evaluate differences in functional echocardiographic parameters between patients with CS and extracardiac sarcoidosis (ECS) to improve early recognition and management. …”
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Synthesis of nitrogen-purged biochar and modification with hydrothermal activation: comparative assessment as adsorbents for effective elimination of Pb(II) and Cd(II) from wastewa... by Madhumonti Saha, Pabitra Kumar Biswas, Jayanta Kumar Saha, Abhijit Sarkar, Sandip Mandal, Dinesh Kumar Yadav, Sangeeta Lenka, M. Vassanda Coumar, Biraj Bandhu Basak

“…SABC was more porous and amorphous in nature with higher specific surface area (SSA), but consisted relatively less polar surface functional groups than that of NPBC. The external layer of both NPBC and SABC were negatively charged (pH > pHPZC). …”
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High throughput multiplex immunoassays stratify patients according to symptom burden across the anti-Ro positive systemic autoimmune rheumatic disease spectrum by Sarah Dyball, Rudresh Shukla, Anastasia-Vasiliki Madenidou, Maya H. Buch, Ian N. Bruce, Ben Parker

“…Unsupervised hierarchical clustering of baseline NPX identified patient clusters. Functional protein association networks were visualized using String V.12.0. …”
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Prognostic value of temporalis muscle thickness as a marker of sarcopenia in intracerebral hemorrhage by Waldemar Gubarev, Jan Klinke, Ulrike Voßmann, Daniel Cantré, Bijan Zendeh Zartoshti, Artem Rafaelian, Milos Arsenovic, Daniel Dubinski, Sae-Yeon Won, Florian Gessler, Thomas Freiman, Alexander Storch, Matthias Wittstock

“…It has not been conclusively clarified whether sarcopenia is predictive for the functional outcome in ICH. Determining the temporalis muscle thickness (TMT) may be helpful for estimating sarcopenia. …”
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Ligilactobacillus salivarius regulating translocation of core bacteria to enrich mouse intrinsic microbiota of heart and liver in defense of heat stress by Jiajun Yang, Jiajun Yang, Peng Shang, Peng Shang, Zongliang Liu, Jing Wang, Bo Zhang, Hao Zhang

“…The aim of this study was to elucidate the intrinsic microbiota residing in the heart and liver, which was enriched with Ligilactobacillus salivarius supplementation and its roles in defending anti-oxidation of heat stress. …”
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ACTUAL PROBLEMS OF PROFESSIONAL AND PERSONAL DEVELOPMENT QUALIFIED PERSONS RESPONSIBLE FOR QUALITY OF MEDICINAL PRODUCTS FOR HUMAN USE by Zh. I. Aladysheva, N. V. Pyatigorskaya, V. V. Belyaev, N. S. Nikolenko, E. I. Nesterkina, S. A. Loseva

“…The aim of the study is to investigate topical problems of the professional and personal development of qualified persons responsible for quality of medicinal products for human use.Materials and methods. …”
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Cognitive behavioral therapy for ADHD predominantly inattentive presentation: randomized controlled trial of two psychological treatments by Elinor Eskilsson Strålin, Lisa B. Thorell, Tobias Lundgren, Sven Bölte, Sven Bölte, Sven Bölte, Benjamin Bohman

“…Self-reported scales were used to assess outcome measures of behavioral activation, procrastination, symptoms of ADHD, depression, quality of life and functional impairment. Data were analyzed for between and within-group effects using multilevel modeling.ResultsBetween-group analysis showed that participants in the CADDI group had significantly greater improvement on the primary outcome measure of activation at post assessment (p = .045, d = 0.49). …”
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Methodological quality of multivariate prognostic models for intracranial haemorrhages in intensive care units: a systematic review by Denis Frasca, Fanny Feuillet, Maxime Leger, Raphaël Cinotti, Yohann Foucher, Jeanne Simon-Pimmel, Laetitia Bodet-Contentin, Etienne Dantan

“…Prognostic tools help clinicians in counselling patients and relatives and guide therapeutic decisions. We aimed to methodologically assess prognostic tools for functional outcomes in severe spontaneous intracranial haemorrhages.Data sources Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations, we conducted a systematic review querying Medline, Embase, Web of Science, and the Cochrane in January 2020.Study selection We included development or validation of multivariate prognostic models for severe intracerebral or subarachnoid haemorrhage.Data extraction We evaluated the articles following the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies and Transparent Reporting of multivariable prediction model for Individual Prognosis Or Diagnosis statements to assess the tools’ methodological reporting.Results Of the 6149 references retrieved, we identified 85 articles eligible. …”
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The MinDag app for symptom monitoring and feedback to patients and clinicians during the initial treatment of bipolar disorder – a feasibility study by Margrethe Collier Høegh, Stine Holmstul Glastad, Siv Hege Lyngstad, Magnus Johan Engen, Sofie Ragnhild Aminoff, Ingrid Melle, Thomas Bjella, Trine Vik Lagerberg

“…Methods The MinDag app includes six content modules covering mood, sleep, functioning/activities, substance use, emotional reactivity, and psychotic symptoms. …”
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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

“…We assessed treatment response with Reveal Lite 2 scores (all patients had N-terminal-pro-brain natriuretic peptide, 6-minute walk, and functional class assessment at both visits) and followed clinical outcomes for 3 years. …”
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Survival impact and risk factors of skeletal muscle loss during first-line EGFR-TKIs therapy in advanced lung adenocarcinoma patients by Xin Nie, Mingzhu Zou, Chenhui Song, Ping Zhang, Di Ma, Di Cui, Gang Cheng, Lin Li

“…Targeted panel sequencing of tumor tissue was used to detect genetic alterations. Functional enrichment analysis of genes interacting with EGFR-TKIs and muscle loss was performed to elucidate the potential toxicological mechanisms. …”
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Barriers and facilitators to accessing healthcare services among elderly people living in a rural Amazonian community, Brazil by Gleica Soyan Barbosa Alves, Fernando José Herkrath, Rosana Cristina Pereira Parente, Rita Dariene da Silva Pinheiro, Mario Vianna Vettore

“…Older adults living in rural areas appear to face greater barriers to health care, particularly in areas of the Amazon region. The aim of this study was to examine the relationships between predisposing, enabling, and need characteristics, and utilisation of medical services among elderly people living in rural areas in Amazon region, Brazil. …”
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Biomimetic cancer cell membrane engineered lipid nanoparticles for enhanced chemotherapy of homologous malignant tumor by Fengtian Zhang, Weihong Luo, Zhongjie Min, Longping Wu, Ziyang Wang, Yufei Wang, Wenbin Liao, Yu Liu, Weiliang Chen, Lijuan Wen

“…A particularly noteworthy approach involves the use of various cell membranes, which can impart distinctive functionalities to the nanoparticles, including specific recognition of target cells, prolonged circulation within the bloodstream, and enhanced ability to evade the immune system, as surface coatings on nanoparticles. …”
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In silico studies to understand the interactions of flavonoid inhibitor with nsp12-RNA dependent RNA polymerase of SARS-CoV-2 and its homologs by Shamiya Anwar Kizhakkiniyakath, Tejaswini Choudhury, Madhan Vishal Rajan, Sagar Rathee, Basant Meena, Gururao Hariprasad

“…Aim: COVID 19 continues to be a major health concern. …”
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Chronic ankle instability: a meta-analysis and systematic review comparing clinical outcomes of anterior talofibular ligament repair with or without reinforcement of the lower exte... by Haoyang Liu, Hongxu Li, Mengran Shen, Yu Zhou, Bailiang Wang, Jinhui Ma

“…The funnel plots for AOFAS scores, talar tilt, and complications were symmetrical, indicating no publication bias or other biases in the studies.ConclusionsThe findings suggest that for patients with CAI, the Broström procedure with or without the Gould modification yields comparable postoperative functional outcomes. This has significant implications for the surgical management of CAI, potentially simplifying treatment protocols.Level of evidence: Level II, systematic review of Level II studies.…”
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Comprehensive bioinformatics analysis and experimental verification identify mitochondrial gene Dgat2 as a novel therapeutic biomarker for myocardial ischemia-reperfusion by Hong Li, Hong Li, Yixin Zhou, Wenya Xue, Pan Yin, Luyu Liu, Shaobo Wu, Yahao Zhao, Qi An, Yang Sun

“…Dgat2 was significantly elevated in ischemia-reperfusion mouse models, confirmed by RT-PCR and Western blot. Functional enrichment indicated that Dgat2 may be involved in biological oxidation and lipid metabolism. …”
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Tenosynovial giant cell tumours of the foot and ankle: a retrospective single centre experience with surgical treatment of 34 cases by Christian Scheele, Norbert Harrasser, Simone Beischl, Dietmar Dammerer, Ulrich Lenze, Carolin Knebel, Rüdiger von Eisenhart-Rothe, Florian Lenze

“…It’s important for orthopaedic surgeons to weigh surgical margins against functional results, as stable outcomes appear to be attainable even in cases of residual or recurrent tumours.…”
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Determination of a willingness-to-pay threshold and decision-making in financing the healthcare technologies by T. S. Teptsova, T. P. Bezdenezhnyh, V. K. Fedyaeva, N. Z Musina, G. R. Hachatryan, V. V. Tarasov

“…The aim was to develop a methodology for determining the willingness to pay threshold (WTPT) and its upper limit value within the Russian health care system.Materials and methods. …”
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The orchestrated feature of Cornus kousa fruit and gut microbiota against obesity via integrated pharmacology by Ki‐Kwang Oh, Sang‐Jun Yoon, Sang Youn Lee, Satya Priya Sharma, Sung‐Min Won, Jin‐Ju Jeong, Dong Joon Kim, Ki‐Tae Suk

“…Finally, molecular docking assay and density functional theory (DFT) were performed to validate its affinity. …”
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